David R Jones

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis
    Chadrick E Denlinger
    Department of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 78:1207-14; discussion 1207-14. 2004
  2. ncbi request reprint Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    K Robert Shen
    Division of Thoracic Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Chest 132:290S-305S. 2007
  3. pmc Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancer
    David R Jones
    Department of Surgery, University of Virginia, Charlottesville, VA, USA
    J Thorac Oncol 7:1683-90. 2012
  4. pmc Donor factors are associated with bronchiolitis obliterans syndrome after lung transplantation
    Sara A Hennessy
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 89:1555-62. 2010
  5. doi request reprint Combined proteasome and histone deacetylase inhibition attenuates epithelial-mesenchymal transition through E-cadherin in esophageal cancer cells
    Matthew D Taylor
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 139:1224-32, 1232.e1. 2010
  6. pmc Fluorodeoxyglucose positron emission tomography and tumor marker expression in non-small cell lung cancer
    Matthew D Taylor
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 137:43-8. 2009
  7. doi request reprint Tumor recurrence after complete resection for non-small cell lung cancer
    Matthew D Taylor
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 93:1813-20; discussion 1820-1. 2012
  8. pmc Correlations between selected tumor markers and fluorodeoxyglucose maximal standardized uptake values in esophageal cancer
    Matthew D Taylor
    Department of Surgery, University of Virginia, Charlottesville, VA, USA
    Eur J Cardiothorac Surg 35:699-705. 2009
  9. ncbi request reprint Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species
    Chadrick E Denlinger
    Department of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 128:740-8. 2004
  10. pmc Bronchiolitis obliterans syndrome occurs earlier in the post-lung allocation score era
    Abbas Emaminia
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 141:1278-82. 2011

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Proteasome inhibition sensitizes non-small-cell lung cancer to gemcitabine-induced apoptosis
    Chadrick E Denlinger
    Department of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 78:1207-14; discussion 1207-14. 2004
    ..We hypothesized that inhibition of NF-kappaB by using the proteasome inhibitor bortezomib (Velcade) would sensitize NSCLC to gemcitabine-induced apoptosis...
  2. ncbi request reprint Special treatment issues in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)
    K Robert Shen
    Division of Thoracic Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    Chest 132:290S-305S. 2007
    ..This includes patients with Pancoast tumors, T4N0,1M0 tumors, satellite nodules in the same lobe, synchronous and metachronous multiple primary lung cancers (MPLCs), solitary brain and adrenal metastases, and chest wall involvement...
  3. pmc Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancer
    David R Jones
    Department of Surgery, University of Virginia, Charlottesville, VA, USA
    J Thorac Oncol 7:1683-90. 2012
    ..On the basis of prior preclinical evaluations, we hypothesized that combined induction proteasome and histone deacetylase inhibitor therapy, followed by tumor resection, is feasible...
  4. pmc Donor factors are associated with bronchiolitis obliterans syndrome after lung transplantation
    Sara A Hennessy
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 89:1555-62. 2010
    ..Recipient and perioperative risk factors have been investigated in BOS, but less is known about donor factors. Therefore, we investigated what donor factors are important in the development of BOS...
  5. doi request reprint Combined proteasome and histone deacetylase inhibition attenuates epithelial-mesenchymal transition through E-cadherin in esophageal cancer cells
    Matthew D Taylor
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 139:1224-32, 1232.e1. 2010
    ..This study investigated effects of vorinostat (histone deacetylase inhibitor) and bortezomib (proteasome inhibitor) on esophageal cancer epithelial-mesenchymal transition...
  6. pmc Fluorodeoxyglucose positron emission tomography and tumor marker expression in non-small cell lung cancer
    Matthew D Taylor
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 137:43-8. 2009
    ..However, there are limited data correlating FDG-PET with tumor markers. The purpose of this study was to determine the correlation of tumor marker expression with FDG-PET maximal standardized uptake values in NSCLC...
  7. doi request reprint Tumor recurrence after complete resection for non-small cell lung cancer
    Matthew D Taylor
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 93:1813-20; discussion 1820-1. 2012
    ..The purpose of this study was to identify independent perioperative and pathologic variables that are associated with NSCLC recurrence after complete surgical resection...
  8. pmc Correlations between selected tumor markers and fluorodeoxyglucose maximal standardized uptake values in esophageal cancer
    Matthew D Taylor
    Department of Surgery, University of Virginia, Charlottesville, VA, USA
    Eur J Cardiothorac Surg 35:699-705. 2009
    ..The purpose of this study was to determine the correlation of tumor markers with FDG-PET SUVmax in esophageal cancer...
  9. ncbi request reprint Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species
    Chadrick E Denlinger
    Department of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 128:740-8. 2004
    ....
  10. pmc Bronchiolitis obliterans syndrome occurs earlier in the post-lung allocation score era
    Abbas Emaminia
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 141:1278-82. 2011
    ..The objective of this study was to evaluate the impact of LAS on the development of bronchiolitis obliterans syndrome as well as on overall 3-year and bronchiolitis obliterans syndrome-related survival...
  11. pmc Gender, race, and socioeconomic status affects outcomes after lung cancer resections in the United States
    Damien J LaPar
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 92:434-9. 2011
    ..We hypothesized that risk-adjusted outcomes for lung cancer resections would not be influenced by these factors...
  12. doi request reprint Pulmonary resections performed at hospitals with thoracic surgery residency programs have superior outcomes
    Castigliano M Bhamidipati
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 145:60-6, 67.e1-2; discussion 66-7. 2013
    ..We hypothesize that morbidity and mortality for these procedures are different between hospitals and that operations performed at TR teaching hospitals have superior results...
  13. pmc Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis
    Yuan Liu
    Department of Surgery, Box 800679, University of Virginia, Charlottesville, VA 22908 0679, USA
    Mol Cell Biol 26:8683-96. 2006
    ..Collectively, these results suggest that BRMS1 suppresses metastasis through its ability to function as a transcriptional corepressor of antiapoptotic genes regulated by NF-kappaB...
  14. doi request reprint Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cancers treated with stereotactic body radiation therapy (SBRT)
    Neal E Dunlap
    Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 140:583-9. 2010
    ..The purpose of this study was to compare the outcomes and local control rates of patients with peripheral T1 and T2 non-small-cell lung cancer treated with stereotactic body radiation therapy...
  15. doi request reprint Effects of induction immunosuppression regimen on acute rejection, bronchiolitis obliterans, and survival after lung transplantation
    Gorav Ailawadi
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 135:594-602. 2008
    ..We hypothesized that daclizumab results in less acute rejection and bronchiolitis obliterans and better survival than antithymocyte globulin...
  16. doi request reprint Does positron emission tomography prevent nontherapeutic pulmonary resections for clinical stage IA lung cancer?
    Benjamin D Kozower
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 85:1166-9; discussion 1169-70. 2008
    ..This study evaluates whether PET prevents nontherapeutic pulmonary resections in clinical stage IA patients by finding advanced disease or by declaring a nodule as benign...
  17. pmc BRMS1 transcriptional repression correlates with CpG island methylation and advanced pathological stage in non-small cell lung cancer
    Alykhan S Nagji
    Department of Surgery, University of Virginia, Charlottesville, VA, USA
    J Pathol 221:229-37. 2010
    ....
  18. ncbi request reprint Clinical experience with radiotracer-guided thoracoscopic biopsy of small, indeterminate lung nodules
    Brendon M Stiles
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 82:1191-6; discussion 1196-7. 2006
    ..This report describes our series of the first 46 patients evaluated with this technique...
  19. pmc Seasonal variation influences outcomes following lung cancer resections
    Damien J LaPar
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA
    Eur J Cardiothorac Surg 40:83-90. 2011
    ..We hypothesized that postoperative outcomes following surgical resection for lung cancer within the United States would not be impacted by operative season...
  20. doi request reprint Identification of small lung nodules: technique of radiotracer-guided thoracoscopic biopsy
    Eric L Grogan
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Ann Thorac Surg 85:S772-7. 2008
    ..This study describes a thoracoscopic technique to reliably locate and excise lung nodules that were not thought to be thoracoscopically visible or instrumentally palpable...
  21. doi request reprint Differences in reported esophageal cancer resection outcomes between national clinical and administrative databases
    Damien J LaPar
    Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 144:1152-7. 2012
    ..The purpose of the present study was to determine whether the GTSD esophagectomy outcomes are representative of nationwide outcomes by comparing them with other national clinical and administrative databases...
  22. pmc BRMS1 suppresses lung cancer metastases through an E3 ligase function on histone acetyltransferase p300
    Yuan Liu
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    Cancer Res 73:1308-17. 2013
    ....
  23. doi request reprint Special treatment issues in non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
    Benjamin D Kozower
    Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA
    Chest 143:e369S-99S. 2013
    ....
  24. pmc Geographic distance between donor and recipient does not influence outcomes after lung transplantation
    Sara A Hennessy
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 92:1847-53. 2011
    ..Expanding the donor pool would be beneficial. We investigated the importance of geographic distance between the donor and recipient and hypothesized that it would not be a critical determinant of outcomes after lung transplantation...
  25. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo
    Chadrick E Denlinger
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 130:1422-9. 2005
    ..We hypothesize that inhibition of phosphatidylinositol 3-kinase/Akt will sensitize non-small cell lung cancer cells to histone deacetylase inhibitor-induced apoptosis...
  26. pmc Donor age is associated with chronic allograft vasculopathy after adult heart transplantation: implications for donor allocation
    Alykhan S Nagji
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 90:168-75. 2010
    ..Although recipient factors have been implicated, little is known of the role of donor factors in CAV development. We sought to identify donor factors associated with development of CAV after heart transplantation...
  27. ncbi request reprint Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer
    Chadrick E Denlinger
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Thorac Cardiovasc Surg 127:1078-86. 2004
    ..We hypothesize that nuclear factor kappa B inhibition with the proteasome inhibitor bortezomib (formerly known as PS-341) will sensitize non-small cell lung cancer cells to histone deacetylase inhibitor-mediated apoptosis...
  28. ncbi request reprint Obesity does not increase complications after anatomic resection for non-small cell lung cancer
    Philip W Smith
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 84:1098-105; discussion 1105-6. 2007
    ..The effect of obesity on complications after resection for lung cancer is unknown. We hypothesized that obesity is associated with increased complications after anatomic resections for non-small cell lung cancer...
  29. ncbi request reprint Does FDG-PET add information to EUS and CT in the initial management of esophageal cancer? A prospective single center study
    Patrick B McDonough
    Department of Gastroenterology, University of Virginia, Charlottesville, Virginia, USA
    Am J Gastroenterol 103:570-4. 2008
    ..This prospective blinded study analyzes the utility of FDG-PET as an adjunct to EUS and CT for the management of patients with esophageal cancer...
  30. ncbi request reprint Stage IB nonsmall cell lung cancers: are they all the same?
    David R Jones
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Ann Thorac Surg 81:1958-62; discussion 1962. 2006
    ..Given the heterogeneity of the T2 classification, we hypothesize that there are survival differences in patients with stage IB NSCLC based on specific histopathologic tumor characteristics...
  31. pmc Multigene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer
    Alykhan S Nagji
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Mol Cancer Ther 9:2834-43. 2010
    ..Use of this refined COXEN method has significant implications for the a priori examination of targeted therapies to more effectively streamline subsequent clinical trial design and cost...
  32. doi request reprint Radiotracer-guided thoracoscopic resection is a cost-effective technique for the evaluation of subcentimeter pulmonary nodules
    Eric L Grogan
    Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Ann Thorac Surg 86:934-40; discussion 934-40. 2008
    ..Decision analysis, used to model cost and effectiveness, is useful to compare treatment options. We hypothesize that RGTR strategy is more cost-effective compared with thoracotomy for subcentimeter pulmonary nodules...
  33. doi request reprint Induction chemoradiotherapy and surgery for esophageal cancer: survival benefit with downstaging
    Matthew D Taylor
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 96:225-30: discussion 230-1. 2013
    ..The purpose of this study was to evaluate the comparative effectiveness of induction chemoradiation therapy on perioperative and postoperative outcomes as well as the effect of downstaging in patients with esophageal cancer...
  34. doi request reprint Transplant pneumonectomy in a patient with an acutely thrombosed allograft
    Sara A Hennessy
    Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 89:975-7. 2010
    ..She required an allograft pneumonectomy as treatment for this and was eventually discharged on bi-level nasal positive pressure at night and 3 L nasal cannula oxygen during the day...
  35. doi request reprint Does reperfusion injury still cause significant mortality after lung transplantation?
    Gorav Ailawadi
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 137:688-94. 2009
    ..The purpose of this investigation was to identify whether our improved 1-year survival after lung transplantation is related to a change in reperfusion injury...
  36. pmc Primary payer status affects mortality for major surgical operations
    Damien J LaPar
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908 0679, USA
    Ann Surg 252:544-50; discussion 550-1. 2010
    ..Medicaid and Uninsured populations are a significant focus of current healthcare reform. We hypothesized that outcomes following major surgical operations in the United States is dependent on primary payer status...
  37. doi request reprint STS database risk models: predictors of mortality and major morbidity for lung cancer resection
    Benjamin D Kozower
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 90:875-81; discussion 881-3. 2010
    ..The aim of this study is to create models for perioperative risk of lung cancer resection using the STS GTDB (Society of Thoracic Surgeons General Thoracic Database)...
  38. pmc Characterization of novel synthesized small molecular compounds against non-small cell lung cancer
    Yunge Zhao
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 92:1031-7. 2011
    ..Therefore it is highly desirable to develop innovative therapeutic agents for NSCLC treatment...
  39. doi request reprint Hospital procedure volume should not be used as a measure of surgical quality
    Damien J LaPar
    Departments of Surgery and Public Health Sciences, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Ann Surg 256:606-15. 2012
    ..However, controversy exists regarding the strength and validity of the evidence for the volume-outcome association. The purpose of this study was to reevaluate the volume-outcome relationship for these procedures...
  40. doi request reprint The Society of Thoracic Surgeons General Thoracic Surgery Database: establishing generalizability to national lung cancer resection outcomes
    Damien J LaPar
    Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 94:216-21; discussion 221. 2012
    ..The purpose of this study was to establish the generalizability of the GTDB by comparing lung cancer resection results with those of the Nationwide Inpatient Sample (NIS), the largest all-payer inpatient database in the United States...
  41. doi request reprint Phase I trial of intrapleural docetaxel administered through an implantable catheter in subjects with a malignant pleural effusion
    David R Jones
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    J Thorac Oncol 5:75-81. 2010
    ..This dose escalation phase I study was designed to determine the maximum tolerated dose of intrapleural docetaxel administered through an implantable catheter in subjects with MPE...
  42. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
    ....
  43. doi request reprint Rosai-Dorfman disease presenting as a pulmonary artery mass
    Dustin M Walters
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 89:300-2. 2010
    ..We present a case of Rosai-Dorfman disease affecting the pulmonary arteries in a 22-year-old woman with severe, symptomatic right heart failure...
  44. doi request reprint Reproducibility of interfraction lung motion probability distribution function using dynamic MRI: statistical analysis
    Jing Cai
    Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA
    Int J Radiat Oncol Biol Phys 72:1228-35. 2008
    ..To investigate the statistical reproducibility of craniocaudal probability distribution function (PDF) of interfraction lung motion using dynamic magnetic resonance imaging...
  45. ncbi request reprint Novel targeted therapies for non-small cell lung cancer
    Philip W Smith
    University of Virginia, School of Medicine, P O Box 800679, Lee Street, Charlottesville, VA 22908 0679, USA
    Thorac Surg Clin 16:353-66. 2006
    ..Advances in targeted therapy in NSCLC are already yielding exciting results, and promises to become an increasingly important adjunct to surgical management of NSCLC...
  46. pmc Predicted risk of mortality models: surgeons need to understand limitations of the University HealthSystem Consortium models
    Benjamin D Kozower
    Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA
    J Am Coll Surg 209:551-6. 2009
    ....
  47. ncbi request reprint Lung transplantation in patients 60 years and older: results, complications, and outcomes
    Philip W Smith
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 82:1835-41; discussion 1841. 2006
    ..Advanced recipient age is reported to negatively affect survival after lung transplantation (LTX). We hypothesized that LTX in patients aged > or = 60 years could be performed with acceptable outcomes...
  48. doi request reprint The impact of the lung allocation score on short-term transplantation outcomes: a multicenter study
    Benjamin D Kozower
    Department of Surgery, University of Virginia Health System, Charlottesville 22908 0679, USA
    J Thorac Cardiovasc Surg 135:166-71. 2008
    ..The purpose of this study was to evaluate the impact of the lung allocation score on short-term outcomes after lung transplantation...
  49. pmc Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription
    David F Allison
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 109:16888-93. 2012
    ..Our work provides evidence for a unique regulation where attachment of the O-GlcNAc moiety to RelA potentiates p300 acetylation and NF-κB transcription...
  50. pmc S-nitrosoglutathione reductase in human lung cancer
    Nadzeya V Marozkina
    Department of Pediatric Respiratory Medicine, University of Virginia, Charlottesville, 22908 0386, USA
    Am J Respir Cell Mol Biol 46:63-70. 2012
    ..This potential should be considered when developing therapies that inhibit pulmonary GSNO reductase to treat asthma and other conditions...
  51. ncbi request reprint Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65
    Yuan Liu
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:31359-68. 2006
    ....
  52. pmc Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation
    Yunge Zhao
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Physiol Lung Cell Mol Physiol 300:L718-29. 2011
    ..These results suggest that tPA could serve as an important therapeutic target for the prevention and treatment of acute IR injury after lung transplantation...
  53. ncbi request reprint Endoscopic ultrasound-guided fine needle aspiration of a malignant pleural effusion to diagnose and stage lung cancer: when should this approach be considered?
    Vanessa M Shami
    Department of Medicine, Division of Gastroenterology, University of Virginia Health Sciences, Charlottesville, VA 22908, USA
    Dig Dis Sci 53:757-9. 2008
  54. doi request reprint Influence of hemodialysis on clinical outcomes after lung transplantation
    Sara A Hennessy
    Department of Surgery, University of Virginia, Charlottesville, VA 22908 0679, USA
    J Surg Res 183:916-21. 2013
    ..We hypothesized that hemodialysis (HD)-dependent AKI after lung transplantation is associated with significant mortality...
  55. pmc A diagnostic consideration for all ages: pseudoachalasia in a 22-year-old male
    Matthew L Stone
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 93:e11-2. 2012
    ..This unfortunate presentation reinforces the importance of a careful preoperative workup for dysphagia irrespective of age...
  56. ncbi request reprint Economic assessment of the general thoracic surgery outpatient service
    David R Jones
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 82:1068-71. 2006
    ..Program requests for future resource allocations depend, in part, on that information. The purpose of this project was to determine the ROI for initial outpatient visits only for our General Thoracic Surgery (GTS) program...
  57. doi request reprint VATS lobectomy is better than open thoracotomy: what is the evidence for short-term outcomes?
    Eric L Grogan
    Division of Thoracic and Cardiovascular Surgery, University of Virginia, P O Box 800679, Charlottesville, VA 22908 0679, USA
    Thorac Surg Clin 18:249-58. 2008
    ..More data are needed to better show an improvement in the economic efficacy, ability to more effectively administer adjuvant therapies, and benefit of robotic assistance in VATS lobectomy...
  58. ncbi request reprint Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway
    Marty W Mayo
    Department of Surgery, The University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:18980-9. 2003
    ..Our study indicates that the ineffectiveness of HDAC inhibitors to induce apoptosis in NSCLC cancer cells is associated with the ability of these molecules to stimulate NF-kappa B-dependent transcription and cell survival...
  59. doi request reprint A thoracic surgeon-directed tobacco cessation intervention
    Benjamin D Kozower
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 89:926-30; discussion 930. 2010
    ..The purpose of this study was to prospectively evaluate a brief tobacco cessation intervention offered by surgeons in an outpatient thoracic surgery clinic...
  60. doi request reprint Preoperative embolization of Castleman's disease using microspheres
    Warren Swee
    Department of Radiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 88:1999-2001. 2009
    ..Compared with the literature, a decrease in the amount of perioperative bleeding was noted in both cases...
  61. doi request reprint Intraoperative factors and the risk of respiratory complications after pneumonectomy
    Randal S Blank
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, USA
    Ann Thorac Surg 92:1188-94. 2011
    ..The potential effect of intraoperative factors on respiratory complications after pneumonectomy is still unclear...
  62. ncbi request reprint Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation
    David R Jones
    Department of Surgery, The University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 123:310-7. 2002
    ....
  63. ncbi request reprint PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    Marty W Mayo
    Department of Biochemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11116-25. 2002
    ..Maintenance of the PTEN tumor suppressor protein is therefore required to modulate Akt activity and to concomitantly control the transcriptional activity of the anti-apoptotic transcription factor NF-kappaB...
  64. doi request reprint The legends behind cardiothoracic surgical instruments
    Gorav Ailawadi
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 89:1693-700. 2010
    ..In this report, we highlight common surgical instruments used in cardiac and thoracic operations, and we provide a brief historical glimpse of the surgeons whose names are attached to these instruments...
  65. ncbi request reprint Dose as a function of lung volume and planned treatment volume in helical tomotherapy intensity-modulated radiation therapy-based stereotactic body radiation therapy for small lung tumors
    Joseph M Baisden
    Department of Radiation Oncology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Int J Radiat Oncol Biol Phys 68:1229-37. 2007
    ..The Radiation Therapy Oncology Group (RTOG) 0236 protocol is currently evaluating three-dimensional conformal SBRT that delivers 60 Gy in three fractions...
  66. ncbi request reprint EUS-FNA as the initial diagnostic modality in centrally located primary lung cancers
    Alfredo Hernandez
    Digestive Health Center of Excellence, Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    J Clin Gastroenterol 41:657-60. 2007
    ..A small amount of data exists on the use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) as the initial diagnostic modality of primary lung cancer...
  67. ncbi request reprint Quality of life following primary vs. redo transthoracic paraesophageal hernia repairs
    Matthew D Taylor
    Department of Surgery, University of Virginia, Box 800679, Charlottesville, VA 22908 0679, USA
    Interact Cardiovasc Thorac Surg 7:71-4. 2008
    ..These differences, while statistically significant, have limited clinical relevance as the overall QOL was not different between groups and low GERD symptom scores were found in both groups...
  68. ncbi request reprint Pulmonary segmentectomy: results and complications
    David R Jones
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 76:343-8; discussion 348-9. 2003
    ..Segmentectomy is an anatomic pulmonary parenchymal-sparing resection performed for certain benign lesions and on selected patients with lung cancer. We reviewed our experience with segmentectomy in this highly select group of patients...
  69. doi request reprint Helical tomotherapy-based STAT stereotactic body radiation therapy: Dosimetric evaluation for a real-time SBRT treatment planning and delivery program
    Neal Dunlap
    Department of Radiation Oncology, University of Virginia, Charlottesville, 22908, USA
    Med Dosim 35:312-9. 2010
    ....
  70. doi request reprint Genetic markers of mediastinal tumors
    Matthew D Taylor
    Department of Surgery, University of Virginia, Box 801359, Charlottesville, VA 22908, USA
    Thorac Surg Clin 19:17-27. 2009
    ..Despite the progress made in the understanding of genetic markers of select mediastinal tumors, significantly more investigation is required to elucidate the molecular pathways involved in the pathogenesis of these tumors...
  71. pmc Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells
    Khalequz Zaman
    Department of Pediatrics, University of Virginia Health System, P O Box 800386, Charlottesville, VA 22908, USA
    Am J Respir Cell Mol Biol 34:387-93. 2006
    ..However, GSNO at concentrations>5microM suppresses 5-LO expression. These data suggest that GSNO might inhibit 5-LO expression in the clinical setting...
  72. ncbi request reprint A novel technique for localization and excisional biopsy of small or ill-defined pulmonary lesions
    Thomas M Daniel
    Department of Surgery, University of Virginia Health System, Charlottesville, 22908 0679, USA
    Ann Thorac Surg 77:1756-62; discussion 1762. 2004
    ..The purpose of this study was to develop and evaluate radiotracer-guided localization of small or ill-defined pulmonary nodules for thoracoscopic excisional biopsy...
  73. ncbi request reprint Laparoscopic gastric bypass complicated by gastric pouch necrosis: considerations in gastroesophageal reconstruction
    Brian K Rundall
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0679, USA
    J Gastrointest Surg 9:938-40. 2005
    ..We present a case in which the colon was found to be unacceptable for use in reconstruction; the remaining stomach was used as the conduit for a transhiatal reconstruction of gastrointestinal continuity instead...
  74. ncbi request reprint Coronary risk stratification in patients with end-stage lung disease
    Aditya K Kaza
    Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia 22908 1359, USA
    J Heart Lung Transplant 21:334-9. 2002
    ..We hypothesize that coronary risk stratification can help identify a sub-set of patients who need additional diagnostic tools and intervention...
  75. ncbi request reprint Invited commentary
    David R Jones
    Thoracic and Cardiovascular Surgery, University of Virginia, Lee St, 4th Floor, Suite 4823, Charlottesville, VA 22908 0679, USA
    Ann Thorac Surg 82:2023. 2006
  76. doi request reprint A positive return on investment: research funding by the Thoracic Surgery Foundation for Research and Education (TSFRE)
    David R Jones
    Department of Surgery at the University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 141:1103-6. 2011
    ..The purpose of this article is to determine how effective the TSFRE has been in achieving these goals...
  77. ncbi request reprint Esophageal leiomyosarcoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration
    Edward B Stelow
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Diagn Cytopathol 35:167-70. 2007
    ..To the best of our knowledge, this represents the first reported case of an esophageal leiomyosarcoma diagnosed by EUS-FNA. Clinical, imaging, and cytologic features as well as differential diagnosis are discussed...
  78. ncbi request reprint Combined bronchial sleeve resection and repair of partial anomalous pulmonary venous return
    Robert L Smith
    University of Virginia School of Medicine, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 132:982-3. 2006
  79. ncbi request reprint High dose melphalan in the treatment of advanced neuroblastoma: results of a randomised trial (ENSG-1) by the European Neuroblastoma Study Group
    Jon Pritchard
    Department of Surgery, Institute of Child Health, London, United Kingdom
    Pediatr Blood Cancer 44:348-57. 2005
    ..High dose myeloablative chemotherapy ("megatherapy"), with haematopoietic stem cell support, is now widely used to consolidate response to induction chemotherapy in patients with advanced neuroblastoma...
  80. ncbi request reprint Combined histone deacetylase and NF-kappaB inhibition sensitizes non-small cell lung cancer to cell death
    Brian K Rundall
    Department of Surgery, University of Virginia School of Medicine Charlottesville, VA 22908 0679, USA
    Surgery 136:416-25. 2004
    ..We hypothesize that inhibition of NF-kappaB using BAY-11-7085 will sensitize NSCLC cells to death, induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)...
  81. ncbi request reprint Modulation of antiapoptotic cell signaling pathways in non-small cell lung cancer: the role of NF-kappaB
    Chadrick E Denlinger
    Department of Surgery, University of Virginia School of Medicine Charlottesville, VA, USA
    Semin Thorac Cardiovasc Surg 16:28-39. 2004
    ..Modulation of the antiapoptotic cascade mediated by NF-kappaB, combined with either traditional or novel chemotherapeutic agents, represents a promising treatment strategy for patients with NSCLC...
  82. ncbi request reprint Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer
    Brian K Rundall
    Department of Surgery, University of Virginia School of Medicine, Charlottesville 22908 0679, USA
    Surgery 138:360-7. 2005
    ..HDIs also promote chromatin remodeling, potentially making the DNA more accessible to chemotherapy. We hypothesize that combined SAHA and gemcitabine sensitizes NSCLC to apoptosis...
  83. ncbi request reprint Providing more up-to-date estimates of patient survival: a comparison of standard survival analysis with period analysis using life-table methods and proportional hazards models
    Lucy K Smith
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester, LE1 6TP, UK
    J Clin Epidemiol 57:14-20. 2004
    ..We use statistical models to further develop the method of period analysis, providing more up-to-date estimates of survival and the ability to explore differences in survival by covariates and adjust for case mix...
  84. ncbi request reprint The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
    Or Gozani
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 114:99-111. 2003
    ..Together, our data identify the PHD finger as a phosphoinositide binding module and a nuclear PtdInsP receptor, and suggest that PHD-phosphoinositide interactions directly regulate nuclear responses to DNA damage...
  85. ncbi request reprint Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial
    Mark S Allen
    Ann Thorac Surg 81:1013-9; discussion 1019-20. 2006
    ..Little prospective, multiinstitutional data exist regarding the morbidity and mortality after major pulmonary resections for lung cancer or whether a mediastinal lymph node dissection increases morbidity and mortality...
  86. ncbi request reprint Ischemia-reperfusion injury after lung transplantation increases risk of late bronchiolitis obliterans syndrome
    Steven M Fiser
    Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Ann Thorac Surg 73:1041-7; discussion 1047-8. 2002
    ..Our hypothesis was that early ischemia-reperfusion injury after lung transplantation increases the risk of BOS...
  87. ncbi request reprint Association between nonalcoholic hepatic steatosis and hepatic cytochrome P-450 3A activity
    Dhanashri Kolwankar
    Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Clin Gastroenterol Hepatol 5:388-93. 2007
    ..There is significant interindividual variability in CYP3A expression. However, human studies that systematically examined the relationship between hepatic steatosis and hepatic CYP3A activity are lacking...
  88. ncbi request reprint Lung cancer. Special treatment issues
    Frank C Detterbeck
    Multidisciplinary Thoracic Oncology Program, Division of Cardiothoracic Surgery, University of North Carolina, CB 7605, 108 Burnett Womack Building, Chapel Hill, NC 27599 7065, USA
    Chest 123:244S-258S. 2003
    ..Finally, some patients with a solitary focus of metastatic disease in the brain or adrenal gland appear to benefit substantially from resection...
  89. ncbi request reprint A Bayesian approach to evaluating net clinical benefit allowed for parameter uncertainty
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
    J Clin Epidemiol 58:26-40. 2005
    ..The potential benefits and harms of a treatment policy may differ between individuals. If these benefits and harms are not evaluated distinctly, and in a quantitative framework, transparency can be lost in the decision-making process...
  90. ncbi request reprint Factors affecting uptake of childhood immunisation: a Bayesian synthesis of qualitative and quantitative evidence
    Karen A Roberts
    Epidemiology and Public Health, University of Leicester, Leicester, UK
    Lancet 360:1596-9. 2002
    ..Further development of our methods might enable rigorous synthesis of qualitative and quantitative evidence in this and other contexts...
  91. ncbi request reprint The role of sleep-disordered breathing, daytime sleepiness, and impaired performance in motor vehicle crashes-a case control study
    Ruth N Kingshott
    Department of Respiratory Research, University of Otago, Dunedin, New Zealand
    Sleep Breath 8:61-72. 2004
    ..To examine levels of sleep-disordered breathing, daytime sleepiness, and impaired performance in 60 motor vehicle crash drivers and 60 controls matched for age, gender, and body mass index...
  92. ncbi request reprint Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes
    J Andrew Williams
    Department of Drug Disposition, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Drug Metab Dispos 30:1266-73. 2002
    ..This study demonstrates that the interactions of substrates and inhibitors at the active site of UGT1A1 are complex, yielding both activation and competitive inhibition kinetics...
  93. ncbi request reprint The efficacy of a novel tongue-stabilizing device on polysomnographic variables in sleep-disordered breathing: a pilot study
    Ruth N Kingshott
    Respiratory Research Unit, Dunedin School of Medicine, New Zealand
    Sleep Breath 6:69-76. 2002
    ..Additional larger prospective studies are required to identify suitable candidates for TSD use in the treatment of snoring and SDB...
  94. ncbi request reprint T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation
    Miguel A Sanjuan
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Campus de Cantoblanco, Madrid, Spain
    J Immunol 170:2877-83. 2003
    ..This study is the first demonstration of in vivo regulation of DGK alpha, and provides new insight into the functional role of a member of this family of lipid kinases in the regulation of the immune response...
  95. ncbi request reprint Mechanism-based inactivation of CYP3A by HIV protease inhibitors
    C Steven Ernest
    Division of Clinical Pharmacology, Wishard Memorial Hospital, 1001 W 10th St, WD Myers Bldg, W7123, Indianapolis, IN 46202, USA
    J Pharmacol Exp Ther 312:583-91. 2005
    ..In conclusion, all the PIs exhibited mechanism-based inactivation, and predictions of the extent and time course of drug interactions with PIs could be underestimated if based solely on reversible inhibition...
  96. doi request reprint Relative survival: what can cardiovascular disease learn from cancer?
    Christopher P Nelson
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 2nd Floor, Adrian Building, University Road, Leicester LE1 7RH, UK
    Eur Heart J 29:941-7. 2008
    ..Relative survival, the ratio of the observed and the expected survival rates, is applied routinely in cancer studies and may improve on current methods for assessment of survival in CHD...
  97. doi request reprint Cell culture conditions potentiate differences in the response to ionising radiation of peripheral blood leukocytes isolated from breast cancer patients and healthy subjects
    Miroslav Adzic
    Vinca Institute of Nuclear Sciences, Belgrade, Serbia
    Redox Rep 13:17-22. 2008
    ..The data presented in this current study indicate that brief ex vivo culture of peripheral blood leukocytes potentiates oxidative stress imposed by a breast cancer tumour...
  98. pmc Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation
    Carlo Serra
    The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037 1062, USA
    Mol Cell 28:200-13. 2007
    ....
  99. ncbi request reprint Computational approaches that predict metabolic intermediate complex formation with CYP3A4 (+b5)
    David R Jones
    Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Wishard Memorial Hospital, Myers Bldg W7123, Indianapolis, IN 46220, USA
    Drug Metab Dispos 35:1466-75. 2007
    ..The preliminary pharmacophores provide structural insights that complement those for CYP3A4 inhibitors and substrates...
  100. ncbi request reprint The effect of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis
    Ivona Baricević
    Institute for the Application of Nuclear Energy INEP, University of Belgrade, Belgrade, Serbia
    Clin Endocrinol (Oxf) 65:373-9. 2006
    ..We sought to determine the impact of laparoscopy on the IGF system in patients diagnosed with acute cholecystitis...
  101. ncbi request reprint Could cholesterol bound to haemoglobin be a missing link for the occasional inverse relationship between superoxide dismutase and glutathione peroxidase activities?
    Milan Nikolic
    Department of Chemistry, University of Belgrade, Studentski trg 16, 11001 Belgrade, Serbia and Montenegro
    Biochem Biophys Res Commun 348:265-70. 2006
    ..We propose that cholesterol could affect membrane lipid peroxidation and superoxide generation in erythrocytes via the recently found fraction of cholesterol bound to haemoglobin, termed haemoglobin-cholesterol...