Genomes and Genes
Affiliation: University of Iowa
- Fungal pathogen recognition by the NLRP3 inflammasomeSophie Joly
Inflammation Program, University of Iowa, Iowa City, IA, USA
Virulence 1:276-80. 2010..Here we will review these findings and discuss the role of the NLRP3 inflammasome in initiating an innate immune response to invasive C. albicans...
- Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicansSophie Joly
Inflammation Program, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
J Immunol 189:4713-7. 2012..albicans. However, Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection...
- Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasomeSophie Joly
Division of Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
J Immunol 183:3578-81. 2009..Nlrp3-deficient mice also demonstrated increased susceptibility to infection with C. albicans, which is consistent with a key role for Nlrp3 in innate immune responses to the pathogen C. albicans...
- Carriage frequency, intensity of carriage, and strains of oral yeast species vary in the progression to oral candidiasis in human immunodeficiency virus-positive individualsKaaren G Vargas
College of Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
J Clin Microbiol 40:341-50. 2002..These results suggest that commensal strains colonizing HIV-positive individuals can undergo alterations prior to producing an episode of thrush...
- Racial distribution of Candida dubliniensis colonization among South AfricansElaine Blignaut
Department of Biological Sciences and College of Dentistry, University of Iowa, Iowa City, Iowa 52242, USA
J Clin Microbiol 41:1838-42. 2003..albicans. These results suggest that in South Africa, C. dubliniensis carriage is influenced more by race than by HIV infection status...
- The NLRP3 inflammasome: a sensor of immune danger signalsSUZANNE L CASSEL
Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
Semin Immunol 21:194-8. 2009..One of the best-studied members of the NLR family is NLRP3 for which a number of divergent activators have recently been described. These and other studies examining the NLRP3 inflammasome will be discussed in this review...
- Candida albicans switch phenotypes display differential levels of fitnessKeeren Vargas
The University of Iowa, College of Dentistry, Iowa City, IA 52242, USA
Med Sci Monit 10:BR198-206. 2004..It was therefore, the purpose of this study to assess the variability among C. albicans switch phenotypes isolated from a single strain...
- Microevolutionary changes and chromosomal translocations are more frequent at RPS loci in Candida dubliniensis than in Candida albicansSophie Joly
Department of Biological Sciences, Room 440, University of Iowa, Iowa City, IA 52242, USA
Infect Genet Evol 2:19-37. 2002..dubliniensis strains, but not in C. albicans strains, suggesting that RPS clusters may function as recombination hot spots in C. dubliniensis...
- Ca3 fingerprinting of Candida albicans isolates from human immunodeficiency virus-positive and healthy individuals reveals a new clade in South AfricaElaine Blignaut
Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242, USA
J Clin Microbiol 40:826-36. 2002..Why group SA isolates represent 53 and 33% of colonizing strains in black and white South Africans and are absent in the U.S. collection represents an interesting epidemiological question...
- Phenotypic switching and filamentation in Candida glabrataSalil A Lachke
Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
Microbiology 148:2661-74. 2002..Core switching, pseudohypha formation and tube formation occurred in a majority of 62 tested clinical isolates, demonstrating that these developmental programmes are general characteristics of most strains of C. glabrata...
- Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganismsSophie Joly
Dows Institute for Dental Research, University of Iowa, Iowa City, Iowa 52242, USA
J Clin Microbiol 42:1024-9. 2004..Finally, the significant variability between strains underlies the importance of testing multiple strains when evaluating activities of antimicrobial peptides...