T P Johnston

Summary

Affiliation: University of Missouri-Kansas City
Country: USA

Publications

  1. ncbi request reprint Canine periodontal disease control using a clindamycin hydrochloride gel
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, MO, USA
    J Vet Dent 28:224-9. 2011
  2. ncbi request reprint The P-407-induced murine model of dose-controlled hyperlipidemia and atherosclerosis: a review of findings to date
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    J Cardiovasc Pharmacol 43:595-606. 2004
  3. ncbi request reprint Inhibition of pancreatic lipase by poloxamer 407 may provide an adjunct treatment strategy for weight loss
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, 64110 2499, USA
    J Pharm Pharmacol 58:1099-105. 2006
  4. ncbi request reprint Inducing a change in the pharmacokinetics and biodistribution of poly-L-lysine in rats by complexation with heparin
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    J Pharm Pharmacol 55:1083-90. 2003
  5. ncbi request reprint Oxidation of low-density lipoprotein cholesterol following administration of poloxamer 407 to mice results from an indirect effect
    Thomas P Johnston
    School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    J Cardiovasc Pharmacol 49:246-52. 2007
  6. ncbi request reprint An attempt to modulate the microporous diffusion of a model polypeptide by altering its secondary structure
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Missouri 64110 2499, USA
    Drug Deliv 10:65-72. 2003
  7. pmc The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    J Pharm Pharmacol 60:753-9. 2008
  8. pmc Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO, USA
    Can J Physiol Pharmacol 86:643-9. 2008
  9. doi request reprint Poloxamer 407 increases soluble adhesion molecules, ICAM-1, VCAM-1 and E-selectin, in C57BL/6 mice
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy and University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Pharm Pharmacol 61:1681-8. 2009
  10. doi request reprint Poloxamer 407 as a general lipase inhibitor: its implications in lipid metabolism and atheroma formation in C57BL/6 mice
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108 2718, USA
    J Pharm Pharmacol 62:1807-12. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Canine periodontal disease control using a clindamycin hydrochloride gel
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, MO, USA
    J Vet Dent 28:224-9. 2011
    ..In summary, a professional teeth cleaning procedure including root planning and the addition of CHgel improves the gingival index and reduces periodontal pocket depth...
  2. ncbi request reprint The P-407-induced murine model of dose-controlled hyperlipidemia and atherosclerosis: a review of findings to date
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    J Cardiovasc Pharmacol 43:595-606. 2004
    ....
  3. ncbi request reprint Inhibition of pancreatic lipase by poloxamer 407 may provide an adjunct treatment strategy for weight loss
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, 64110 2499, USA
    J Pharm Pharmacol 58:1099-105. 2006
    ..While not as potent as orlistat, P-407 may potentially represent an additional treatment strategy for weight loss, especially when combined with caloric restriction, regular exercise, and anti-obesity medications of other drug classes...
  4. ncbi request reprint Inducing a change in the pharmacokinetics and biodistribution of poly-L-lysine in rats by complexation with heparin
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    J Pharm Pharmacol 55:1083-90. 2003
    ..Due to the macromolecular complex being nontoxic and uncharged, potentially it might serve as a suitable carrier for both conventional and peptidic drugs to increase drug distribution to liver, kidney, or muscle tissue...
  5. ncbi request reprint Oxidation of low-density lipoprotein cholesterol following administration of poloxamer 407 to mice results from an indirect effect
    Thomas P Johnston
    School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    J Cardiovasc Pharmacol 49:246-52. 2007
    ....
  6. ncbi request reprint An attempt to modulate the microporous diffusion of a model polypeptide by altering its secondary structure
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Missouri 64110 2499, USA
    Drug Deliv 10:65-72. 2003
    ..45 or 45% of the molecules can be converted to the alpha-helix structure at Ca(2+) concentrations >or= 20 mM) may have limited the extent of transport of the alpha-helix conformer...
  7. pmc The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    J Pharm Pharmacol 60:753-9. 2008
    ..On the basis of these findings it is concluded that PPARalpha does not mediate the P-407-dependent reduction in apoA1-facilitated cholesterol efflux from macrophages...
  8. pmc Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO, USA
    Can J Physiol Pharmacol 86:643-9. 2008
    ..It is concluded that P-407 does not interfere with the functional activity of PPARgamma after administration to mice...
  9. doi request reprint Poloxamer 407 increases soluble adhesion molecules, ICAM-1, VCAM-1 and E-selectin, in C57BL/6 mice
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy and University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Pharm Pharmacol 61:1681-8. 2009
    ....
  10. doi request reprint Poloxamer 407 as a general lipase inhibitor: its implications in lipid metabolism and atheroma formation in C57BL/6 mice
    Thomas P Johnston
    Division of Pharmaceutical Science, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64108 2718, USA
    J Pharm Pharmacol 62:1807-12. 2010
    ....
  11. ncbi request reprint Potency of select statin drugs in a new mouse model of hyperlipidemia and atherosclerosis
    T P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    Int J Pharm 229:75-86. 2001
    ..The percent reduction in plasma triglycerides in the present model appears to be a useful parameter with which to predict the relative reduction in plasma LDL-C expected for these agents in humans...
  12. ncbi request reprint Regression of poloxamer 407-induced atherosclerotic lesions in C57BL/6 mice using atorvastatin
    T P Johnston
    Division of Pharmaceutical Sciences, Rm 211A, School of Pharmacy, University of Missouri, 5100 Rockhill Rd, Kansas City, MO 64110 2499, USA
    Atherosclerosis 149:303-13. 2000
    ....
  13. ncbi request reprint Potential downregulation of HMG-CoA reductase after prolonged administration of P-407 in C57BL/6 mice
    T P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City 64110 2499, USA
    J Cardiovasc Pharmacol 34:831-42. 1999
    ..These data demonstrate that P-407 administration to C57BL/6 mice significantly decreased the amount of HMG-CoA reductase mRNA detected in liver...
  14. ncbi request reprint Poloxamer 407 (P-407)-mediated reduction in the gene expression of ATP-binding-cassette transporter A1 may contribute to increased cholesterol in peripheral tissues of P-407-treated rats
    Thomas P Johnston
    Division of Pharmaceutical Science, Rm 211A, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, Missouri 64110 2499, United States
    Eur J Pharmacol 536:232-40. 2006
    ....
  15. ncbi request reprint Interplay of secondary structure and charge on the diffusion of a polypeptide through negatively charged aqueous pores
    Montakarn Chittchang
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Katz Pharmacy Building, 5005 Rockhill Road, Kansas City, Missouri 64110 2499, USA
    Pharm Res 24:502-11. 2007
    ..This study was conducted to investigate the interplay of secondary structure and charge of a polypeptide on its permeability through negatively charged pores of synthetic porous membranes and Caco-2 cell monolayers...
  16. ncbi request reprint Permeation of unfolded basic fibroblast growth factor (bFGF) across rabbit buccal mucosa--does unfolding of bFGF enhance transport?
    T P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City 64110 2499, USA
    Pharm Res 15:246-53. 1998
    ..In addition, the effect of a permeation enhancer (Na+ glycocholate) and the possibility of reversibly unfolding the globular protein to a more linear conformation to increase the permeability of the test protein was evaluated...
  17. ncbi request reprint Sex does not seem to influence the formation of aortic lesions in the P-407-induced mouse model of hyperlipidemia and atherosclerosis
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    J Cardiovasc Pharmacol 39:404-11. 2002
    ..Thus, male C57BL/6 mice form atherosclerotic lesions as extensive as female mice in the P-407 mouse model of atherosclerosis...
  18. ncbi request reprint Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and microporous membrane transport, part 2: diffusion studies
    Montakarn Chittchang
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5005 Rockhill Road, Kansas City, MO 64110 2499, USA
    J Pharm Pharmacol 54:1497-505. 2002
    ..This strategy may represent a potential mechanism to sustain the delivery of therapeutic peptide drugs from a controlled drug delivery device...
  19. ncbi request reprint A clinical comparison of calculated versus direct measurement of low-density lipoprotein cholesterol level
    Cameron C Lindsey
    Department of Pharmacy Practice, School of Pharmacy, University of Missouri Kansas City, USA
    Pharmacotherapy 24:167-72. 2004
    ..A secondary objective was to determine and compare the percentages of patients meeting LDL goal using each of these two methods...
  20. pmc Poloxamer 407-induced atherosclerosis in mice appears to be due to lipid derangements and not due to its direct effects on endothelial cells and macrophages
    Thomas P Johnston
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64110 2499, USA
    Mediators Inflamm 12:147-55. 2003
    ....
  21. pmc Deranged aortic intima-media thickness, plasma triglycerides and granulopoiesis in Sl/Sl(d) mice
    Kottarappat N Dileepan
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Mediators Inflamm 13:335-41. 2004
    ..Interestingly, the high-fat diet regimen elevated leukocyte counts and the number of monocytes and granulocytes in Sl/Sl(d) mice...
  22. ncbi request reprint Shape imposed by secondary structure of a polypeptide affects its free diffusion through liquid-filled pores
    Nazila Salamat-Miller
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Katz Pharmacy Building, Room 211 A, 5005 Rockhill Road, Kansas City, MO 64110 2499, USA
    Int J Pharm 244:1-8. 2002
    ....
  23. ncbi request reprint A randomly coiled, high-molecular-weight polypeptide exhibits increased paracellular diffusion in vitro and in situ relative to the highly ordered alpha-helix conformer
    Nazila Salamat-Miller
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    Pharm Res 22:245-54. 2005
    ..The current investigation was conducted to examine the effect of secondary structure of model polypeptides on their hindered paracellular diffusion...
  24. doi request reprint Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells
    Pradeep K Karla
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri 64110 2499, USA
    Curr Eye Res 34:1-9. 2009
    ..The objective of this study was to explore physical barriers for ocular drug absorption and to verify the presence and possible role of BCRP as a barrier for ocular drug resistance...
  25. ncbi request reprint Poly(L-lysine) as a model drug macromolecule with which to investigate secondary structure and membrane transport, part I: Physicochemical and stability studies
    Montakarn Chittchang
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, MO 64110 2499, USA
    J Pharm Pharmacol 54:315-23. 2002
    ..Thus, poly(L-lysine) may represent an ideal model polypeptide with which to further investigate the effects of secondary structure on membrane diffusion or permeation...
  26. ncbi request reprint Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium
    Nazila Salamat-Miller
    Division of Pharmaceutical Sciences, Room 211A, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO 64110 2499, USA
    Int J Pharm 294:201-16. 2005
    ....
  27. ncbi request reprint Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats
    Kishor M Wasan
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    J Pharm Pharm Sci 6:189-97. 2003
    ..The present study was aimed to determine whether P-407-induced hyperlipidemia in the rat is associated with alterations in the activities of enzymes responsible for lipid metabolism...
  28. ncbi request reprint Acute P-407 administration to mice causes hypercholesterolemia by inducing cholesterolgenesis and down-regulating low-density lipoprotein receptor expression
    Carlos Leon
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Pharm Res 23:1597-607. 2006
    ..Poloxamer 407 (P-407) is a chemical that induces a dose-controlled dyslipidemia in mice. Our aim was to determine the acute effects of P-407 treatment on the mechanisms that influence hepatic cholesterol homeostasis...
  29. ncbi request reprint Perfusion of hearts with triglyceride-rich particles reproduces the metabolic abnormalities in lipotoxic cardiomyopathy
    Priya Pillutla
    Dept of Medicine, Columbia Univ, 630 West 168th St, New York, NY 10032, USA
    Am J Physiol Endocrinol Metab 288:E1229-35. 2005
    ..This physiology is reproduced with perfusion of hearts with TG-containing particles. Together, the results demonstrate that cardiac uptake of TG-derived FA reduces utilization of albumin-FA...
  30. pmc The molecular basis of retinoid absorption: a genetic dissection
    Nuttaporn Wongsiriroj
    Institute of Human Nutrition and Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 283:13510-9. 2008
    ..Contrary to what has been proposed in the literature based on in vitro studies, CRBPII does not directly prevent retinol from being acted upon by DGAT1 or other intestinal ARATs in vivo...