S Claiborne Johnston

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc NIH disease funding levels and burden of disease
    Leslie A Gillum
    Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e16837. 2011
  2. ncbi request reprint Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA, USA
    Int J Stroke 8:479-83. 2013
  3. pmc Comparative evaluation of stroke triage algorithms for emergency medical dispatchers (MeDS): prospective cohort study protocol
    Prasanthi Govindarajan
    Department of Emergency Medicine, 505 Parnassus Avenue L 126 Mail Code 0208, University of California San Francisco, San Francisco, CA 94143 0208, USA
    BMC Neurol 11:14. 2011
  4. ncbi request reprint Preventing cerebrovascular and cardiovascular events after stroke: eprosartan or nitrendipine?
    S Claiborne Johnston
    Stroke Service, University of California, San Francisco, CA, USA
    Nat Clin Pract Neurol 2:24-5. 2006
  5. ncbi request reprint Early recovery after cerebral ischemia risk of subsequent neurological deterioration
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Ann Neurol 54:439-44. 2003
  6. ncbi request reprint Knowledge and management of transient ischemic attacks among US primary care physicians
    Mai N Nguyen-Huynh
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 61:1455-6. 2003
  7. pmc The economic case for new stroke thrombolytics
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 41:S59-62. 2010
  8. ncbi request reprint National Stroke Association guidelines for the management of transient ischemic attacks
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Ann Neurol 60:301-13. 2006
  9. doi request reprint The 2008 William M. Feinberg lecture: prioritizing stroke research
    S Claiborne Johnston
    Department of Neurology, Neurovascular Service, University of California, San Francisco, San Francisco, CA 94143 0114, USA
    Stroke 39:3431-6. 2008
  10. ncbi request reprint Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) study
    S Claiborne Johnston
    Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
    Stroke 39:120-5. 2008

Research Grants

Detail Information

Publications105 found, 100 shown here

  1. pmc NIH disease funding levels and burden of disease
    Leslie A Gillum
    Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e16837. 2011
    ..We examined whether the association between current burden and funding has changed since that time...
  2. ncbi request reprint Platelet-oriented inhibition in new TIA and minor ischemic stroke (POINT) trial: rationale and design
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA, USA
    Int J Stroke 8:479-83. 2013
    ..The highest risk period for these outcomes is the early hours and days immediately following the ischemic event. Aspirin is the most common antithrombotic treatment used for these patients...
  3. pmc Comparative evaluation of stroke triage algorithms for emergency medical dispatchers (MeDS): prospective cohort study protocol
    Prasanthi Govindarajan
    Department of Emergency Medicine, 505 Parnassus Avenue L 126 Mail Code 0208, University of California San Francisco, San Francisco, CA 94143 0208, USA
    BMC Neurol 11:14. 2011
    ..The objective of this study is to determine whether the addition of CSS improves diagnostic accuracy of stroke triage...
  4. ncbi request reprint Preventing cerebrovascular and cardiovascular events after stroke: eprosartan or nitrendipine?
    S Claiborne Johnston
    Stroke Service, University of California, San Francisco, CA, USA
    Nat Clin Pract Neurol 2:24-5. 2006
  5. ncbi request reprint Early recovery after cerebral ischemia risk of subsequent neurological deterioration
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Ann Neurol 54:439-44. 2003
    ..7-5.2; p < 0.001). Among patients with acute cerebral ischemia, those who recover substantially within 24 hours may be at greater risk of subsequent neurological deterioration due to causes other than hemorrhage...
  6. ncbi request reprint Knowledge and management of transient ischemic attacks among US primary care physicians
    Mai N Nguyen-Huynh
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 61:1455-6. 2003
  7. pmc The economic case for new stroke thrombolytics
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 41:S59-62. 2010
    ..Similarly, the societal impact of new thrombolytics with improved efficacy or safety or extending eligibility can also be modeled...
  8. ncbi request reprint National Stroke Association guidelines for the management of transient ischemic attacks
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Ann Neurol 60:301-13. 2006
    ..Management varies widely, and most published guidelines have not been updated in several years. We sought to create comprehensive, unbiased, evidence-based guidelines for the management of patients with transient ischemic attacks...
  9. doi request reprint The 2008 William M. Feinberg lecture: prioritizing stroke research
    S Claiborne Johnston
    Department of Neurology, Neurovascular Service, University of California, San Francisco, San Francisco, CA 94143 0114, USA
    Stroke 39:3431-6. 2008
    ..Nonetheless, there were obvious opportunities for improvement...
  10. ncbi request reprint Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) study
    S Claiborne Johnston
    Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
    Stroke 39:120-5. 2008
    ..The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated...
  11. ncbi request reprint Effect of a US National Institutes of Health programme of clinical trials on public health and costs
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Lancet 367:1319-27. 2006
    ..The total costs and benefits to society of a clinical trial, the final step in testing an intervention, can be estimated by evaluating the effect of trial results on medical care and health...
  12. doi request reprint Standardized discharge orders after stroke: results of the quality improvement in stroke prevention (QUISP) cluster randomized trial
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0114, USA
    Ann Neurol 67:579-89. 2010
    ..Proven strategies to reduce risk of stroke recurrence are under-utilized. We sought to evaluate the impact of standardized stroke discharge orders on treatment practices in a cluster-randomized trial...
  13. ncbi request reprint Ischemic preconditioning from transient ischemic attacks? Data from the Northern California TIA Study
    S Claiborne Johnston
    Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Ave, M 798 San Francisco, CA 94143 0114, USA
    Stroke 35:2680-2. 2004
    ..Given the potential hazards of inducing therapeutic transient brain ischemia in humans, a trial may not be advisable, and proof may require testing of agents that safely mimic the effects of ischemia...
  14. doi request reprint Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modelling
    S Claiborne Johnston
    Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Avenue, M 798, San Francisco, CA 94143 0114, USA
    Lancet Neurol 8:345-54. 2009
    ..However, little is known about the global distribution of stroke and its relations to the prevalence of cardiovascular disease risk factors and sociodemographic and economic characteristics...
  15. ncbi request reprint Are patients with acutely recovered cerebral ischemia more unstable?
    S Claiborne Johnston
    Department of Neurology, Box 0114, University of California at San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
    Stroke 34:2446-50. 2003
    ..Recent studies suggest that the short-term risk of stroke may be greater after transient ischemic attack (TIA) than after stroke...
  16. doi request reprint National Stroke Association recommendations for systems of care for transient ischemic attack
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0114, USA
    Ann Neurol 69:872-7. 2011
    ....
  17. ncbi request reprint Short-term prognosis after a TIA: a simple score predicts risk
    S Claiborne Johnston
    Stroke Service, Department of Neurology, University of California, San Francisco 94143 0114, USA
    Cleve Clin J Med 74:729-36. 2007
    ..Most patients should be hospitalized after a TIA, to provide an opportunity to monitor, thoroughly evaluate, and treat conditions promptly if indicated...
  18. ncbi request reprint Early editorial manuscript screening versus obligate peer review: a randomized trial
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 61:A10-2. 2007
    ..Editorial screening is now journal policy...
  19. ncbi request reprint Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack
    S Claiborne Johnston
    Stroke Service, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Lancet 369:283-92. 2007
    ....
  20. ncbi request reprint Modeling treatment effects on binary outcomes with grouped-treatment variables and individual covariates
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, 94143, USA
    Am J Epidemiol 156:753-60. 2002
    ....
  21. ncbi request reprint Clinical practice. Transient ischemic attack
    S Claiborne Johnston
    Department of Neurology, University of California San Francisco, San Francisco 94143 0114, USA
    N Engl J Med 347:1687-92. 2002
  22. ncbi request reprint A comparison of risk factors for recurrent TIA and stroke in patients diagnosed with TIA
    S Claiborne Johnston
    Neurovascular Service, Department of Neurology, University of California, San Francisco, USA
    Neurology 60:280-5. 2003
    ..Some spells consistent with TIA may be benign, such as those produced by migraine or migraine accompaniments in the elderly. Distinguishing these from embolic or thrombotic events may be difficult...
  23. doi request reprint Enhancing ties between academia and industry to improve health
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, USA
    Nat Med 17:434-6. 2011
    ..New models for such partnerships are developing and should be encouraged...
  24. ncbi request reprint Factors associated with the decision to hospitalize patients after transient ischemic attack before publication of prediction rules
    S Andrew Josephson
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 39:411-3. 2008
    ..We sought to identify factors associated with the decision to admit patients with TIA from the emergency department (ED) and to see whether those at highest risk of stroke were selected for admission...
  25. ncbi request reprint Prevalence and knowledge of transient ischemic attack among US adults
    S C Johnston
    Neurovascular Service, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 60:1429-34. 2003
    ..Little information is available about public knowledge of TIA and prevalence of a TIA diagnosis...
  26. ncbi request reprint Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patients
    Helen Kim
    Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94115, USA
    Stroke 38:2430-7. 2007
    ..We evaluated whether race/ethnicity was a risk factor for ICH in the natural course in a large, multiethnic cohort of patients with brain arteriovenous malformation followed longitudinally...
  27. ncbi request reprint Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatment
    Achal S Achrol
    Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
    Neurosurgery 61:731-9; discussion 740. 2007
    ..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes...
  28. ncbi request reprint Is hospitalization after TIA cost-effective on the basis of treatment with tPA?
    Mai N Nguyen-Huynh
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 65:1799-801. 2005
    ..The overall cost-effectiveness ratio was 55,044 dollars per quality-adjusted life-year, a value considered borderline cost-effective. For patients with higher risk of stroke, admission was cost-effective...
  29. ncbi request reprint Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging
    Heather J Fullerton
    Department of Neurology, University of California, Box 0114, 513 Parnassus Ave, S 784, San Francisco, CA 94143 0114, USA
    Pediatrics 119:495-501. 2007
    ..We sought to establish such rates within a large, multiethnic population and determine whether clinical vascular imaging predicts recurrence...
  30. doi request reprint Detection of atrial fibrillation after stroke and the risk of recurrent stroke
    Hooman Kamel
    Department of Neurology, University of California San Francisco, San Francisco, California, USA
    J Stroke Cerebrovasc Dis 21:726-31. 2012
    ..These findings identify a subset of patients at high risk for recurrent stroke and highlight the importance of timely detection of AF in patients with stroke...
  31. ncbi request reprint Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations
    Heather J Fullerton
    Department of Neurology, University of California, San Francisco, CA 94143 0137, USA
    Stroke 36:2099-104. 2005
    ..Children with brain arteriovenous malformations (BAVMs) are said to be at higher risk for intracranial hemorrhage (ICH) than adults. Although this notion affects treatment decisions, the evidence to support this claim is limited...
  32. doi request reprint Epidemiology of intracranial stenosis
    M Fareed K Suri
    Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroimaging 19:11S-6S. 2009
    ..Associations of intracranial atherosclerosis with diabetes mellitus, metabolic syndrome, Alzheimer's disease, aortic plaques, radiotherapy, and meningitis are less well documented...
  33. pmc Significance of large vessel intracranial occlusion causing acute ischemic stroke and TIA
    Wade S Smith
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 40:3834-40. 2009
    ..Because little prospective angiographic data have been reported on a cohort of unselected patients with stroke and with transient ischemic attack, the clinical impact of LVO has been difficult to quantify...
  34. ncbi request reprint Regionalization of treatment for subarachnoid hemorrhage: a cost-utility analysis
    Naomi S Bardach
    School of Medicine, University of California, San Francisco, CA 94143 01, USA
    Circulation 109:2207-12. 2004
    ..Whether regionalization of care for SAH is cost-effective is unknown...
  35. ncbi request reprint Head computed tomography findings predict short-term stroke risk after transient ischemic attack
    Vanja C Douglas
    Department of Neurology, University of California, San Francisco 94143 0114, USA
    Stroke 34:2894-8. 2003
    ..Current guidelines recommend the use of head CT in the evaluation of patients with transient ischemic attack (TIA), but data supporting its value are sparse...
  36. doi request reprint Prevention of stroke following transient ischemic attack
    Sharon Poisson
    Department of Neurology, University of California San Francisco, USA
    Curr Atheroscler Rep 13:330-7. 2011
    ..In this review, we discuss appropriate diagnostic testing, acute management, and long-term management for preventing stroke after TIA, current research in progress, as well as areas of need for future research...
  37. ncbi request reprint Antihypertensive medications prescribed at discharge after an acute ischemic cerebrovascular event
    Bruce Ovbiagele
    Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
    Stroke 36:1944-7. 2005
    ..We aimed to evaluate the discharge antihypertensive prescription patterns in patients hospitalized for an ischemic cerebrovascular event and to determine factors associated with treatment utilization...
  38. ncbi request reprint Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformations
    Ludmila Pawlikowska
    The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
    Neurosurgery 58:838-43; discussion 838-43. 2006
    ..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention...
  39. pmc Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture
    Helen Kim
    Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Epidemiol 171:1317-22. 2010
    ..The data also suggest a biologic change around age 10 years influencing ICH rate...
  40. pmc The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study
    Lori C Jordan
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 40:400-5. 2009
    ..Prior population-based studies of pediatric hemorrhagic stroke (HS) had too few incident cases to assess predictors of cerebral aneurysms, a HS etiology that requires urgent intervention...
  41. ncbi request reprint Characteristics of brain arteriovenous malformations with coexisting aneurysms: a comparison of two referral centers
    Alexander X Halim
    Departments of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
    Stroke 33:675-9. 2002
    ..We studied the association between coexisting aneurysms and initial presentation with intracranial hemorrhage (ICH) in patients with BAVM evaluated at two tertiary-care centers...
  42. ncbi request reprint Why are eligible thrombolysis candidates left untreated?
    Nancy K Hills
    Department of Neurology, University of California, San Francisco 94143 0114, USA
    Am J Prev Med 31:S210-6. 2006
    ..This study sought to identify barriers to tissue-type plasminogen activator (tPA) treatment among eligible patients with acute ischemic stroke...
  43. doi request reprint Predictors and outcomes of intraprocedural rupture in patients treated for ruptured intracranial aneurysms: the CARAT study
    Lucas Elijovich
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0114, USA
    Stroke 39:1501-6. 2008
    ..Intraprocedural rupture (IPR) is a well known complication of intracranial aneurysm treatment. Risks and predictors of IPR and its impact on outcome have not been clearly established...
  44. ncbi request reprint Prevalence and predictors of perinatal hemorrhagic stroke: results from the kaiser pediatric stroke study
    Jennifer Armstrong-Wells
    University of California, Department of Neurology, Box 0114, 505 Parnassus Ave, San Francisco, CA 94143 0114, USA
    Pediatrics 123:823-8. 2009
    ..We sought to determine both the prevalence and predictors of perinatal hemorrhagic stroke within a large, multiethnic population...
  45. pmc Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population
    Rodney A Gabriel
    UCSF Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Room 3C 38, San Francisco, CA 94110, USA
    Stroke 41:21-6. 2010
    ....
  46. pmc Financing of U.S. biomedical research and new drug approvals across therapeutic areas
    E Ray Dorsey
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 4:e7015. 2009
    ..We estimated U.S. biomedical research funding across therapeutic areas, determined the association with disease burden, and evaluated new drug approvals that resulted from this investment...
  47. pmc Regional variation in hospitalization for stroke among Asians/Pacific Islanders in the United States: a nationwide retrospective cohort study
    Mai N Nguyen-Huynh
    Department of Neurology, University of California San Francisco, California 94143, USA
    BMC Neurol 5:21. 2005
    ....
  48. ncbi request reprint The learning curve for coil embolization of unruptured intracranial aneurysms
    Vineeta Singh
    Department of Neurology, University of California, San Francisco, 94143 0114, USA
    AJNR Am J Neuroradiol 23:768-71. 2002
    ..Our purpose was to determine whether outcomes for coil embolization improved with the experience of the practitioner, after adjusting for the perceived risk of treatment...
  49. ncbi request reprint Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia
    Wade S Smith
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurocrit Care 4:14-7. 2006
    ..Because large-vessel occlusion and stroke severity are likely correlated, it is unclear if largevessel occlusion independently predicts outcome or is simply a marker for stroke severity...
  50. pmc Urgent neurology consultation from the ED for transient ischemic attack
    Anthony S Kim
    Department of Neurology, University of California, San Francisco, 94143 0114, USA
    Am J Emerg Med 29:601-8. 2011
    ..The objective of this study was to evaluate the association between urgent neurology consultation and outcomes for patients with transient ischemic attack (TIA)...
  51. ncbi request reprint Secondary-prevention drug prescription in the very elderly after ischemic stroke or TIA
    Bruce Ovbiagele
    Stroke Center, Department of Neurology, UCLA Medical Center, San Francisco, CA, USA
    Neurology 66:313-8. 2006
    ..An age bias may exist in the prescription of important secondary-preventive therapies in the elderly...
  52. ncbi request reprint Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imaging
    Bradley P Dispensa
    Department of Anesthesia and Perioperative Care and Center for Cerebrovascular Research, University of California San Francisco, San Francisco, California 94110, USA
    J Magn Reson Imaging 26:177-83. 2007
    ..Intracranial aneurysm (IA) growth is associated with increased morbidity. We sought to establish a quantitative computational method based on contrast-enhanced MR angiography (CE-MRA) for estimating aneurysmal volume changes over time...
  53. ncbi request reprint Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformations
    Achal S Achrol
    Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
    Stroke 37:231-4. 2006
    ....
  54. ncbi request reprint Electrocardiographic findings predict short-term cardiac morbidity after transient ischemic attack
    Jacob S Elkins
    Department of Neurology, UCSF Box 0114, University of California, San Francisco, 505 Parnassus Ave, Room M 798, San Francisco, CA 94143 0114, USA
    Arch Neurol 59:1437-41. 2002
    ..Current guidelines recommend the use of electrocardiography (ECG) in the evaluation of transient ischemic attack (TIA), but the data supporting its value in acute management are sparse...
  55. ncbi request reprint Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformations
    Michael T Lawton
    Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 56:485-93; discussion 485-93. 2005
    ..We hypothesized that patients with unruptured arteriovenous malformations (AVMs) at presentation have an increased risk of deterioration compared with patients with ruptured AVMs...
  56. ncbi request reprint Association between subarachnoid hemorrhage outcomes and number of cases treated at California hospitals
    Naomi S Bardach
    School of Medicine, University of California, San Francisco, CA 94143 0114, USA
    Stroke 33:1851-6. 2002
    ..Studies of several complex medical conditions have shown that outcomes are better at hospitals that treat more cases. We tested the hypothesis that patients with subarachnoid hemorrhage treated at high-volume hospitals have better outcomes...
  57. ncbi request reprint Risk of stroke in children: ethnic and gender disparities
    Heather J Fullerton
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 61:189-94. 2003
    ..Incidence rates were estimated as the number of first hospitalizations divided by the person-years at risk; case fatality rates were based on in-hospital deaths...
  58. ncbi request reprint Hospital usage of early do-not-resuscitate orders and outcome after intracerebral hemorrhage
    J Claude Hemphill
    Department of Neurology, University of California, San Francisco, Calif, USA
    Stroke 35:1130-4. 2004
    ..Do-not-resuscitate (DNR) orders are commonly used after severe stroke. We hypothesized that there is significant variability in how these orders are applied after intracerebral hemorrhage and that this influences outcome...
  59. ncbi request reprint Declining diagnosis of birth asphyxia in California: 1991-2000
    Yvonne W Wu
    Department of Neurology, University of California, San Francisco, Box 0136, 500 Parnassus Ave, Room 411, San Francisco, CA 94143 0136, USA
    Pediatrics 114:1584-90. 2004
    ..Whether advances in perinatal care have altered the incidence of birth asphyxia is unknown. We determined the incidence of birth asphyxia diagnoses made over a 10-year period in California...
  60. ncbi request reprint Cognitive function predicts first-time stroke and heart disease
    Jacob S Elkins
    University of California, San Francisco, CA 94143, USA
    Neurology 64:1750-5. 2005
    ..To investigate whether impaired cognitive function is an early manifestation of vascular injury in the brain and therefore predicts risk of subsequent cardiovascular disease...
  61. doi request reprint Funding of Parkinson research from industry and US federal and foundation sources
    E Ray Dorsey
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14620, USA
    Mov Disord 24:731-7. 2009
    ..These companies will likely require partnerships to drive successful development of new PD therapies...
  62. pmc Duration of hospital participation in a nationwide stroke registry is associated with improved quality of care
    Nancy K Hills
    Department of Neurology, Box 0114, University of California San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
    BMC Neurol 6:20. 2006
    ..Stroke registries have been promoted as a means of increasing use of such interventions, which are currently underutilized...
  63. ncbi request reprint Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older women
    Jacob S Elkins
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Epidemiol 166:672-8. 2007
    ..035). Although the strength of the observed associations was modest, these results lend some support to the theory that an elevated homocysteine level contributes to cognitive decline...
  64. ncbi request reprint Declining stroke rates in Californian children with sickle cell disease
    Heather J Fullerton
    University of California, San Francisco, Department of Neurology, 505 Parnassus Ave, Box 0114, San Francisco, CA 94143, USA
    Blood 104:336-9. 2004
    ..88/100 person-years compared to 0.50 in 1999 and 0.17 in 2000 (P <.005 for trend). Since the publication of the STOP study in 1998, annual rates of admissions for first stroke for Californian children with SCD have declined...
  65. doi request reprint Delayed detection of atrial fibrillation after ischemic stroke
    Hooman Kamel
    Department of Neurology, University of California, San Francisco, CA, USA
    J Stroke Cerebrovasc Dis 18:453-7. 2009
    ..The aim of this study was to characterize the rate, timing, and predictors of delayed detection of AF after stroke...
  66. doi request reprint Risk of vascular events in emergency department patients discharged home with diagnosis of dizziness or vertigo
    Anthony S Kim
    Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
    Ann Emerg Med 57:34-41. 2011
    ..Given the concern that important diagnoses could be missed, we measure the incidence of subsequent major vascular events in patients after discharge home...
  67. ncbi request reprint Recurrent hemorrhagic stroke in children: a population-based cohort study
    Heather J Fullerton
    Department of Neurology, University of California, San Francisco, Box 0114, San Francisco, CA 94143 0114, USA
    Stroke 38:2658-62. 2007
    ..Although hemorrhagic strokes (HS) account for half of all strokes in children, rates and predictors of recurrent HS have not been studied...
  68. ncbi request reprint NIH Stroke Scale reliability in ratings from a large sample of clinicians
    S Andrew Josephson
    Stroke Sciences Group, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Cerebrovasc Dis 22:389-95. 2006
    ..To investigate the reliability of the NIHSS in a representative sample of raters, we examined the results of the most frequently used certification examination...
  69. ncbi request reprint Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Wade S Smith
    Department of Neurology, University of California, San Francisco, Calif 94134 0114, USA
    Stroke 35:2518-22. 2004
    ..Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage. However, papaverine inhibits cellular respiration in vitro and could cause neurotoxicity in humans...
  70. doi request reprint Higher ABCD2 score predicts patients most likely to have true transient ischemic attack
    S Andrew Josephson
    Stroke Sciences Group, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 39:3096-8. 2008
    ..We investigated this hypothesis in a cohort of patients with TIA identified in the emergency department whose records were reviewed by an expert neurologist...
  71. pmc Imaging data reveal a higher pediatric stroke incidence than prior US estimates
    Nidhi Agrawal
    Department of Pediatrics, University of California, San Francisco, San Francisco, Calif 94143 0114, USA
    Stroke 40:3415-21. 2009
    ..We sought to obtain a new estimate using both diagnostic code searches and searches of radiology reports and to assess the relative value of these 2 strategies...
  72. doi request reprint Intracranial large vessel occlusion as a predictor of decline in functional status after transient ischemic attack
    Sharon N Poisson
    Department of Neurology, University of California, San Francisco, CA, USA
    Stroke 42:44-7. 2011
    ..Intracranial large vessel occlusion (LVO) predicts poor outcome after stroke, but the natural history of symptomatic intracranial LVO in patients with TIA is unknown...
  73. ncbi request reprint Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular disease
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143 0114, USA
    Ann Intern Med 140:237-47. 2004
    ..If this is the case, diminished performance on the Modified Mini-Mental State Examination should be more common in persons with left carotid artery disease than in those with right carotid artery disease...
  74. pmc Gender differences in treatment of severe carotid stenosis after transient ischemic attack
    Sharon N Poisson
    National Taiwan University Hospital, Taipei, Taiwan
    Stroke 41:1891-5. 2010
    ..Gender differences in carotid endarterectomy (CEA) rates after transient ischemic attack are not well studied, although some reports suggest that eligible men are more likely to have CEA than women after stroke...
  75. pmc Is the NIHSS certification process too lenient?
    Nancy K Hills
    Stroke Sciences Group, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Cerebrovasc Dis 27:426-32. 2009
    ..We examined the range of possible total NIHSS scores from answers given in certification tests by over 7,000 individual raters who were certified...
  76. ncbi request reprint Transient ischemic attack: a dangerous Harbinger and an opportunity to intervene
    S Claiborne Johnston
    Departments of Neurology and Epidemiology, University of California, San Francisco, California 94143 0114, USA
    Semin Neurol 25:362-70. 2005
    ..e., on the inferred reversal of ischemia) than on the completeness of recovery at 24 hours. Patients with substantial rapid recovery may be those for whom acute intervention is most warranted...
  77. ncbi request reprint Pre-existing hypertension and the impact of stroke on cognitive function
    Jacob S Elkins
    University of California, San Francisco, CA 94143, USA
    Ann Neurol 58:68-74. 2005
    ..13; 95% CI, 1.04-1.22) (p for interaction = 0.032). Pre-existing hypertension in women is associated with a greater impact of stroke on cognitive function, possibly by influencing the ability to tolerate or recover from brain injury...
  78. ncbi request reprint Recruiting subjects for acute stroke trials: a meta-analysis
    Jacob S Elkins
    The University of California, San Francisco, CA 94143, USA
    Stroke 37:123-8. 2006
    ..Recruitment rate is a major determinant of the duration, cost, and feasibility of acute stroke trials...
  79. doi request reprint Urinary tract infections complicating stroke: mechanisms, consequences, and possible solutions
    Sharon N Poisson
    Department of Neurology, University of California, San Francisco, CA, USA
    Stroke 41:e180-4. 2010
    ....
  80. ncbi request reprint Midlife obesity and long-term risk of nursing home admission
    Jacob S Elkins
    Department of Neurology, University of California, 505 Parnassus Avenue, Box 0114, San Francisco, CA 94143, USA
    Obesity (Silver Spring) 14:1472-8. 2006
    ..We investigated whether obesity in middle-aged individuals influences the need for future nursing home care and whether the risk of nursing home admission associated with obesity is greater in whites than in blacks...
  81. ncbi request reprint Thirty-year projections for deaths from ischemic stroke in the United States
    Jacob S Elkins
    Department of Neurology, Box 0114, University of California, San Francisco 94143 0114, USA
    Stroke 34:2109-12. 2003
    ..Deaths from ischemic stroke may rise unless future declines in stroke death rates offset the projected growth in high-risk populations...
  82. doi request reprint How accurate is CT angiography in evaluating intracranial atherosclerotic disease?
    Mai N Nguyen-Huynh
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 39:1184-8. 2008
    ..However, it is invasive and can only be carried out at specialized centers. We sought to compare CT angiography (CTA) to DSA for detection and measurement of stenosis in large intracranial arteries...
  83. ncbi request reprint Education and the cognitive decline associated with MRI-defined brain infarct
    J S Elkins
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neurology 67:435-40. 2006
    ..To assess whether educational attainment, a correlate of cognitive reserve, predicts the amount of cognitive decline associated with a new brain infarct...
  84. doi request reprint Is mechanical clot removal or disruption a cost-effective treatment for acute stroke?
    M N Nguyen-Huynh
    Departments of Neurology, University of California, San Francisco, 94143 0114, USA
    AJNR Am J Neuroradiol 32:244-9. 2011
    ..We examined whether interventions such as mechanical clot removal or disruption with angioplasty are cost-effective for acute ischemic stroke compared with best medical therapy...
  85. pmc Influence of physician specialty on outcomes after acute ischemic stroke
    Leslie Allison Gillum
    Department of Neurology, University of California, San Francisco, California, USA
    J Hosp Med 3:184-92. 2008
    ..For patients with ischemic stroke, prior studies have suggested that admission to the care of neurologists is associated with better outcomes, but these studies may have incompletely controlled for confounding prognostic differences...
  86. ncbi request reprint Alzheimer disease risk and genetic variation in ACE: a meta-analysis
    Jacob S Elkins
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 62:363-8. 2004
    ..Numerous studies have tested for associations between common variants of the angiotensin-converting enzyme gene (ACE) and late-onset Alzheimer disease (AD), but results have been inconclusive...
  87. ncbi request reprint Evaluation and management of transient ischemic attack: an important component of stroke prevention
    Mai N Nguyen-Huynh
    Department of Neurology, UCSF, San Francisco, CA 94143 0114, USA
    Nat Clin Pract Cardiovasc Med 4:310-8. 2007
    ..In this Review, we summarize the recent literature on stroke risk after TIA and risk stratification, and recently published guidelines on evaluation and treatment...
  88. ncbi request reprint Spinal manipulative therapy is an independent risk factor for vertebral artery dissection
    W S Smith
    Department of Neurology, University of California, San Francisco 94143 0114, USA
    Neurology 60:1424-8. 2003
    ..To determine whether spinal manipulative therapy (SMT) is an independent risk factor for cervical artery dissection...
  89. ncbi request reprint Short-term prognosis after emergency department diagnosis of TIA
    S C Johnston
    Department of Neurology, University of California, San Francisco 94143 0114, USA
    JAMA 284:2901-6. 2000
    ..Defining the short-term prognosis and risk factors for stroke after TIA may provide guidance in determining which patients need rapid evaluation...
  90. ncbi request reprint Evaluation of carotid stenosis using CT angiography in the initial evaluation of stroke and TIA
    S A Josephson
    Department of Neurology, University of California, San Francisco, CA, USA
    Neurology 63:457-60. 2004
    ..To evaluate the accuracy of CTA, the authors compared the degree of stenosis found using CTA with digital subtraction angiography (DSA) in consecutive patients during a 3-year period...
  91. ncbi request reprint Stroke risk factors and loss of high cognitive function
    J S Elkins
    University of California, San Francisco, CA 94143 0114, USA
    Neurology 63:793-9. 2004
    ..Individuals with high levels of cognitive function after midlife may have less exposure to these stroke risk factors or may be less susceptible to their effects on cognition...
  92. ncbi request reprint Chronic dyspnea and hyperventilation in an awake patient with small subcortical infarcts
    S C Johnston
    Neurovascular Service, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Neurology 57:2131-3. 2001
    ..Central neurogenic hyperventilation was diagnosed in this alert patient. The case may illustrate a role for the thalamus in regulating ventilation, but another small infarct not visible on MRI also could be responsible...
  93. ncbi request reprint Recommendations for the endovascular treatment of intracranial aneurysms: a statement for healthcare professionals from the Committee on Cerebrovascular Imaging of the American Heart Association Council on Cardiovascular Radiology
    S Claiborne Johnston
    Stroke 33:2536-44. 2002
  94. ncbi request reprint Safety and feasibility of a CT protocol for acute stroke: combined CT, CT angiography, and CT perfusion imaging in 53 consecutive patients
    Wade S Smith
    Department of Neurology, University of California, San Francisco, 94143, USA
    AJNR Am J Neuroradiol 24:688-90. 2003
    ..High-speed, multisection, helical CT scanners allow rapid, safe imaging of the entire neurovascular axis in patients with acute stroke by use of combined CT imaging, CT perfusion imaging, and CTA...
  95. ncbi request reprint Lipid assessment and treatment patterns in hospitalized TIA and ischemic stroke patients
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, California 90095, USA
    J Hosp Med 1:214-20. 2006
    ..We aimed to study the frequency and predictors of lipid assessment and discharge utilization of lipid-lowering therapies among patients hospitalized for stroke and TIA...
  96. doi request reprint Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack
    Robert J Adams
    Stroke 39:1647-52. 2008
  97. ncbi request reprint Impact of hospital-related factors on outcome after treatment of cerebral aneurysms
    Mitchell F Berman
    Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Stroke 34:2200-7. 2003
    ..The goal of this study was to examine the impact of hospital characteristics on outcome after the treatment of ruptured and unruptured cerebral aneurysms...
  98. doi request reprint Trends in usage of alternative antiplatelet therapy after stroke and transient ischemic attack
    Nancy K Hills
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Stroke 39:1228-32. 2008
    ..Because public data on their usage are limited, we examined trends in their prescription after stroke and transient ischemic attack to assess the impact of marketing and trial results...
  99. ncbi request reprint Recent advances in management of transient ischaemic attacks and minor ischaemic strokes
    Peter M Rothwell
    Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
    Lancet Neurol 5:323-31. 2006
    ....
  100. ncbi request reprint Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on C
    Ralph L Sacco
    Circulation 113:e409-49. 2006
    ....
  101. ncbi request reprint Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    Deepak L Bhatt
    Cleveland Clinic, Cleveland, USA
    N Engl J Med 354:1706-17. 2006
    ..Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events...

Research Grants1

  1. OPTIMIZING MANAGEMENT OF TRANSIENT ISCHEMIC ATTACKS
    S Johnston; Fiscal Year: 2005
    ..This research will provide important results for clinicians and policy makers, and will foster the applicant's development as a health services researcher in cerebrovascular disease. ..