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Genomes and Genes | S Claiborne JohnstonSummaryAffiliation: University of California Country: USA Publications
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Publications
Comparative evaluation of stroke triage algorithms for emergency medical dispatchers (MeDS): prospective cohort study protocolPrasanthi Govindarajan
Department of Emergency Medicine, 505 Parnassus Avenue L 126 Mail Code 0208, University of California San Francisco, San Francisco, CA 94143 0208, USA
BMC Neurol 11:14. 2011..The objective of this study is to determine whether the addition of CSS improves diagnostic accuracy of stroke triage...
Effect of a US National Institutes of Health programme of clinical trials on public health and costsS Claiborne Johnston
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Lancet 367:1319-27. 2006..The total costs and benefits to society of a clinical trial, the final step in testing an intervention, can be estimated by evaluating the effect of trial results on medical care and health...- Early recovery after cerebral ischemia risk of subsequent neurological deteriorationS Claiborne Johnston
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Ann Neurol 54:439-44. 2003..7-5.2; p < 0.001). Among patients with acute cerebral ischemia, those who recover substantially within 24 hours may be at greater risk of subsequent neurological deterioration due to causes other than hemorrhage... - Knowledge and management of transient ischemic attacks among US primary care physiciansMai N Nguyen-Huynh
Department of Neurology, University of California, San Francisco, CA 94143-0114, USA
Neurology 61:1455-6. 2003 
Global variation in stroke burden and mortality: estimates from monitoring, surveillance, and modellingS Claiborne Johnston
Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Avenue, M 798, San Francisco, CA 94143 0114, USA
Lancet Neurol 8:345-54. 2009..However, little is known about the global distribution of stroke and its relations to the prevalence of cardiovascular disease risk factors and sociodemographic and economic characteristics...- Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) studyS Claiborne Johnston
Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
Stroke 39:120-5. 2008..The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated... - The 2008 William M. Feinberg lecture: prioritizing stroke researchS Claiborne Johnston
Department of Neurology, Neurovascular Service, University of California, San Francisco, San Francisco, CA 94143 0114, USA
Stroke 39:3431-6. 2008..Nonetheless, there were obvious opportunities for improvement. METHODS: meta--research--on topics not just relevant to stroke, but to the study of all disease... - Factors associated with the decision to hospitalize patients after transient ischemic attack before publication of prediction rulesS Andrew Josephson
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Stroke 39:411-3. 2008..We sought to identify factors associated with the decision to admit patients with TIA from the emergency department (ED) and to see whether those at highest risk of stroke were selected for admission... - Short-term prognosis after a TIA: a simple score predicts riskS Claiborne Johnston
Stroke Service, Department of Neurology, University of California, San Francisco 94143 0114, USA
Cleve Clin J Med 74:729-36. 2007..Most patients should be hospitalized after a TIA, to provide an opportunity to monitor, thoroughly evaluate, and treat conditions promptly if indicated... - Ischemic preconditioning from transient ischemic attacks? Data from the Northern California TIA StudyS Claiborne Johnston
Department of Neurology, Box 0114, University of California, San Francisco, 505 Parnassus Ave, M 798 San Francisco, CA 94143 0114, USA
Stroke 35:2680-2. 2004..Given the potential hazards of inducing therapeutic transient brain ischemia in humans, a trial may not be advisable, and proof may require testing of agents that safely mimic the effects of ischemia... - Early editorial manuscript screening versus obligate peer review: a randomized trialS Claiborne Johnston
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
Ann Neurol 61:A10-2. 2007..Editorial screening is now journal policy... - Validation and refinement of scores to predict very early stroke risk after transient ischaemic attackS Claiborne Johnston
Stroke Service, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Lancet 369:283-92. 2007.... - Preventing cerebrovascular and cardiovascular events after stroke: eprosartan or nitrendipine?S Claiborne Johnston
Stroke Service, University of California, San Francisco, CA, USA
Nat Clin Pract Neurol 2:24-5. 2006 - National Stroke Association guidelines for the management of transient ischemic attacksS Claiborne Johnston
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Ann Neurol 60:301-13. 2006..Management varies widely, and most published guidelines have not been updated in several years. We sought to create comprehensive, unbiased, evidence-based guidelines for the management of patients with transient ischemic attacks... - Are patients with acutely recovered cerebral ischemia more unstable?S Claiborne Johnston
Department of Neurology, Box 0114, University of California at San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
Stroke 34:2446-50. 2003..Recent studies suggest that the short-term risk of stroke may be greater after transient ischemic attack (TIA) than after stroke... - Clinical practice. Transient ischemic attackS Claiborne Johnston
Department of Neurology, University of California-San Francisco, San Francisco 94143-0114, USA
N Engl J Med 347:1687-92. 2002 - Modeling treatment effects on binary outcomes with grouped-treatment variables and individual covariatesS Claiborne Johnston
Department of Neurology, University of California, San Francisco, 94143, USA
Am J Epidemiol 156:753-60. 2002.... - Enhancing ties between academia and industry to improve healthS Claiborne Johnston
Department of Neurology, University of California, San Francisco, USA
Nat Med 17:434-6. 2011..New models for such partnerships are developing and should be encouraged... - A comparison of risk factors for recurrent TIA and stroke in patients diagnosed with TIAS Claiborne Johnston
Neurovascular Service, Department of Neurology, University of California, San Francisco, USA
Neurology 60:280-5. 2003..Some spells consistent with TIA may be benign, such as those produced by migraine or migraine accompaniments in the elderly. Distinguishing these from embolic or thrombotic events may be difficult... - Standardized discharge orders after stroke: results of the quality improvement in stroke prevention (QUISP) cluster randomized trialS Claiborne Johnston
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0114, USA
Ann Neurol 67:579-89. 2010..Proven strategies to reduce risk of stroke recurrence are under-utilized. We sought to evaluate the impact of standardized stroke discharge orders on treatment practices in a cluster-randomized trial... - Prevalence and knowledge of transient ischemic attack among US adultsS C Johnston
Neurovascular Service, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurology 60:1429-34. 2003..Little information is available about public knowledge of TIA and prevalence of a TIA diagnosis... - The economic case for new stroke thrombolyticsS Claiborne Johnston
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Stroke 41:S59-62. 2010..Similarly, the societal impact of new thrombolytics with improved efficacy or safety or extending eligibility can also be modeled... - National Stroke Association recommendations for systems of care for transient ischemic attackS Claiborne Johnston
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0114, USA
Ann Neurol 69:872-7. 2011.... - Racial/Ethnic differences in longitudinal risk of intracranial hemorrhage in brain arteriovenous malformation patientsHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94115, USA
Stroke 38:2430-7. 2007..We evaluated whether race/ethnicity was a risk factor for ICH in the natural course in a large, multiethnic cohort of patients with brain arteriovenous malformation followed longitudinally... - Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatmentAchal S Achrol
Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
Neurosurgery 61:731-9; discussion 740. 2007..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes... - Is hospitalization after TIA cost-effective on the basis of treatment with tPA?Mai N Nguyen-Huynh
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurology 65:1799-801. 2005..The overall cost-effectiveness ratio was 55,044 dollars per quality-adjusted life-year, a value considered borderline cost-effective. For patients with higher risk of stroke, admission was cost-effective... - Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imagingHeather J Fullerton
Department of Neurology, University of California, Box 0114, 513 Parnassus Ave, S 784, San Francisco, CA 94143 0114, USA
Pediatrics 119:495-501. 2007..We sought to establish such rates within a large, multiethnic population and determine whether clinical vascular imaging predicts recurrence... - Long-term hemorrhage risk in children versus adults with brain arteriovenous malformationsHeather J Fullerton
Department of Neurology, University of California, San Francisco, CA 94143 0137, USA
Stroke 36:2099-104. 2005..Children with brain arteriovenous malformations (BAVMs) are said to be at higher risk for intracranial hemorrhage (ICH) than adults. Although this notion affects treatment decisions, the evidence to support this claim is limited... - Prevention of stroke following transient ischemic attackSharon Poisson
Department of Neurology, University of California San Francisco, USA
Curr Atheroscler Rep 13:330-7. 2011..In this review, we discuss appropriate diagnostic testing, acute management, and long-term management for preventing stroke after TIA, current research in progress, as well as areas of need for future research... - Regionalization of treatment for subarachnoid hemorrhage: a cost-utility analysisNaomi S Bardach
School of Medicine, University of California, San Francisco, CA 94143-01, USA
Circulation 109:2207-12. 2004..However, current estimates of the impact of hospital volume on outcome require confirmation in more detailed cohort studies... - Head computed tomography findings predict short-term stroke risk after transient ischemic attackVanja C Douglas
Department of Neurology, University of California, San Francisco 94143-0114, USA
Stroke 34:2894-8. 2003..Head CT appears to have prognostic value in patients with TIA and, for this reason alone, may be justified in their evaluation... - Significance of large vessel intracranial occlusion causing acute ischemic stroke and TIAWade S Smith
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Stroke 40:3834-40. 2009..Because little prospective angiographic data have been reported on a cohort of unselected patients with stroke and with transient ischemic attack, the clinical impact of LVO has been difficult to quantify... - Epidemiology of intracranial stenosisM Fareed K Suri
Zeenat Qureshi Stroke Research Center, Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
J Neuroimaging 19:11S-6S. 2009..Associations of intracranial atherosclerosis with diabetes mellitus, metabolic syndrome, Alzheimer's disease, aortic plaques, radiotherapy, and meningitis are less well documented... - Antihypertensive medications prescribed at discharge after an acute ischemic cerebrovascular eventBruce Ovbiagele
Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA, USA
Stroke 36:1944-7. 2005..We aimed to evaluate the discharge antihypertensive prescription patterns in patients hospitalized for an ischemic cerebrovascular event and to determine factors associated with treatment utilization... - Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformationsLudmila Pawlikowska
The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
Neurosurgery 58:838-43; discussion 838-43. 2006..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention... - Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation ruptureHelen Kim
Department of Anesthesia and Perioperative Care, School of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
Am J Epidemiol 171:1317-22. 2010..The data also suggest a biologic change around age 10 years influencing ICH rate... - The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based studyLori C Jordan
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 40:400-5. 2009..Prior population-based studies of pediatric hemorrhagic stroke (HS) had too few incident cases to assess predictors of cerebral aneurysms, a HS etiology that requires urgent intervention... - Characteristics of brain arteriovenous malformations with coexisting aneurysms: a comparison of two referral centersAlexander X Halim
Departments of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94110, USA
Stroke 33:675-9. 2002..This heterogeneity between populations undermines the validity of inferences on the role of aneurysms from any single referral series, and emphasizes the complexity in creating BAVM risk-stratification models that incorporate aneurysms... - Why are eligible thrombolysis candidates left untreated?Nancy K Hills
Department of Neurology, University of California, San Francisco 94143 0114, USA
Am J Prev Med 31:S210-6. 2006..This study sought to identify barriers to tissue-type plasminogen activator (tPA) treatment among eligible patients with acute ischemic stroke... - Predictors and outcomes of intraprocedural rupture in patients treated for ruptured intracranial aneurysms: the CARAT studyLucas Elijovich
Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0114, USA
Stroke 39:1501-6. 2008..Intraprocedural rupture (IPR) is a well known complication of intracranial aneurysm treatment. Risks and predictors of IPR and its impact on outcome have not been clearly established... - Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined populationRodney A Gabriel
UCSF Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Room 3C 38, San Francisco, CA 94110, USA
Stroke 41:21-6. 2010.... - Prevalence and predictors of perinatal hemorrhagic stroke: results from the kaiser pediatric stroke studyJennifer Armstrong-Wells
University of California, Department of Neurology, Box 0114, 505 Parnassus Ave, San Francisco, CA 94143 0114, USA
Pediatrics 123:823-8. 2009..We sought to determine both the prevalence and predictors of perinatal hemorrhagic stroke within a large, multiethnic population... 
Regional variation in hospitalization for stroke among Asians/Pacific Islanders in the United States: a nationwide retrospective cohort studyMai N Nguyen-Huynh
Department of Neurology, University of California San Francisco, California 94143, USA
BMC Neurol 5:21. 2005....- Secondary-prevention drug prescription in the very elderly after ischemic stroke or TIABruce Ovbiagele
Stroke Center, Department of Neurology, UCLA Medical Center, San Francisco, CA, USA
Neurology 66:313-8. 2006..An age bias may exist in the prescription of important secondary-preventive therapies in the elderly... - Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemiaWade S Smith
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurocrit Care 4:14-7. 2006..Because large-vessel occlusion and stroke severity are likely correlated, it is unclear if largevessel occlusion independently predicts outcome or is simply a marker for stroke severity... - The learning curve for coil embolization of unruptured intracranial aneurysmsVineeta Singh
Department of Neurology, University of California, San Francisco, 94143-0114, USA
AJNR Am J Neuroradiol 23:768-71. 2002..Because the physicians in this study were highly experienced in other endovascular techniques at study onset, the rate of learning may not be generalizable to other centers... - Urgent neurology consultation from the ED for transient ischemic attackAnthony S Kim
Department of Neurology, University of California, San Francisco, 94143 0114, USA
Am J Emerg Med 29:601-8. 2011..The objective of this study was to evaluate the association between urgent neurology consultation and outcomes for patients with transient ischemic attack (TIA)... - Cognitive function predicts first-time stroke and heart diseaseJacob S Elkins
University of California, San Francisco, CA 94143, USA
Neurology 64:1750-5. 2005..To investigate whether impaired cognitive function is an early manifestation of vascular injury in the brain and therefore predicts risk of subsequent cardiovascular disease... - Effect of presenting hemorrhage on outcome after microsurgical resection of brain arteriovenous malformationsMichael T Lawton
Department of Neurological Surgery, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, California 94143 0112, USA
Neurosurgery 56:485-93; discussion 485-93. 2005..We hypothesized that patients with unruptured arteriovenous malformations (AVMs) at presentation have an increased risk of deterioration compared with patients with ruptured AVMs... - Hospital usage of early do-not-resuscitate orders and outcome after intracerebral hemorrhageJ Claude Hemphill
Department of Neurology, University of California, San Francisco, Calif, USA
Stroke 35:1130-4. 2004..Do-not-resuscitate (DNR) orders are commonly used after severe stroke. We hypothesized that there is significant variability in how these orders are applied after intracerebral hemorrhage and that this influences outcome... - Risk of stroke in children: ethnic and gender disparitiesHeather J Fullerton
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurology 61:189-94. 2003..Incidence rates were estimated as the number of first hospitalizations divided by the person-years at risk; case fatality rates were based on in-hospital deaths... - Declining diagnosis of birth asphyxia in California: 1991-2000Yvonne W Wu
Department of Neurology, University of California, San Francisco, Box 0136, 500 Parnassus Ave, Room 411, San Francisco, CA 94143 0136, USA
Pediatrics 114:1584-90. 2004..Whether advances in perinatal care have altered the incidence of birth asphyxia is unknown. We determined the incidence of birth asphyxia diagnoses made over a 10-year period in California... - Association between subarachnoid hemorrhage outcomes and number of cases treated at California hospitalsNaomi S Bardach
School of Medicine, University of California, San Francisco, CA 94143-0114, USA
Stroke 33:1851-6. 2002..Few patients with subarachnoid hemorrhage are being transferred to high-volume centers... - Electrocardiographic findings predict short-term cardiac morbidity after transient ischemic attackJacob S Elkins
Department of Neurology, UCSF Box 0114, University of California, San Francisco, 505 Parnassus Ave, Room M-798, San Francisco, CA 94143-0114, USA
Arch Neurol 59:1437-41. 2002..Electrocardiographic findings disclose new atrial fibrillation in a significant portion of patients with TIA and can identify a group of patients at a substantially higher risk for short-term cardiac events... - Duration of hospital participation in a nationwide stroke registry is associated with improved quality of careNancy K Hills
Department of Neurology, Box 0114, University of California San Francisco, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
BMC Neurol 6:20. 2006..Stroke registries have been promoted as a means of increasing use of such interventions, which are currently underutilized... - Risk of vascular events in emergency department patients discharged home with diagnosis of dizziness or vertigoAnthony S Kim
Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
Ann Emerg Med 57:34-41. 2011..Given the concern that important diagnoses could be missed, we measure the incidence of subsequent major vascular events in patients after discharge home... - Declining stroke rates in Californian children with sickle cell diseaseHeather J Fullerton
University of California, San Francisco, Department of Neurology, 505 Parnassus Ave, Box 0114, San Francisco, CA 94143, USA
Blood 104:336-9. 2004..88/100 person-years compared to 0.50 in 1999 and 0.17 in 2000 (P <.005 for trend). Since the publication of the STOP study in 1998, annual rates of admissions for first stroke for Californian children with SCD have declined... - Estimation of fusiform intracranial aneurysm growth by serial magnetic resonance imagingBradley P Dispensa
Department of Anesthesia and Perioperative Care and Center for Cerebrovascular Research, University of California San Francisco, San Francisco, California 94110, USA
J Magn Reson Imaging 26:177-83. 2007..Intracranial aneurysm (IA) growth is associated with increased morbidity. We sought to establish a quantitative computational method based on contrast-enhanced MR angiography (CE-MRA) for estimating aneurysmal volume changes over time... - Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older womenJacob S Elkins
Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Am J Epidemiol 166:672-8. 2007..035). Although the strength of the observed associations was modest, these results lend some support to the theory that an elevated homocysteine level contributes to cognitive decline... - Delayed detection of atrial fibrillation after ischemic strokeHooman Kamel
Department of Neurology, University of California, San Francisco, CA, USA
J Stroke Cerebrovasc Dis 18:453-7. 2009..The aim of this study was to characterize the rate, timing, and predictors of delayed detection of AF after stroke... - Recurrent hemorrhagic stroke in children: a population-based cohort studyHeather J Fullerton
Department of Neurology, University of California, San Francisco, Box 0114, San Francisco, CA 94143 0114, USA
Stroke 38:2658-62. 2007..Although hemorrhagic strokes (HS) account for half of all strokes in children, rates and predictors of recurrent HS have not been studied... - Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformationsAchal S Achrol
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
Stroke 37:231-4. 2006.... - NIH Stroke Scale reliability in ratings from a large sample of cliniciansS Andrew Josephson
Stroke Sciences Group, Department of Neurology, University of California, San Francisco, CA 94143-0114, USA
Cerebrovasc Dis 22:389-95. 2006..Whether additional training, modification of examination elements, or clearer definitions for scoring could improve reliability requires further study... - Higher ABCD2 score predicts patients most likely to have true transient ischemic attackS Andrew Josephson
Stroke Sciences Group, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Stroke 39:3096-8. 2008..We investigated this hypothesis in a cohort of patients with TIA identified in the emergency department whose records were reviewed by an expert neurologist... - Neurotoxicity of intra-arterial papaverine preserved with chlorobutanol used for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhageWade S Smith
Department of Neurology, University of California, San Francisco, Calif 94134 0114, USA
Stroke 35:2518-22. 2004..Papaverine is used to vasodilate cerebral arteries undergoing vasospasm from subarachnoid hemorrhage. However, papaverine inhibits cellular respiration in vitro and could cause neurotoxicity in humans... - Imaging data reveal a higher pediatric stroke incidence than prior US estimatesNidhi Agrawal
Department of Pediatrics, University of California, San Francisco, San Francisco, Calif 94143 0114, USA
Stroke 40:3415-21. 2009..We sought to obtain a new estimate using both diagnostic code searches and searches of radiology reports and to assess the relative value of these 2 strategies... - Gender differences in treatment of severe carotid stenosis after transient ischemic attackSharon N Poisson
National Taiwan University Hospital, Taipei, Taiwan
Stroke 41:1891-5. 2010..Gender differences in carotid endarterectomy (CEA) rates after transient ischemic attack are not well studied, although some reports suggest that eligible men are more likely to have CEA than women after stroke... - Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular diseaseS Claiborne Johnston
Department of Neurology, University of California, San Francisco, San Francisco, California 94143-0114, USA
Ann Intern Med 140:237-47. 2004..The persistence of the association after adjustment for right-sided stenosis indicates that the association is not due to underlying vascular risk factors or atherosclerosis in general... - How accurate is CT angiography in evaluating intracranial atherosclerotic disease?Mai N Nguyen-Huynh
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Stroke 39:1184-8. 2008..However, it is invasive and can only be carried out at specialized centers. We sought to compare CT angiography (CTA) to DSA for detection and measurement of stenosis in large intracranial arteries... - Is the NIHSS certification process too lenient?Nancy K Hills
Stroke Sciences Group, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Cerebrovasc Dis 27:426-32. 2009..We examined the range of possible total NIHSS scores from answers given in certification tests by over 7,000 individual raters who were certified... - Thirty-year projections for deaths from ischemic stroke in the United StatesJacob S Elkins
Department of Neurology, Box 0114, University of California, San Francisco 94143-0114, USA
Stroke 34:2109-12. 2003..CONCLUSIONS: If recent trends in ischemic stroke mortality continue, increases in US stroke deaths will outpace overall population growth, with a doubling in deaths over the next 30 years... - Urinary tract infections complicating stroke: mechanisms, consequences, and possible solutionsSharon N Poisson
Department of Neurology, University of California, San Francisco, CA, USA
Stroke 41:e180-4. 2010.... - Transient ischemic attack: a dangerous Harbinger and an opportunity to interveneS Claiborne Johnston
Departments of Neurology and Epidemiology, University of California, San Francisco, California 94143-0114, USA
Semin Neurol 25:362-70. 2005..e., on the inferred reversal of ischemia) than on the completeness of recovery at 24 hours. Patients with substantial rapid recovery may be those for whom acute intervention is most warranted... - Recruiting subjects for acute stroke trials: a meta-analysisJacob S Elkins
The University of California, San Francisco, CA 94143, USA
Stroke 37:123-8. 2006..52 patients per center per month). CONCLUSIONS: Recruitment rates for acute stroke trials are influenced by organizational structure and study entry criteria. Characterizing predictors of recruitment may help optimize future trial design... - Midlife obesity and long-term risk of nursing home admissionJacob S Elkins
Department of Neurology, University of California, 505 Parnassus Avenue, Box 0114, San Francisco, CA 94143, USA
Obesity (Silver Spring) 14:1472-8. 2006..We investigated whether obesity in middle-aged individuals influences the need for future nursing home care and whether the risk of nursing home admission associated with obesity is greater in whites than in blacks... - Intracranial large vessel occlusion as a predictor of decline in functional status after transient ischemic attackSharon N Poisson
Department of Neurology, University of California, San Francisco, CA, USA
Stroke 42:44-7. 2011..Intracranial large vessel occlusion (LVO) predicts poor outcome after stroke, but the natural history of symptomatic intracranial LVO in patients with TIA is unknown... - Pre-existing hypertension and the impact of stroke on cognitive functionJacob S Elkins
University of California, San Francisco, CA 94143, USA
Ann Neurol 58:68-74. 2005..13; 95% CI, 1.04-1.22) (p for interaction = 0.032). Pre-existing hypertension in women is associated with a greater impact of stroke on cognitive function, possibly by influencing the ability to tolerate or recover from brain injury... - Education and the cognitive decline associated with MRI-defined brain infarctJ S Elkins
Department of Neurology, University of California, San Francisco, CA 94143, USA
Neurology 67:435-40. 2006..To assess whether educational attainment, a correlate of cognitive reserve, predicts the amount of cognitive decline associated with a new brain infarct... - Is mechanical clot removal or disruption a cost-effective treatment for acute stroke?M N Nguyen-Huynh
Departments of Neurology, University of California, San Francisco, 94143 0114, USA
AJNR Am J Neuroradiol 32:244-9. 2011..We examined whether interventions such as mechanical clot removal or disruption with angioplasty are cost-effective for acute ischemic stroke compared with best medical therapy... - Influence of physician specialty on outcomes after acute ischemic strokeLeslie Allison Gillum
Department of Neurology, University of California, San Francisco, California, USA
J Hosp Med 3:184-92. 2008..For patients with ischemic stroke, prior studies have suggested that admission to the care of neurologists is associated with better outcomes, but these studies may have incompletely controlled for confounding prognostic differences... - Alzheimer disease risk and genetic variation in ACE: a meta-analysisJacob S Elkins
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurology 62:363-8. 2004..Numerous studies have tested for associations between common variants of the angiotensin-converting enzyme gene (ACE) and late-onset Alzheimer disease (AD), but results have been inconclusive... - Evaluation and management of transient ischemic attack: an important component of stroke preventionMai N Nguyen Huynh
Department of Neurology, UCSF, San Francisco, CA 94143 0114, USA
Nat Clin Pract Cardiovasc Med 4:310-8. 2007..In this Review, we summarize the recent literature on stroke risk after TIA and risk stratification, and recently published guidelines on evaluation and treatment... - Chronic dyspnea and hyperventilation in an awake patient with small subcortical infarctsS C Johnston
Neurovascular Service, Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurology 57:2131-3. 2001..Central neurogenic hyperventilation was diagnosed in this alert patient. The case may illustrate a role for the thalamus in regulating ventilation, but another small infarct not visible on MRI also could be responsible... - Spinal manipulative therapy is an independent risk factor for vertebral artery dissectionW S Smith
Department of Neurology, University of California, San Francisco 94143 0114, USA
Neurology 60:1424-8. 2003..To determine whether spinal manipulative therapy (SMT) is an independent risk factor for cervical artery dissection... - Stroke risk factors and loss of high cognitive functionJ S Elkins
University of California, San Francisco, CA 94143-0114, USA
Neurology 63:793-9. 2004..Additional studies are needed to determine whether modification of stroke risk factors can reduce the cognitive decline that is often attributed to normal aging... - Evaluation of carotid stenosis using CT angiography in the initial evaluation of stroke and TIAS A Josephson
Department of Neurology, University of California, San Francisco, CA, USA
Neurology 63:457-60. 2004..CT angiography appears to be an excellent screening test for internal carotid artery stenosis, and the authors advocate its use for the initial imaging of patients with suspected stroke or TIA... - Short-term prognosis after emergency department diagnosis of TIAS C Johnston
Department of Neurology, University of California, San Francisco 94143 0114, USA
JAMA 284:2901-6. 2000..Defining the short-term prognosis and risk factors for stroke after TIA may provide guidance in determining which patients need rapid evaluation... - Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic eventsDeepak L Bhatt
Cleveland Clinic, Cleveland, USA
N Engl J Med 354:1706-17. 2006..Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone in reducing the rate of myocardial infarction, stroke, or death from cardiovascular causes. (ClinicalTrials.gov number, NCT00050817.)... - Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on CRalph L Sacco
Circulation 113:e409-49. 2006.... - Recent advances in management of transient ischaemic attacks and minor ischaemic strokesPeter M Rothwell
Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK
Lancet Neurol 5:323-31. 2006.... - Recommendations for the endovascular treatment of intracranial aneurysms: a statement for healthcare professionals from the Committee on Cerebrovascular Imaging of the American Heart Association Council on Cardiovascular RadiologyS Claiborne Johnston
Stroke 33:2536-44. 2002 - Lipid assessment and treatment patterns in hospitalized TIA and ischemic stroke patientsBruce Ovbiagele
Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, California 90095, USA
J Hosp Med 1:214-20. 2006..We aimed to study the frequency and predictors of lipid assessment and discharge utilization of lipid-lowering therapies among patients hospitalized for stroke and TIA... - Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on CRalph L Sacco
Stroke 37:577-617. 2006.... - Poststroke neurological improvement within 7 days is associated with subsequent deteriorationStella Aslanyan
Division of Cardiovascular and Medical Sciences, University of Glasgow, Gardiner Institute, Western Infirmary, Glasgow G11 6NT, United Kingdom
Stroke 35:2165-70. 2004..We evaluated the degree of NIHSS improvement at 7 days (recovery) as a predictor of subsequent neurological deterioration from day 7 to day 90... - Breast vascular calcification and risk of coronary heart disease, stroke, and heart failureCarlos Iribarren
Kaiser Permanente of Northern California Division of Research, Oakland, California 94612, USA
J Womens Health (Larchmt) 13:381-9; discussion 390-2. 2004..Vascular calcification holds promise as a useful cardiovascular risk maker. Our objective was to examine the association between breast vascular calcification and risk of cardiovascular disease (CVD) outcomes... - Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attackRobert J Adams
Stroke 39:1647-52. 2008 - Trends in usage of alternative antiplatelet therapy after stroke and transient ischemic attackNancy K Hills
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Stroke 39:1228-32. 2008..Because public data on their usage are limited, we examined trends in their prescription after stroke and transient ischemic attack to assess the impact of marketing and trial results... - Impact of hospital-related factors on outcome after treatment of cerebral aneurysmsMitchell F Berman
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Stroke 34:2200-7. 2003..The goal of this study was to examine the impact of hospital characteristics on outcome after the treatment of ruptured and unruptured cerebral aneurysms... - Safety and feasibility of a CT protocol for acute stroke: combined CT, CT angiography, and CT perfusion imaging in 53 consecutive patientsWade S Smith
Department of Neurology, University of California, San Francisco, 94143, USA
AJNR Am J Neuroradiol 24:688-90. 2003..High-speed, multisection, helical CT scanners allow rapid, safe imaging of the entire neurovascular axis in patients with acute stroke by use of combined CT imaging, CT perfusion imaging, and CTA... - Midlife cardiovascular risk factors and risk of dementia in late lifeR A Whitmer
Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612, USA
Neurology 64:277-81. 2005..To evaluate if midlife cardiovascular risk factors are associated with risk of late-life dementia in a large, diverse cohort...
Research Grants
- OPTIMIZING MANAGEMENT OF TRANSIENT ISCHEMIC ATTACKSS Johnston; Fiscal Year: 2005..This research will provide important results for clinicians and policy makers, and will foster the applicant's development as a health services researcher in cerebrovascular disease. ..