S A Johnston

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi The Gal4 activation domain binds Sug2 protein, a proteasome component, in vivo and in vitro
    C Chang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    J Biol Chem 276:30956-63. 2001
  2. ncbi Evidence that Gal11 protein is a target of the Gal4 activation domain in the mediator
    C J Jeong
    Department of Internal Medicine, Ryburn Center for Molecular Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8573, USA
    Biochemistry 40:9421-7. 2001
  3. ncbi Isolation and characterization of SUG2. A novel ATPase family component of the yeast 26 S proteasome
    S J Russell
    Department of Internal Medicine, Graduate Program in Biochemistry and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    J Biol Chem 271:32810-7. 1996
  4. ncbi The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast
    W Zheng
    Departments of Medicine and Biochemistry, Graduate Program in Biochemistry and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    J Biol Chem 272:30350-5. 1997
  5. ncbi The 19S complex of the proteasome regulates nucleotide excision repair in yeast
    T G Gillette
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Genes Dev 15:1528-39. 2001
  6. ncbi Evidence that proteolysis of Gal4 cannot explain the transcriptional effects of proteasome ATPase mutations
    S J Russell
    Department of Internal Medicine, Biochemistry and Molecular Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas 75390 8573, USA
    J Biol Chem 276:9825-31. 2001
  7. ncbi Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases
    S J Russell
    Center for Biomedical Inventions, Department of Medicine, University of Texas Southwestern Meidcal School, Dallas, 75390 8573, USA
    Chem Biol 8:941-50. 2001
  8. ncbi The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II
    A Ferdous
    Departments of Internal Medicine and Biochemistry, Ryburn Center for Molecular Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX7 5390 8573, USA
    Mol Cell 7:981-91. 2001
  9. ncbi The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair
    S J Russell
    Department of Medicine and Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Mol Cell 3:687-95. 1999
  10. ncbi The DNA binding and activation domains of Gal4p are sufficient for conveying its regulatory signals
    W V Ding
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8573, USA
    Mol Cell Biol 17:2538-49. 1997

Collaborators

Detail Information

Publications24

  1. ncbi The Gal4 activation domain binds Sug2 protein, a proteasome component, in vivo and in vitro
    C Chang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    J Biol Chem 276:30956-63. 2001
    ....
  2. ncbi Evidence that Gal11 protein is a target of the Gal4 activation domain in the mediator
    C J Jeong
    Department of Internal Medicine, Ryburn Center for Molecular Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8573, USA
    Biochemistry 40:9421-7. 2001
    ....
  3. ncbi Isolation and characterization of SUG2. A novel ATPase family component of the yeast 26 S proteasome
    S J Russell
    Department of Internal Medicine, Graduate Program in Biochemistry and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    J Biol Chem 271:32810-7. 1996
    ..With its highly conserved mammalian homologs, human p42 and ground squirrel CADp44, SUG2 defines a new class of proteasomal CAD proteins...
  4. ncbi The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast
    W Zheng
    Departments of Medicine and Biochemistry, Graduate Program in Biochemistry and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    J Biol Chem 272:30350-5. 1997
    ..Neither the peptidase nor the nucleic acid binding activity of Gal6p as assayed is apparently required to convey this regulation, implying yet another function for this new member of the GAL regulon...
  5. ncbi The 19S complex of the proteasome regulates nucleotide excision repair in yeast
    T G Gillette
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Genes Dev 15:1528-39. 2001
    ..The 19S regulatory complex of the yeast proteasome functions in nucleotide excision repair independent of proteolysis...
  6. ncbi Evidence that proteolysis of Gal4 cannot explain the transcriptional effects of proteasome ATPase mutations
    S J Russell
    Department of Internal Medicine, Biochemistry and Molecular Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas 75390 8573, USA
    J Biol Chem 276:9825-31. 2001
    ..These findings suggest that the 19S regulatory complex may play a more direct role in transcription...
  7. ncbi Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases
    S J Russell
    Center for Biomedical Inventions, Department of Medicine, University of Texas Southwestern Meidcal School, Dallas, 75390 8573, USA
    Chem Biol 8:941-50. 2001
    ..Using this technique the individual contributions of Sug1 and Sug2 to proteasome function can be assessed...
  8. ncbi The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II
    A Ferdous
    Departments of Internal Medicine and Biochemistry, Ryburn Center for Molecular Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX7 5390 8573, USA
    Mol Cell 7:981-91. 2001
    ..Inhibition of the 20S proteolytic core of the proteasome has no effect on elongation. This work defines a nonproteolytic role for the 19S complex in RNAP II transcription...
  9. ncbi The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair
    S J Russell
    Department of Medicine and Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Mol Cell 3:687-95. 1999
    ..Surprisingly, blockage of protein degradation by the proteasome has no effect on the efficiency of NER. This establishes that the regulatory complex of the proteasome has a function independent of protein degradation...
  10. ncbi The DNA binding and activation domains of Gal4p are sufficient for conveying its regulatory signals
    W V Ding
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8573, USA
    Mol Cell Biol 17:2538-49. 1997
    ..Our observations imply that the internal region of Gal4 protein may serve as a spacer to augment transcription and/or may be involved in intramolecular or Gal4p-Gal4p interactions...
  11. ncbi Subcellular localization, stoichiometry, and protein levels of 26 S proteasome subunits in yeast
    S J Russell
    Departments of Internal Medicine and Biochemistry, Biochemistry and Molecular Biology Graduate Program, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    J Biol Chem 274:21943-52. 1999
    ..This information will be useful in comparing and contrasting the yeast and mammalian proteasomes and should contribute to a mechanistic understanding of how this complex functions...
  12. ncbi Are all DNA binding and transcription regulation by an activator physiologically relevant?
    Q Li
    Department of Internal Medicine and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    Mol Cell Biol 21:2467-74. 2001
    ..We suggest that the occurrence of these sites may not be related to galactose regulation and a manifestation of the "noise" in the occurrence of Gal4 binding sites...
  13. ncbi GAL4 interacts with TATA-binding protein and coactivators
    K Melcher
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8573, USA
    Mol Cell Biol 15:2839-48. 1995
    ..This suggests that these two prototypic activators make similar contacts with TBP...
  14. ncbi The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase
    W Zheng
    Center for Biomedical Inventions, Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8573, USA
    Cell 93:103-9. 1998
    ..We propose a model to explain these diverse activities and Gal6's singular ability to inactivate bleomycin...
  15. ncbi Genetic live vaccines mimic the antigenicity but not pathogenicity of live viruses
    K F Sykes
    Center for Biomedical Inventions, Department of Internal Medicine, The University Texas Southwestern Medical Center, Dallas 75235 8573, USA
    DNA Cell Biol 18:521-31. 1999
    ..We propose that the characteristics of GLVs support their further investigation as an approach to protection against HIV and other viral pathogens...
  16. ncbi The nucleic acid binding activity of bleomycin hydrolase is involved in bleomycin detoxification
    W Zheng
    Departments of Medicine and Biochemistry, Graduate Program in Biochemistry and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
    Mol Cell Biol 18:3580-5. 1998
    ....
  17. ncbi Affinity purification of proteins binding to GST fusion proteins
    J C Swaffield
    University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Protoc Mol Biol . 2001
    ..A describes preparation of an E. coli extract that is added to the reaction mixture with purified test protein to reduce nonspecific binding...
  18. ncbi A combination vaccine confers full protection against co-infections with influenza, herpes simplex and respiratory syncytial viruses
    A M Talaat
    Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX 75390-8573, USA
    Vaccine 20:538-44. 2001
    ..If these results are extendable to other combinations of vaccines in other hosts, it would support the development of gene vaccines as multi-component, combination vaccines...
  19. ncbi Development of a Langerhans cell-targeted gene therapy format using a dendritic cell-specific promoter
    A Morita
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Gene Ther 8:1729-37. 2001
    ..These results introduce a new concept that LC function can be genetically manipulated in situ by the combination of gene gun-mediated DNA delivery and a DC-specific promoter...
  20. ncbi Analysis of the galactose signal transduction pathway in Saccharomyces cerevisiae: interaction between Gal3p and Gal80p
    T Suzuki-Fujimoto
    Department of Microbiology, Keio University School of Medicine, Japan
    Mol Cell Biol 16:2504-8. 1996
    ..Reexamination of the DNA sequence of GAL3 revealed several mistakes, including an extension at the 3' end of another predicted 97 amino acids...
  21. ncbi Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease
    P A O'Farrell
    WM Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, NY 11724, USA
    Structure 7:619-27. 1999
    ..In addition, it has been reported that an allelic variant of hBH is genetically linked to Alzheimer's disease...
  22. ncbi Interaction of thyroid-hormone receptor with a conserved transcriptional mediator
    J W Lee
    Department of Molecular Biology, Wellman 9, Massachusetts General Hospital, Boston 02114
    Nature 374:91-4. 1995
    ..Here we show that Trip1 can functionally substitute for Sug1 in yeast, and that both proteins interact in vitro with the thyroid-hormone receptor, and with the transcriptional activation domains of yeast GAL4 and of herpes virus VP16...
  23. ncbi A highly conserved ATPase protein as a mediator between acidic activation domains and the TATA-binding protein
    J C Swaffield
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75325 8573
    Nature 374:88-91. 1995
    ..We also demonstrate that Sug1 is not a component of the 26S proteasome, contrary to previous reports. Sug1 is a member of a large, highly conserved family of ATPases, implying a role for ATP hydrolysis in the activation of transcription...
  24. ncbi Yeast bleomycin hydrolase is a DNA-binding cysteine protease. Identification, purification, biochemical characterization
    H E Xu
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 8573
    J Biol Chem 269:21177-83. 1994
    ..This protein may represent the first example of a eukaryotic DNA-binding protease. The discovery of a DNA binding activity for BLM hydrolase suggests an in vivo interaction between it and BLM on DNA...