Research Topics
| Karen C JohnstonSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Detail Information
Publications
Medical and neurological complications of ischemic stroke: experience from the RANTTAS trial. RANTTAS InvestigatorsK C Johnston
Department of Neurology, University of Virginia, Charlottesville 22908, USA
Stroke 29:447-53. 1998..Our objective was to identify the types, severity, and frequency of medical and neurological complications following acute ischemic stroke and to determine their role in mortality and functional outcome...
Relationship between 3-month National Institutes of Health Stroke Scale score and dependence in ischemic stroke patientsKaren C Johnston
Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
Neuroepidemiology 27:96-100. 2006..The relationship between NIHSS score and functional dependence is unknown. The purpose of this study was to assess the relationship between NIHSS score and accepted measures of dependence in surviving ischemic stroke patients...- Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome?Karen C Johnston
Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
Stroke 38:1820-5. 2007..The purpose of this study was to combine acute clinical data and DWI lesion volume for ischemic stroke patients to determine whether DWI improves the prediction of clinical outcome... - Clinical and imaging data at 5 days as a surrogate for 90-day outcome in ischemic strokeKaren C Johnston
MSc, University of Virginia Health System, Department of Neurology, 800394, Charlottesville, VA 22908 0394
Stroke 40:1332-3. 2009.... - Risk adjustment effect on stroke clinical trialsKaren C Johnston
Department of Neurology, University of Virginia, Charlottesville, USA
Stroke 35:e43-5. 2004.... - Responding to the ACGME's competency requirements: an innovative instrument from the University of Virginia's neurology residencyKaren C Johnston
University of Virginia School of Medicine, Charlottesville, Virginia, USA
Acad Med 78:1217-20. 2003..She also suggests that these instruments, with some modifications, may be of value to other residency programs... - Glucose Regulation in Acute Stroke Patients (GRASP) trial: a randomized pilot trialKaren C Johnston
Department of Neurology, University of Virginia, PO Box 800394, Charlottesville, VA 22908, USA
Stroke 40:3804-9. 2009..Hyperglycemia is associated with worse outcome in patients with acute stroke... - Acute physiology of stroke scoreKaren C Johnston
Departments of Neurology, University of Virginia, Charlottesville, VA, USA
Stroke 42:2336-8. 2011..We hypothesized that a physiology score for stroke patients (Acute Physiology of Stroke Score [APSS]) when added to a validated clinical prediction model would improve outcome prediction... - Microhemorrhages on gradient echo MRIKaren C Johnston
University of Virginia Health System, Department of Neurology, 800394, Charlottesville, VA 22908, USA
Neurology 60:518. 2003 - Predicting outcome in ischemic stroke: external validation of predictive risk modelsKaren C Johnston
Department of Neurology, University of Virginia, Charlottesville, USA
Stroke 34:200-2. 2003..Six multivariable models predicting 3-month outcome of acute ischemic stroke have been developed and internally validated previously. The purpose of this study was to externally validate the previous models in an independent data set... - Combined clinical and imaging information as an early stroke outcome measureKaren C Johnston
Departments of Neurology, University of Virginia Health System, Charlottesville, VA 22908, USA
Stroke 33:466-72. 2002..The purpose of this study was to determine whether an early outcome measure combining clinical and imaging information is better than either alone in predicting 3-month outcome in acute ischemic stroke patients... - A predictive risk model for outcomes of ischemic strokeK C Johnston
Departments of Neurology, University of Virginia, Charlottesville, VA 22908, USA
Stroke 31:448-55. 2000..The purpose of this study was to determine the multivariable relationship between infarct volume, 6 clinical variables, and 3-month outcomes in ischemic stroke patients... - What are surrogate outcome measures and why do they fail in clinical research?K Johnston
Department of Neurology and Health Evaluation Sciences, University of Virginia, Charlottesville, VA 22908, USA
Neuroepidemiology 18:167-73. 1999..The definition of a surrogate outcome measure, its consideration in clinical stroke research and some of the potential mechanisms for failure of surrogate measures will be discussed... - Predicting major neurological improvement with intravenous recombinant tissue plasminogen activator treatment of strokeDevin L Brown
Department of Neurology, University of Virginia Health System, Charlottesville, USA
Stroke 35:147-50. 2004..We explored the relationship between MNI and 3-month favorable outcome and sought clinical predictors of MNI... - Ninety-day outcome rates of a prospective cohort of consecutive patients with mild ischemic strokePooja Khatri
Department of Neurology, University of Cincinnati, 260 Stetson Street, Suite 2300, ML 0525, Cincinnati, OH 45267 0525, USA
Stroke 43:560-2. 2012..We sought to determine disability rates at 90 days among patients not treated with thrombolytic therapy and explore the role of early neurological worsening... - Change in diffusion-weighted imaging infarct volume predicts neurologic outcome at 90 days: results of the Acute Stroke Accurate Prediction (ASAP) trial serial imaging substudyKevin M Barrett
Department of Neurology, Mayo Clinic Florida, Department of Neurology, Jacksonville, FL 32224, USA
Stroke 40:2422-7. 2009..We hypothesized that serial measurements of DWI infarct volume would be predictive of functional outcome after ischemic stroke... - Considering hyperglycemia and thrombolysis in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trialAndrew M Southerland
Division of Vascular Neurology, Department of Neurology, University of Virginia Health System, Charlottesville, Virginia, USA
Ann N Y Acad Sci 1268:72-8. 2012..With enrollment recently underway, the stratified results from the SHINE trial could substantially influence future treatment decisions for hyperglycemic stroke patients... - Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trialE Clarke Haley
Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
Stroke 41:707-11. 2010..If promise was established, then the trial would continue as a Phase III efficacy trial comparing the selected tenecteplase dose to standard rtPA... - Predict Resident Exam Performance (PREP) studyVern C Juel
Department of Neurology, University of Virginia, Charlottesville, USA
Neurology 60:1385-7. 2003..Residency programs should consider developing training tools that predict outcome on the oral ABPN examination... - A pilot dose-escalation safety study of tenecteplase in acute ischemic strokeE Clarke Haley
Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA
Stroke 36:607-12. 2005..This open-label, dose-escalation safety study was conducted to develop initial experience with TNK in the treatment of ischemic stroke... - Teleradiology Assessment of Computerized Tomographs Online Reliability Study (TRACTORS) for acute stroke evaluationKaren C Johnston
Department of Neurology, University of Virginia, Charlottesville, USA
Telemed J E Health 9:227-33. 2003..Further analysis in a larger sample is necessary to validate these results... - Statin therapy improves outcomes after valvular heart surgeryLynn M Fedoruk
Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
Ann Thorac Surg 85:1521-5; discussion 1525-6. 2008..Reduced mortality rates and clinical events have been demonstrated. These outcomes were examined in patients taking statins who underwent cardiac valve operations... - Stroke risk factor profiles in African American women: an interim report from the African-American Antiplatelet Stroke Prevention StudyBradford B Worrall
Department of Neurology, University of Virginia, Charlottesville, 22908, USA
Stroke 33:913-9. 2002..Although limited, these data provide an important first characterization of sex differences in African Americans with stroke... - Timing of stroke after cardiopulmonary bypass determines mortalityTurner C Lisle
Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
Ann Thorac Surg 85:1556-62; discussion 1562-3. 2008..Stroke is an important complication of cardiopulmonary bypass (CPB). This study determined if the timing of stroke events after CPB predicted stroke-related mortality or rehabilitation needs at hospital discharge... - Health care resource use after acute stroke in the Glycine Antagonist in Neuroprotection (GAIN) Americas trialTanja Rundek
Department of Neurology, Neurological Institute, Columbia University, New York, NY, USA
Stroke 35:1368-74. 2004..Further research is required to determine the most cost-effective treatment and rehabilitation plan for people who have a stroke... - Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trialsJeffrey L Saver
Department of Neurology, Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Stroke 40:2594-600. 2009..a. thrombolysis or devices may be acceptable. Statistical considerations and definitions of successful recanalization/reperfusion are suggested for these trials... - Applying a phase II futility study design to therapeutic stroke trialsYuko Y Palesch
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
Stroke 36:2410-4. 2005..We determined whether some phase III studies could have been avoided if preceded by smaller single-arm phase II studies to evaluate the futility of proceeding to phase III... - Managing hyperglycemia in acute ischemic stroke patientsKaren C Johnston
Stroke 38:e137; author reply e139. 2007 - Clinical diagnosis of lacunar stroke in the first 6 hours after symptom onset: analysis of data from the glycine antagonist in neuroprotection (GAIN) Americas trialStephen J Phillips
Queen Elizabeth II Health Sciences Centre, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Stroke 38:2706-11. 2007..We conducted a study of the accuracy of a clinical diagnosis of lacunar stroke in the first 6 hours after symptom onset... - Blood pressure reduction in ischemic stroke: a two-edged sword?Karen C Johnston
Neurology 61:1030-1. 2003 - Introducing the resident and fellow pageKaren C Johnston
Neurology 62:12. 2004 - Translating research into treatmentsJohn H Noseworthy
Neurology 71:232-3. 2008 - New transient ischemic attack guidelines: a step forward but journey just begunKevin M Barrett
Ann Neurol 60:273-4. 2006 - Effect of sildenafil (Viagra) on cerebral blood vesselsKaren C Johnston
Neurology 65:785. 2005
Research Grants
- PREDICTIVE RISK MODEL IN ACUTE ISCHEMIC STROKEKaren Johnston; Fiscal Year: 2004..This will be valuable to patients with stroke, providers, payers and developers of new drug therapies. ..
- Glucose Regulation in Acute Stroke Patients (GRASP)Karen Johnston; Fiscal Year: 2007....
- The Acute Physiology of Stroke Score (APSS)Karen Johnston; Fiscal Year: 2007..abstract_text> ..