Karen C Johnston

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Medical and neurological complications of ischemic stroke: experience from the RANTTAS trial. RANTTAS Investigators
    K C Johnston
    Department of Neurology, University of Virginia, Charlottesville 22908, USA
    Stroke 29:447-53. 1998
  2. pmc Relationship between 3-month National Institutes of Health Stroke Scale score and dependence in ischemic stroke patients
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
    Neuroepidemiology 27:96-100. 2006
  3. ncbi request reprint Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome?
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
    Stroke 38:1820-5. 2007
  4. pmc Clinical and imaging data at 5 days as a surrogate for 90-day outcome in ischemic stroke
    Karen C Johnston
    MSc, University of Virginia Health System, Department of Neurology, 800394, Charlottesville, VA 22908 0394
    Stroke 40:1332-3. 2009
  5. pmc Risk adjustment effect on stroke clinical trials
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, USA
    Stroke 35:e43-5. 2004
  6. ncbi request reprint Responding to the ACGME's competency requirements: an innovative instrument from the University of Virginia's neurology residency
    Karen C Johnston
    University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Acad Med 78:1217-20. 2003
  7. pmc Glucose Regulation in Acute Stroke Patients (GRASP) trial: a randomized pilot trial
    Karen C Johnston
    Department of Neurology, University of Virginia, PO Box 800394, Charlottesville, VA 22908, USA
    Stroke 40:3804-9. 2009
  8. pmc Acute physiology of stroke score
    Karen C Johnston
    Departments of Neurology, University of Virginia, Charlottesville, VA, USA
    Stroke 42:2336-8. 2011
  9. ncbi request reprint Microhemorrhages on gradient echo MRI
    Karen C Johnston
    University of Virginia Health System, Department of Neurology, 800394, Charlottesville, VA 22908, USA
    Neurology 60:518. 2003
  10. pmc Predicting outcome in ischemic stroke: external validation of predictive risk models
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, USA
    Stroke 34:200-2. 2003

Research Grants

  1. PREDICTIVE RISK MODEL IN ACUTE ISCHEMIC STROKE
    Karen Johnston; Fiscal Year: 2004
  2. Glucose Regulation in Acute Stroke Patients (GRASP)
    Karen Johnston; Fiscal Year: 2007
  3. The Acute Physiology of Stroke Score (APSS)
    Karen Johnston; Fiscal Year: 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Medical and neurological complications of ischemic stroke: experience from the RANTTAS trial. RANTTAS Investigators
    K C Johnston
    Department of Neurology, University of Virginia, Charlottesville 22908, USA
    Stroke 29:447-53. 1998
    ..Our objective was to identify the types, severity, and frequency of medical and neurological complications following acute ischemic stroke and to determine their role in mortality and functional outcome...
  2. pmc Relationship between 3-month National Institutes of Health Stroke Scale score and dependence in ischemic stroke patients
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
    Neuroepidemiology 27:96-100. 2006
    ..The relationship between NIHSS score and functional dependence is unknown. The purpose of this study was to assess the relationship between NIHSS score and accepted measures of dependence in surviving ischemic stroke patients...
  3. ncbi request reprint Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome?
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
    Stroke 38:1820-5. 2007
    ..The purpose of this study was to combine acute clinical data and DWI lesion volume for ischemic stroke patients to determine whether DWI improves the prediction of clinical outcome...
  4. pmc Clinical and imaging data at 5 days as a surrogate for 90-day outcome in ischemic stroke
    Karen C Johnston
    MSc, University of Virginia Health System, Department of Neurology, 800394, Charlottesville, VA 22908 0394
    Stroke 40:1332-3. 2009
    ....
  5. pmc Risk adjustment effect on stroke clinical trials
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, USA
    Stroke 35:e43-5. 2004
    ....
  6. ncbi request reprint Responding to the ACGME's competency requirements: an innovative instrument from the University of Virginia's neurology residency
    Karen C Johnston
    University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Acad Med 78:1217-20. 2003
    ..She also suggests that these instruments, with some modifications, may be of value to other residency programs...
  7. pmc Glucose Regulation in Acute Stroke Patients (GRASP) trial: a randomized pilot trial
    Karen C Johnston
    Department of Neurology, University of Virginia, PO Box 800394, Charlottesville, VA 22908, USA
    Stroke 40:3804-9. 2009
    ..Hyperglycemia is associated with worse outcome in patients with acute stroke...
  8. pmc Acute physiology of stroke score
    Karen C Johnston
    Departments of Neurology, University of Virginia, Charlottesville, VA, USA
    Stroke 42:2336-8. 2011
    ..We hypothesized that a physiology score for stroke patients (Acute Physiology of Stroke Score [APSS]) when added to a validated clinical prediction model would improve outcome prediction...
  9. ncbi request reprint Microhemorrhages on gradient echo MRI
    Karen C Johnston
    University of Virginia Health System, Department of Neurology, 800394, Charlottesville, VA 22908, USA
    Neurology 60:518. 2003
  10. pmc Predicting outcome in ischemic stroke: external validation of predictive risk models
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, USA
    Stroke 34:200-2. 2003
    ..Six multivariable models predicting 3-month outcome of acute ischemic stroke have been developed and internally validated previously. The purpose of this study was to externally validate the previous models in an independent data set...
  11. pmc Combined clinical and imaging information as an early stroke outcome measure
    Karen C Johnston
    Departments of Neurology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Stroke 33:466-72. 2002
    ..The purpose of this study was to determine whether an early outcome measure combining clinical and imaging information is better than either alone in predicting 3-month outcome in acute ischemic stroke patients...
  12. ncbi request reprint A predictive risk model for outcomes of ischemic stroke
    K C Johnston
    Departments of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 31:448-55. 2000
    ..The purpose of this study was to determine the multivariable relationship between infarct volume, 6 clinical variables, and 3-month outcomes in ischemic stroke patients...
  13. ncbi request reprint What are surrogate outcome measures and why do they fail in clinical research?
    K Johnston
    Department of Neurology and Health Evaluation Sciences, University of Virginia, Charlottesville, VA 22908, USA
    Neuroepidemiology 18:167-73. 1999
    ..The definition of a surrogate outcome measure, its consideration in clinical stroke research and some of the potential mechanisms for failure of surrogate measures will be discussed...
  14. ncbi request reprint Predicting major neurological improvement with intravenous recombinant tissue plasminogen activator treatment of stroke
    Devin L Brown
    Department of Neurology, University of Virginia Health System, Charlottesville, USA
    Stroke 35:147-50. 2004
    ..We explored the relationship between MNI and 3-month favorable outcome and sought clinical predictors of MNI...
  15. pmc Ninety-day outcome rates of a prospective cohort of consecutive patients with mild ischemic stroke
    Pooja Khatri
    Department of Neurology, University of Cincinnati, 260 Stetson Street, Suite 2300, ML 0525, Cincinnati, OH 45267 0525, USA
    Stroke 43:560-2. 2012
    ..We sought to determine disability rates at 90 days among patients not treated with thrombolytic therapy and explore the role of early neurological worsening...
  16. pmc Change in diffusion-weighted imaging infarct volume predicts neurologic outcome at 90 days: results of the Acute Stroke Accurate Prediction (ASAP) trial serial imaging substudy
    Kevin M Barrett
    Department of Neurology, Mayo Clinic Florida, Department of Neurology, Jacksonville, FL 32224, USA
    Stroke 40:2422-7. 2009
    ..We hypothesized that serial measurements of DWI infarct volume would be predictive of functional outcome after ischemic stroke...
  17. pmc Considering hyperglycemia and thrombolysis in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial
    Andrew M Southerland
    Division of Vascular Neurology, Department of Neurology, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann N Y Acad Sci 1268:72-8. 2012
    ..With enrollment recently underway, the stratified results from the SHINE trial could substantially influence future treatment decisions for hyperglycemic stroke patients...
  18. pmc Phase IIB/III trial of tenecteplase in acute ischemic stroke: results of a prematurely terminated randomized clinical trial
    E Clarke Haley
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Stroke 41:707-11. 2010
    ..If promise was established, then the trial would continue as a Phase III efficacy trial comparing the selected tenecteplase dose to standard rtPA...
  19. ncbi request reprint Predict Resident Exam Performance (PREP) study
    Vern C Juel
    Department of Neurology, University of Virginia, Charlottesville, USA
    Neurology 60:1385-7. 2003
    ..Residency programs should consider developing training tools that predict outcome on the oral ABPN examination...
  20. ncbi request reprint A pilot dose-escalation safety study of tenecteplase in acute ischemic stroke
    E Clarke Haley
    Department of Neurology, University of Virginia Health System, Charlottesville, VA, USA
    Stroke 36:607-12. 2005
    ..This open-label, dose-escalation safety study was conducted to develop initial experience with TNK in the treatment of ischemic stroke...
  21. ncbi request reprint Teleradiology Assessment of Computerized Tomographs Online Reliability Study (TRACTORS) for acute stroke evaluation
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, USA
    Telemed J E Health 9:227-33. 2003
    ..Further analysis in a larger sample is necessary to validate these results...
  22. pmc Statin therapy improves outcomes after valvular heart surgery
    Lynn M Fedoruk
    Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, Virginia 22908 0679, USA
    Ann Thorac Surg 85:1521-5; discussion 1525-6. 2008
    ..Reduced mortality rates and clinical events have been demonstrated. These outcomes were examined in patients taking statins who underwent cardiac valve operations...
  23. pmc Stroke risk factor profiles in African American women: an interim report from the African-American Antiplatelet Stroke Prevention Study
    Bradford B Worrall
    Department of Neurology, University of Virginia, Charlottesville, 22908, USA
    Stroke 33:913-9. 2002
    ..The purpose of this study was to determine whether medical and lifestyle factors differ among women and men who have enrolled in the African-American Antiplatelet Stroke Prevention Study (AAASPS)...
  24. pmc Timing of stroke after cardiopulmonary bypass determines mortality
    Turner C Lisle
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Thorac Surg 85:1556-62; discussion 1562-3. 2008
    ..Stroke is an important complication of cardiopulmonary bypass (CPB). This study determined if the timing of stroke events after CPB predicted stroke-related mortality or rehabilitation needs at hospital discharge...
  25. ncbi request reprint Health care resource use after acute stroke in the Glycine Antagonist in Neuroprotection (GAIN) Americas trial
    Tanja Rundek
    Department of Neurology, Neurological Institute, Columbia University, New York, NY, USA
    Stroke 35:1368-74. 2004
    ..Delivery of medical care for stroke patients, often driven by efforts to curb costs, varies substantially between countries. Data on the potential impact of these variations on clinical outcomes are sparse...
  26. pmc Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials
    Jeffrey L Saver
    Department of Neurology, Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    Stroke 40:2594-600. 2009
    ..a. thrombolysis or devices may be acceptable. Statistical considerations and definitions of successful recanalization/reperfusion are suggested for these trials...
  27. ncbi request reprint Applying a phase II futility study design to therapeutic stroke trials
    Yuko Y Palesch
    Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, P O Box 250835, Charleston, SC 29425, USA
    Stroke 36:2410-4. 2005
    ..We determined whether some phase III studies could have been avoided if preceded by smaller single-arm phase II studies to evaluate the futility of proceeding to phase III...
  28. ncbi request reprint Managing hyperglycemia in acute ischemic stroke patients
    Karen C Johnston
    Stroke 38:e137; author reply e139. 2007
  29. pmc Clinical diagnosis of lacunar stroke in the first 6 hours after symptom onset: analysis of data from the glycine antagonist in neuroprotection (GAIN) Americas trial
    Stephen J Phillips
    Queen Elizabeth II Health Sciences Centre, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 38:2706-11. 2007
    ..We conducted a study of the accuracy of a clinical diagnosis of lacunar stroke in the first 6 hours after symptom onset...
  30. ncbi request reprint Blood pressure reduction in ischemic stroke: a two-edged sword?
    Karen C Johnston
    Neurology 61:1030-1. 2003
  31. ncbi request reprint Introducing the resident and fellow page
    Karen C Johnston
    Neurology 62:12. 2004
  32. doi request reprint Translating research into treatments
    John H Noseworthy
    Neurology 71:232-3. 2008
  33. ncbi request reprint New transient ischemic attack guidelines: a step forward but journey just begun
    Kevin M Barrett
    Ann Neurol 60:273-4. 2006
  34. ncbi request reprint Effect of sildenafil (Viagra) on cerebral blood vessels
    Karen C Johnston
    Neurology 65:785. 2005

Research Grants6

  1. PREDICTIVE RISK MODEL IN ACUTE ISCHEMIC STROKE
    Karen Johnston; Fiscal Year: 2004
    ..This will be valuable to patients with stroke, providers, payers and developers of new drug therapies. ..
  2. Glucose Regulation in Acute Stroke Patients (GRASP)
    Karen Johnston; Fiscal Year: 2007
    ....
  3. The Acute Physiology of Stroke Score (APSS)
    Karen Johnston; Fiscal Year: 2007
    ..abstract_text> ..