Ian N Johnston
Affiliation: University of Colorado
- Inhibition of morphine analgesia by LPS: role of opioid and NMDA receptors and spinal gliaIan N Johnston
School of Psychology, Griffith Taylor Building, A19, University of Sydney, Sydney, NSW 2006, Australia
Behav Brain Res 156:75-83. 2005..These results demonstrate that LPS recruits similar, if not the same mechanisms that reduce morphine tolerance following opiate administration: namely, stimulation of opioid and NMDA receptors and recruitment of spinal glia...
- Acute and conditioned sickness reduces morphine analgesiaIan N Johnston
Department of Psychology, University of Colorado, Boulder, CO 80303 0345, USA
Behav Brain Res 142:89-97. 2003..Thus, in addition to provoking hyperalgesia, illness-inducing agents also activate endogenous antianalgesic mechanisms...
- Inhibition of morphine analgesia by lithium: role of peripheral and central opioid receptorsIan N Johnston
Department of Psychology, University of Colorado, Campus Box 0345, Boulder, CO 80309, USA
Behav Brain Res 151:151-8. 2004..Thus, activity at peripheral and central opioid receptors is necessary for the inhibition of morphine analgesia by LiCl, but peripheral opioid receptors are not critical for the expression of this inhibition...
- A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphineIan N Johnston
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 24:7353-65. 2004..Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates...
- Glia: novel counter-regulators of opioid analgesiaLinda R Watkins
Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Trends Neurosci 28:661-9. 2005..New data suggest that glia also release neuroexcitatory substances in response to morphine, thereby opposing its effects. Controlling glial activation could therefore increase the clinical utility of analgesic drugs...