Research Topics
Species | Daniel JohnstonSummaryAffiliation: University of Texas Country: USA Publications
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Publications
Active dendrites: colorful wings of the mysterious butterfliesDaniel Johnston
Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712, USA
Trends Neurosci 31:309-16. 2008..In this brief historical perspective, we track important milestones in the chameleonic transmogrification of these mysterious butterflies...
The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neuronsRishikesh Narayanan
Center for Learning and Memory, The University of Texas at Austin, Austin, Texas 78712, USA
J Neurosci 28:5846-60. 2008..Our analyses and results also establish impedance as a powerful measure of intrinsic dynamics and excitability, given that it quantifies temporal relationships among signals and excitability as functions of input frequency...
Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neuronsXixi Chen
Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712, USA
J Neurosci 26:12143-51. 2006..2 knock-out and wild-type neurons. Our results support the hypothesis that dendritic A-type K+ channels, composed of Kv4.2 subunits, regulate action potential backpropagation and the induction of specific forms of synaptic plasticity...- The h current is a candidate mechanism for regulating the sliding modification threshold in a BCM-like synaptic learning ruleRishikesh Narayanan
Center for Learning and Memory, The University of Texas, Austin, Texas 78712 0805, USA
J Neurophysiol 104:1020-33. 2010..Our results underscore the heavy mutual interdependence of synaptic and intrinsic properties/plasticity in regulating learning and homeostasis in single neurons and their networks under both physiological and pathological brain states... - Anatomical and electrophysiological comparison of CA1 pyramidal neurons of the rat and mouseBrandy N Routh
Center for Learning and Memory, University of Texas at Austin, 1 University Station, Austin, Texas 78712, USA
J Neurophysiol 102:2288-302. 2009..Our findings indicate that comparisons of data obtained across strains or species will need to account for these and potentially other physiological and anatomical differences... - Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h)Yuan Fan
Center for Learning and Memory, University of Texas at Austin, 1 University Station, C7000, Austin, Texas 78712, USA
Nat Neurosci 8:1542-51. 2005..The occurrence of such a reduction in cellular excitability in parallel with synaptic potentiation would be a negative feedback mechanism to normalize neuronal output firing and thus promote network stability... - Kinase-dependent modification of dendritic excitability after long-term potentiationJ Amiel Rosenkranz
Center for Learning and Memory, University of Texas at Austin, Austin, TX, USA
J Physiol 587:115-25. 2009..Furthermore, this study uncovers an additional contribution of kinase activation to plasticity that may occur during learning... - Projection-specific neuromodulation of medial prefrontal cortex neuronsNikolai C Dembrow
Center for Learning and Memory, The University of Texas at Austin, Austin, Texas 78712, USA
J Neurosci 30:16922-37. 2010..Together, these data suggest that the two categories of projection neurons may subserve separate functions in PFC and may be engaged differently during working memory processes... - State-dependent modulation of amygdala inputs by dopamine-induced enhancement of sodium currents in layer V entorhinal cortexJ Amiel Rosenkranz
Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712, USA
J Neurosci 27:7054-69. 2007..Functionally, by enhancement of amygdala inputs that arrive in concert with other inputs, or during depolarized states, DA can facilitate the impact of affect on memory in a subset of conditions... - Voltage-gated ion channels in dendrites of hippocampal pyramidal neuronsXixi Chen
Center for Learning and Memory, University of Texas at Austin, Austin, TX, 78712, USA
Pflugers Arch 453:397-401. 2006..In this report, we provide some new evidence for the role of the delayed-rectifier K(+) channel in shaping the dendritic action potential at different membrane potentials... - Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortexJ Amiel Rosenkranz
Center for Learning and Memory, University of Texas, Austin, Texas 78712, USA
J Neurosci 26:3229-44. 2006..The data suggest that DA can directly influence the membrane properties of layer V EC pyramidal neurons by modulation of h-channels. These actions may underlie some of the effects of DA on memory formation... - Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neuronsXixi Chen
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 25:3787-92. 2005..Therefore, these channels are GIRK channels, which are constitutively active at rest in the apical dendrites of CA1 pyramidal neurons and can be further activated via G-protein-coupled neurotransmitter receptors... - Target cell-dependent normalization of transmitter release at neocortical synapsesHelmut J Koester
Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, D 69120 Heidelberg, Germany
Science 308:863-6. 2005..We propose that the mechanisms that regulate the functional properties of boutons of a pyramid normalize the presynaptic Ca2+ influx and release probability for all those boutons that innervate the same target cell... - Calcium store depletion induces persistent perisomatic increases in the functional density of h channels in hippocampal pyramidal neuronsRishikesh Narayanan
Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712, USA
Neuron 68:921-35. 2010..We postulate that this form of depletion-induced intrinsic plasticity is a neuroprotective mechanism that reduces excitability after depletion of calcium stores triggered through altered network activity during pathological conditions... - Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviorsChung Sub Kim
Center for Learning and Memory, The Institute for Neuroscience, and Section of Neurobiology University of Texas at Austin, Austin, TX 78712, USA
Neuron 75:503-16. 2012..Our results suggest that HCN1 protein could be a potential target for treatment of anxiety and depression disorders... - The ascent of channels with memoryRishikesh Narayanan
Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712, USA
Neuron 60:735-8. 2008.... - Impaired dendritic expression and plasticity of h-channels in the fmr1(-/y) mouse model of fragile X syndromeDarrin H Brager
Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712, USA
Cell Rep 1:225-33. 2012.... - Long-term potentiation in rat hippocampal neurons is accompanied by spatially widespread changes in intrinsic oscillatory dynamics and excitabilityRishikesh Narayanan
Center for Learning and Memory, The University of Texas at Austin, Austin, TX 78712, USA
Neuron 56:1061-75. 2007..Our results suggest that the frequency response of these neurons depends on the dendritic location of their inputs and that activity can regulate their response dynamics within an oscillating neural network... - Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neuronsDarrin H Brager
Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712, USA
J Neurosci 27:13926-37. 2007..We propose these changes as part of a homeostatic and bidirectional control mechanism for intrinsic excitability during learning... - Active dendrites, potassium channels and synaptic plasticityDaniel Johnston
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Philos Trans R Soc Lond B Biol Sci 358:667-74. 2003..The results support the view that the active properties of dendrites play important roles in synaptic integration and synaptic plasticity of these neurons... - Normalization of Ca2+ signals by small oblique dendrites of CA1 pyramidal neuronsAndreas Frick
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 23:3243-50. 2003..The higher density of I(K(A)) may have important implications for our understanding of synaptic integration and plasticity in these structures... - Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendritesNicholas P Poolos
Division of Neuroscience, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Neurosci 5:767-74. 2002..These results demonstrate that neuronal excitability can be altered by drugs acting selectively on dendrites, and suggest an important role for I(h) in controlling dendritic excitability and epileptogenesis... - Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathwayLi-Lian Yuan
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 22:4860-8. 2002..2 subunits... - Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neuronsShigeo Watanabe
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 99:8366-71. 2002..These results support the hypothesis that dendritic K(+) channels and the boosting of back-propagating action potentials contribute to the induction of LTP in CA1 neurons... - Requirement for hippocampal CA3 NMDA receptors in associative memory recallKazu Nakazawa
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 297:211-8. 2002..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall... - Channeling a 'funny' side of memoryDaniel Johnston
Nat Neurosci 8:134-5. 2005 - Photolysis of postsynaptic caged Ca2+ can potentiate and depress mossy fiber synaptic responses in rat hippocampal CA3 pyramidal neuronsJun Wang
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
J Neurophysiol 91:1596-607. 2004..Our results are consistent with a postsynaptic locus for the induction of at least some forms of synaptic plasticity at mossy fiber synapses... - Associative pairing enhances action potential back-propagation in radial oblique branches of CA1 pyramidal neuronsSonia Gasparini
Neuroscience Center, Louisiana State University Health Science Center, 2020 Gravier Street, New Orleans, LA 70112, USA
J Physiol 580:787-800. 2007..We hypothesize that these two signals may be involved in the regulation of the expression and activity of dendritic voltage- and ligand-gated ion channels... - Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neuronsMala M Shah
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Neuron 44:495-508. 2004..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks... - Plasticity of dendritic excitabilityAndreas Frick
Baylor College of Medicine, Division of Neuroscience, Houston, Texas 77030, USA
J Neurobiol 64:100-15. 2005..In this review we discuss how this plasticity of dendritic excitability could alter information transfer and processing within dendrites, neurons, and neural networks under physiological and pathological conditions... - Plasticity of dendritic functionJeffrey C Magee
Neuroscience Center, Louisiana State University Health Science Center, 2020 Gravier Street, New Orleans, Louisiana 70112, USA
Curr Opin Neurobiol 15:334-42. 2005..Indeed, voltage gated ion channel modulation shapes the active properties of neuronal dendrites to specific conditions, thus tailoring the functional role of the single neuron within its circuit... - Acquired dendritic channelopathy in temporal lobe epilepsyChristophe Bernard
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
Science 305:532-5. 2004..Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE... - Neuroscience. The neuron doctrine, reduxTheodore H Bullock
Scripps Institution of Oceanography and Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA
Science 310:791-3. 2005 - Properties of single voltage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampusXixi Chen
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
J Physiol 559:187-203. 2004..These results suggest both functional and molecular complexity for K(+) channels in dendrites of CA1 pyramidal neurones... - Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currentsAndrew W Varga
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 24:3643-54. 2004..Thus CaMKII can directly modulate neuronal excitability by increasing cell-surface expression of A-type K(+) channels... - LTP is accompanied by an enhanced local excitability of pyramidal neuron dendritesAndreas Frick
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Nat Neurosci 7:126-35. 2004..These results suggest an important mechanism associated with LTP for shaping signal processing and controlling dendritic function... - Calcium signaling at single mossy fiber presynaptic terminals in the rat hippocampusYong Liang
Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
J Neurophysiol 87:1132-7. 2002.... - Out of control in the dendritesNelson Spruston
Nat Neurosci 11:733-4. 2008 - Acceleration of K+ channel inactivation by MEK inhibitor U0126Li Lian Yuan
Dept of Neuroscience, Univ of Minnesota, 6 145 Jackson Hall, 321 Church St, Minneapolis, MN 55455, USA
Am J Physiol Cell Physiol 290:C165-71. 2006..Our data favor the conclusion that the increase in the rate of channel inactivation by U0126 is likely to be independent of protein kinase inhibition and instead represents a direct action on channel gating... - A modified Sindbis vector for prolonged gene expression in neuronsAndreas Jeromin
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurophysiol 90:2741-5. 2003..In addition, the use of this vector for the functional expression of mammalian voltage-gated ion channels in organotypic slices is demonstrated...
Research Grants
- Modulation of Dendritic K+ Channels in HippocampusDaniel Johnston; Fiscal Year: 2004..The results of these experiments will provide basic information important for studies of temporal lobe epilepsy, Alzheimer's disease, schizophrenia, and depression. ..
- CELLULAR INFORMATION PROCESSING IN THE HIPPOCAMPUSDaniel Johnston; Fiscal Year: 2005..We expect that the results of our studies will provide important information about the functional significance of these disease-related changes in dendrites. ..
- PHARMACOLOGY OF MOSSY FIBER SYNAPTIC PLASTICITYDaniel Johnston; Fiscal Year: 2007..abstract_text> ..
- CELLULAR INFORMATION PROCESSING IN HIPPOCAMPUSDaniel Johnston; Fiscal Year: 1993..potential in the dendrites during synaptic activity? 4) How do dendrites of CA3 neurons integrate and modify incoming synaptic inputs and how do active synapses communicate with other active (and inactive) synapses in the dendrites?..
- CELLULAR INFORMATION PROCESSING IN HIPPOCAMPUSDaniel Johnston; Fiscal Year: 2000..It is expected that the results of the study will provide important information about the functional significance of these disease-related changes. ..
- CELLULAR INFORMATION PROCESSING IN THE HIPPOCAMPUSDaniel Johnston; Fiscal Year: 2010..We expect that the results of our studies will provide important information about the functional significance of these disease-related changes in dendrites. ..