Christine Johnston

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Current status and prospects for development of an HSV vaccine
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, WA, United States Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Electronic address
    Vaccine 32:1553-60. 2014
  2. pmc Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Lancet 379:641-7. 2012
  3. doi request reprint Herpes simplex virus viremia during primary genital infection
    Christine Johnston
    Department of Medicine, Universityof Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Infect Dis 198:31-4. 2008
  4. pmc Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in Uganda
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e4222. 2009
  5. pmc HSV-2: in pursuit of a vaccine
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Clin Invest 121:4600-9. 2011
  6. pmc High-dose valacyclovir decreases plasma HIV-1 RNA more than standard-dose acyclovir in persons coinfected with HIV-1 and HSV-2: a randomized crossover trial
    Tara Perti
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 63:201-8. 2013
  7. pmc Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Virol 88:4921-31. 2014
  8. pmc Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection
    Elizabeth Tronstein
    Department of Medicine, University of Washington, Seattle, USA
    JAMA 305:1441-9. 2011
  9. pmc Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa
    Sunitha Tata
    Vaccine and Infectious Disease Institute, University of Washington, Seattle, USA
    J Infect Dis 201:499-504. 2010
  10. pmc Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection
    Jia Zhu
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Nature 497:494-7. 2013

Collaborators

Detail Information

Publications15

  1. doi request reprint Current status and prospects for development of an HSV vaccine
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, WA, United States Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States Electronic address
    Vaccine 32:1553-60. 2014
    ..We discuss HSV-2 pathogenesis, immunity, and vaccine efforts to date, as well as the current pipeline of candidate vaccines and design of trials to evaluate new vaccine constructs. ..
  2. pmc Standard-dose and high-dose daily antiviral therapy for short episodes of genital HSV-2 reactivation: three randomised, open-label, cross-over trials
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Lancet 379:641-7. 2012
    ..Skin and mucosal herpes simplex virus type 2 (HSV-2) shedding predominantly occurs in short subclinical episodes. We assessed whether standard-dose or high-dose antiviral therapy reduces the frequency of such shedding...
  3. doi request reprint Herpes simplex virus viremia during primary genital infection
    Christine Johnston
    Department of Medicine, Universityof Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Infect Dis 198:31-4. 2008
    ..61%; P=.01). Viremia was detected more frequently and at a higher number of copies per milliliter early in infection. We conclude that HSV viremia during primary genital HSV infection is common, especially among women...
  4. pmc Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in Uganda
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e4222. 2009
    ..Human herpesvirus-8 (HHV-8) replication is important both in transmission of HHV-8 and progression to KS. We characterized the sites and frequency of HHV-8 detection in Ugandans with and without HIV and KS...
  5. pmc HSV-2: in pursuit of a vaccine
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Clin Invest 121:4600-9. 2011
    ....
  6. pmc High-dose valacyclovir decreases plasma HIV-1 RNA more than standard-dose acyclovir in persons coinfected with HIV-1 and HSV-2: a randomized crossover trial
    Tara Perti
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 63:201-8. 2013
    ..We hypothesized that high-dose valacyclovir would further reduce plasma HIV-1 RNA and that the effect would be mediated by greater suppression of HSV shedding...
  7. pmc Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Virol 88:4921-31. 2014
    ..These data provide evidence that asymptomatic HSV-2 shedding contributes to chronic inflammation throughout the genital tract...
  8. pmc Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection
    Elizabeth Tronstein
    Department of Medicine, University of Washington, Seattle, USA
    JAMA 305:1441-9. 2011
    ..The course of natural history of HSV-2 in asymptomatic, seropositive persons is uncertain...
  9. pmc Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa
    Sunitha Tata
    Vaccine and Infectious Disease Institute, University of Washington, Seattle, USA
    J Infect Dis 201:499-504. 2010
    ..Genital shedding of herpes simplex virus (HSV) type 2 occurs frequently. Anatomic patterns of genital HSV-2 reactivation have not been intensively studied...
  10. pmc Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection
    Jia Zhu
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Nature 497:494-7. 2013
    ..Elicitation of CD8αα(+) T cells may be a critical component for developing effective vaccines against skin and mucosal infections...
  11. pmc Clinician and patient recognition of anogenital herpes disease in HIV positive men who have sex with men
    Michael Isiah Sandlin
    School of Medicine, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 38:833-6. 2011
    ..When compared with clinician examination, HIV/HSV-2 coinfected men who have sex with men are frequently unaware of anogenital ulcers. These data highlight the importance of condom use and the need for new HSV-2 prevention strategies...
  12. pmc Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract
    Joshua T Schiffer
    Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, United States Department of Medicine, University of Washington, Seattle, United States
    elife 2:e00288. 2013
    ..We conclude that HSV-2 infection is characterized by extremely rapid virological growth and containment at multiple contemporaneous sites within genital epithelium. DOI:http://dx.doi.org/10.7554/eLife.00288.001...
  13. pmc Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009
    ..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition...
  14. pmc Diversity in CD8(+) T cell function and epitope breadth among persons with genital herpes
    Kerry J Laing
    Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Clin Immunol 30:703-22. 2010
    ..The diversity in T cell response in these ex vivo assessments offers the potential of defining immune correlates of HSV-2 reactivation in humans...
  15. doi request reprint Herpes simplex virus type 2 serological testing and psychosocial harm: a systematic review
    Kaile Ross
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Sex Transm Infect 87:594-600. 2011
    ..This review aimed to examine the evidence regarding the psychosocial effects of HSV-2 serological testing...