Tyler A Johnson

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, United States
    Phytomedicine 20:143-7. 2013
  2. pmc Natural product libraries to accelerate the high-throughput discovery of therapeutic leads
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Nat Prod 74:2545-55. 2011
  3. pmc Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges
    Taro Amagata
    Department of Chemistry and Biochemistry and Department of Ocean Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA
    J Med Chem 51:7234-42. 2008
  4. pmc The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis
    Tyler A Johnson
    Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA
    Org Lett 11:1975-8. 2009
  5. pmc Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Bioorg Med Chem 20:4348-55. 2012
  6. pmc Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products
    Tyler A Johnson
    Department of Chemistry and Biochemistry and Department of Ocean Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA
    J Nat Prod 73:359-64. 2010
  7. ncbi Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase
    Erika N Segraves
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Med Chem 47:4060-5. 2004
  8. ncbi Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage
    Patrick C Still
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95060, United States
    J Nat Prod 77:690-702. 2014
  9. doi The unexpected isolation of CTP-431, a novel thiopyrone from the sponge Cacospongia mycofijiensis
    Tyler A Johnson
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Org Chem 73:7255-9. 2008
  10. pmc Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties
    Tyler A Johnson
    Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, CA 95064, USA
    J Med Chem 50:3795-803. 2007

Collaborators

Detail Information

Publications14

  1. pmc Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, United States
    Phytomedicine 20:143-7. 2013
    ..A chemical investigation into the lipophilic extracts of stinging nettle to identify the bioactive compound(s) responsible for their observed anti-inflammatory activity is further warranted...
  2. pmc Natural product libraries to accelerate the high-throughput discovery of therapeutic leads
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Nat Prod 74:2545-55. 2011
    ..Overall, these results highlight the advantages of applying modern methods in natural products-based research to accelerate the HT discovery of therapeutic leads and/or new molecular structures using LC-MS-UV-ELSD-based libraries...
  3. pmc Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges
    Taro Amagata
    Department of Chemistry and Biochemistry and Department of Ocean Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA
    J Med Chem 51:7234-42. 2008
    ..Among the cytotoxic derivatives, compound 9 did not exhibit microfilament-disrupting activity at 5 microM. The implications of this observation and the value of further therapeutic study on key latrunculin derivatives are discussed...
  4. pmc The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis
    Tyler A Johnson
    Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA
    Org Lett 11:1975-8. 2009
    ..Two of these metabolites, 1 and 2, were moderately active against Trypanosoma brucei, the parasite responsible for sleeping sickness...
  5. pmc Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Bioorg Med Chem 20:4348-55. 2012
    ....
  6. pmc Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products
    Tyler A Johnson
    Department of Chemistry and Biochemistry and Department of Ocean Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA
    J Nat Prod 73:359-64. 2010
    ..These results demonstrate that ASE can serve as an effective high-throughput methodology for extracting marine organisms to streamline the discovery of novel and bioactive natural products...
  7. ncbi Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase
    Erika N Segraves
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Med Chem 47:4060-5. 2004
    ..We report herein the effects of 21 simple and complex organobromine compounds against human platelet 12-LO, human reticulocyte 15-LO, and soybean 15-LO-1...
  8. ncbi Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage
    Patrick C Still
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95060, United States
    J Nat Prod 77:690-702. 2014
    ....
  9. doi The unexpected isolation of CTP-431, a novel thiopyrone from the sponge Cacospongia mycofijiensis
    Tyler A Johnson
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    J Org Chem 73:7255-9. 2008
    ..It is possible that the tricyclic skeleton of CTP-431 (1) is biosynthetically related to the macrolide latrunculin A, however the thiopyrone moiety of 1 has no previous precedent in natural products chemistry...
  10. pmc Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties
    Tyler A Johnson
    Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, CA 95064, USA
    J Med Chem 50:3795-803. 2007
    ..An in vivo evaluation of 2 using tumor-bearing severe combined immuno-deficiency mice demonstrated significant inhibition of growth in HCT-116 tumors over 28 days...
  11. doi (+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines
    Tyler A Johnson
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Bioorg Med Chem 21:4358-64. 2013
    ..Conversely the selective cytotoxicity and in vivo anti-tumor and anti-inflammatory activity previously reported for 1 do not appear to arise from a mechanism that is linked to the NF-κB immune mediated pathway...
  12. pmc Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries
    Joshua D Deschamps
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Bioorg Med Chem 15:6900-8. 2007
    ....
  13. pmc A reassignment of (-)-mycothiazole and the isolation of a related diol
    Rachel N Sonnenschein
    Department of Chemistry and Biochemistry and Institute of Marine Sciences, University of California, Santa Cruz, California 95064, USA
    J Nat Prod 69:145-7. 2006
    ..These compounds, which presumably arise by the action of a polyketide-nonribosomal peptide synthetase (PKS/NRPS) hybrid, possess cytotoxic properties that need further exploration...
  14. ncbi Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases
    Taro Amagata
    Department of Chemistry, Institute for Marine Sciences, University of California Santa Cruz, Santa Cruz, California 95064, USA
    J Nat Prod 66:230-5. 2003
    ..The structural elucidation of 1 and the SAR results for 13 natural products are reported. This study suggests that sponge-derived terpenes are a promising source for new lipoxygenase inhibitors...