Affiliation: University of Wisconsin
- Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adultsO C Okonkwo
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
Neurology 78:1769-76. 2012..To evaluate the longitudinal influence of family history (FH) of Alzheimer disease (AD) and apolipoprotein E ε4 allele (APOE4) on brain atrophy and cognitive decline over 4 years among asymptomatic middle-aged individuals...
- Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeysAuriel A Willette
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
Diabetes 61:1036-42. 2012..These results suggest that CR improves glucose regulation and may positively influence specific brain regions and at least motor task performance. Additional studies are warranted to validate these relationships...
- The effect of body mass index on global brain volume in middle-aged adults: a cross sectional studyMichael A Ward
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI, USA
BMC Neurol 5:23. 2005..The purpose of this study was to determine whether body type affects global brain volume, a marker of atrophy, in middle-aged men and women...
- A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 alleleRyan J Haasl
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
BMC Med Genet 9:37. 2008....
- Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional studyMehul A Trivedi
Geriatric Research Education and Clinical Center, William S Middleton Veteran s Affairs Hospital, Madison, WI, USA
BMC Med 4:1. 2006....
- Activation of brain regions vulnerable to Alzheimer's disease: the effect of mild cognitive impairmentS C Johnson
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, 2500 Overlook Terrace 11G, GRECC, Madison, WI 53705, USA
Neurobiol Aging 27:1604-12. 2006..Our results suggest that a change in function in the PC may account, in part, for memory recollection failure in AD...
- The cerebral response during subjective choice with and without self-referenceSterling C Johnson
William S Middleton VA Medical Center, Madison, WI 53705, USA
J Cogn Neurosci 17:1897-906. 2005..The findings suggest that self-referential processing, rather than subjective judgments among ambiguous response alternatives, accounted for the AMPFC and RSC response...
- The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activationSterling C Johnson
University of Wisconsin Madison, Wisconsin 53705, USA
J Neurosci 26:6069-76. 2006....
- Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adultsSterling C Johnson
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Arch Gen Psychiatry 64:1163-71. 2007....
- Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairmentSterling C Johnson
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI 53705, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:129-45. 2008..The absence of an associative learning effect in the MCIa sample reaffirms an important link between the learning difficulties that are commonly encountered in MCIa and the mesial temporal region...
- Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairmentSterling C Johnson
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI 53705, USA
Neuropsychologia 42:980-9. 2004..Results suggest that the medial temporal response over repeated presentation is related to clinical status. Probes of incremental encoding processes over trials may be useful markers of medial temporal lobe integrity...
- Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trialWhitney Wharton
University of Wisconsin, School of Medicine and Public Health, William S Middleton Memorial VA Hospital, 2500 Overlook Terrace, GRECC11G Madison, WI 53705, USA
J Alzheimers Dis 26:495-505. 2011..Moreover, treatment-related changes in plasma estradiol were positively correlated with improvements in visual memory. Short-term HT that includes the use of estradiol has favorable effects on cognition in women with AD...
- Effect of parental family history of Alzheimer's disease on serial position profilesAsenath La Rue
Wisconsin Alzheimer s Institute, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Alzheimers Dement 4:285-90. 2008..Our study sought to determine whether there were similar alterations in serial position learning among asymptomatic persons at risk for AD as a result of parental family history...
- Clinical pharmacology and differential cognitive efficacy of estrogen preparationsCarey E Gleason
Department of Medicine, University of Wisconsin Medical School, and Geriatric Research, Education and Clinical Center GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Ann N Y Acad Sci 1052:93-115. 2005....
- Neuroprotective effects of female sex steroids in humans: current controversies and future directionsC E Gleason
Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
Cell Mol Life Sci 62:299-312. 2005..Further, the paper briefly discusses variables that may account for the unexpected findings of WHIMS, and offers suggestions for future research...
- Midlife predictors of Alzheimer's diseaseB B Bendlin
William S Middleton Memorial Veterans Hospital, Geriatric Research Educational and Clinical Center, Madison, WI, USA
Maturitas 65:131-7. 2010..Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife...
- Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparationC E Gleason
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave, Suite 106, Madison, WI 53705, USA
Neurology 67:2039-41. 2006..These preliminary findings emphasize the need to characterize differential neural effects of various HTs...
- Neurophysiology of swallowing: effects of age and bolus typeIanessa A Humbert
William S Middleton Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, Madison, WI, USA
Neuroimage 44:982-91. 2009..These findings suggest that older adults without neurological insult elicit more cortical involvement to complete the same swallowing tasks as younger adults...
- MKL for robust multi-modality AD classificationChris Hinrichs
Dept of Computer Sciences, University of Wisconsin Madison, USA
Med Image Comput Comput Assist Interv 12:786-94. 2009..We present promising multi-modal classification experiments on a large dataset of images from the ADNI project...
- Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's diseaseCynthia M Carlsson
Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Alzheimers Dis 13:187-97. 2008..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD...
- Brain mapping in cognitive disorders: a multidisciplinary approach to learning the tools and applications of functional neuroimagingDaniel J Kelley
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
BMC Med Educ 7:39. 2007..We identify key components of an active learning course design that impact student learning gains in methods and issues pertaining to functional neuroimaging that deserve consideration when optimizing the medical neuroimaging curriculum...
- fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's diseaseMehul A Trivedi
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuropsychologia 46:1667-78. 2008..These results suggest that FH and aging are exerting independent effects in both tasks while APOE affected the relationship with age in the hippocampus in one of the two tasks given...
- Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trialD Larry Sparks
Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
Cleve Clin J Med 75:S87-93. 2008....
- Neuroimaging correlates of the Halstead Finger Tapping Test several years post-traumatic brain injuryGeorge P Prigatano
Division of Neurology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Brain Inj 18:661-9. 2004..Different patterns of brain activation in patients with TBI compared to healthy controls may be seen even when the level of behavioural performance of patients is generally within normal limits...
- Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a reviewMichele L Ries
William S Middleton Memorial Veterans Hospital Geriatric Research Education and Clinical Center, Madison, Wisconsin 53705, USA
J Am Geriatr Soc 56:920-34. 2008..Third, we will make recommendations regarding the current clinical use of MRI in identification of MCI. As a conclusion, we will look to the future of neuroimaging as a tool in early AD detection...
- Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of comaMehul A Trivedi
William S Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center GRECC, Madison, Wisconsin 53705, USA
J Neurotrauma 24:766-71. 2007..Greater %BVC was associated with longer duration of post-injury coma. These results confirm previous findings from cross-sectional studies and argue that the brain undergoes continued structural change for several months post-injury...
- Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisalMichele L Ries
Geriatric Research Education and Clinical Center, William S Middleton VA Hospital, Madison, Wisconsin 53705, USA
J Int Neuropsychol Soc 13:450-61. 2007..This finding highlights the level of anosognosia in MCI as an important predictor of response to self-appraisal in cortical midline structures, brain regions vulnerable to changes in early AD...
- Metacognitive evaluation, self-relevance, and the right prefrontal cortexTaylor W Schmitz
William S. Middleton VA Medical Center, Madison, WI 53705, USA
Neuroimage 22:941-7. 2004..The present study extends upon the prior findings of separate research domains by directly comparing the cerebral response to ME about the self and others, and finding right PFC activation increases as a function of self-relevance...
- Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matterAlan B McMillan
Department of Medical Physics, University of Wisconsin Madison, Madison, WI 53706, USA
Neuroimage 23:167-74. 2004....
- Functional MRI neuroanatomic correlates of the Hooper Visual Organization TestChad H Moritz
Department of Radiology, University of Wisconsin Medical School, Madison, USA
J Int Neuropsychol Soc 10:939-47. 2004..Discussion is made of interpretive limitations when adapting neuropsychological tests to fMRI analysis...
- Task-dependent posterior cingulate activation in mild cognitive impairmentMichele L Ries
William S. Middleton VA Medical Center, GRECC, 2500 Overlook Terrace, 11G, Madison, WI 53705, USA
Neuroimage 29:485-92. 2006..This result suggests in MCI that the PCC shows functional degradation during episodic retrieval; however, the PCC's role in retrieval and evaluation of highly elaborated information regarding the self is more well-preserved...
- Neural correlates of self-evaluative accuracy after traumatic brain injuryTaylor W Schmitz
William S. Middleton VA Medical Center, 2500 Overlook Terrace (11G, Madison, WI 53705, USA
Neuropsychologia 44:762-73. 2006..The results suggest that one's post-injury level of self-referential insight is related to a network inclusive of the medial and right dorsal PFC...
- Application of Brodmann's area templates for ROI selection in white matter tractography studiesPaul Thottakara
Waisman Laboratory for Brain Imaging and Behavior, The Waisman Center, 1500 Highland Avenue Madison, WI 53705, USA
Neuroimage 29:868-78. 2006..In the future, this method could be used to help elucidate relationships between function and anatomical structure...
- Relationship of cognitive measures and gray and white matter in Alzheimer's diseaseLeslie C Baxter
Barrow Neurological Institute, Phoenix, AZ 85013, USA
J Alzheimers Dis 9:253-60. 2006..To examine the relationship between commonly used screening cognitive measures with gray and white matter integrity in patients with mild to moderate AD...
- Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's diseaseLeslie C Baxter
Neuropsychology Neuroimaging Laboratory, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, 222 W Thomas Rd, Suite 310, Phoenix, AZ 85013, USA
Neurobiol Aging 24:947-52. 2003..This suggests that longitudinal study of new learning is a sensitive measure for detecting early cognitive changes in at-risk individuals that precede the symptomatic onset of mild cognitive impairment and AD...
- Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networksTaylor W Schmitz
William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuroimage 30:1050-8. 2006..These aMPFC networks appear to subserve distinct contributory processes inherent to self-appraisal decisions, specifically a dorsally mediated cognitive and a ventrally mediated affective/self-relevance network...
- Neural correlates of self-reflectionSterling C Johnson
Department of Clinical Neuropsychology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
Brain 125:1808-14. 2002..These data are consistent with lesion studies of impaired awareness, and suggest that the medial prefrontal and posterior cingulate cortex are part of a neural system subserving self-reflective thought...
- Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortexLe H Hua
Atkinson Research Laboratory, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
Am J Physiol Regul Integr Comp Physiol 289:R319-R325. 2005..Finally, another focus of strongly graded activation, which we interpret to represent thermoregulatory behavioral motivation elicited by dynamic cooling, was observed in the dorsal medial cortex...
- Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brainJohn K Wung
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Curr Alzheimer Res 4:67-72. 2007....
- Relevance to self: A brief review and framework of neural systems underlying appraisalTaylor W Schmitz
William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neurosci Biobehav Rev 31:585-96. 2007..As a whole, the purpose of this framework is to re-conceive the functionality of these systems in terms of supramodal processes that more directly reflect the influences of relevance to the self...
- Functional MRI and Wada determination of language lateralization: a case of crossed dominanceMichele L Ries
St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Epilepsia 45:85-9. 2004....
- The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADSterling C Johnson; Fiscal Year: 2010..If a preclinical signal can be reliably observed and is predictive of cognitive decline, this will greatly strengthen the rationale for earlier intervention rather than waiting for symptomatic AD to present itself. ..
- fMRI of Neurobehavioral Recovery After TBISterling Johnson; Fiscal Year: 2005..abstract_text> ..
- fMRI of Vulnerable Brain Areas in People at Risk for ADSterling Johnson; Fiscal Year: 2009..In the future this information may lead to improved methods for earlier detection of the disease. ..