Research Topics
Species | Sterling C JohnsonSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotypeSterling C Johnson
Wisconsin Alzheimer s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Alzheimers Dement 7:456-65. 2011..In this study, we tested the hypothesis that brain and cognitive changes suggestive of presymptomatic LOAD may be associated with this TOMM40 polymorphism...- Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adultsSterling C Johnson
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Arch Gen Psychiatry 64:1163-71. 2007.... - The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memoryGuofan Xu
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Brain 132:383-91. 2009..The findings lend further support to the idea that functional brain changes may begin far in advance of symptomatic Alzheimer's disease... - fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's diseaseMehul A Trivedi
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuropsychologia 46:1667-78. 2008..These results suggest that FH and aging are exerting independent effects in both tasks while APOE affected the relationship with age in the hippocampus in one of the two tasks given... - A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeysErik K Kastman
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
J Neurosci 32:11897-904. 2012..Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species... - White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-threeBarbara B Bendlin
Geriatric Research Educational and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
Dev Neuropsychol 35:257-77. 2010..The complex relationships between cognition, white matter microstructure, and white matter volume still require further investigation... - Medial prefrontal functional connectivity--relation to memory self-appraisal accuracy in older adults with and without memory disordersMichele L Ries
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuropsychologia 50:603-11. 2012..Results reported here corroborate findings of variable memory self-appraisal accuracy during the earliest emergence of AD symptoms and reveal alterations in MPFC functional connectivity that correspond to impaired memory self-appraisal... - Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeysAuriel A Willette
Harlow Primate Laboratory, Department of Psychology, University of Wisconsin Madison, Madison, WI, USA
Neurobiol Aging 33:670-80. 2012..The data suggest that CR may ameliorate the influence of Hcy on several important age-related parameters of parenchymal health... - Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairmentFeng Lin
School of Nursing, Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
Dement Geriatr Cogn Disord 30:83-92. 2010.... - White matter is altered with parental family history of Alzheimer's diseaseBarbara B Bendlin
Geriatric Research Educational and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
Alzheimers Dement 6:394-403. 2010..We examined the main effects of family history and APOE varepsilon4 on brain integrity, in addition to assessing possible additive effects of these two risk factors... - Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisalMichele L Ries
Geriatric Research Education and Clinical Center, William S Middleton VA Hospital, Madison, Wisconsin 53705, USA
J Int Neuropsychol Soc 13:450-61. 2007..This finding highlights the level of anosognosia in MCI as an important predictor of response to self-appraisal in cortical midline structures, brain regions vulnerable to changes in early AD... - A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's diseaseCatherine L Gallagher
William S Middleton Memorial Veterans Hospital, Madison, WI 53792, USA
Brain Imaging Behav 5:203-11. 2011..These findings provide evidence that regional loss of nigrostriatal inputs to frontostriatal networks affects specific aspects of motor function... - Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeysAuriel A Willette
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Psychoneuroendocrinology 37:903-16. 2012..Dietary interventions, such as calorie restriction (CR), affect stress biology and may moderate the pathogenic relationship between stress reactivity and brain in limbic and prefrontal regions... - Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional studyMehul A Trivedi
Geriatric Research Education and Clinical Center, William S Middleton Veteran s Affairs Hospital, Madison, WI, USA
BMC Med 4:1. 2006.... - Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeysAuriel A Willette
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
Diabetes 61:1036-42. 2012..These results suggest that CR improves glucose regulation and may positively influence specific brain regions and at least motor task performance. Additional studies are warranted to validate these relationships... - Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairmentSterling C Johnson
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI 53705, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:129-45. 2008..The absence of an associative learning effect in the MCIa sample reaffirms an important link between the learning difficulties that are commonly encountered in MCIa and the mesial temporal region... - Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a reviewMichele L Ries
William S Middleton Memorial Veterans Hospital Geriatric Research Education and Clinical Center, Madison, Wisconsin 53705, USA
J Am Geriatr Soc 56:920-34. 2008..Third, we will make recommendations regarding the current clinical use of MRI in identification of MCI. As a conclusion, we will look to the future of neuroimaging as a tool in early AD detection... 
Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's diseaseCynthia M Carlsson
Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Alzheimers Dis 13:187-97. 2008..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD...- The cerebral response during subjective choice with and without self-referenceSterling C Johnson
William S Middleton VA Medical Center, Madison, WI 53705, USA
J Cogn Neurosci 17:1897-906. 2005..The findings suggest that self-referential processing, rather than subjective judgments among ambiguous response alternatives, accounted for the AMPFC and RSC response... - Effects of hypoperfusion in Alzheimer's diseaseBenjamin P Austin
UW Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 3252, USA
J Alzheimers Dis 26:123-33. 2011..Finally, given that perfusion is a vascular phenomenon, we provide insights from a vascular lesion model (i.e., stroke) and illustrate the influence of disrupted perfusion on brain structure and function and, ultimately, cognition in AD... - A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeysErik K Kastman
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
J Neurosci 30:7940-7. 2010..Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species... - Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imagingBarbara B Bendlin
Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
Neuroimage 42:503-14. 2008.... - Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeysAadhavi Sridharan
Neuroscience Training Program, University of Wisconsin Madison Madison, WI, USA Medical Scientist Training Program, University of Wisconsin Madison Madison, WI, USA
Front Aging Neurosci 4:31. 2012..Finally, these brain-behavior correlations for the motor task were attenuated in CR animals compared to controls, indicating a potential protective effect of the dietary intervention... - A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's diseaseCatherine L Gallagher
William S Middleton Veterans Hospital, Madison, Wisconsin, USA
Mov Disord 26:2032-8. 2011..These results also imply that L-aromatic amino acid decarboxylase activity is a major determinant of clinical status... - A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and womenCarey E Gleason
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
Age Ageing 38:86-93. 2009..Unfortunately, few studies enrolled adults over the age of 70, and none included older men... - Predictive markers for AD in a multi-modality framework: an analysis of MCI progression in the ADNI populationChris Hinrichs
Department of Computer Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
Neuroimage 55:574-89. 2011..These differences were most significant in MMDMs based on imaging data. We also discuss the relationship between our MMDM and an individual's conversion from MCI to AD... - Rate of 6-[18F]fluorodopa uptake decline in striatal subregions in Parkinson's diseaseCatherine L Gallagher
William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792, USA
Mov Disord 26:614-20. 2011..Rate of decline in 6-L-[(18)F]fluorodopa (FDOPA) uptake within the striatum has been reported as showing regional differences in Parkinson's disease (PD)... - Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of comaMehul A Trivedi
William S Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center GRECC, Madison, Wisconsin 53705, USA
J Neurotrauma 24:766-71. 2007..Greater %BVC was associated with longer duration of post-injury coma. These results confirm previous findings from cross-sectional studies and argue that the brain undergoes continued structural change for several months post-injury... - A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 alleleRyan J Haasl
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
BMC Med Genet 9:37. 2008.... - Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot studyCynthia M Carlsson
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
Curr Alzheimer Res 9:990-7. 2012..Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD... - Topology-based kernels with application to inference problems in Alzheimer's diseaseDeepti Pachauri
Alzheimer s Disease Neuroimaging Initiative and Department of Computer Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
IEEE Trans Med Imaging 30:1760-70. 2011.... - Rhesus macaque brain morphometry: a methodological comparison of voxel-wise approachesDonald G McLaren
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Methods 50:157-65. 2010..Using flow field deformations (DARTEL) improved inter-subject alignment leading to results that were more likely due to morphometry differences as opposed to registration differences... - Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matterAlan B McMillan
Department of Medical Physics, University of Wisconsin Madison, Madison, WI 53706, USA
Neuroimage 23:167-74. 2004.... - Neural correlates of self-evaluative accuracy after traumatic brain injuryTaylor W Schmitz
William S. Middleton VA Medical Center, 2500 Overlook Terrace (11G, Madison, WI 53705, USA
Neuropsychologia 44:762-73. 2006..The results suggest that one's post-injury level of self-referential insight is related to a network inclusive of the medial and right dorsal PFC... - Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's diseaseGuofan Xu
GRECC, Madison VA Hospital, Madison, WI, USA
NMR Biomed 23:286-93. 2010..pcASL perfusion MRI offers an alternative method for non-invasive in vivo examination of early pathophysiological changes in AD... - Spatially augmented LPboosting for AD classification with evaluations on the ADNI datasetChris Hinrichs
Department of Computer Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
Neuroimage 48:138-49. 2009.... - Relevance to self: A brief review and framework of neural systems underlying appraisalTaylor W Schmitz
William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neurosci Biobehav Rev 31:585-96. 2007..As a whole, the purpose of this framework is to re-conceive the functionality of these systems in terms of supramodal processes that more directly reflect the influences of relevance to the self... - A population-average MRI-based atlas collection of the rhesus macaqueDonald G McLaren
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuroimage 45:52-9. 2009..It is anticipated that these tools will help facilitate voxel-based imaging methodologies in non-human primate species, which in turn may increase our understanding of brain function, development, and evolution... - Task-dependent posterior cingulate activation in mild cognitive impairmentMichele L Ries
William S. Middleton VA Medical Center, GRECC, 2500 Overlook Terrace, 11G, Madison, WI 53705, USA
Neuroimage 29:485-92. 2006..This result suggests in MCI that the PCC shows functional degradation during episodic retrieval; however, the PCC's role in retrieval and evaluation of highly elaborated information regarding the self is more well-preserved... - A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approachesDonald G McLaren
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Neuroimage 61:1277-86. 2012..In sum, the generalized form of context-dependent PPI approach has increased flexibility of statistical modeling, and potentially improves model fit, specificity to true negative findings, and sensitivity to true positive findings... - Brain mapping in cognitive disorders: a multidisciplinary approach to learning the tools and applications of functional neuroimagingDaniel J Kelley
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
BMC Med Educ 7:39. 2007..We identify key components of an active learning course design that impact student learning gains in methods and issues pertaining to functional neuroimaging that deserve consideration when optimizing the medical neuroimaging curriculum... - The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activationSterling C Johnson
University of Wisconsin Madison, Wisconsin 53705, USA
J Neurosci 26:6069-76. 2006.... - The effect of body mass index on global brain volume in middle-aged adults: a cross sectional studyMichael A Ward
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI, USA
BMC Neurol 5:23. 2005..The purpose of this study was to determine whether body type affects global brain volume, a marker of atrophy, in middle-aged men and women... - Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networksTaylor W Schmitz
William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuroimage 30:1050-8. 2006..These aMPFC networks appear to subserve distinct contributory processes inherent to self-appraisal decisions, specifically a dorsally mediated cognitive and a ventrally mediated affective/self-relevance network... - The effects of ramipril in individuals at risk for Alzheimer's disease: results of a pilot clinical trialWhitney Wharton
Alzheimer s Disease Research Center, University of Wisconsin, Madison, WI 53705, USA
J Alzheimers Dis 32:147-56. 2012.... - Functional MRI neuroanatomic correlates of the Hooper Visual Organization TestChad H Moritz
Department of Radiology, University of Wisconsin Medical School, Madison, USA
J Int Neuropsychol Soc 10:939-47. 2004..Discussion is made of interpretive limitations when adapting neuropsychological tests to fMRI analysis... - Caloric restriction delays disease onset and mortality in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
Science 325:201-4. 2009..Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species... - Metacognitive evaluation, self-relevance, and the right prefrontal cortexTaylor W Schmitz
William S. Middleton VA Medical Center, Madison, WI 53705, USA
Neuroimage 22:941-7. 2004..The present study extends upon the prior findings of separate research domains by directly comparing the cerebral response to ME about the self and others, and finding right PFC activation increases as a function of self-relevance... - Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairmentSterling C Johnson
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI 53705, USA
Neuropsychologia 42:980-9. 2004..Results suggest that the medial temporal response over repeated presentation is related to clinical status. Probes of incremental encoding processes over trials may be useful markers of medial temporal lobe integrity...