Sterling C Johnson

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype
    Sterling C Johnson
    Wisconsin Alzheimer s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Alzheimers Dement 7:456-65. 2011
  2. pmc Low cerebral blood flow is associated with lower memory function in metabolic syndrome
    Alex C Birdsill
    Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veteran s Hospital, Madison, Wisconsin, USA
    Obesity (Silver Spring) 21:1313-20. 2013
  3. pmc The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory
    Guofan Xu
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Brain 132:383-91. 2009
  4. pmc Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults
    Sterling C Johnson
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Arch Gen Psychiatry 64:1163-71. 2007
  5. pmc fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's disease
    Mehul A Trivedi
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neuropsychologia 46:1667-78. 2008
  6. pmc A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys
    Erik K Kastman
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    J Neurosci 32:11897-904. 2012
  7. pmc White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three
    Barbara B Bendlin
    Geriatric Research Educational and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    Dev Neuropsychol 35:257-77. 2010
  8. pmc Medial prefrontal functional connectivity--relation to memory self-appraisal accuracy in older adults with and without memory disorders
    Michele L Ries
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neuropsychologia 50:603-11. 2012
  9. pmc Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys
    Auriel A Willette
    Harlow Primate Laboratory, Department of Psychology, University of Wisconsin Madison, Madison, WI, USA
    Neurobiol Aging 33:670-80. 2012
  10. pmc A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's disease
    Catherine L Gallagher
    William S Middleton Memorial Veterans Hospital, Madison, WI 53792, USA
    Brain Imaging Behav 5:203-11. 2011

Detail Information

Publications60

  1. pmc The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype
    Sterling C Johnson
    Wisconsin Alzheimer s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    Alzheimers Dement 7:456-65. 2011
    ..In this study, we tested the hypothesis that brain and cognitive changes suggestive of presymptomatic LOAD may be associated with this TOMM40 polymorphism...
  2. pmc Low cerebral blood flow is associated with lower memory function in metabolic syndrome
    Alex C Birdsill
    Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veteran s Hospital, Madison, Wisconsin, USA
    Obesity (Silver Spring) 21:1313-20. 2013
    ..Additionally, the extent to which MetS was associated with cognitive performance was assessed...
  3. pmc The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory
    Guofan Xu
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Brain 132:383-91. 2009
    ..The findings lend further support to the idea that functional brain changes may begin far in advance of symptomatic Alzheimer's disease...
  4. pmc Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults
    Sterling C Johnson
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Arch Gen Psychiatry 64:1163-71. 2007
    ....
  5. pmc fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's disease
    Mehul A Trivedi
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neuropsychologia 46:1667-78. 2008
    ..These results suggest that FH and aging are exerting independent effects in both tasks while APOE affected the relationship with age in the hippocampus in one of the two tasks given...
  6. pmc A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys
    Erik K Kastman
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    J Neurosci 32:11897-904. 2012
    ..Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species...
  7. pmc White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three
    Barbara B Bendlin
    Geriatric Research Educational and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    Dev Neuropsychol 35:257-77. 2010
    ..The complex relationships between cognition, white matter microstructure, and white matter volume still require further investigation...
  8. pmc Medial prefrontal functional connectivity--relation to memory self-appraisal accuracy in older adults with and without memory disorders
    Michele L Ries
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neuropsychologia 50:603-11. 2012
    ..Results reported here corroborate findings of variable memory self-appraisal accuracy during the earliest emergence of AD symptoms and reveal alterations in MPFC functional connectivity that correspond to impaired memory self-appraisal...
  9. pmc Homocysteine, neural atrophy, and the effect of caloric restriction in rhesus monkeys
    Auriel A Willette
    Harlow Primate Laboratory, Department of Psychology, University of Wisconsin Madison, Madison, WI, USA
    Neurobiol Aging 33:670-80. 2012
    ..The data suggest that CR may ameliorate the influence of Hcy on several important age-related parameters of parenchymal health...
  10. pmc A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson's disease
    Catherine L Gallagher
    William S Middleton Memorial Veterans Hospital, Madison, WI 53792, USA
    Brain Imaging Behav 5:203-11. 2011
    ..These findings provide evidence that regional loss of nigrostriatal inputs to frontostriatal networks affects specific aspects of motor function...
  11. pmc Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal
    Michele L Ries
    Geriatric Research Education and Clinical Center, William S Middleton VA Hospital, Madison, Wisconsin 53705, USA
    J Int Neuropsychol Soc 13:450-61. 2007
    ..This finding highlights the level of anosognosia in MCI as an important predictor of response to self-appraisal in cortical midline structures, brain regions vulnerable to changes in early AD...
  12. pmc White matter is altered with parental family history of Alzheimer's disease
    Barbara B Bendlin
    Geriatric Research Educational and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
    Alzheimers Dement 6:394-403. 2010
    ..We examined the main effects of family history and APOE varepsilon4 on brain integrity, in addition to assessing possible additive effects of these two risk factors...
  13. pmc Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment
    Feng Lin
    School of Nursing, Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    Dement Geriatr Cogn Disord 30:83-92. 2010
    ....
  14. pmc Calorie restriction reduces psychological stress reactivity and its association with brain volume and microstructure in aged rhesus monkeys
    Auriel A Willette
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Psychoneuroendocrinology 37:903-16. 2012
    ..Dietary interventions, such as calorie restriction (CR), affect stress biology and may moderate the pathogenic relationship between stress reactivity and brain in limbic and prefrontal regions...
  15. pmc Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study
    Mehul A Trivedi
    Geriatric Research Education and Clinical Center, William S Middleton Veteran s Affairs Hospital, Madison, WI, USA
    BMC Med 4:1. 2006
    ....
  16. pmc Longitudinal volumetric changes following traumatic brain injury: a tensor-based morphometry study
    Kimberly D M Farbota
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792, USA
    J Int Neuropsychol Soc 18:1006-18. 2012
    ....
  17. pmc Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults
    Auriel A Willette
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
    Diabetes Care 36:443-9. 2013
    ..This longitudinal study examined whether insulin resistance among late middle-aged, cognitively healthy individuals was associated with 1) less gray matter in Alzheimer disease-sensitive brain regions and 2) worse cognitive performance...
  18. pmc Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys
    Auriel A Willette
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
    Diabetes 61:1036-42. 2012
    ..These results suggest that CR improves glucose regulation and may positively influence specific brain regions and at least motor task performance. Additional studies are warranted to validate these relationships...
  19. ncbi request reprint Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 13:187-97. 2008
    ..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD...
  20. pmc Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review
    Michele L Ries
    William S Middleton Memorial Veterans Hospital Geriatric Research Education and Clinical Center, Madison, Wisconsin 53705, USA
    J Am Geriatr Soc 56:920-34. 2008
    ..Third, we will make recommendations regarding the current clinical use of MRI in identification of MCI. As a conclusion, we will look to the future of neuroimaging as a tool in early AD detection...
  21. pmc Associative learning over trials activates the hippocampus in healthy elderly but not mild cognitive impairment
    Sterling C Johnson
    Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI 53705, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15:129-45. 2008
    ..The absence of an associative learning effect in the MCIa sample reaffirms an important link between the learning difficulties that are commonly encountered in MCIa and the mesial temporal region...
  22. pmc Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot study
    Cynthia M Carlsson
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Curr Alzheimer Res 9:990-7. 2012
    ..Statins improve vascular reactivity, but it is unknown if they increase regional cerebral blood flow (CBF) in individuals at risk for AD...
  23. pmc The effects of ramipril in individuals at risk for Alzheimer's disease: results of a pilot clinical trial
    Whitney Wharton
    Alzheimer s Disease Research Center, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 32:147-56. 2012
    ....
  24. pmc The cerebral response during subjective choice with and without self-reference
    Sterling C Johnson
    William S Middleton VA Medical Center, Madison, WI 53705, USA
    J Cogn Neurosci 17:1897-906. 2005
    ..The findings suggest that self-referential processing, rather than subjective judgments among ambiguous response alternatives, accounted for the AMPFC and RSC response...
  25. ncbi request reprint Effect of age and calorie restriction on corpus callosal integrity in rhesus macaques: A fiber tractography study
    Aadhavi Sridharan
    Neuroscience Training Program, University of Wisconsin Madison, 1300 University Avenue, Madison, WI 53706, USA Medical Scientist Training Program, University of Wisconsin Madison, 750 Highland Avenue, Madison, WI 53705, USA
    Neurosci Lett 569:38-42. 2014
    ..Further studies are warranted to critically evaluate the effect of calorie restriction on brain aging in this unique cohort of elderly primates. ..
  26. pmc Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study
    Aadhavi Sridharan
    Medical Scientist Training Program, University of Wisconsin Madison, 750 Highland Ave, Madison, WI 53705, USA
    Brain Res 1508:1-8. 2013
    ..The present study is a preliminary post-mortem histological analysis of the effects of CR on brain health, and further studies using molecular and biochemical techniques are warranted to elucidate underlying mechanisms...
  27. pmc Effects of hypoperfusion in Alzheimer's disease
    Benjamin P Austin
    UW Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 3252, USA
    J Alzheimers Dis 26:123-33. 2011
    ..Finally, given that perfusion is a vascular phenomenon, we provide insights from a vascular lesion model (i.e., stroke) and illustrate the influence of disrupted perfusion on brain structure and function and, ultimately, cognition in AD...
  28. pmc Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging
    Barbara B Bendlin
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
    Neuroimage 42:503-14. 2008
    ....
  29. pmc A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys
    Erik K Kastman
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    J Neurosci 30:7940-7. 2010
    ..Our observations suggest that the CR-induced benefit of reduced iron deposition and preserved motor function may indicate neural protection similar to effects described previously in aging rodent and primate species...
  30. pmc Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer's disease
    Ozioma C Okonkwo
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, WI, USA
    Cereb Cortex 24:978-88. 2014
    ....
  31. pmc Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys
    Aadhavi Sridharan
    Neuroscience Training Program, University of Wisconsin Madison Madison, WI, USA Medical Scientist Training Program, University of Wisconsin Madison Madison, WI, USA
    Front Aging Neurosci 4:31. 2012
    ..Finally, these brain-behavior correlations for the motor task were attenuated in CR animals compared to controls, indicating a potential protective effect of the dietary intervention...
  32. pmc A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease
    Catherine L Gallagher
    William S Middleton Veterans Hospital, Madison, Wisconsin, USA
    Mov Disord 26:2032-8. 2011
    ..These results also imply that L-aromatic amino acid decarboxylase activity is a major determinant of clinical status...
  33. pmc A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women
    Carey E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
    Age Ageing 38:86-93. 2009
    ..Unfortunately, few studies enrolled adults over the age of 70, and none included older men...
  34. pmc A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele
    Ryan J Haasl
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    BMC Med Genet 9:37. 2008
    ....
  35. pmc Rate of 6-[18F]fluorodopa uptake decline in striatal subregions in Parkinson's disease
    Catherine L Gallagher
    William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792, USA
    Mov Disord 26:614-20. 2011
    ..Rate of decline in 6-L-[(18)F]fluorodopa (FDOPA) uptake within the striatum has been reported as showing regional differences in Parkinson's disease (PD)...
  36. pmc Predictive markers for AD in a multi-modality framework: an analysis of MCI progression in the ADNI population
    Chris Hinrichs
    Department of Computer Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuroimage 55:574-89. 2011
    ..These differences were most significant in MMDMs based on imaging data. We also discuss the relationship between our MMDM and an individual's conversion from MCI to AD...
  37. pmc Longitudinal changes in global brain volume between 79 and 409 days after traumatic brain injury: relationship with duration of coma
    Mehul A Trivedi
    William S Middleton Memorial VA Hospital, Geriatric Research Education and Clinical Center GRECC, Madison, Wisconsin 53705, USA
    J Neurotrauma 24:766-71. 2007
    ..Greater %BVC was associated with longer duration of post-injury coma. These results confirm previous findings from cross-sectional studies and argue that the brain undergoes continued structural change for several months post-injury...
  38. pmc Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults
    Martina Ly
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veteran s Hospital, Madison, Wisconsin Department of Medicine, Wisconsin Alzheimer s Disease Research Center, University of Wisconsin, Madison, Wisconsin Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin
    Hum Brain Mapp 35:2044-54. 2014
    ..Hum Brain Mapp 35:2044-2054, 2014. © 2013 Wiley Periodicals, Inc. ..
  39. pmc Regional white matter hyperintensities: aging, Alzheimer's disease risk, and cognitive function
    Alex C Birdsill
    Geriatric Research, Education and Clinical Center GRECC, William S Middleton Memorial Veteran s Hospital, Madison, WI, USA Wisconsin Alzheimer s Disease Research Center, Department of Medicine, University of Wisconsin, Madison, WI, USA
    Neurobiol Aging 35:769-76. 2014
    ....
  40. pmc Rhesus macaque brain morphometry: a methodological comparison of voxel-wise approaches
    Donald G McLaren
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Methods 50:157-65. 2010
    ..Using flow field deformations (DARTEL) improved inter-subject alignment leading to results that were more likely due to morphometry differences as opposed to registration differences...
  41. pmc Topology-based kernels with application to inference problems in Alzheimer's disease
    Deepti Pachauri
    Alzheimer s Disease Neuroimaging Initiative and Department of Computer Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    IEEE Trans Med Imaging 30:1760-70. 2011
    ....
  42. pmc Reliability and precision of pseudo-continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O-water PET in elderly subjects at risk for Alzheimer's disease
    Guofan Xu
    GRECC, Madison VA Hospital, Madison, WI, USA
    NMR Biomed 23:286-93. 2010
    ..pcASL perfusion MRI offers an alternative method for non-invasive in vivo examination of early pathophysiological changes in AD...
  43. ncbi request reprint Neural correlates of self-evaluative accuracy after traumatic brain injury
    Taylor W Schmitz
    William S Middleton VA Medical Center, 2500 Overlook Terrace 11G, Madison, WI 53705, USA
    Neuropsychologia 44:762-73. 2006
    ..The results suggest that one's post-injury level of self-referential insight is related to a network inclusive of the medial and right dorsal PFC...
  44. ncbi request reprint Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matter
    Alan B McMillan
    Department of Medical Physics, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuroimage 23:167-74. 2004
    ....
  45. pmc Spatially augmented LPboosting for AD classification with evaluations on the ADNI dataset
    Chris Hinrichs
    Department of Computer Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Neuroimage 48:138-49. 2009
    ....
  46. ncbi request reprint Multi-resolutional shape features via non-Euclidean wavelets: applications to statistical analysis of cortical thickness
    Won Hwa Kim
    Department of Computer Sciences, University of Wisconsin Madison, Madison, WI 53706, USA Geriatric Research Education and Clinical Center, William S Middleton Memorial Veteran s Hospital, Madison, WI 53705, USA Electronic address
    Neuroimage 93:107-23. 2014
    ..In particular, we contrast traditional univariate methods with our multi-resolution approach which show increased sensitivity and improved statistical power to detect a group-level effects. We also provide an open source implementation...
  47. pmc Task-dependent posterior cingulate activation in mild cognitive impairment
    Michele L Ries
    William S Middleton VA Medical Center, GRECC, 2500 Overlook Terrace, 11G, Madison, WI 53705, USA
    Neuroimage 29:485-92. 2006
    ..This result suggests in MCI that the PCC shows functional degradation during episodic retrieval; however, the PCC's role in retrieval and evaluation of highly elaborated information regarding the self is more well-preserved...
  48. pmc Relevance to self: A brief review and framework of neural systems underlying appraisal
    Taylor W Schmitz
    William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neurosci Biobehav Rev 31:585-96. 2007
    ..As a whole, the purpose of this framework is to re-conceive the functionality of these systems in terms of supramodal processes that more directly reflect the influences of relevance to the self...
  49. pmc A population-average MRI-based atlas collection of the rhesus macaque
    Donald G McLaren
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neuroimage 45:52-9. 2009
    ..It is anticipated that these tools will help facilitate voxel-based imaging methodologies in non-human primate species, which in turn may increase our understanding of brain function, development, and evolution...
  50. pmc Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    Nat Commun 5:3557. 2014
    ..Our data indicate that the benefits of CR on ageing are conserved in primates. ..
  51. pmc Amyloid burden and neural function in people at risk for Alzheimer's Disease
    Sterling C Johnson
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial VA Hospital, Madison, WI, USA Alzheimer s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Wisconsin Alzheimer s Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA Electronic address
    Neurobiol Aging 35:576-84. 2014
    ..This asymptomatic stage may be an opportune window for intervention to prevent progression to symptomatic AD. ..
  52. pmc A generalized form of context-dependent psychophysiological interactions (gPPI): a comparison to standard approaches
    Donald G McLaren
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Neuroimage 61:1277-86. 2012
    ..In sum, the generalized form of context-dependent PPI approach has increased flexibility of statistical modeling, and potentially improves model fit, specificity to true negative findings, and sensitivity to true positive findings...
  53. pmc Brain mapping in cognitive disorders: a multidisciplinary approach to learning the tools and applications of functional neuroimaging
    Daniel J Kelley
    Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    BMC Med Educ 7:39. 2007
    ..We identify key components of an active learning course design that impact student learning gains in methods and issues pertaining to functional neuroimaging that deserve consideration when optimizing the medical neuroimaging curriculum...
  54. pmc The influence of Alzheimer disease family history and apolipoprotein E epsilon4 on mesial temporal lobe activation
    Sterling C Johnson
    University of Wisconsin Madison, Wisconsin 53705, USA
    J Neurosci 26:6069-76. 2006
    ....
  55. pmc Self-appraisal decisions evoke dissociated dorsal-ventral aMPFC networks
    Taylor W Schmitz
    William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neuroimage 30:1050-8. 2006
    ..These aMPFC networks appear to subserve distinct contributory processes inherent to self-appraisal decisions, specifically a dorsally mediated cognitive and a ventrally mediated affective/self-relevance network...
  56. pmc The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study
    Michael A Ward
    Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI, USA
    BMC Neurol 5:23. 2005
    ..The purpose of this study was to determine whether body type affects global brain volume, a marker of atrophy, in middle-aged men and women...
  57. pmc Caloric restriction delays disease onset and mortality in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 325:201-4. 2009
    ..Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species...
  58. ncbi request reprint Functional MRI neuroanatomic correlates of the Hooper Visual Organization Test
    Chad H Moritz
    Department of Radiology, University of Wisconsin Medical School, Madison, USA
    J Int Neuropsychol Soc 10:939-47. 2004
    ..Discussion is made of interpretive limitations when adapting neuropsychological tests to fMRI analysis...
  59. ncbi request reprint Metacognitive evaluation, self-relevance, and the right prefrontal cortex
    Taylor W Schmitz
    William S Middleton VA Medical Center, Madison, WI 53705, USA
    Neuroimage 22:941-7. 2004
    ..The present study extends upon the prior findings of separate research domains by directly comparing the cerebral response to ME about the self and others, and finding right PFC activation increases as a function of self-relevance...
  60. ncbi request reprint Hippocampal adaptation to face repetition in healthy elderly and mild cognitive impairment
    Sterling C Johnson
    Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, Madison, WI 53705, USA
    Neuropsychologia 42:980-9. 2004
    ..Results suggest that the medial temporal response over repeated presentation is related to clinical status. Probes of incremental encoding processes over trials may be useful markers of medial temporal lobe integrity...