RICHARD JOSEPH JOHNSON

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice
    Xiaosen Ouyang
    Division of Nephrology, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 289:F902-10. 2005
  2. ncbi A unifying pathway for essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Hypertens 18:431-40. 2005
  3. ncbi Uric acid, evolution and primitive cultures
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Semin Nephrol 25:3-8. 2005
  4. pmc Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Comp Physiol B 179:67-76. 2009
  5. ncbi Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
  6. pmc Pathogenesis of essential hypertension: historical paradigms and modern insights
    Richard J Johnson
    Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    J Hypertens 26:381-91. 2008
  7. ncbi Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
    Richard J Johnson
    University of Florida, Division of Nephrology, Hypertension, and Transplantation, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:1909-19. 2005
  8. pmc The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
    Med Hypotheses 71:22-31. 2008
  9. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
  10. ncbi A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002

Research Grants

Detail Information

Publications66

  1. ncbi Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice
    Xiaosen Ouyang
    Division of Nephrology, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 289:F902-10. 2005
    ..In conclusion, the absence of the AT(1) receptor is associated with marked renal alterations in vasoactive, profibrotic, and immune mediators with an inflammatory pattern favoring a Th1 phenotype...
  2. ncbi A unifying pathway for essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Hypertens 18:431-40. 2005
    ..This pathway unites many of the previous hypotheses on the etiology of hypertension, and offers insights into ways to prevent, ameliorate, or cure the underlying process...
  3. ncbi Uric acid, evolution and primitive cultures
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Semin Nephrol 25:3-8. 2005
    ..Although other mechanisms certainly contribute to the pathogenesis of hypertension, the possibility that serum uric acid level may have a major role is suggested by these studies...
  4. pmc Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Comp Physiol B 179:67-76. 2009
    ....
  5. ncbi Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
    ..Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis...
  6. pmc Pathogenesis of essential hypertension: historical paradigms and modern insights
    Richard J Johnson
    Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    J Hypertens 26:381-91. 2008
    ....
  7. ncbi Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
    Richard J Johnson
    University of Florida, Division of Nephrology, Hypertension, and Transplantation, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:1909-19. 2005
    ..Understanding the pathogenetic pathways mediating renal progression in hypertensive subjects should help identify those subjects at highest risk and may provide insights into new therapeutic maneuvers to slow or prevent progression...
  8. pmc The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
    Med Hypotheses 71:22-31. 2008
    ....
  9. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
    ..If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace...
  10. ncbi A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
    ..These studies provide direct evidence that uric acid may be a true mediator of renal disease and progression...
  11. ncbi Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
    ..Addition of potassium supplements and allopurinol with thiazides might be helpful in the management of metabolic syndrome...
  12. pmc Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 297:F481-8. 2009
    ..In conclusion, hyperuricemia has a pathogenic role in the mild tubulointerstitial injury associated with diabetic nephropathy but not glomerular damage in db/db mice. Lowering uric acid may reduce tubulointerstitial injury in diabetes...
  13. ncbi Effect of elevated serum uric acid on cisplatin-induced acute renal failure
    Carlos A Roncal
    Division of Nephrology, Hypertension, and Transplantation and North Florida South Georgia Veterans Health System, Pathology and Laboratory Medicine Service, University of Florida, Gainesville 32610 0224, USA
    Am J Physiol Renal Physiol 292:F116-22. 2007
    ..The mechanism may relate to a proinflammatory pathway involving chemokine expression with leukocyte infiltration...
  14. pmc Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism
    Wei Mu
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    Am J Physiol Renal Physiol 296:F145-52. 2009
    ..However, its anti-angiogenic actions suggest countering effects that could partially offset its benefit in chronic kidney diseases...
  15. pmc Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
    Takahiro Nakayama
    Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 296:F317-27. 2009
    ..A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Impaired endothelial function is likely a direct risk factor for renal disease...
  16. ncbi Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease
    Carlos Roncal
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1391-6. 2007
    ..In conclusion, lead accelerates chronic renal disease, primarily by raising blood pressure and accelerating microvascular and tubulointerstitial injury...
  17. pmc Dietary fructose causes tubulointerstitial injury in the normal rat kidney
    Takahiro Nakayama
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 298:F712-20. 2010
    ..The effect is independent of total energy intake and is associated with focal tubulointerstitial injury. These studies may provide a mechanism by which metabolic syndrome causes renal disease...
  18. pmc Nitric oxide modulates vascular disease in the remnant kidney model
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 161:239-48. 2002
    ..Interestingly, inhibition of NO synthesis did not lead to a loss of the preglomerular endothelium, which may relate to the effect of NO blockade to stimulate VEGF synthesis in the adjacent vascular smooth muscle cell...
  19. ncbi Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
    Susumu Watanabe
    Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 40:355-60. 2002
    ..Although it provided a survival advantage to early hominoids, hyperuricemia may have a major role in the current cardiovascular disease epidemic...
  20. ncbi Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, Houston 77030, USA
    N Engl J Med 346:913-23. 2002
  21. ncbi A single pathway for the development of essential hypertension
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cardiol Rev 11:180-96. 2003
  22. pmc Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 20:545-53. 2009
    ..Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. In summary, postprandial concentrations of fructose stimulate redox- and urate-dependent inflammatory mediators in proximal tubular cells...
  23. ncbi IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease
    Wei Mu
    Division of Nephrology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:3651-60. 2005
    ..The feasibility of long-term overexpression of a gene using the AAV serotype 1 vector system in a model of renal disease is also demonstrated...
  24. pmc Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway
    Ryuji Ohashi
    Division of Nephrology, Baylor College of Medicine, Houston Texas 77030, USA
    Am J Pathol 164:477-85. 2004
    ..We conclude that blocking p38-dependent inflammation may have resulted in enhanced proliferation and increased ERK1/2 activation, and thereby explains the worse renal lesions observed...
  25. ncbi Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
    Mark S Segal
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 46:406-17. 2007
    ..We propose the use of a fructose index to categorize foods and propose studies to determine the effect of low fructose diets as a means to prevent obesity, diabetes, and cardiovascular disease in the population...
  26. pmc Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver
    Laura G Sanchez-Lozada
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 49:1-9. 2010
    ....
  27. pmc Inactivation of nitric oxide by uric acid
    Christine Gersch
    Department of Medicine, Division of Nephrology and Hypertension, University of Florida, Gainesville, Florida 32610, USA
    Nucleosides Nucleotides Nucleic Acids 27:967-78. 2008
    ..This study shows a potential mechanism by which UA may deplete NO and cause endothelial dysfunction, particularly under conditions of oxidative stress in which UA is elevated and intracellular glutathione is depleted...
  28. ncbi Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Renal Physiol 282:F991-7. 2002
    ..Thus hyperuricemia induces a renal arteriolopathy in rats that is blood pressure independent and involves the renin-angiotensin system...
  29. ncbi Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    ..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy...
  30. ncbi Hypertension: a microvascular and tubulointerstitial disease
    Richard J Johnson
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, SM 1273, 6550 Fannin Street, Houston, Texas 77030, USA
    J Hypertens Suppl 20:S1-7. 2002
    ..We propose that subtle acquired renal injury may underlie the etiology of some forms of salt-sensitive hypertension...
  31. ncbi Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Nat Clin Pract Nephrol 1:80-6. 2005
    ..Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition...
  32. pmc Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding
    Alexandra Shapiro
    Dept of Pharmacology and Therapeutics, Box 100267, Univ of Florida, Gainesville, Florida 32610, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1370-5. 2008
    ..Our data indicate that chronic fructose consumption induces leptin resistance prior to body weight, adiposity, serum leptin, insulin, or glucose increases, and this fructose-induced leptin resistance accelerates high-fat induced obesity...
  33. pmc Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells
    Sergey Zharikov
    SB Rm M452, Div of Pulmonary, Critical Care, and Sleep Medicine, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Cell Physiol 295:C1183-90. 2008
    ..We conclude that UA-induced arginase activation is a potential mechanism for reduction of NO production in PAEC...
  34. pmc Urinary CD80 excretion increases in idiopathic minimal-change disease
    Eduardo H Garin
    Division of Pediatric Nephrology, University of Florida, Gainesville, FL 32610, USA
    J Am Soc Nephrol 20:260-6. 2009
    ..In conclusion, urinary soluble CD80 is elevated in idiopathic MCD, which could be relevant to both diagnosis and pathogenesis...
  35. pmc Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry
    Kyung Mee Kim
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, FL 32610 0226, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:65-70. 2009
    ..The new method was used to show that smoking, which can induce oxidative stress, is associated with elevated triuret levels in urine. Thus, the method may be helpful in identifying pathways of oxidative stress in biological samples...
  36. pmc Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress
    Christine Gersch
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
    Nucleosides Nucleotides Nucleic Acids 28:118-49. 2009
    ..These reactive intermediates could possibly explain how uric acid contributes to the pathogenesis of diseases such as the metabolic syndrome and hypertension...
  37. ncbi Effects of cyclosporine in osteopontin null mice
    Marilda Mazzali
    Division of Nephrology, Department of Pathology, University of Washington, Seattle, Washington, USA
    Kidney Int 62:78-85. 2002
    ..This study tested the hypothesis that the absence of OPN would ameliorate CsA nephropathy...
  38. pmc A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid
    Kyung Mee Kim
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009
    ..10 to 103.59% and 98.74 to 106.12% for in vivo and in vitro analyses, respectively. This study demonstrates that intracellular levels of UA can be measured using LC-MS/MS with isotope labeled UA as an internal standard...
  39. ncbi A breakthrough in diabetic nephropathy: the role of endothelial dysfunction
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 22:2775-7. 2007
  40. doi Prophylactic nesiritide does not prevent dialysis or all-cause mortality in patients undergoing high-risk cardiac surgery
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    J Thorac Cardiovasc Surg 138:959-64. 2009
    ....
  41. doi Uric acid: a novel risk factor for acute kidney injury in high-risk cardiac surgery patients?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    Am J Nephrol 30:425-9. 2009
    ..Uric acid has been reported to be a risk factor for the development of chronic kidney disease; however, no study has examined whether uric acid may confer a risk for acute kidney injury...
  42. pmc Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?
    Sergey I Zharikov
    Division of Pulmonary, University of Florida, Gainesville, FL, USA
    Med Hypotheses 74:1069-74. 2010
    ..We propose studies to investigate the role of uric acid in pulmonary hypertension and to determine if lowering serum uric acid may have clinical benefit in this condition...
  43. pmc Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry
    Witcha Imaram
    Department of Chemistry, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 49:275-81. 2010
    ..The ions of m/z 352 were characterized as the PBN-triuretcarbonyl radical adduct and the m/z 223 ion was identified as the PBN-aminocarbonyl radical adduct. Their mechanism of formation is discussed...
  44. pmc Diabetic eNOS-knockout mice develop accelerated retinopathy
    Qiuhong Li
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida 32610 0284, USA
    Invest Ophthalmol Vis Sci 51:5240-6. 2010
    ..This study was undertaken to determine the role of eNOS in the development of diabetic retinopathy (DR), by investigating the functional consequences of its deficiency in the diabetic state...
  45. ncbi Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610, USA
    Hypertension 45:326-30. 2005
  46. ncbi Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
    ..Because TSP-1 is a major antiangiogenic molecule and an activator of TGF-beta1, this provides an important insight to the mechanism by which TGF-beta1 may mediate interstitial fibrosis and progressive renal disease...
  47. pmc Fructose induces the inflammatory molecule ICAM-1 in endothelial cells
    Olena Glushakova
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 19:1712-20. 2008
    ..These data suggest that fructose induces inflammatory changes in vascular cells at physiologic concentrations...
  48. ncbi Uric acid and the immune response
    Michael S Gersch
    University of Florida, Department of Medicine, Room CG98, 1600 SW Archer Rd, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 21:3046-7. 2006
  49. ncbi Uric acid, the metabolic syndrome, and renal disease
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, PO Box 100224, Gainesville, FL 32608, USA
    J Am Soc Nephrol 17:S165-8. 2006
    ..It is proposed that fructose- and purine-rich foods that have in common the raising of uric acid may have a role in the epidemic of metabolic syndrome and renal disease that is occurring throughout the world...
  50. ncbi Role of uric acid in hypertension, renal disease, and metabolic syndrome
    Marcelo Heinig
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville 32610, USA
    Cleve Clin J Med 73:1059-64. 2006
    ..Furthermore, we suggest that the recent increased intake in the American diet of fructose, which is a known cause of hyperuricemia, may be contributing to the current epidemic of obesity and diabetes...
  51. ncbi Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis?
    Michael S Gersch
    University of Florida, 1600 SW Archer Road, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 21:2938-42. 2006
    ..Thus, an attractive hypothesis could be that THP would bind to uric acid in the distal tubule, and decrease its subsequent reabsorption in the distal nephron...
  52. ncbi Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    Yuri Y Sautin
    Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Cell Physiol 293:C584-96. 2007
    ....
  53. ncbi Effectiveness of nesiritide on dialysis or all-cause mortality in patients undergoing cardiothoracic surgery
    Thomas M Beaver
    Division of Thoracic and Cardiovascular Surgery, University of Florida, P O Box 100286, Gainesville, FL 32610 0286, USA
    Clin Cardiol 29:18-24. 2006
    ..Natriuretic peptides have been shown to have favorable renal effects. However, recent evidence suggests potential renal side effects in patients with congestive heart failure...
  54. ncbi Fructose, but not dextrose, accelerates the progression of chronic kidney disease
    Michael S Gersch
    Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1256-61. 2007
    ..In conclusion, consumption of a high-fructose diet greatly accelerates progression of chronic kidney disease in the rat remnant kidney model...
  55. ncbi Could uric acid have a role in acute renal failure?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 2:16-21. 2007
    ..It is suggested that studies are needed to investigate the role of chronic hyperuricemia on renal outcomes after acute tubular injury...
  56. ncbi Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
    J Am Soc Nephrol 17:736-45. 2006
    ..These results may provide new insights into the understanding of the mechanism of diabetic vascular disease...
  57. ncbi Uric acid--a uremic toxin?
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Blood Purif 24:67-70. 2006
    ..In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease...
  58. ncbi Microvascular and tubulointerstitial injury associated with chronic hypoxia-induced hypertension
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Kidney Int 63:2088-93. 2003
    ..We examined whether chronic hypoxia might induce subtle renal injury since studies in other animal models of hypertension suggest this may cause persistent hypertension...
  59. pmc The conundrum of hyperuricemia, metabolic syndrome, and renal disease
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL, 32610, USA
    Intern Emerg Med 3:313-8. 2008
    ..In this review, we discuss the clinical and experimental evidence for a causal role of hyperuricemia in renal diseases and potential relationships of hyperuricemia with metabolic syndrome...
  60. pmc Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome
    William Baldwin
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Diabetes 60:1258-69. 2011
    ..Previously, we showed that soluble uric acid directly stimulated the redox-dependent proinflammatory signaling in adipocytes. In this study we demonstrate the role of hyperuricemia in the production of key adipokines...
  61. ncbi Loss of nitric oxide and endothelial-derived hyperpolarizing factor-mediated responses in aging
    David A Long
    Section of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, USA
    Kidney Int 68:2154-63. 2005
    ..Therefore, we hypothesized that aging attenuates vasodilatory responses in the kidney. These changes may be mediated by a loss of nitric oxide and endothelial-derived hyperpolarizing factor (EDHF)...
  62. ncbi A causal role for uric acid in fructose-induced metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 290:F625-31. 2006
    ..Fructose may have a major role in the epidemic of metabolic syndrome and obesity due to its ability to raise uric acid...
  63. ncbi Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
    ..It was postulated that endothelial dysfunction should predict nephropathy and that correction of the dysfunction may prevent these important complications...
  64. ncbi Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 287:F658-64. 2004
    ..Thus TGF-beta and hypoxia act via additive/synergistic but distinct pathways to stimulate VEGF in proximal tubular cells, a finding that may be important in understanding how VEGF is stimulated in renal disease...
  65. ncbi TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
    Takahiko Nakagawa
    Division of Nephrology Medicine, Baylor College of Medicine, Houston, Texas, USA
    Kidney Int 66:605-13. 2004
    ..Recent studies have shown that VEGF-A as well as TSP-1 is regulated by transforming growth factor-beta1 (TGF-beta1), but the mechanism remains unclear...
  66. doi Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis
    Eduardo H Garin
    Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Kidney Int 78:296-302. 2010
    ..Thus, our study supports the hypothesis that MCD and FSGS represent two different diseases rather than a continuum of one disease. Urinary CD80 excretion may be a useful marker to differentiate between MCD and FSGS...

Research Grants5

  1. Pre & Post-Doctoral Training in Nephrology & Hypertension
    Richard Johnson; Fiscal Year: 2007
    ..This training grant will support a focused program for training promising candidates in basic, translational, and clinical research which should help them prepare for an academic career in nephrology. ..
  2. Pre & Post-Doctoral Training in Nephrology & Hypertension
    Richard Johnson; Fiscal Year: 2007
    ..This training grant will support a focused program for training promising candidates in basic, translational, and clinical research which should help them prepare for an academic career in nephrology. ..