Research Topics
| Richard J JohnsonSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Uric acid and cardiovascular riskDaniel I Feig
Baylor College of Medicine, Houston, TX 77030, USA
N Engl J Med 359:1811-21. 2008
Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney diseaseCarlos Roncal
Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Am J Physiol Renal Physiol 293:F1391-6. 2007..In conclusion, lead accelerates chronic renal disease, primarily by raising blood pressure and accelerating microvascular and tubulointerstitial injury...- Could uric acid have a role in acute renal failure?A Ahsan Ejaz
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Clin J Am Soc Nephrol 2:16-21. 2007..It is suggested that studies are needed to investigate the role of chronic hyperuricemia on renal outcomes after acute tubular injury... - Fructose, but not dextrose, accelerates the progression of chronic kidney diseaseMichael S Gersch
Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
Am J Physiol Renal Physiol 293:F1256-61. 2007..In conclusion, consumption of a high-fructose diet greatly accelerates progression of chronic kidney disease in the rat remnant kidney model... - A breakthrough in diabetic nephropathy: the role of endothelial dysfunctionTakahiko Nakagawa
Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610-0224, USA
Nephrol Dial Transplant 22:2775-7. 2007 - Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertensionRichard J Johnson
Division of Nephrology, Hypertension, and Transplantation, University of Florida, P.O. Box 100224, Gainesville, FL 32610, USA
Hypertension 45:326-30. 2005 - Effect of elevated serum uric acid on cisplatin-induced acute renal failureCarlos A Roncal
Division of Nephrology, Hypertension, and Transplantation and North Florida South Georgia Veterans Health System, Pathology and Laboratory Medicine Service, University of Florida, Gainesville 32610 0224, USA
Am J Physiol Renal Physiol 292:F116-22. 2007..The mechanism may relate to a proinflammatory pathway involving chemokine expression with leukocyte infiltration... - Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathyTakahiko Nakagawa
Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
J Am Soc Nephrol 18:539-50. 2007..It was postulated that endothelial dysfunction should predict nephropathy and that correction of the dysfunction may prevent these important complications... - Role of uric acid in hypertension, renal disease, and metabolic syndromeMarcelo Heinig
Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville 32610, USA
Cleve Clin J Med 73:1059-64. 2006..Furthermore, we suggest that the recent increased intake in the American diet of fructose, which is a known cause of hyperuricemia, may be contributing to the current epidemic of obesity and diabetes... - Uric acid, the metabolic syndrome, and renal diseasePietro Cirillo
Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, PO Box 100224, Gainesville, FL 32608, USA
J Am Soc Nephrol 17:S165-8. 2006..It is proposed that fructose- and purine-rich foods that have in common the raising of uric acid may have a role in the epidemic of metabolic syndrome and renal disease that is occurring throughout the world... - J-shaped mortality relationship for uric acid in CKDMohamed E Suliman
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
Am J Kidney Dis 48:761-71. 2006..Moreover, uric acid level was associated with calcium/phosphate metabolism, dyslipidemia, and inflammation... - Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in ratsLaura G Sanchez-Lozada
Dept of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1 14080, Mexico City, Mexico
Am J Physiol Renal Physiol 292:F423-9. 2007..These changes are best observed in rats administered high doses (60% diet) of fructose... - Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndromeTakahiko Nakagawa
Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610, USA
Nat Clin Pract Nephrol 1:80-6. 2005..Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition... - Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis?Michael S Gersch
University of Florida, 1600 SW Archer Road, PO Box 100224, Gainesville, FL 32610 0224, USA
Nephrol Dial Transplant 21:2938-42. 2006..Thus, an attractive hypothesis could be that THP would bind to uric acid in the distal tubule, and decrease its subsequent reabsorption in the distal nephron... - Everolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathyKatja Keller
Division of Nephrology, , Loschgestrasse 8, 91054 Erlangen, Germany
Nephrol Dial Transplant 21:2724-35. 2006.... - Serum uric acid: a risk factor and a target for treatment?Daniel I Feig
Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
J Am Soc Nephrol 17:S69-73. 2006..Although the investigations are still preliminary, serum uric acid represents a possible new and intriguing target for the reduction of morbidity and mortality associated with hypertension and CV disease... - Effectiveness of nesiritide on dialysis or all-cause mortality in patients undergoing cardiothoracic surgeryThomas M Beaver
Division of Thoracic and Cardiovascular Surgery, University of Florida, P O Box 100286, Gainesville, FL 32610 0286, USA
Clin Cardiol 29:18-24. 2006..Natriuretic peptides have been shown to have favorable renal effects. However, recent evidence suggests potential renal side effects in patients with congestive heart failure... - Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathyTakahiko Nakagawa
Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
J Am Soc Nephrol 17:736-45. 2006..These results may provide new insights into the understanding of the mechanism of diabetic vascular disease... - Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stressYuri Y Sautin
Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
Am J Physiol Cell Physiol 293:C584-96. 2007.... - Inflammation, angiotensin II, and hypertensionBernardo Rodriguez-Iturbe
Hypertension 52:e135; author reply e136. 2008 - Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trialDaniel I Feig
Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
JAMA 300:924-32. 2008..Experimentally increasing uric acid levels using a uricase inhibitor causes systemic hypertension in animal models... 
Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemiaLaura G Sanchez-Lozada
Department of Nephrology, INC Ignacio Chavez, Mexico City, Mexico
Nephron Physiol 108:p69-78. 2008..The effect of febuxostat (Fx), a non-purine and selective xanthine oxidase inhibitor, on glomerular microcirculatory changes in 5/6 nephrectomy (5/6 Nx) Wistar rats with and without oxonic acid (OA)-induced hyperuricemia was evaluated...- The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular diseaseRichard J Johnson
Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
Med Hypotheses 71:22-31. 2008.... - Pathogenesis of essential hypertension: historical paradigms and modern insightsRichard J Johnson
Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
J Hypertens 26:381-91. 2008.... - Hypokalemic nephropathy is associated with impaired angiogenesisSirirat Reungjui
Division of Nephrology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
J Am Soc Nephrol 19:125-34. 2008..In conclusion, hypokalemic nephropathy is associated with impaired renal angiogenesis, evidenced by progressive capillary loss, reduced endothelial cell proliferation, and loss of VEGF expression... - Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemiaLaura G Sanchez-Lozada
Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, 14080 Mexico City, Mexico
Nephrol Dial Transplant 23:1179-85. 2008..We therefore tested the hypothesis that Fx might be useful in treating hyperuricemia-induced hypertension and renal damage... - A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathyBernd Hohenstein
Department of Nephrology and Hypertension, University Erlangen Nuremberg, Loschgestrasse 8, 91054 Erlangen, Germany
Nephrol Dial Transplant 23:1144-56. 2008.... - Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular diseaseRichard J Johnson
Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Clin Nutr 86:899-906. 2007..Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis... - Thiazide diuretics exacerbate fructose-induced metabolic syndromeSirirat Reungjui
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
J Am Soc Nephrol 18:2724-31. 2007..Addition of potassium supplements and allopurinol with thiazides might be helpful in the management of metabolic syndrome... - Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?Mark S Segal
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
Eur J Nutr 46:406-17. 2007..We propose the use of a fructose index to categorize foods and propose studies to determine the effect of low fructose diets as a means to prevent obesity, diabetes, and cardiovascular disease in the population... - Uric acid--a uremic toxin?Takahiko Nakagawa
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Blood Purif 24:67-70. 2006..In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease... - IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal diseaseWei Mu
Division of Nephrology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
J Am Soc Nephrol 16:3651-60. 2005..The feasibility of long-term overexpression of a gene using the AAV serotype 1 vector system in a model of renal disease is also demonstrated... - Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cellsDuk Hee Kang
Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
J Am Soc Nephrol 16:3553-62. 2005..The observation that UA alters the proliferation/migration and NO release of human vascular cells, mediated by the expression of CRP, calls for careful reconsideration of the role of UA in hypertension and vascular disease... - Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?Richard J Johnson
Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
Hypertension 41:1183-90. 2003..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy... - Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanismsShin Ichi Suga
National Cardiovascular Center Research Institute, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
J Am Soc Nephrol 14:397-406. 2003..Thus, ETA as well as ETB blockade may be renoprotective in hypokalemic nephropathy... - Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosisDuk Hee Kang
Division of Nephrology, Ewha Women s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
Curr Opin Nephrol Hypertens 12:43-9. 2003.... - A role for uric acid in the progression of renal diseaseDuk Hee Kang
Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
J Am Soc Nephrol 13:2888-97. 2002..These studies provide direct evidence that uric acid may be a true mediator of renal disease and progression... - Mild hyperuricemia induces glomerular hypertension in normal ratsLaura G Sanchez-Lozada
Department of Nephrology, Instituto Nacional de Cardiologia I Chavez, 14080 Mexico City, Mexico
Am J Physiol Renal Physiol 283:F1105-10. 2002..Glomerular hypertension may be partially mediated by an abnormal vascular response to systemic hypertension due to arteriolopathy of the afferent arteriole... - Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivitySusumu Watanabe
Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
Hypertension 40:355-60. 2002..Although it provided a survival advantage to early hominoids, hyperuricemia may have a major role in the current cardiovascular disease epidemic... - Hypertension: a microvascular and tubulointerstitial diseaseRichard J Johnson
Division of Nephrology, Department of Medicine, Baylor College of Medicine, SM 1273, 6550 Fannin Street, Houston, Texas 77030, USA
J Hypertens Suppl 20:S1-7. 2002..We propose that subtle acquired renal injury may underlie the etiology of some forms of salt-sensitive hypertension... - Nitric oxide modulates vascular disease in the remnant kidney modelDuk Hee Kang
Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
Am J Pathol 161:239-48. 2002..Interestingly, inhibition of NO synthesis did not lead to a loss of the preglomerular endothelium, which may relate to the effect of NO blockade to stimulate VEGF synthesis in the adjacent vascular smooth muscle cell... - Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activationJin H Li
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Soc Nephrol 13:1464-72. 2002.... - Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanismMarilda Mazzali
Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Physiol Renal Physiol 282:F991-7. 2002..Thus hyperuricemia induces a renal arteriolopathy in rats that is blood pressure independent and involves the renin-angiotensin system... - Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney modelChristian Hugo
Medizinische Klinik IV, Universitat Erlangen Nurnberg, Germany
Nephron 90:460-70. 2002..We studied the expression of TSP-1 mRNA and protein during the development of glomerular and tubulointerstitial nephrosclerosis in the renal ablation model particularly in relation to TGF-beta1 expression... - Subtle acquired renal injury as a mechanism of salt-sensitive hypertensionRichard J Johnson
Division of Nephrology, Baylor College of Medicine, Houston 77030, USA
N Engl J Med 346:913-23. 2002 - Role of the microvascular endothelium in progressive renal diseaseDuk Hee Kang
Baylor College of Medicine, Houston, Texas, USA
J Am Soc Nephrol 13:806-16. 2002..Therefore, angiogenic agents may represent a novel therapeutic approach for slowing the progression of renal disease... - Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular diseaseJin H Li
Department of Medicine-Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
FASEB J 18:176-8. 2004..Thus, AGEs act by activating Smad signaling to mediate diabetic complications via both TGF-beta-dependent and -independent pathways, shedding new light on the pathogenesis of diabetic organ injury... - Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2John Kanellis
Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston TX 77030
Hypertension 41:1287-93. 2003..Uric acid regulates critical proinflammatory pathways in VSMCs, suggesting it may have a role in the vascular changes associated with hypertension and vascular disease... - Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?Richard J Johnson
University of Florida, Division of Nephrology, Hypertension, and Transplantation, 1600 SW Archer Road, Gainesville, FL 32610, USA
J Am Soc Nephrol 16:1909-19. 2005..Understanding the pathogenetic pathways mediating renal progression in hypertensive subjects should help identify those subjects at highest risk and may provide insights into new therapeutic maneuvers to slow or prevent progression... - Hemodynamics of hyperuricemiaLaura G Sanchez-Lozada
Department of Nephrology, Instituto Nacional de Cardiologia, Ignacio Chavez, 14080 Mexico City, Mexico
Semin Nephrol 25:19-24. 2005..Lumen obliteration induced by vascular wall thickening results in severe vasoconstriction. The resulting ischemia is a potent stimulus that induces tubulointerstitial inflammation and fibrosis as well as arterial hypertension... - Uric acid, evolution and primitive culturesRichard J Johnson
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
Semin Nephrol 25:3-8. 2005..Although other mechanisms certainly contribute to the pathogenesis of hypertension, the possibility that serum uric acid level may have a major role is suggested by these studies... - TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathwaysTakahiko Nakagawa
Division of Nephrology Medicine, Baylor College of Medicine, Houston, Texas, USA
Kidney Int 66:605-13. 2004..Recent studies have shown that VEGF-A as well as TSP-1 is regulated by transforming growth factor-beta1 (TGF-beta1), but the mechanism remains unclear... - Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cellsTakahiko Nakagawa
Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Am J Physiol Renal Physiol 287:F658-64. 2004..Thus TGF-beta and hypoxia act via additive/synergistic but distinct pathways to stimulate VEGF in proximal tubular cells, a finding that may be important in understanding how VEGF is stimulated in renal disease... - Hypertension in the hemodialysis patient and the "lag phenomenon": insights into pathophysiology and clinical managementUday M Khosla
Am J Kidney Dis 43:739-51. 2004 - How does angiotensin II cause renal injury?David A Long
Hypertension 43:722-3. 2004 - Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathwayRyuji Ohashi
Division of Nephrology, Baylor College of Medicine, Houston Texas 77030, USA
Am J Pathol 164:477-85. 2004..We conclude that blocking p38-dependent inflammation may have resulted in enhanced proliferation and increased ERK1/2 activation, and thereby explains the worse renal lesions observed... - Hyperuricemia in childhood primary hypertensionDaniel I Feig
Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
Hypertension 42:247-52. 2003..These results are consistent with the hypothesis that uric acid might have a role in the early pathogenesis of primary hypertension... - Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vesselsKatsuyuki Matsui
Institute of Clinical Pathology, University of Vienna, Allgemeines Krankenhaus, Vienna, Austria
J Am Soc Nephrol 14:1981-9. 2003..As lymphatic endothelial cells secrete chemokines that attract dendritic cells, it is possible that the increase in lymphatic vascularization could enhance the immunologic surveillance of remnant kidneys... - A single pathway for the development of essential hypertensionJohn Kanellis
Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
Cardiol Rev 11:180-96. 2003 - Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO modelHui Y Lan
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
J Am Soc Nephrol 14:1535-48. 2003..TGF-beta-mediated renal fibrosis is regulated positively by Smad2/3, but negatively by Smad7. Target blockade of TGF-beta/Smad signaling by expression of Smad7 may provide a new therapeutic potential for renal fibrosis... - Microvascular and tubulointerstitial injury associated with chronic hypoxia-induced hypertensionMarilda Mazzali
Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
Kidney Int 63:2088-93. 2003..CONCLUSION: Both afferent arteriolar disease and subtle tubulointerstitial inflammation and injury occur early in hypoxic rats. These changes may predispose these animals to persistent hypertension... - Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive ratsBernardo Rodriguez-Iturbe
Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomedicas, Universidad del Zulia, Maracaibo, Zulia 4001 A, Venezuela
Am J Physiol Renal Physiol 282:F191-201. 2002..We conclude that the renal immune infiltrate plays a major role in the hypertension in SHR...