Richard J Johnson

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  2. ncbi request reprint Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease
    Carlos Roncal
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1391-6. 2007
  3. ncbi request reprint Could uric acid have a role in acute renal failure?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 2:16-21. 2007
  4. ncbi request reprint Fructose, but not dextrose, accelerates the progression of chronic kidney disease
    Michael S Gersch
    Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1256-61. 2007
  5. ncbi request reprint A breakthrough in diabetic nephropathy: the role of endothelial dysfunction
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 22:2775-7. 2007
  6. ncbi request reprint Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610, USA
    Hypertension 45:326-30. 2005
  7. pmc Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Comp Physiol B 179:67-76. 2009
  8. pmc Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 297:F481-8. 2009
  9. ncbi request reprint Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
  10. pmc Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism
    Wei Mu
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    Am J Physiol Renal Physiol 296:F145-52. 2009

Detail Information

Publications100

  1. pmc Uric acid and cardiovascular risk
    Daniel I Feig
    Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 359:1811-21. 2008
  2. ncbi request reprint Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease
    Carlos Roncal
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1391-6. 2007
    ..In conclusion, lead accelerates chronic renal disease, primarily by raising blood pressure and accelerating microvascular and tubulointerstitial injury...
  3. ncbi request reprint Could uric acid have a role in acute renal failure?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Clin J Am Soc Nephrol 2:16-21. 2007
    ..It is suggested that studies are needed to investigate the role of chronic hyperuricemia on renal outcomes after acute tubular injury...
  4. ncbi request reprint Fructose, but not dextrose, accelerates the progression of chronic kidney disease
    Michael S Gersch
    Division of Nephrology, Dialysis and Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    Am J Physiol Renal Physiol 293:F1256-61. 2007
    ..In conclusion, consumption of a high-fructose diet greatly accelerates progression of chronic kidney disease in the rat remnant kidney model...
  5. ncbi request reprint A breakthrough in diabetic nephropathy: the role of endothelial dysfunction
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 22:2775-7. 2007
  6. ncbi request reprint Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610, USA
    Hypertension 45:326-30. 2005
  7. pmc Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Comp Physiol B 179:67-76. 2009
    ....
  8. pmc Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 297:F481-8. 2009
    ..In conclusion, hyperuricemia has a pathogenic role in the mild tubulointerstitial injury associated with diabetic nephropathy but not glomerular damage in db/db mice. Lowering uric acid may reduce tubulointerstitial injury in diabetes...
  9. ncbi request reprint Thiazide diuretics exacerbate fructose-induced metabolic syndrome
    Sirirat Reungjui
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 18:2724-31. 2007
    ..Addition of potassium supplements and allopurinol with thiazides might be helpful in the management of metabolic syndrome...
  10. pmc Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism
    Wei Mu
    Division of Nephrology, University of Florida, Gainesville, FL, USA
    Am J Physiol Renal Physiol 296:F145-52. 2009
    ..However, its anti-angiogenic actions suggest countering effects that could partially offset its benefit in chronic kidney diseases...
  11. doi request reprint Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
    Takahiro Nakayama
    Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 296:F317-27. 2009
    ..A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Impaired endothelial function is likely a direct risk factor for renal disease...
  12. ncbi request reprint Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
    Richard J Johnson
    Division of Nephrology and Department of Medicine, University of Florida, Gainesville, FL, USA
    Am J Clin Nutr 86:899-906. 2007
    ..Finally, we suggest that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and we provide a list of testable predictions to evaluate this hypothesis...
  13. ncbi request reprint A role for uric acid in the progression of renal disease
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:2888-97. 2002
    ..These studies provide direct evidence that uric acid may be a true mediator of renal disease and progression...
  14. pmc Dietary fructose causes tubulointerstitial injury in the normal rat kidney
    Takahiro Nakayama
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 298:F712-20. 2010
    ..The effect is independent of total energy intake and is associated with focal tubulointerstitial injury. These studies may provide a mechanism by which metabolic syndrome causes renal disease...
  15. ncbi request reprint Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    Yuri Y Sautin
    Division of Nephrology, Hypertension, and Transplantation, Dept of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Cell Physiol 293:C584-96. 2007
    ....
  16. ncbi request reprint Effect of elevated serum uric acid on cisplatin-induced acute renal failure
    Carlos A Roncal
    Division of Nephrology, Hypertension, and Transplantation and North Florida South Georgia Veterans Health System, Pathology and Laboratory Medicine Service, University of Florida, Gainesville 32610 0224, USA
    Am J Physiol Renal Physiol 292:F116-22. 2007
    ..The mechanism may relate to a proinflammatory pathway involving chemokine expression with leukocyte infiltration...
  17. pmc Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver
    Laura G Sanchez-Lozada
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 49:1-9. 2010
    ....
  18. pmc Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 20:545-53. 2009
    ..Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. In summary, postprandial concentrations of fructose stimulate redox- and urate-dependent inflammatory mediators in proximal tubular cells...
  19. pmc Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension
    Mohamed Shafiu
    College of Pharmacy and Center for Pharmacogenomics, University of Florida, Gainesville, Fla, USA mshafiu rapadocs com
    Kidney Blood Press Res 35:477-82. 2012
    ..URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects...
  20. ncbi request reprint Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
    J Am Soc Nephrol 17:736-45. 2006
    ..These results may provide new insights into the understanding of the mechanism of diabetic vascular disease...
  21. pmc The conundrum of hyperuricemia, metabolic syndrome, and renal disease
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL, 32610, USA
    Intern Emerg Med 3:313-8. 2008
    ..In this review, we discuss the clinical and experimental evidence for a causal role of hyperuricemia in renal diseases and potential relationships of hyperuricemia with metabolic syndrome...
  22. pmc Fructose induces the inflammatory molecule ICAM-1 in endothelial cells
    Olena Glushakova
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 19:1712-20. 2008
    ..These data suggest that fructose induces inflammatory changes in vascular cells at physiologic concentrations...
  23. ncbi request reprint Uric acid--a uremic toxin?
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Blood Purif 24:67-70. 2006
    ..In progressive renal disease, such as cyclosporine nephropathy and remnant kidney in rat, uric acid accelerated the progression of renal disease. Thus, we concluded that uric acid is not a simple marker, but a cause of renal disease...
  24. pmc Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress
    Christine Gersch
    Division of Nephrology and Hypertension, Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
    Nucleosides Nucleotides Nucleic Acids 28:118-49. 2009
    ..These reactive intermediates could possibly explain how uric acid contributes to the pathogenesis of diseases such as the metabolic syndrome and hypertension...
  25. doi request reprint Lowering serum uric acid to prevent acute kidney injury
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, USA
    Med Hypotheses 78:796-9. 2012
    ..Data from recent studies are presented to support the hypothesis that uric acid may have a role in AKI via a crystal-independent process in addition to its traditionally accepted role to induce injury via crystal-dependent pathways...
  26. ncbi request reprint Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 16:899-904. 2005
    ..Because TSP-1 is a major antiangiogenic molecule and an activator of TGF-beta1, this provides an important insight to the mechanism by which TGF-beta1 may mediate interstitial fibrosis and progressive renal disease...
  27. ncbi request reprint Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice
    Xiaosen Ouyang
    Division of Nephrology, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 289:F902-10. 2005
    ..In conclusion, the absence of the AT(1) receptor is associated with marked renal alterations in vasoactive, profibrotic, and immune mediators with an inflammatory pattern favoring a Th1 phenotype...
  28. ncbi request reprint Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston, Tex 77030, USA
    Hypertension 41:1183-90. 2003
    ..Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy...
  29. ncbi request reprint Vascular endothelial growth factor administration does not improve microvascular disease in the salt-dependent phase of post-angiotensin II hypertension
    David A Long
    Section of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, Florida, USA
    Am J Physiol Renal Physiol 291:F1248-54. 2006
    ..Therefore, VEGF therapy has only limited benefits on the healing of renal lesions in the salt-dependent phase of post-ANG II-mediated hypertension...
  30. ncbi request reprint Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity
    Susumu Watanabe
    Division of Nephrology, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 40:355-60. 2002
    ..Although it provided a survival advantage to early hominoids, hyperuricemia may have a major role in the current cardiovascular disease epidemic...
  31. doi request reprint Post-operative serum uric acid and acute kidney injury
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    J Nephrol 25:497-505. 2012
    ..We hypothesized that post-operative serum uric acid (SUA) may be associated with acute kidney injury (AKI)...
  32. ncbi request reprint A single pathway for the development of essential hypertension
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cardiol Rev 11:180-96. 2003
  33. doi request reprint Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Int Urol Nephrol 45:449-58. 2013
    ..This pilot study investigated the effect of lowering SUA therapy on AKI, by using traditional and non-traditional markers...
  34. pmc Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells
    Sergey Zharikov
    SB Rm M452, Div of Pulmonary, Critical Care, and Sleep Medicine, Dept of Medicine, Univ of Florida, Gainesville, FL 32610, USA
    Am J Physiol Cell Physiol 295:C1183-90. 2008
    ..We conclude that UA-induced arginase activation is a potential mechanism for reduction of NO production in PAEC...
  35. pmc Diabetic eNOS-knockout mice develop accelerated retinopathy
    Qiuhong Li
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, Florida 32610 0284, USA
    Invest Ophthalmol Vis Sci 51:5240-6. 2010
    ..This study was undertaken to determine the role of eNOS in the development of diabetic retinopathy (DR), by investigating the functional consequences of its deficiency in the diabetic state...
  36. ncbi request reprint Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
    ..It was postulated that endothelial dysfunction should predict nephropathy and that correction of the dysfunction may prevent these important complications...
  37. pmc Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects
    Myphuong T Le
    Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
    Metabolism 61:641-51. 2012
    ..Compared with sucrose, HFCS leads to greater fructose systemic exposure and significantly different acute metabolic effects...
  38. doi request reprint Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis
    Eduardo H Garin
    Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    Kidney Int 78:296-302. 2010
    ..Thus, our study supports the hypothesis that MCD and FSGS represent two different diseases rather than a continuum of one disease. Urinary CD80 excretion may be a useful marker to differentiate between MCD and FSGS...
  39. pmc Pathogenesis of essential hypertension: historical paradigms and modern insights
    Richard J Johnson
    Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
    J Hypertens 26:381-91. 2008
    ....
  40. ncbi request reprint Role of uric acid in hypertension, renal disease, and metabolic syndrome
    Marcelo Heinig
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville 32610, USA
    Cleve Clin J Med 73:1059-64. 2006
    ..Furthermore, we suggest that the recent increased intake in the American diet of fructose, which is a known cause of hyperuricemia, may be contributing to the current epidemic of obesity and diabetes...
  41. doi request reprint Prophylactic nesiritide does not prevent dialysis or all-cause mortality in patients undergoing high-risk cardiac surgery
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    J Thorac Cardiovasc Surg 138:959-64. 2009
    ....
  42. ncbi request reprint Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 287:F658-64. 2004
    ..Thus TGF-beta and hypoxia act via additive/synergistic but distinct pathways to stimulate VEGF in proximal tubular cells, a finding that may be important in understanding how VEGF is stimulated in renal disease...
  43. ncbi request reprint Tubulointerstitial disease: role of ischemia and microvascular disease
    Takahiko Nakagawa
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Opin Nephrol Hypertens 12:233-41. 2003
    ..Here we summarize recent studies on the pathogenesis and consequences of tubulointerstitial disease, emphasizing the role of ischemia and the microvasculature...
  44. ncbi request reprint Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
    Richard J Johnson
    University of Florida, Division of Nephrology, Hypertension, and Transplantation, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:1909-19. 2005
    ..Understanding the pathogenetic pathways mediating renal progression in hypertensive subjects should help identify those subjects at highest risk and may provide insights into new therapeutic maneuvers to slow or prevent progression...
  45. ncbi request reprint Human vascular smooth muscle cells express a urate transporter
    Karen L Price
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, Florida, USA
    J Am Soc Nephrol 17:1791-5. 2006
    ..It is proposed that URAT1 may provide a mechanism by which uric acid enters the human vascular smooth muscle cell, a finding that may be relevant to the role of uric acid in cardiovascular disease...
  46. pmc Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, Florida 32620 0224, USA
    Endocr Rev 30:96-116. 2009
    ..If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace...
  47. ncbi request reprint Uric acid, the metabolic syndrome, and renal disease
    Pietro Cirillo
    Division of Nephrology, Hypertension and Transplantation, Department of Medicine, University of Florida, PO Box 100224, Gainesville, FL 32608, USA
    J Am Soc Nephrol 17:S165-8. 2006
    ..It is proposed that fructose- and purine-rich foods that have in common the raising of uric acid may have a role in the epidemic of metabolic syndrome and renal disease that is occurring throughout the world...
  48. pmc Inactivation of nitric oxide by uric acid
    Christine Gersch
    Department of Medicine, Division of Nephrology and Hypertension, University of Florida, Gainesville, Florida 32610, USA
    Nucleosides Nucleotides Nucleic Acids 27:967-78. 2008
    ..This study shows a potential mechanism by which UA may deplete NO and cause endothelial dysfunction, particularly under conditions of oxidative stress in which UA is elevated and intracellular glutathione is depleted...
  49. ncbi request reprint Hypertension: a microvascular and tubulointerstitial disease
    Richard J Johnson
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, SM 1273, 6550 Fannin Street, Houston, Texas 77030, USA
    J Hypertens Suppl 20:S1-7. 2002
    ..We propose that subtle acquired renal injury may underlie the etiology of some forms of salt-sensitive hypertension...
  50. pmc Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?
    Sergey I Zharikov
    Division of Pulmonary, University of Florida, Gainesville, FL, USA
    Med Hypotheses 74:1069-74. 2010
    ..We propose studies to investigate the role of uric acid in pulmonary hypertension and to determine if lowering serum uric acid may have clinical benefit in this condition...
  51. doi request reprint Uric acid: a novel risk factor for acute kidney injury in high-risk cardiac surgery patients?
    A Ahsan Ejaz
    Division of Nephrology, Hypertension and Transplantation, University of Florida, P O Box 100224, Gainesville, FL 32610 0224, USA
    Am J Nephrol 30:425-9. 2009
    ..Uric acid has been reported to be a risk factor for the development of chronic kidney disease; however, no study has examined whether uric acid may confer a risk for acute kidney injury...
  52. pmc Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway
    Ryuji Ohashi
    Division of Nephrology, Baylor College of Medicine, Houston Texas 77030, USA
    Am J Pathol 164:477-85. 2004
    ..We conclude that blocking p38-dependent inflammation may have resulted in enhanced proliferation and increased ERK1/2 activation, and thereby explains the worse renal lesions observed...
  53. pmc The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, and the Foundation of Applied Molecular Evolution, Gainesville, FL 32610 0224, United States
    Med Hypotheses 71:22-31. 2008
    ....
  54. ncbi request reprint A causal role for uric acid in fructose-induced metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 290:F625-31. 2006
    ..Fructose may have a major role in the epidemic of metabolic syndrome and obesity due to its ability to raise uric acid...
  55. pmc Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding
    Alexandra Shapiro
    Dept of Pharmacology and Therapeutics, Box 100267, Univ of Florida, Gainesville, Florida 32610, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1370-5. 2008
    ..Our data indicate that chronic fructose consumption induces leptin resistance prior to body weight, adiposity, serum leptin, insulin, or glucose increases, and this fructose-induced leptin resistance accelerates high-fat induced obesity...
  56. doi request reprint Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation
    Gabriela E Garcia
    Division of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas 80045, USA
    Kidney Int 80:378-88. 2011
    ..Thus, A(2A)R activation can arrest GN and prevent progressive fibrosis in established pathological lesions...
  57. pmc Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome
    William Baldwin
    Department of Medicine, University of Florida, Gainesville, Florida, USA
    Diabetes 60:1258-69. 2011
    ..Previously, we showed that soluble uric acid directly stimulated the redox-dependent proinflammatory signaling in adipocytes. In this study we demonstrate the role of hyperuricemia in the production of key adipokines...
  58. ncbi request reprint A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome
    Carlos E Araya
    Department of Pediatrics, College of Medicine, University of Florida, 100296 Gainesville, Florida 32610 0296, USA
    Pediatr Nephrol 21:603-10. 2006
    ..Differences in patient population, type of cells studies, sample preservation, and methodology used to measure cytokines are some of the factors that could account for the disparity of observed results...
  59. pmc Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals
    Myphuong T Le
    Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    PLoS ONE 8:e52062. 2013
    ....
  60. pmc A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid
    Kyung Mee Kim
    Department of Medicine, Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2032-8. 2009
    ..10 to 103.59% and 98.74 to 106.12% for in vivo and in vitro analyses, respectively. This study demonstrates that intracellular levels of UA can be measured using LC-MS/MS with isotope labeled UA as an internal standard...
  61. ncbi request reprint Uric acid, evolution and primitive cultures
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Semin Nephrol 25:3-8. 2005
    ..Although other mechanisms certainly contribute to the pathogenesis of hypertension, the possibility that serum uric acid level may have a major role is suggested by these studies...
  62. ncbi request reprint A unifying pathway for essential hypertension
    Richard J Johnson
    Division of Nephrology, Hypertension and Transplantation, PO Box 100224, University of Florida, Gainesville, FL 32610, USA
    Am J Hypertens 18:431-40. 2005
    ..This pathway unites many of the previous hypotheses on the etiology of hypertension, and offers insights into ways to prevent, ameliorate, or cure the underlying process...
  63. ncbi request reprint IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease
    Wei Mu
    Division of Nephrology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:3651-60. 2005
    ..The feasibility of long-term overexpression of a gene using the AAV serotype 1 vector system in a model of renal disease is also demonstrated...
  64. pmc Radicals in the reaction between peroxynitrite and uric acid identified by electron spin resonance spectroscopy and liquid chromatography mass spectrometry
    Witcha Imaram
    Department of Chemistry, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 49:275-81. 2010
    ..The ions of m/z 352 were characterized as the PBN-triuretcarbonyl radical adduct and the m/z 223 ion was identified as the PBN-aminocarbonyl radical adduct. Their mechanism of formation is discussed...
  65. doi request reprint Elevated uric acid increases the risk for acute kidney injury
    Vijay Lapsia
    Division of Nephrology, Mount Sinai School of Medicine, New York, NY, USA
    Am J Med 125:302.e9-17. 2012
    ..The primary aims were to investigate the incidence of acute kidney injury, peak serum creatinine (SCr) concentrations, hospital length of stay, and days on mechanical ventilation...
  66. ncbi request reprint Microvascular and tubulointerstitial injury associated with chronic hypoxia-induced hypertension
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Kidney Int 63:2088-93. 2003
    ..We examined whether chronic hypoxia might induce subtle renal injury since studies in other animal models of hypertension suggest this may cause persistent hypertension...
  67. ncbi request reprint Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism
    Marilda Mazzali
    Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Renal Physiol 282:F991-7. 2002
    ..Thus hyperuricemia induces a renal arteriolopathy in rats that is blood pressure independent and involves the renin-angiotensin system...
  68. ncbi request reprint Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    Hui Y Lan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 14:1535-48. 2003
    ..TGF-beta-mediated renal fibrosis is regulated positively by Smad2/3, but negatively by Smad7. Target blockade of TGF-beta/Smad signaling by expression of Smad7 may provide a new therapeutic potential for renal fibrosis...
  69. ncbi request reprint Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomedicas, Universidad del Zulia, Maracaibo, Zulia 4001 A, Venezuela
    Am J Physiol Renal Physiol 282:F191-201. 2002
    ..We conclude that the renal immune infiltrate plays a major role in the hypertension in SHR...
  70. ncbi request reprint Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2
    John Kanellis
    Division of Nephrology, Baylor College of Medicine, SM 1273, 6550 Fannin St, Houston TX 77030
    Hypertension 41:1287-93. 2003
    ..Uric acid regulates critical proinflammatory pathways in VSMCs, suggesting it may have a role in the vascular changes associated with hypertension and vascular disease...
  71. ncbi request reprint Role of the microvascular endothelium in progressive renal disease
    Duk Hee Kang
    Baylor College of Medicine, Houston, Texas, USA
    J Am Soc Nephrol 13:806-16. 2002
    ..Therefore, angiogenic agents may represent a novel therapeutic approach for slowing the progression of renal disease...
  72. ncbi request reprint Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease
    Jin H Li
    Department of Medicine Nephrology, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:176-8. 2004
    ..Thus, AGEs act by activating Smad signaling to mediate diabetic complications via both TGF-beta-dependent and -independent pathways, shedding new light on the pathogenesis of diabetic organ injury...
  73. ncbi request reprint Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms
    Shin Ichi Suga
    National Cardiovascular Center Research Institute, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Am Soc Nephrol 14:397-406. 2003
    ..Thus, ETA as well as ETB blockade may be renoprotective in hypokalemic nephropathy...
  74. ncbi request reprint Subtle acquired renal injury as a mechanism of salt-sensitive hypertension
    Richard J Johnson
    Division of Nephrology, Baylor College of Medicine, Houston 77030, USA
    N Engl J Med 346:913-23. 2002
  75. ncbi request reprint Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model
    Christian Hugo
    Medizinische Klinik IV, Universitat Erlangen Nurnberg, Germany
    Nephron 90:460-70. 2002
    ..We studied the expression of TSP-1 mRNA and protein during the development of glomerular and tubulointerstitial nephrosclerosis in the renal ablation model particularly in relation to TGF-beta1 expression...
  76. ncbi request reprint Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University College of Medicine, Ewha Medical Research Center, Seoul, Korea
    Curr Opin Nephrol Hypertens 12:43-9. 2003
    ....
  77. ncbi request reprint Mild hyperuricemia induces glomerular hypertension in normal rats
    Laura G Sanchez-Lozada
    Department of Nephrology, Instituto Nacional de Cardiologia I Chavez, 14080 Mexico City, Mexico
    Am J Physiol Renal Physiol 283:F1105-10. 2002
    ..Glomerular hypertension may be partially mediated by an abnormal vascular response to systemic hypertension due to arteriolopathy of the afferent arteriole...
  78. pmc Nitric oxide modulates vascular disease in the remnant kidney model
    Duk Hee Kang
    Division of Nephrology, Baylor College of Medicine, Houston, Texas, USA
    Am J Pathol 161:239-48. 2002
    ..Interestingly, inhibition of NO synthesis did not lead to a loss of the preglomerular endothelium, which may relate to the effect of NO blockade to stimulate VEGF synthesis in the adjacent vascular smooth muscle cell...
  79. ncbi request reprint Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation
    Jin H Li
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Soc Nephrol 13:1464-72. 2002
    ....
  80. ncbi request reprint Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels
    Katsuyuki Matsui
    Institute of Clinical Pathology, University of Vienna, Allgemeines Krankenhaus, Vienna, Austria
    J Am Soc Nephrol 14:1981-9. 2003
    ..As lymphatic endothelial cells secrete chemokines that attract dendritic cells, it is possible that the increase in lymphatic vascularization could enhance the immunologic surveillance of remnant kidneys...
  81. pmc Hyperuricemia in childhood primary hypertension
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    Hypertension 42:247-52. 2003
    ..These results are consistent with the hypothesis that uric acid might have a role in the early pathogenesis of primary hypertension...
  82. ncbi request reprint How does angiotensin II cause renal injury?
    David A Long
    Hypertension 43:722-3. 2004
  83. ncbi request reprint J-shaped mortality relationship for uric acid in CKD
    Mohamed E Suliman
    Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 48:761-71. 2006
    ..Hyperuricemia has been associated with increased cardiovascular mortality in the general population, but less is known about this association in patients with CKD...
  84. ncbi request reprint Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats
    Laura G Sanchez-Lozada
    Dept of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1 14080, Mexico City, Mexico
    Am J Physiol Renal Physiol 292:F423-9. 2007
    ..These changes are best observed in rats administered high doses (60% diet) of fructose...
  85. ncbi request reprint A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy
    Bernd Hohenstein
    Department of Nephrology and Hypertension, University Erlangen Nuremberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Nephrol Dial Transplant 23:1144-56. 2008
    ....
  86. ncbi request reprint Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia
    Laura G Sanchez-Lozada
    Department of Nephrology, Instituto Nacional de Cardiologia Ignacio Chavez, Juan Badiano 1, 14080 Mexico City, Mexico
    Nephrol Dial Transplant 23:1179-85. 2008
    ..We therefore tested the hypothesis that Fx might be useful in treating hyperuricemia-induced hypertension and renal damage...
  87. pmc Hypokalemic nephropathy is associated with impaired angiogenesis
    Sirirat Reungjui
    Division of Nephrology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    J Am Soc Nephrol 19:125-34. 2008
    ..In conclusion, hypokalemic nephropathy is associated with impaired renal angiogenesis, evidenced by progressive capillary loss, reduced endothelial cell proliferation, and loss of VEGF expression...
  88. ncbi request reprint Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome
    Takahiko Nakagawa
    Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville, FL 32610, USA
    Nat Clin Pract Nephrol 1:80-6. 2005
    ..Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition...
  89. ncbi request reprint Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis?
    Michael S Gersch
    University of Florida, 1600 SW Archer Road, PO Box 100224, Gainesville, FL 32610 0224, USA
    Nephrol Dial Transplant 21:2938-42. 2006
    ..Thus, an attractive hypothesis could be that THP would bind to uric acid in the distal tubule, and decrease its subsequent reabsorption in the distal nephron...
  90. ncbi request reprint Everolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathy
    Katja Keller
    Division of Nephrology, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Nephrol Dial Transplant 21:2724-35. 2006
    ..The effects of an everolimus therapy were investigated in a model of renal thrombotic microangiopathy (TMA) with specific endothelial cell (EC) injury in the rat in vivo as well as in glomerular ECs in vitro...
  91. doi request reprint Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia
    Laura G Sanchez-Lozada
    Department of Nephrology, INC Ignacio Chavez, Mexico City, Mexico
    Nephron Physiol 108:p69-78. 2008
    ..The effect of febuxostat (Fx), a non-purine and selective xanthine oxidase inhibitor, on glomerular microcirculatory changes in 5/6 nephrectomy (5/6 Nx) Wistar rats with and without oxonic acid (OA)-induced hyperuricemia was evaluated...
  92. ncbi request reprint Serum uric acid: a risk factor and a target for treatment?
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    J Am Soc Nephrol 17:S69-73. 2006
    ..Although the investigations are still preliminary, serum uric acid represents a possible new and intriguing target for the reduction of morbidity and mortality associated with hypertension and CV disease...
  93. ncbi request reprint Effectiveness of nesiritide on dialysis or all-cause mortality in patients undergoing cardiothoracic surgery
    Thomas M Beaver
    Division of Thoracic and Cardiovascular Surgery, University of Florida, P O Box 100286, Gainesville, FL 32610 0286, USA
    Clin Cardiol 29:18-24. 2006
    ..Natriuretic peptides have been shown to have favorable renal effects. However, recent evidence suggests potential renal side effects in patients with congestive heart failure...
  94. ncbi request reprint Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells
    Duk Hee Kang
    Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
    J Am Soc Nephrol 16:3553-62. 2005
    ..The observation that UA alters the proliferation/migration and NO release of human vascular cells, mediated by the expression of CRP, calls for careful reconsideration of the role of UA in hypertension and vascular disease...
  95. pmc Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial
    Daniel I Feig
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX 77030, USA
    JAMA 300:924-32. 2008
    ..Experimentally increasing uric acid levels using a uricase inhibitor causes systemic hypertension in animal models...
  96. pmc Inflammation, angiotensin II, and hypertension
    Bernardo Rodriguez-Iturbe
    Hypertension 52:e135; author reply e136. 2008
  97. ncbi request reprint Hemodynamics of hyperuricemia
    Laura G Sanchez-Lozada
    Department of Nephrology, Instituto Nacional de Cardiologia, Ignacio Chavez, 14080 Mexico City, Mexico
    Semin Nephrol 25:19-24. 2005
    ..Lumen obliteration induced by vascular wall thickening results in severe vasoconstriction. The resulting ischemia is a potent stimulus that induces tubulointerstitial inflammation and fibrosis as well as arterial hypertension...
  98. ncbi request reprint TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways
    Takahiko Nakagawa
    Division of Nephrology Medicine, Baylor College of Medicine, Houston, Texas, USA
    Kidney Int 66:605-13. 2004
    ..Recent studies have shown that VEGF-A as well as TSP-1 is regulated by transforming growth factor-beta1 (TGF-beta1), but the mechanism remains unclear...
  99. ncbi request reprint Hypertension in the hemodialysis patient and the "lag phenomenon": insights into pathophysiology and clinical management
    Uday M Khosla
    Am J Kidney Dis 43:739-51. 2004
  100. ncbi request reprint Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
    Mark S Segal
    Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL, USA
    Eur J Nutr 46:406-17. 2007
    ..We propose the use of a fructose index to categorize foods and propose studies to determine the effect of low fructose diets as a means to prevent obesity, diabetes, and cardiovascular disease in the population...