R W Johnson

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint The concept of sickness behavior: a brief chronological account of four key discoveries
    R W Johnson
    Laboratory of Integrative Biology, 390 Animal Science Laboratory, Department of Animal Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA
    Vet Immunol Immunopathol 87:443-50. 2002
  2. doi request reprint Mannan oligosaccharide modulates gene expression profile in pigs experimentally infected with porcine reproductive and respiratory syndrome virus
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Anim Sci 89:3016-29. 2011
  3. doi request reprint Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Anim Sci 90:2784-93. 2012
  4. pmc In vivo vitamin E administration attenuates interleukin-6 and interleukin-1beta responses to an acute inflammatory insult in mouse skeletal and cardiac muscle
    K A Huey
    Department of Kinesiology, University of Illinois at Urbana Champaign, 120 Freer Hall, 906 South Goodwin Avenue, Urbana, IL 61801, USA
    Exp Physiol 93:1263-72. 2008
  5. pmc Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation
    C P Krzyszton
    Integrative Immunology and Behavior Program, University of Illinois, Urbana, Illinois 61801, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1109-14. 2008
  6. ncbi request reprint C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts
    Klemen Strle
    Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 147:4363-73. 2006
  7. doi request reprint Effects of mannan oligosaccharide on cytokine secretions by porcine alveolar macrophages and serum cytokine concentrations in nursery pigs
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Anim Sci 90:657-68. 2012
  8. pmc Neuroinflammation and cognitive function in aged mice following minor surgery
    H A Rosczyk
    Neuroscience Program, University of Illinois, Urbana, IL 61801, USA
    Exp Gerontol 43:840-6. 2008
  9. doi request reprint Mannan oligosaccharide improves immune responses and growth efficiency of nursery pigs experimentally infected with porcine reproductive and respiratory syndrome virus
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Anim Sci 89:2592-602. 2011
  10. ncbi request reprint Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide
    Klemen Strle
    University of Illinois, Laboratory of Immunophysiology, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    Endocrinology 145:4592-602. 2004

Research Grants

Collaborators

Detail Information

Publications64

  1. ncbi request reprint The concept of sickness behavior: a brief chronological account of four key discoveries
    R W Johnson
    Laboratory of Integrative Biology, 390 Animal Science Laboratory, Department of Animal Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA
    Vet Immunol Immunopathol 87:443-50. 2002
    ....
  2. doi request reprint Mannan oligosaccharide modulates gene expression profile in pigs experimentally infected with porcine reproductive and respiratory syndrome virus
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Anim Sci 89:3016-29. 2011
    ..In short, MOS regulated the expression of nonimmune and immune genes in pig leukocytes, perhaps providing benefits by enhancing the immune responses of the pigs to an infection, while preventing overstimulation of the immune system...
  3. doi request reprint Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Anim Sci 90:2784-93. 2012
    ..Feeding ACT may be useful as ACT is related to increased PRRSV antibody titers and G:F in infected pigs at certain times during infection...
  4. pmc In vivo vitamin E administration attenuates interleukin-6 and interleukin-1beta responses to an acute inflammatory insult in mouse skeletal and cardiac muscle
    K A Huey
    Department of Kinesiology, University of Illinois at Urbana Champaign, 120 Freer Hall, 906 South Goodwin Avenue, Urbana, IL 61801, USA
    Exp Physiol 93:1263-72. 2008
    ....
  5. pmc Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation
    C P Krzyszton
    Integrative Immunology and Behavior Program, University of Illinois, Urbana, Illinois 61801, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1109-14. 2008
    ..These data suggest that IL-10 may inhibit motor deficits and fatigue associated with peripheral infections via its anti-inflammatory effects...
  6. ncbi request reprint C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts
    Klemen Strle
    Laboratories of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 147:4363-73. 2006
    ..These results establish that the resistance of muscle progenitor cells to IGF-I, which is caused by inflammatory stimuli, is mediated by the JNK stress kinase pathway...
  7. doi request reprint Effects of mannan oligosaccharide on cytokine secretions by porcine alveolar macrophages and serum cytokine concentrations in nursery pigs
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Anim Sci 90:657-68. 2012
    ..These immunomodulatory properties of MOS may have important implications for both host defense and avoidance of harmful overstimulation of the immune system...
  8. pmc Neuroinflammation and cognitive function in aged mice following minor surgery
    H A Rosczyk
    Neuroscience Program, University of Illinois, Urbana, IL 61801, USA
    Exp Gerontol 43:840-6. 2008
    ..Overall these results suggest that minor surgery leads to an exaggerated neuroinflammatory response in aged mice but does not result in significantly impaired performance in the Morris water maze...
  9. doi request reprint Mannan oligosaccharide improves immune responses and growth efficiency of nursery pigs experimentally infected with porcine reproductive and respiratory syndrome virus
    T M Che
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Anim Sci 89:2592-602. 2011
    ..The results also indicate that the reduced intensity of inflammation by MOS may be related to changes in inflammatory mediator levels at the end of the acute phase...
  10. ncbi request reprint Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide
    Klemen Strle
    University of Illinois, Laboratory of Immunophysiology, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    Endocrinology 145:4592-602. 2004
    ....
  11. ncbi request reprint Tumor necrosis factor(alpha) and insulin-like growth factor-I in the brain: is the whole greater than the sum of its parts?
    H D Venters
    Laboratory of Immunophysiology, Department of Animal Sciences, College of Medicine, University of Illinois, 207 Edward R Madigan Laboratory, 1207 West Gregory Drive, Urbana, IL 61801, USA
    J Neuroimmunol 119:151-65. 2001
    ..We propose the framework of a molecular model of hormone-cytokine receptor cross talk in which disparate cell surface receptors share intracellular substrates that regulate neuronal survival...
  12. doi request reprint Expression of inflammatory cytokines and Toll-like receptors in the brain and respiratory tract of pigs infected with porcine reproductive and respiratory syndrome virus
    J C Miguel
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, United States
    Vet Immunol Immunopathol 135:314-9. 2010
    ..The findings are interpreted to suggest the innate immune system of the brain is responsive to PRRSV infection...
  13. pmc Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120
    J Abraham
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    Neurobiol Aging 29:614-21. 2008
    ..These results suggest that aging increases the sensitivity of mice to behavioral deficits caused by ICV gp120, perhaps by increasing expression of CCR5 and augmenting production of cytokines...
  14. pmc Methamphetamine sensitization attenuates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus
    J B Buchanan
    Laboratory of Integrative Immunology and Behavior, Department of Animal Sciences, University of Illinois Urbana Champaign, 1207 W Gregory Drive, Urbana, IL 61801, USA
    Brain Behav Immun 24:502-11. 2010
    ..Taken together, these data show that MA sensitization interferes with the normal central immune response, preventing the CNS from efficiently responding to signals from the peripheral immune system...
  15. ncbi request reprint Central interleukin-1 receptors as mediators of sickness
    K W Kelley
    Laboratory of Immunophysiology, University of Illinois, Urbana 61801, USA
    Ann N Y Acad Sci 823:234-46. 1997
    ..It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease...
  16. ncbi request reprint Improved psychomotor performance in aged mice fed diet high in antioxidants is associated with reduced ex vivo brain interleukin-6 production
    A F Richwine
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    Brain Behav Immun 19:512-20. 2005
    ..Collectively, these data indicate that antioxidants improve psychomotor performance in aged mice, and suggest antioxidants may be useful for reducing brain IL-6 production, which has been shown to increase in aged mice...
  17. ncbi request reprint An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice
    S M Ye
    Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    Neuroimmunomodulation 9:183-92. 2001
    ..The purpose of this study was to determine if in the brain of aged mice a decrease in the anti-inflammatory cytokine IL-10 contributes to the increase in IL-6...
  18. ncbi request reprint Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    J P Godbout
    Division of Nutritional Sciences, University of Illinois, Urbana, Illinois 61801, USA
    FASEB J 19:1329-31. 2005
    ..This dysregulated link between the peripheral and central innate immune system is likely to be involved in the severe behavioral deficits that frequently occur in older adults with systemic infections...
  19. pmc Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta
    Klemen Strle
    Laboratory of Integrative Immunophysiology, Integrative Immunology and Behavior Program, Department of Animal Sciences, College of Agricultural, Consumer and Enviromental Sciences, University of Illinois, Urbana, IL 61801, USA
    Am J Physiol Endocrinol Metab 294:E709-18. 2008
    ..Collectively, these data demonstrate that IL-10 acts in a novel, nonclassical, protective manner in nonhematopoietic cells to inhibit the IL-1beta receptor-induced JNK kinase pathway, resulting in prevention of IGF-I resistance...
  20. pmc From inflammation to sickness and depression: when the immune system subjugates the brain
    Robert Dantzer
    Integrative Immunology and Behavior, Department of Animal Sciences, College of Agricultural, Consumer and Environmental Sciences, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Nat Rev Neurosci 9:46-56. 2008
    ..Inflammation is therefore an important biological event that might increase the risk of major depressive episodes, much like the more traditional psychosocial factors...
  21. pmc Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice
    Saebyeol Jang
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 140:1892-8. 2010
    ..Therefore, luteolin consumption may be beneficial in preventing or treating conditions involving increased microglial cell activity and inflammation...
  22. ncbi request reprint Cytokine-induced sickness behavior
    Keith W Kelley
    Department of Animal Sciences, Laboratory of Immunophysiology, University of Illinois, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana 61801, USA
    Brain Behav Immun 17:S112-8. 2003
    ..Advances that have been made during the past decade should now be extended to clinical studies in an attempt to alleviate sickness symptoms and improve quality of life for cancer patients...
  23. ncbi request reprint IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts
    Suzanne R Broussard
    Laboratories of Immunophysiology, 207 Edward R Madigan Laboratory, University of Illinois at Urbana Champaign, 1201 West Gregory Drive, Urbana, IL 61801, USA
    J Immunol 172:7713-20. 2004
    ..Collectively, the results are consistent with the notion that very low concentrations of IL-1beta significantly impair myogenesis, but they are unable to do so in the absence of the growth factor IGF-I...
  24. ncbi request reprint Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts
    Suzanne R Broussard
    Laboratory of Immunophysiology, Department of Animal Sciences and Pathology, College of Medicine, University of Illinois at Urbana Champaign, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, IL 61801, USA
    Endocrinology 144:2988-96. 2003
    ..These data are consistent with the notion that very low physiological concentrations of TNFalpha interfere with both protein synthesis and muscle cell development by inducing a state of IGF-I receptor resistance...
  25. ncbi request reprint Insulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons
    Robert H McCusker
    250 Edward R Madigan Laboratory, Urbana, IL 61801 3873, USA
    J Neuroimmunol 179:186-90. 2006
    ..IGF-I enhanced expression of BDNF receptors (Trk-B) and increased the ability of BDNF to induce ERK1/2 phosphorylation. This IGF-I-induced increase in BDNF responsiveness describes a new interaction between these peptides in the brain...
  26. ncbi request reprint Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB
    J R Heyen
    Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Brain Res Mol Brain Res 77:138-47. 2000
    ....
  27. pmc Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice
    J B Buchanan
    Laboratory of Integrative Immunology and Behavior, Department of Animal Sciences, University of Illinois Urbana Champaign, 1207 W Gregory Drive, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:755-65. 2008
    ..These data show that aged mice are more sensitive to both the cognitive and inflammatory effects of mild stress than are adult mice and suggest a possible role for IL-1beta...
  28. doi request reprint Effects of IL-10 and age on IL-6, IL-1beta, and TNF-alpha responses in mouse skeletal and cardiac muscle to an acute inflammatory insult
    B M Meador
    Departments of Kinesiology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    J Appl Physiol (1985) 104:991-7. 2008
    ..05). The results provide the first in vivo evidence that the absence of IL-10 is associated with a greater IL-6 response to LPS in skeletal and cardiac muscles, and in skeletal muscle aging further exaggerates these responses...
  29. ncbi request reprint Interleukin-10 in the brain
    K Strle
    Department of Animal Sciences, College of Medicine, University of Illinois, Urbana 61801, USA
    Crit Rev Immunol 21:427-49. 2001
    ..These discoveries could lead to development of innovative approaches for the use of antiinflammatory cytokines in major debilitating diseases of the CNS...
  30. ncbi request reprint IL-10 promotes survival of microglia without activating Akt
    Klemen Strle
    Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, 207 ERML, 1201 W Gregory Dr, Urbana, IL 61801, USA
    J Neuroimmunol 122:9-19. 2002
    ..These data establish that IL-10 activates Stat3 and inhibits the mitochondrial pathway of cell death without activating the Akt cell survival pathway...
  31. ncbi request reprint Tumor necrosis factor alpha inhibits insulin-like growth factor I-induced hematopoietic cell survival and proliferation
    Wen Hong Shen
    University of Illinois, Laboratory of Immunophysiology, Department of Animal Sciences, 207 Edward R Madigan Laboratory, 1201 West Gregory Drive, Urbana, Illinois 61801, USA
    Endocrinology 145:3101-5. 2004
    ..These results support the general concept that proinflammatory cytokines impair the actions of hormones on hematopoietic cells, leading to IGF-I receptor resistance...
  32. ncbi request reprint Supplementing drinking water with Solutein did not mitigate acute morbidity effects of porcine reproductive and respiratory syndrome virus in nursery pigs
    J Escobar
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Anim Sci 84:2101-9. 2006
    ..Collectively, these results indicate that supplementing water with spray-dried animal plasma improved feed efficiency but did not afford nursery pigs protection from the effects of PRRSV on growth and certain hematological traits...
  33. ncbi request reprint Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kappaB
    S M Ye
    Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois, 390 Animal Science Laboratory, 1207 West Gregory Drive, Urbana, IL 61801, USA
    J Neuroimmunol 117:87-96. 2001
    ..These results show that the DNA-binding activity of NFkappaB is increased in the brain of aged mice and that at least one consequence is increased expression of IL-6...
  34. ncbi request reprint Vitamin E supplementation does not mitigate the acute morbidity effects of porcine reproductive and respiratory syndrome virus in nursery pigs
    T L Toepfer-Berg
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Anim Sci 82:1942-51. 2004
    ..Thus, feeding nursery pigs a diet high in vitamin E may not be useful for mitigating the acute morbidity effects of PRRSV infection...
  35. ncbi request reprint Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice
    J Segreti
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    Physiol Behav 61:873-8. 1997
    ..These data indicate that a genetic mutation in HeJ mice that prevents LPS-induced synthesis of cytokines also renders HeJ mice refractory to the behavioral effects of LPS...
  36. ncbi request reprint Interleukin-6 in the aging brain
    J P Godbout
    Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois at Urbana Champaign, 61801, USA
    J Neuroimmunol 147:141-4. 2004
    ..The purpose of this brief report is to discuss the new evidence that suggests an age-related increase in brain IL-6 and the impact this inflammatory cytokine may have on "successful" aging...
  37. pmc Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice
    Jayne Abraham
    Division of Nutritional Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Rejuvenation Res 12:445-53. 2009
    ....
  38. pmc Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress
    Nathan L Sparkman
    Department of Animal Sciences, Laboratory of Integrative Immunology and Behavior, University of Illinois Urbana Champaign, Urbana, IL 61801, USA
    Neuroimmunomodulation 15:323-30. 2008
    ..This alteration in neuroinflammation and resultant sensitization to extrinsic and intrinsic stressors can have considerable effects upon the elderly's recovery and coping during disease and stress...
  39. doi request reprint Architectural changes to CA1 pyramidal neurons in adult and aged mice after peripheral immune stimulation
    Amy F Richwine
    Integrative Immunology and Behavior Program, University of Illinois, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:1369-77. 2008
    ..Architectural changes to dorsal CA1 hippocampal neurons may contribute to cognitive disorders evident in elderly patients with an infection...
  40. pmc Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts
    Klemen Strle
    Laboratories of Integrative Immunophysiology, College of Medicine, University of Illinois, Urbana, IL 61801, United States
    J Neuroimmunol 188:48-55. 2007
    ..Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I...
  41. ncbi request reprint IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells
    Wen Hong Shen
    Laboratory of Immunophysiology, University of Illinois, Urbana, IL 61801, USA
    J Immunol 172:7272-81. 2004
    ..In this manner, Akt serves as a critical bridge that links proximal receptor signaling events to more distal cell cycle machinery...
  42. ncbi request reprint Dehydroepiandrosterone-sulfate did not mitigate sickness behavior in mice
    Jing Chen
    Division of Nutritional Sciences, Department of Animal Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA
    Physiol Behav 82:713-9. 2004
    ..Collectively, these results suggest that DHEA-S has neuromodulatory effects but is ineffective at ameliorating LPS-induced sickness behavior...
  43. ncbi request reprint Alpha-tocopherol attenuates NFkappaB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior
    J P Godbout
    Division of Nutritional Sciences and Department of Animal Sciences, University of Illinois, 1207 W Gregory Drive, Urbana, IL 61801, USA
    J Neuroimmunol 169:97-105. 2005
    ..Taken together, these data indicate alpha-tocopherol modulates sickness behavior and inflammatory cytokine production in the brain through an NFkappaB-dependent pathway...
  44. ncbi request reprint Regulation of food intake by inflammatory cytokines in the brain
    Jessica B Buchanan
    Laboratory of Integrative Immunology and Behaviour, Division of Nutritional Sciences, University of Illinois Urbana Champaign, Urbana, IL 61801, USA
    Neuroendocrinology 86:183-90. 2007
    ..This review describes the main inflammatory cytokines that influence food intake and explores how peripheral cytokines communicate with hypothalamic nuclei to influence feeding...
  45. ncbi request reprint Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha
    Brian N Finck
    Department of Animal Sciences, University of Illinois at Urbana Champaign, 390 Animal Sciences Laboratory, Urbana, Illinois 61801, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1429-35. 2002
    ..Collectively, these data indicate that TNF-alpha acutely activates leptin expression and that anti-inflammatory agents can abrogate TNF-alpha-induced hyperleptinemia...
  46. ncbi request reprint Alpha-tocopherol attenuates lipopolysaccharide-induced sickness behavior in mice
    Brian M Berg
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    Brain Behav Immun 18:149-57. 2004
    ..001) 24h post LPS. Collectively, these data indicate that alpha-T improved the oxidative status after exposure to LPS, which may explain its ability to ameliorate symptoms of sickness...
  47. pmc Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1
    Saebyeol Jang
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 1207 West Gregory Drive, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 105:7534-9. 2008
    ..Taken together, these data suggest luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia. Thus, luteolin may be useful for mitigating neuroinflammation...
  48. ncbi request reprint Decreased protein accretion in pigs with viral and bacterial pneumonia is associated with increased myostatin expression in muscle
    Jeffery Escobar
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    J Nutr 134:3047-53. 2004
    ..They further suggest that during infection growth of skeletal muscle is limited in part by myostatin...
  49. ncbi request reprint IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes
    Jason C O'Connor
    Department of Animal Sciences, University of Illinois at Urbana Champain, Urbana, IL 61801, USA
    J Immunol 174:4991-7. 2005
    ..Taken together, these results indicate that IL-1beta-mediated innate immunity is augmented in db/db mice both at the periphery and in the brain, and the mechanism is due to diabetes-associated loss of IL-1beta counterregulation...
  50. pmc Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology
    Jason C O'Connor
    Integrative Immunology and Behavior Program, Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell Immunol 252:91-110. 2008
    ..We also highlight that IGF-I can induce resistance or reduce sensitivity to brain TNFalpha and discuss how TNFalpha, IL-1beta, and IGF-I interact to regulate several aspects of behavior and cognition...
  51. ncbi request reprint Heat and social rank impact behavior and physiology of PRRS-virus-infected pigs
    Mhairi A Sutherland
    Department of Animal Sciences, University of Illinois, 1207 W Gregory, 392 ASL, Urbana, IL 61801, USA
    Physiol Behav 90:73-81. 2007
    ..Moreover, heat stress does not have additive negative impact on physiological or performance traits in pigs challenged with PRRS virus...
  52. pmc Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    Jing Chen
    Integrative Immunology and Behavior Program, University of Illinois, Urbana, IL 61801, USA
    Brain Behav Immun 22:301-11. 2008
    ....
  53. ncbi request reprint Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers
    Nathan L Sparkman
    Laboratory of Integrative Immunology and Behavior, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    J Neurosci 26:10709-16. 2006
    ..Collectively, these data suggest that humoral and neural immune-to-brain communication pathways are intact in IL-6-deficient mice but that, in the absence of IL-6, the central cytokine compartment is hyporesponsive...
  54. ncbi request reprint Induction of interleukin-1 beta-converting enzyme (ICE) in murine microglia by lipopolysaccharide
    J Yao
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    Brain Res Mol Brain Res 51:170-8. 1997
    ..That dexamethasone inhibited the expression of ICE, suggests that corticosteroids regulate the secretion of IL-1beta by microglial cells, in part, by regulating the expression of ICE...
  55. ncbi request reprint Mice deficient in interleukin-1beta converting enzyme resist anorexia induced by central lipopolysaccharide
    J H Yao
    Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois at Urbana, Illinois 61801, USA
    Am J Physiol 277:R1435-43. 1999
    ..These results suggest that preventing generation of mature IL-1beta can inhibit anorexia induced by LPS in the brain and, therefore, reveal ICE as a potential target for regulating food intake during brain inflammation...
  56. ncbi request reprint Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor
    B N Finck
    Laboratory of Integrative Biology, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Am J Physiol Regul Integr Comp Physiol 278:R537-43. 2000
    ..These results provide new information on the interplay between cells of the immune system and adipocytes...
  57. ncbi request reprint Growth performance and whole-body composition of pigs experimentally infected with Mycoplasma hyopneumoniae
    J Escobar
    Department of Animal Sciences, University of Illinois, Urbana 61801, USA
    J Anim Sci 80:384-91. 2002
    ..The ability of pigs to contend with Mh may have resulted from the absence of other pathogens that generally co-exist with Mh under commercial conditions...
  58. pmc Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    Ryan N Dilger
    Department of Animal Sciences, University of Illinois, Urbana, Illinois, USA
    J Leukoc Biol 84:932-9. 2008
    ..e., anorexia, weight loss, noncompliance), which ultimately leads to higher rates of hospitalization and mortality...
  59. ncbi request reprint alpha-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain
    Jonathan P Godbout
    Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Neuroimmunol 149:101-9. 2004
    ..Taken together, these data indicate that alpha-tocopherol can mitigate inflammatory cytokine production in the brain...
  60. pmc Central inhibition of interleukin-1beta ameliorates sickness behavior in aged mice
    Jayne Abraham
    Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    Brain Behav Immun 23:396-401. 2009
    ..Thus, inhibiting the central actions of IL-1beta may be useful for minimizing behavioral complications in older individuals with an infection...
  61. ncbi request reprint alpha-Tocopherol and selenium facilitate recovery from lipopolysaccharide-induced sickness in aged mice
    Brian M Berg
    Division of Nutritional Sciences, University of Illinois, Urbana 61801, USA
    J Nutr 135:1157-63. 2005
    ..Taken together, these findings suggest that adequate intake of dietary alpha-T and selenium may help promote recovery from gram-negative bacterial infection in the aged...
  62. pmc Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide
    Amy F Richwine
    Department of Animal Sciences and Integrative Immunology and Behavior Program, University of Illinois, 1207 W Gregory Drive, Urbana, IL 61801, USA
    Brain Behav Immun 23:794-802. 2009
    ..We conclude that IL-10 is critical for maintaining normal neuro-immune communication during infection...
  63. ncbi request reprint Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
    Jonathan P Godbout
    Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Neurol Clin 24:521-38. 2006
    ..Therefore pharmacologic strategies to decrease neuroinflammation associated with infection may be important for improving recovery from sickness and reducing neurobehavioral deficits in the elderly...
  64. ncbi request reprint Enhanced neuronal activation in central autonomic network nuclei in aged mice following acute peripheral immune challenge
    Ronald P A Gaykema
    Program in Sensory and Systems Neuroscience, Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA
    Auton Neurosci 131:137-42. 2007
    ....

Research Grants1

  1. Methamphetamine, HIV, Neuroinflammation and Behavior
    Rodney Johnson; Fiscal Year: 2007
    ..Therefore, the goal of this proposal is to investigate if MA use and HIV-1 infection unite to exacerbate the cognitive and motor complications associated with HIV disease and produce a heightened neuroinflammatory state. ..