R L Johnson

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration
    R L Johnson
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Mol Cell 6:467-78. 2000
  2. ncbi request reprint lunatic fringe is an essential mediator of somite segmentation and patterning
    Y A Evrard
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nature 394:377-81. 1998
  3. ncbi request reprint New players and puzzles in the Hedgehog signaling pathway
    R L Johnson
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5329, USA
    Curr Opin Genet Dev 8:450-6. 1998
  4. ncbi request reprint Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split
    H Kokubo
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, 77030, USA
    Biochem Biophys Res Commun 260:459-65. 1999
  5. ncbi request reprint The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
  6. ncbi request reprint Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    R L Johnson
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5427, USA
    Science 272:1668-71. 1996
  7. ncbi request reprint Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
    V Marigo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Development 122:1225-33. 1996
  8. ncbi request reprint Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog
    L V Goodrich
    Department of Developmental Biology, Howard Hughes Medical Institute HHMI, Stanford University School of Medicine, California 94305 5427, USA
    Genes Dev 10:301-12. 1996
  9. ncbi request reprint patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
    R L Johnson
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5427, USA
    Development 121:4161-70. 1995
  10. ncbi request reprint Hedgehog signaling in vertebrate and invertebrate limb patterning
    J Capdevila
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla California 92037 1099, USA
    Cell Mol Life Sci 57:1682-94. 2000

Collaborators

  • Haiyan Wang
  • Marc Fisher
  • Andrew McMahon
  • J Capdevila
  • Joern Groene
  • M P Scott
  • V Marigo
  • S W Wang
  • C J Tabin
  • M P Smidt
  • A Kania
  • H Chen
  • C L Pressman
  • L Gan
  • H Kokubo
  • L V Goodrich
  • Y Lun
  • M Kengaku
  • M Aszterbaum
  • Y A Evrard
  • J A Cygan
  • D M Stone
  • B S Kim
  • K Ding
  • W H Klein
  • D Sun
  • J P Burbach
  • T M Jessell
  • J J Cox
  • C H Asbreuk
  • A Rothman
  • A Aulehla
  • J C Izpisua Belmonte
  • X Zhang
  • C Rodriguez-Esteban
  • J Xie
  • E H Epstein
  • J M Bonifas
  • J De La Pena
  • Q Gu
  • F de Sauvage
  • T A Swanson
  • M Noll
  • M Hynes
  • L Milenkovic
  • A Vortkamp
  • A Goddard
  • D Pennica
  • R D Riddle
  • H Phillips
  • A Rosenthal
  • M Armanini
  • J E Hooper
  • J A McMahon
  • C Tabin
  • E Laufer

Detail Information

Publications23

  1. ncbi request reprint In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration
    R L Johnson
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Mol Cell 6:467-78. 2000
    ..We observe little or no association of full-length or partially deleted Ptc with the membrane protein Smoothened in Drosophila cultured cells...
  2. ncbi request reprint lunatic fringe is an essential mediator of somite segmentation and patterning
    Y A Evrard
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nature 394:377-81. 1998
    ....
  3. ncbi request reprint New players and puzzles in the Hedgehog signaling pathway
    R L Johnson
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5329, USA
    Curr Opin Genet Dev 8:450-6. 1998
    ..The role of Hh in carcinogenesis is underscored by the identification of mutations in several pathway components in skin and brain tumors...
  4. ncbi request reprint Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split
    H Kokubo
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, 77030, USA
    Biochem Biophys Res Commun 260:459-65. 1999
    ....
  5. ncbi request reprint The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
    D M Stone
    Department of Neuroscience, Genentech, Inc, South San Francisco, California 94080, USA
    Nature 384:129-34. 1996
    ..These findings, combined with available genetic evidence from Drosophila, support the hypothesis that Ptc is a receptor for Shh, and that vSmo could be a signalling component that is linked to Ptc...
  6. ncbi request reprint Human homolog of patched, a candidate gene for the basal cell nevus syndrome
    R L Johnson
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305 5427, USA
    Science 272:1668-71. 1996
    ..The human PTC gene appears to be crucial for proper embryonic development and for tumor suppression...
  7. ncbi request reprint Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
    V Marigo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Development 122:1225-33. 1996
    ..It is therefore a more direct target of Sonic hedgehog than previously reported patterning genes...
  8. ncbi request reprint Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog
    L V Goodrich
    Department of Developmental Biology, Howard Hughes Medical Institute HHMI, Stanford University School of Medicine, California 94305 5427, USA
    Genes Dev 10:301-12. 1996
    ..As in flies, mouse ptc transcription appears to be indicative of hedgehog signal reception. The results support the existence of a conserved signaling pathway used for pattern formation in insects and mammals...
  9. ncbi request reprint patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets
    R L Johnson
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305 5427, USA
    Development 121:4161-70. 1995
    ..Thus patched influences wing disc patterning by decreasing Ci protein levels and inactivating hedgehog target genes in the anterior compartment...
  10. ncbi request reprint Hedgehog signaling in vertebrate and invertebrate limb patterning
    J Capdevila
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla California 92037 1099, USA
    Cell Mol Life Sci 57:1682-94. 2000
    ..Here we highlight the similarities and differences between the use of Hedgehog signaling in these two systems...
  11. ncbi request reprint Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb
    A Kania
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 102:161-73. 2000
    ..Thus, LIM homeodomain proteins act within motor neurons and cells that guide motor axons to establish the fidelity of a binary choice in axonal trajectory...
  12. ncbi request reprint A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
    M P Smidt
    Section of Molecular Neuroscience, Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Medical Faculty, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Nat Neurosci 3:337-41. 2000
    ..The data suggest that at least two molecular cascades operate during the specification of the mesDA system, one specifying neurotransmitter phenotype and another essential for other aspects of mesDA neuron differentiation...
  13. ncbi request reprint LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye
    C L Pressman
    Department of Biochemistry and Molecular Biology, Program in Genes and Development, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 26:15-25. 2000
    ..Taken together, our studies suggest a developmental etiology for glaucoma in NPS patients and highlight lmx1b as an essential regulator of anterior segment morphogenesis and patterning. genesis 26:15-25, 2000...
  14. ncbi request reprint The long and short of hedgehog signaling
    R L Johnson
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 81:313-6. 1995
  15. ncbi request reprint Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome
    M Aszterbaum
    Department of Dermatology, University of California, San Francisco, USA
    J Invest Dermatol 110:885-8. 1998
    ..The most common mutations were frameshifts resulting in premature chain termination. These results provide further evidence for the crucial role of PTC as a tumor suppressor in human keratinocytes...
  16. ncbi request reprint Control of cell growth and fate by patched genes
    R L Johnson
    Howard Hughes Medical Institute, Department of Developmental Biology, Stanford University School of Medicine, California 94305 5427, USA
    Cold Spring Harb Symp Quant Biol 62:205-15. 1997
  17. ncbi request reprint Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud
    M Kengaku
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 280:1274-7. 1998
    ..In contrast, neither beta-catenin nor Lef1 affects the Wnt7a-regulated dorsoventral polarity of the limb. Thus, two related Wnt genes elicit distinct responses in the same tissues by using different intracellular pathways...
  18. ncbi request reprint Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants
    J A Cygan
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Development 124:5021-32. 1997
    ..Unlike the normal AER, ectopic AER formation is dependent upon Wnt-7a activity, indicating that distinct genetic mechanisms may be involved in primary and secondary AER formation...
  19. ncbi request reprint Molecular models for vertebrate limb development
    R L Johnson
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cell 90:979-90. 1997
  20. ncbi request reprint Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
    V Marigo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Biol 180:273-83. 1996
    ..In conjunction with evidence from a mouse Gli3 mutant, our data suggest that GLI and GLI3 may have taken two different functions of their Drosophila homolog cubitus interruptus...
  21. ncbi request reprint Sonic hedgehog mediates the polarizing activity of the ZPA
    R D Riddle
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 75:1401-16. 1993
    ..Like the ZPA, Sonic hedgehog expression leads to the activation of Hox genes. Sonic hedgehog thus appears to function as the signal for antero-posterior patterning in the limb...
  22. ncbi request reprint Sonic hedgehog: a key mediator of anterior-posterior patterning of the limb and dorso-ventral patterning of axial embryonic structures
    R L Johnson
    Department of Genetics, Harvard Medical School, Boston, MA 02115
    Biochem Soc Trans 22:569-74. 1994
    ..The isolation of Sonic heralds a new era in the investigation of the molecular mechanisms of these key inductive interactions in vertebrate development...
  23. pmc Requirement for math5 in the development of retinal ganglion cells
    S W Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genes Dev 15:24-9. 2001
    ..These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs...