Mahlon D Johnson

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Cucurbitacin I blocks cerebrospinal fluid and platelet derived growth factor-BB stimulation of leptomeningeal and meningioma DNA synthesis
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Ave, Rochester, NY 14642, USA
    BMC Complement Altern Med 13:303. 2013
  2. ncbi request reprint Radiation-associated meningioma in the elderly: development of meningioma with olfactory neuroblastoma recurrence 10 years after irradiation
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14642, USA phone 585 276 3087 fax 585 273 1027 e mail
    Ann Clin Lab Sci 43:460-3. 2013
  3. doi request reprint Na-K-2Cl cotransporter and aquaporin 1 in arachnoid granulations, meningiomas, and meningiomas invading dura
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Pathol 44:1118-24. 2013
  4. doi request reprint Radiation effects on human leptomeningeal cell response to cerebrospinal fluid and PDGF-BB
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, Rochester, NY, USA
    Int J Radiat Biol 88:547-55. 2012
  5. doi request reprint Cerebrospinal fluid stimulates leptomeningeal and meningioma cell proliferation and activation of STAT3
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    J Neurooncol 107:121-31. 2012
  6. doi request reprint Bone morphogenetic protein 4 and its receptors are expressed in the leptomeninges and meningiomas and signal via the Smad pathway
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology and Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neuropathol Exp Neurol 68:1177-83. 2009
  7. ncbi request reprint Fourth ventricle rosette-forming glioneuronal tumor. Case report
    Mahlon Johnson
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosurg 105:129-31. 2006
  8. ncbi request reprint Neuronal differentiation and expression of neural epitopes in pituitary adenomas
    Mahlon D Johnson
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14623, USA
    J Histochem Cytochem 55:1265-71. 2007
  9. doi request reprint Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway
    Mahlon D Johnson
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Rochester Medical Center, Rochester, New York 14623, USA
    J Neurosurg 112:934-9. 2010
  10. doi request reprint Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    J Neurooncol 92:129-36. 2009

Collaborators

Detail Information

Publications46

  1. doi request reprint Cucurbitacin I blocks cerebrospinal fluid and platelet derived growth factor-BB stimulation of leptomeningeal and meningioma DNA synthesis
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Ave, Rochester, NY 14642, USA
    BMC Complement Altern Med 13:303. 2013
    ..Previously, we have found STAT3 to be activated in meningiomas, particularly higher grade tumors...
  2. ncbi request reprint Radiation-associated meningioma in the elderly: development of meningioma with olfactory neuroblastoma recurrence 10 years after irradiation
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14642, USA phone 585 276 3087 fax 585 273 1027 e mail
    Ann Clin Lab Sci 43:460-3. 2013
    ..For example, in studies including a total of 58 adults receiving RT, only two cases of RAM occurred in patients 50 years old or older [8,9]...
  3. doi request reprint Na-K-2Cl cotransporter and aquaporin 1 in arachnoid granulations, meningiomas, and meningiomas invading dura
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Hum Pathol 44:1118-24. 2013
    ..This was extensive in all subtypes of meningiomas studied. These findings suggest that NKCC1 and AQP1 participate in meningioma biology and invasion. NKCC1 might be targeted by FDA-approved NKCC1 inhibitors...
  4. doi request reprint Radiation effects on human leptomeningeal cell response to cerebrospinal fluid and PDGF-BB
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, Rochester, NY, USA
    Int J Radiat Biol 88:547-55. 2012
    ..We therefore evaluated whether radiation stimulates human leptomeningeal cell proliferation and activates growth regulatory pathways...
  5. doi request reprint Cerebrospinal fluid stimulates leptomeningeal and meningioma cell proliferation and activation of STAT3
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    J Neurooncol 107:121-31. 2012
    ....
  6. doi request reprint Bone morphogenetic protein 4 and its receptors are expressed in the leptomeninges and meningiomas and signal via the Smad pathway
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology and Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neuropathol Exp Neurol 68:1177-83. 2009
    ..These findings suggest that BMP-4 and BMPRs may play autocrine/paracrine roles and interact with other transforming growth factor-beta superfamily members in regulating meningioma growth and differentiation...
  7. ncbi request reprint Fourth ventricle rosette-forming glioneuronal tumor. Case report
    Mahlon Johnson
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosurg 105:129-31. 2006
    ..Recognition of, and long-term follow up for, this recently described pathological entity may clarify the nature of this lesion and strategies for its optimal management...
  8. ncbi request reprint Neuronal differentiation and expression of neural epitopes in pituitary adenomas
    Mahlon D Johnson
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14623, USA
    J Histochem Cytochem 55:1265-71. 2007
    ..These may occur in many forms of adenomas including somatotroph, lactotroph, mixed somatotroph and lactotroph, null cell/gonadotroph cell and, rarely, corticotroph cell adenomas...
  9. doi request reprint Fibroblast growth factor receptor-3 expression in meningiomas with stimulation of proliferation by the phosphoinositide 3 kinase-Akt pathway
    Mahlon D Johnson
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Rochester Medical Center, Rochester, New York 14623, USA
    J Neurosurg 112:934-9. 2010
    ..Fibroblast growth receptor-3 has not been demonstrated in the human CNS or its tumors. Nonetheless, it has been implicated in the pathogenesis of several other forms of neoplasia...
  10. doi request reprint Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 626, Rochester, NY 14642, USA
    J Neurooncol 92:129-36. 2009
    ..Moreover, each of the three major growth regulatory pathways is concomitantly activated in higher grade meningiomas...
  11. pmc Mesothelin expression in the leptomeninges and meningiomas
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology, University of Rochester Medical Center, Rochester, New York 14623, USA
    J Histochem Cytochem 56:579-85. 2008
    ..Future studies may clarify its role in the development of meningiomas, meningeal seeding of gliomas, and metastases to the leptomeninges...
  12. ncbi request reprint New prospects for management and treatment of inoperable and recurrent skull base meningiomas
    Mahlon D Johnson
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14623, USA
    J Neurooncol 86:109-22. 2008
    ..This article reviews some recent findings pathways that appear to regulate meningioma growth. Potential targets for novel therapies are also discussed...
  13. doi request reprint Lopinavir inhibits meningioma cell proliferation by Akt independent mechanism
    Mahlon D Johnson
    Division of Neuropathology, Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Neurooncol 101:441-8. 2011
    ..These studies suggest that lopinavir may inhibit meningioma growth, and does so in part by cell cycle arrest. Additional evaluation of lopinavir as a potential adjunct chemotherapy is warranted...
  14. doi request reprint MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, Rochester, NY 14623, USA
    Appl Immunohistochem Mol Morphol 18:250-3. 2010
    ..Our findings suggest that adenocarcinomas with MUC16 expression may have an increased risk for metastases to pleura/peritoneum but not the leptomeninges or brain...
  15. doi request reprint Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology, University of Rochester Medical Center, 601 Elmwood Ave Box 626, Rochester, NY 14642, USA
    J Neurooncol 103:277-85. 2011
    ..Nonetheless, restoring TGF-β inhibition of meningioma cell proliferation may be an important objective in the design of new chemotherapies for these tumors...
  16. ncbi request reprint Transforming growth factor-beta effects on meningioma cell proliferation and signal transduction pathways
    Mahlon D Johnson
    Department of Pathology, Vanderbilt Medical School, Nashville, TN 37232, USA
    J Neurooncol 66:9-16. 2004
    ..Neutralizing antibody against TGF-beta augmented this stimulation in 2 of 3 cultures. These findings suggest that TGF-beta exerts a largely inhibitory effect on basal meningioma proliferation, perhaps in part through Smad 2/3...
  17. ncbi request reprint Evidence for phosphatidylinositol 3-kinase-Akt-p7S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in meningioma cells
    Mahlon D Johnson
    Department of Pathology, Vanderbilt Medical School, Nashville, Tennessee 37232, USA
    J Neurosurg 97:668-75. 2002
    ..In this study the authors evaluated whether the phosphatidylinositol 3-kinase (PI3-K)-Akt-p70S6K pathway is expressed in meningiomas, regulates their growth, and transduces mitogenic signals of PDGF-BB...
  18. pmc Vascular gene expression patterns are conserved in primary and metastatic brain tumors
    Yang Liu
    Department of Neurosurgery, University of Rochester, 601 Elmwood Avenue, Box 670, Rochester, NY 14642, USA
    J Neurooncol 99:13-24. 2010
    ..Anti-angiogenic therapies currently in development for primary brain tumors may prove beneficial for brain metastases and vice versa...
  19. ncbi request reprint Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary
    Xuemo Fan
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Histochem Cytochem 50:1509-16. 2002
    ..CPE in these cells may process other peptides critical for pituitary cell function, such as chromogranin A or B. These findings suggest that CPs participate in the functioning of pituitary adenomas...
  20. ncbi request reprint Lovastatin is a potent inhibitor of meningioma cell proliferation: evidence for inhibition of a mitogen associated protein kinase
    Mahlon D Johnson
    Department of Pathology, Vanderbilt Medical School, Nashville Veterans Administration Medical Center, TN 37212, USA
    J Neurooncol 56:133-42. 2002
    ..Additional studies are warranted to assess whether lovastatin and similar HMG-CoA reductase inhibitors represent a new adjunctive chemotherapy for recurrent meningiomas...
  21. ncbi request reprint Dural lesions mimicking meningiomas
    Mahlon D Johnson
    Department of Pathology, Vanderbilt Medical School, Nashville, TN 37232, USA
    Hum Pathol 33:1211-26. 2002
    ..Awareness that these lesions involve the dura may facilitate intraoperative recognition and, in some cases, preclude unnecessary additional surgery...
  22. doi request reprint Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study
    Michael T Milano
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 647, Rochester, NY 14642, USA
    J Neurooncol 98:83-92. 2010
    ..Given the retrospective nature of this study, specific recommendations about which situations warrant radiotherapy cannot be determined...
  23. ncbi request reprint Molecular genetic analysis of a primitive neuroectodermal tumor arising after intracranial radiation and chemotherapy for leukemia
    Mahlon D Johnson
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Ann Clin Lab Sci 39:295-302. 2009
    ..This case suggests a possible link between radiation, chemotherapy, and the formation of these tumors, with a potential new pathogenetic role for somatic inactivation of the protooncogene RET...
  24. ncbi request reprint July 2002: 66-year-old female with a one-year history of progressive left proptosis
    Xuemo Fan
    Division of Neuropathology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Brain Pathol 13:111-2, 117. 2003
    ..The histopathological differential diagnoses of spindle cell neoplasms of the orbit are discussed. Five months after surgery, no evidence of tumor recurrence was seen on neuroimaging and her vision was 20/20...
  25. pmc Characterization of TEM1/endosialin in human and murine brain tumors
    Eleanor B Carson-Walter
    Department of Neurosurgery, The University of Rochester, Rochester, NY, USA
    BMC Cancer 9:417. 2009
    ..We characterized the expression pattern of TEM1/endosialin in astrocytic and metastatic brain tumors and investigated its role as a therapeutic target in human endothelial cells and mouse xenograft models...
  26. ncbi request reprint Erdheim-chester disease mimicking multiple meningiomas syndrome
    Mahlon D Johnson
    Department of Pathology, Vanderbilt Medical School, Nashville, TN 37232, USA
    AJNR Am J Neuroradiol 25:134-7. 2004
    ..Biopsy of one orbital mass revealed a non-Langerhans histiocytosis. Subsequently, soft tissue masses, a pericardial effusion, and bone lesions consistent with ECD were identified...
  27. pmc MR diffusion tensor and perfusion-weighted imaging in preoperative grading of supratentorial nonenhancing gliomas
    Xiang Liu
    Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY 14642 8638, USA
    Neuro Oncol 13:447-55. 2011
    ..7%. These findings were better than maximal rCBV ratio, mean ADC, and minimum ADC. The mean FA and maximal FA, used individually or combined, may be useful in preoperative grading of supratentorial nonenhancing gliomas...
  28. ncbi request reprint December 2006: 31-year-old woman with hemiparesis
    Mahlon D Johnson
    Department of Pathology, University of Tennessee Medical Center, Knoxville, TN, USA
    Brain Pathol 17:255-7. 2007
  29. ncbi request reprint Pathologic quiz case: cerebellar hemorrhage in an octogenarian. Gliosarcoma
    Randall L Woltjer
    Department of Pathology, Division of Neuropathology, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Arch Pathol Lab Med 127:e345-6. 2003
  30. doi request reprint Glioblastoma multiforme in skin: a report of 2 cases and review of the literature
    Mark Mentrikoski
    Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA
    Am J Dermatopathol 30:381-4. 2008
    ..It is important to have an accurate clinical history when evaluating scalp nodules in patients with GBM, so that a diagnosis of GBM is not overlooked...
  31. ncbi request reprint Allelic losses in oligodendroglial and oligodendroglioma-like neoplasms: analysis using microsatellite repeats and polymerase chain reaction
    Mahlon D Johnson
    Department of Pathology, Vanderbilt Medical School, Nashville, Tenn 37232, USA
    Arch Pathol Lab Med 127:1573-9. 2003
    ..Oligodendroglial tumors are heterogenous neoplasms with histologic features shared with other central nervous system tumors, such as dysembryoplastic neuroepithelial tumors...
  32. doi request reprint Differential expression of somatostatin receptors, P44/42 MAPK, and mTOR activation in medulloblastomas and primitive neuroectodermal tumors
    Mahlon D Johnson
    Department of Pathology, Division of Neuropathology Departments of Pediatric Neurosurgery Pediatric Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY
    Appl Immunohistochem Mol Morphol 21:532-8. 2013
    ..Immunohistochemical identification of mTOR activation/phosphorylation in biopsies of initial and treatment-resistant PNETs may facilitate development of clinical trials and therapeutic decisions. ..
  33. doi request reprint Mycoplasmal panencephalitis: a neuropathologic documentation
    James M Powers
    Department of Pathology, University of Rochester Medical Center, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Acta Neuropathol 124:143-8. 2012
    ..The pathogenesis of acute childhood encephalitis due to mycoplasma seems to be multifactorial...
  34. ncbi request reprint Proteomics in diagnostic neuropathology
    Mahlon D Johnson
    Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Neuropathol Exp Neurol 65:837-45. 2006
    ..Combined with histology and molecular genetic analyses, new proteomic techniques should refine subclassifications and provide defining information about the pathogenesis of many central and peripheral nervous system diseases...
  35. ncbi request reprint Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene
    Mahlon D Johnson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tenn, USA
    Pediatr Neurosurg 40:124-7. 2004
    ..Careful molecular analysis failed to reveal alterations of the VHL gene. This represents an uncommon presentation for these tumors and suggests that genes other than VHL may be important in the genesis of these tumors...
  36. ncbi request reprint Melanotic neuroectodermal tumor of infancy discovered after head trauma
    Paisit Paueksakon
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tenn 37232, USA
    Pediatr Neurosurg 36:33-6. 2002
    ..Microscopic evaluation revealed a chronic hematoma and MNTI. The tumor recurred within a year. MNTI should be included in the differential diagnosis of epidural and skull lesions in infants...
  37. ncbi request reprint Proteomic-based prognosis of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry
    Sarah A Schwartz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8575, USA
    Cancer Res 65:7674-81. 2005
    ..These results show that this new molecular approach to monitoring gliomas can provide clinically relevant information on tumor malignancy and is suitable for high-throughput clinical screening...
  38. ncbi request reprint Cerebral activation of mitogen-activated protein kinases after circulatory arrest and low flow cardiopulmonary bypass
    Alon S Aharon
    Division of Cardiothoracic Surgery, St Louis University Health Sciences Center, 3635 Vista Avenue at Grand Boulevard, St Louis, Mo 63110 0250, USA
    Eur J Cardiothorac Surg 26:912-9. 2004
    ....
  39. ncbi request reprint 35-year-old woman with progressive bilateral leg weakness
    Kyle J Mangels
    Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA
    Brain Pathol 16:183-4, 187. 2006
    ..She was given focused radiotherapy to the region of the ventral thecal sac to 40 cGy. At one year following surgery, the patient's neurological examination is normal and she remains free of residual disease by MR examination...
  40. ncbi request reprint Cystic cavernous malformation of the cerebellopontine angle. Case illustration
    Charles B Stevenson
    Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2380, USA
    J Neurosurg 103:931. 2005
  41. ncbi request reprint Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity
    Steven A Toms
    Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurosurgery 57:382-91; discussion 382-91. 2005
    ..As the ratio of neoplastic cells to normal cells becomes lower, the ability to detect these cells diminishes. We describe a device designed to augment intraoperative identification of both solid tumor and infiltrating tumor margins...
  42. ncbi request reprint A probability-based spectroscopic diagnostic algorithm for simultaneous discrimination of brain tumor and tumor margins from normal brain tissue
    Shovan K Majumder
    Dept of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    Appl Spectrosc 61:548-57. 2007
    ..Further, the probabilistic nature of the algorithm makes it possible to quantitatively assess the certainty of the classification and recheck the samples that are classified with higher relative uncertainty...
  43. ncbi request reprint Protein profiling in brain tumors using mass spectrometry: feasibility of a new technique for the analysis of protein expression
    Sarah A Schwartz
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Clin Cancer Res 10:981-7. 2004
    ..The purpose of this research was to perform a preliminary assessment of protein patterns in primary brain tumors using a direct-tissue mass spectrometric technique to profile and map biomolecules...
  44. ncbi request reprint In vivo optical spectroscopy detects radiation damage in brain tissue
    Wei Chiang Lin
    Department of Biomedical Engineering, Florida International University, Miami, Florida, USA
    Neurosurgery 57:518-25; discussion 518-25. 2005
    ..Optical spectroscopy may represent a novel technique to identify radiation damage in brain tissues and to differentiate contrast-enhancing lesions from recurrent tumor...
  45. ncbi request reprint Blockade of the extracellular signal-regulated kinase pathway by U0126 attenuates neuronal damage following circulatory arrest
    Deog Gon Cho
    Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Thorac Cardiovasc Surg 127:1033-40. 2004
    ....
  46. ncbi request reprint Differential responsiveness among "high risk" pediatric brain tumors in a pilot study of dose-intensive induction chemotherapy
    Mark T Jennings
    Department of Neurology, Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Pediatr Blood Cancer 43:46-54. 2004
    ..5 cm(2) unresectable tumor, glioblastoma, supratentorial primitive neuroectodermal tumor, and metastatic medulloblastoma (MBL). This pilot study sought to correlate cytoreductive response with progression free survival...