Lincoln V Johnson

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration
    Sergiu T Leu
    Department of Molecular, Cellular and Development Biology, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 74:141-54. 2002
  2. ncbi request reprint Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling
    Joyce Tombran-Tink
    University of Missouri Kansas City, Pharmaceutical Sciences, Kansas City, MO 64110, USA
    Adv Exp Med Biol 533:315-26. 2003
  3. pmc The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93016, USA
    Proc Natl Acad Sci U S A 99:11830-5. 2002
  4. ncbi request reprint Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 78:243-56. 2004
  5. ncbi request reprint Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid
    Monte J Radeke
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 85:366-80. 2007
  6. doi request reprint Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins
    Teisha J Rowland
    Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, CA 93106, USA
    J Tissue Eng Regen Med 7:642-53. 2013
  7. ncbi request reprint Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen
    Patrick T Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, California 93106 5060, USA
    Invest Ophthalmol Vis Sci 46:4788-95. 2005
  8. pmc Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
    Aaron M Newman
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, Biological Sciences 2 Building, University of California, Santa Barbara, CA 93106 5060, USA
    Genome Med 4:16. 2012
  9. pmc Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 108:18277-82. 2011
  10. pmc The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 29:95-112. 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular Degeneration
    Sergiu T Leu
    Department of Molecular, Cellular and Development Biology, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 74:141-54. 2002
    ..The data lead to the speculation that high TIMP-3 concentrations within drusen could inhibit MMPs and as a result slow the proteolytic degradation of these deposits...
  2. ncbi request reprint Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profiling
    Joyce Tombran-Tink
    University of Missouri Kansas City, Pharmaceutical Sciences, Kansas City, MO 64110, USA
    Adv Exp Med Biol 533:315-26. 2003
  3. pmc The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93016, USA
    Proc Natl Acad Sci U S A 99:11830-5. 2002
    ..Thus, A beta deposition could be an important component of the local inflammatory events that contribute to atrophy of the retinal pigmented epithelium, drusen biogenesis, and the pathogenesis of AMD...
  4. ncbi request reprint Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 78:243-56. 2004
    ..We characterized the ultrastructural organization and histochemical staining properties of these Abeta-containing elements in order to further assess their significance in drusen formation and AMD pathogenesis...
  5. ncbi request reprint Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid
    Monte J Radeke
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Exp Eye Res 85:366-80. 2007
    ..These findings lay the groundwork for further studies into the roles of the corresponding gene products in the normal, aged, and diseased macula...
  6. doi request reprint Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins
    Teisha J Rowland
    Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, CA 93106, USA
    J Tissue Eng Regen Med 7:642-53. 2013
    ....
  7. ncbi request reprint Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen
    Patrick T Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, California 93106 5060, USA
    Invest Ophthalmol Vis Sci 46:4788-95. 2005
    ..Drusen are risk factors for age-related macular degeneration and have been shown to negatively impact cells of the RPE and retina. In this study, the effects of drusen on the synaptic machinery of retinal photoreceptors are investigated...
  8. pmc Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
    Aaron M Newman
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, Biological Sciences 2 Building, University of California, Santa Barbara, CA 93106 5060, USA
    Genome Med 4:16. 2012
    ..Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract..
  9. pmc Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 108:18277-82. 2011
    ..This model system will facilitate the analysis of molecular and cellular aspects of AMD pathogenesis, and the testing of new therapeutic agents for its treatment...
  10. pmc The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Prog Retin Eye Res 29:95-112. 2010
    ....
  11. ncbi request reprint A role for local inflammation in the formation of drusen in the aging eye
    Don H Anderson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Am J Ophthalmol 134:411-31. 2002
    ..Identifying the origin and molecular composition of these deposits, therefore, has been an important, yet elusive, objective for many decades. Recently, a more complete profile of the molecular composition of drusen has emerged...
  12. doi request reprint Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin
    Teisha J Rowland
    Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California 93106, USA
    Stem Cells Dev 19:1231-40. 2010
    ..These studies suggest that vitronectin, or derivatives thereof, might substitute for Matrigel in a more defined system for iPSC culture...
  13. ncbi request reprint Age-related macular degeneration and the extracellular matrix
    Lincoln V Johnson
    Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, USA
    N Engl J Med 351:320-2. 2004
  14. ncbi request reprint Drusen-associated degeneration in the retina
    Patrick T Johnson
    Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Invest Ophthalmol Vis Sci 44:4481-8. 2003
    ..The purpose of this study was to investigate the impact of drusen on overlying cells of the retina...
  15. pmc Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures
    Ronald D Gorham
    Department of Bioengineering, University of California, Riverside, CA 92521, USA
    Exp Eye Res 116:96-108. 2013
    ..Our study demonstrates that the RPE cell assay has discriminatory capability for measuring the efficacy and potency of inhibitory peptides in a macular disease environment. ..
  16. doi request reprint Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells
    David E Buchholz
    Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California 93106, USA
    Stem Cells 27:2427-34. 2009
    ..This work shows that iPSCs can differentiate into functional RPE that are quantitatively similar to fRPE and hESC-RPE and further supports the finding that iPSCs are similar to hESCs in their differentiation potential...
  17. ncbi request reprint Age-related macular degeneration--emerging pathogenetic and therapeutic concepts
    Karen M Gehrs
    Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
    Ann Med 38:450-71. 2006
    ..The emergence of this new paradigm of AMD pathogenesis should hasten the development of novel diagnostic and therapeutic approaches for this disease that will dramatically improve the quality of our prolonged lifespan...
  18. pmc Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, The University of Iowa, 11190E PFP, 200 Hawkins Drive, Iowa City, Iowa 52240, USA
    Ann Med 38:592-604. 2006
    ..Aims and Methods. In this study, the structural and evolutionary relationships between these genes and AMD was refined using a combined genetic, molecular and immunohistochemical approach...
  19. pmc A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
    Gregory S Hageman
    Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
    Proc Natl Acad Sci U S A 102:7227-32. 2005
    ..We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population...