Research Topics
Genomes and GenesSpecies | Lincoln V JohnsonSummaryAffiliation: University of California Country: USA Publications
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Publications
Drusen are Cold Spots for Proteolysis: Expression of Matrix Metalloproteinases and Their Tissue Inhibitor Proteins in Age-related Macular DegenerationSergiu T Leu
Department of Molecular, Cellular and Development Biology, University of California, Santa Barbara, CA 93106, USA
Exp Eye Res 74:141-54. 2002..The data lead to the speculation that high TIMP-3 concentrations within drusen could inhibit MMPs and as a result slow the proteolytic degradation of these deposits...- Identification of downstream mechanisms involved in PEDF'S activity in the retina by large scale gene expression profilingJoyce Tombran-Tink
University of Missouri-Kansas City, Pharmaceutical Sciences, Kansas City, MO 64110, USA
Adv Exp Med Biol 533:315-26. 2003 
The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degenerationLincoln V Johnson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93016, USA
Proc Natl Acad Sci U S A 99:11830-5. 2002..Thus, A beta deposition could be an important component of the local inflammatory events that contribute to atrophy of the retinal pigmented epithelium, drusen biogenesis, and the pathogenesis of AMD...- Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degenerationDon H Anderson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Exp Eye Res 78:243-56. 2004..We characterized the ultrastructural organization and histochemical staining properties of these Abeta-containing elements in order to further assess their significance in drusen formation and AMD pathogenesis... - Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroidMonte J Radeke
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Exp Eye Res 85:366-80. 2007..These findings lay the groundwork for further studies into the roles of the corresponding gene products in the normal, aged, and diseased macula... - Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusenPatrick T Johnson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, California 93106 5060, USA
Invest Ophthalmol Vis Sci 46:4788-95. 2005..Drusen are risk factors for age-related macular degeneration and have been shown to negatively impact cells of the RPE and retina. In this study, the effects of drusen on the synaptic machinery of retinal photoreceptors are investigated... - Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networksAaron M Newman
Center for the Study of Macular Degeneration, Neuroscience Research Institute, Biological Sciences 2 Building, University of California, Santa Barbara, CA 93106 5060, USA
Genome Med 4:16. 2012..Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract.. - Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degenerationLincoln V Johnson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Proc Natl Acad Sci U S A 108:18277-82. 2011..This model system will facilitate the analysis of molecular and cellular aspects of AMD pathogenesis, and the testing of new therapeutic agents for its treatment... 
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visitedDon H Anderson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
Prog Retin Eye Res 29:95-112. 2010....- Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteinsTeisha J Rowland
Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, CA, USA Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA Neuroscience Research Institute, University of California, Santa Barbara, CA, USA
J Tissue Eng Regen Med . 2012..Copyright © 2012 John Wiley & Sons, Ltd... - A role for local inflammation in the formation of drusen in the aging eyeDon H Anderson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
Am J Ophthalmol 134:411-31. 2002..Identifying the origin and molecular composition of these deposits, therefore, has been an important, yet elusive, objective for many decades. Recently, a more complete profile of the molecular composition of drusen has emerged... - Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectinTeisha J Rowland
Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California 93106, USA
Stem Cells Dev 19:1231-40. 2010..These studies suggest that vitronectin, or derivatives thereof, might substitute for Matrigel in a more defined system for iPSC culture... - Drusen-associated degeneration in the retinaPatrick T Johnson
Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
Invest Ophthalmol Vis Sci 44:4481-8. 2003..The purpose of this study was to investigate the impact of drusen on overlying cells of the retina... - Age-related macular degeneration and the extracellular matrixLincoln V Johnson
Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, USA
N Engl J Med 351:320-2. 2004 - Derivation of functional retinal pigmented epithelium from induced pluripotent stem cellsDavid E Buchholz
Center for Stem Cell Biology and Engineering, University of California, Santa Barbara, California 93106, USA
Stem Cells 27:2427-34. 2009..This work shows that iPSCs can differentiate into functional RPE that are quantitatively similar to fRPE and hESC-RPE and further supports the finding that iPSCs are similar to hESCs in their differentiation potential... - Age-related macular degeneration--emerging pathogenetic and therapeutic conceptsKaren M Gehrs
Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA 52240, USA
Ann Med 38:450-71. 2006..The emergence of this new paradigm of AMD pathogenesis should hasten the development of novel diagnostic and therapeutic approaches for this disease that will dramatically improve the quality of our prolonged lifespan... - Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implicationsGregory S Hageman
Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, The University of Iowa, 11190E PFP, 200 Hawkins Drive, Iowa City, Iowa 52240, USA
Ann Med 38:592-604. 2006..Aims and Methods. In this study, the structural and evolutionary relationships between these genes and AMD was refined using a combined genetic, molecular and immunohistochemical approach... - A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degenerationGregory S Hageman
Department of Ophthalmology and Visual Sciences, Cell Biology and Functional Genomics Laboratory, University of Iowa, Iowa City, IA 52240, USA
Proc Natl Acad Sci U S A 102:7227-32. 2005..We propose that genetic variation in a regulator of the alternative complement pathway, when combined with a triggering event, such as infection, underlie a major proportion of AMD in the human population...