Kamin J Johnson

Summary

Affiliation: University of Delaware
Country: USA

Publications

  1. pmc Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Toxicol Sci 120:460-74. 2011
  2. pmc Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Biol Reprod 83:774-82. 2010
  3. pmc The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Toxicol Sci 105:360-7. 2008
  4. ncbi request reprint Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types
    Kamin J Johnson
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 77:978-89. 2007
  5. ncbi request reprint Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone
    Kevin W Gaido
    The Hamner Institutes for Health Sciences Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Sci 97:491-503. 2007
  6. pmc A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis
    Erin N McDowell
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware, United States of America
    PLoS ONE 7:e47359. 2012
  7. pmc Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Toxicol Sci 129:235-48. 2012
  8. ncbi request reprint Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages
    Stephanie A Lahousse
    Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 93:369-81. 2006
  9. ncbi request reprint Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity
    Stephanie A Beall
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
    J Androl 26:529-38. 2005
  10. ncbi request reprint Protocadherin alpha3 acts at sites distinct from classic cadherins in rat testis and sperm
    Kamin J Johnson
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biol Reprod 70:303-12. 2004

Collaborators

Detail Information

Publications14

  1. pmc Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Toxicol Sci 120:460-74. 2011
    ..Together, these data suggest that phthalate-induced inhibition of fetal testis steroidogenesis is closely associated with reduced activity of several lipid metabolism pathways and SREBP2-dependent cholesterologenesis in Leydig cells...
  2. pmc Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Biol Reprod 83:774-82. 2010
    ..These data suggest that INSL3 signaling in the fetal gubernaculum induces morphogenetic programs, including BMP and WNT signaling, and support other rodent data suggesting a role for these pathways in development of the gubernaculum...
  3. pmc The orl rat with inherited cryptorchidism has increased susceptibility to the testicular effects of in utero dibutyl phthalate exposure
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Toxicol Sci 105:360-7. 2008
    ....
  4. ncbi request reprint Mapping gene expression changes in the fetal rat testis following acute dibutyl phthalate exposure defines a complex temporal cascade of responding cell types
    Kamin J Johnson
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 77:978-89. 2007
    ..These data reveal a complex early cascade of phthalate-induced cellular responses in the fetal testis, and for the first time suggest that peritubular myoid cells are an important proximal phthalate target cell...
  5. ncbi request reprint Fetal mouse phthalate exposure shows that Gonocyte multinucleation is not associated with decreased testicular testosterone
    Kevin W Gaido
    The Hamner Institutes for Health Sciences Centers for Health Research, Research Triangle Park, NC 27709, USA
    Toxicol Sci 97:491-503. 2007
    ..This response in the mouse occurs without a measurable decrease in testicular testosterone, suggesting that altered seminiferous cord formation and gonocyte multinucleation may not be mechanistically linked to lowered testosterone...
  6. pmc A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis
    Erin N McDowell
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware, United States of America
    PLoS ONE 7:e47359. 2012
    ..Together, these data provide a resource for discovering factors controlling fetal Leydig cell biology and suggest that CRHR1 activation by CRH stimulates rat and mouse fetal Leydig cell steroidogenesis in vivo...
  7. pmc Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent
    Kamin J Johnson
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, Delaware 19803, USA
    Toxicol Sci 129:235-48. 2012
    ..Although this result is unfulfilling from the perspective of identifying environmental contributions to human reproductive maldevelopment, it has important implications for phthalate risk assessment...
  8. ncbi request reprint Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages
    Stephanie A Lahousse
    Division of Biological Sciences, CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 93:369-81. 2006
    ..These data demonstrate that similar genetic targets are altered following fetal and prepubertal phthalate exposure, suggesting that the initial mechanism of fetal and prepubertal phthalate-induced testicular injury is shared...
  9. ncbi request reprint Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity
    Stephanie A Beall
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA
    J Androl 26:529-38. 2005
    ..Collectively, these data indicate that celsr cadherins have a cell type-specific expression pattern, and celsr2 may mediate Sertoli cell-germ cell adhesion outside of classic cadherin-based adhesion junctions...
  10. ncbi request reprint Protocadherin alpha3 acts at sites distinct from classic cadherins in rat testis and sperm
    Kamin J Johnson
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biol Reprod 70:303-12. 2004
    ....
  11. ncbi request reprint 2,5-hexanedione-induced testicular injury
    Kim Boekelheide
    Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA
    Annu Rev Pharmacol Toxicol 43:125-47. 2003
    ..The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research...
  12. ncbi request reprint Defining the cellular and molecular mechanisms of toxicant action in the testis
    John H Richburg
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, 78712, USA
    Toxicol Lett 135:167-83. 2002
    ..These observations strengthen the hypothesis that BCA disrupts spermatogenesis by altering the process of spermiogenesis...
  13. ncbi request reprint Dynamic testicular adhesion junctions are immunologically unique. II. Localization of classic cadherins in rat testis
    Kamin J Johnson
    Department of Pathology and Laboratory Medicine, Brown University, 175 Meeting Street, Providence, Rhode Island 02912, USA
    Biol Reprod 66:992-1000. 2002
    ..These data show that the various testicular cell-cell junctions are molecularly unique and dynamic complexes...
  14. ncbi request reprint Dynamic testicular adhesion junctions are immunologically unique. I. Localization of p120 catenin in rat testis
    Kamin J Johnson
    Department of Pathology and Laboratory Medicine, Brown University, 175 Meeting Street, Providence, Rhode Island 02912, USA
    Biol Reprod 66:983-91. 2002
    ..From these data, we conclude that p120 is a component of most, if not all, desmosome-like junctions, and that desmosome-like junctions between different cell types contain a unique molecular composition...