Jon W Johnson

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Mechanism of action of memantine
    Jon W Johnson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Pharmacol 6:61-7. 2006
  2. pmc Memantine binding to a superficial site on NMDA receptors contributes to partial trapping
    Shawn E Kotermanski
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 587:4589-604. 2009
  3. pmc Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine
    Shawn E Kotermanski
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:2774-9. 2009
  4. pmc A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction
    BETH SIEGLER RETCHLESS
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 15:406-13, S1-2. 2012
  5. pmc Voltage-dependent gating of NR1/2B NMDA receptors
    Richard J Clarke
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 586:5727-41. 2008
  6. pmc Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock
    Richard J Clarke
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 33:4140-50. 2013
  7. ncbi request reprint Amantadine inhibits NMDA receptors by accelerating channel closure during channel block
    Thomas A Blanpied
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 25:3312-22. 2005
  8. pmc Comparison of behavioral effects of the NMDA receptor channel blockers memantine and ketamine in rats
    Shawn E Kotermanski
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 109:67-76. 2013
  9. ncbi request reprint Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors
    Anqi Qian
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:10899-910. 2006
  10. ncbi request reprint NMDA receptor NR2 subunit dependence of the slow component of magnesium unblock
    Richard J Clarke
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:5825-34. 2006

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Mechanism of action of memantine
    Jon W Johnson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Pharmacol 6:61-7. 2006
    ..Because modulation of NMDA receptor activity can increase or decrease excitability of neuronal circuits, subtle differences in the mechanisms of action of NMDA receptor antagonists can strongly impact on their clinical effects...
  2. pmc Memantine binding to a superficial site on NMDA receptors contributes to partial trapping
    Shawn E Kotermanski
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 587:4589-604. 2009
    ..The superficial binding site for memantine may, by causing partial trapping, contribute to memantine's unique therapeutic utility...
  3. pmc Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine
    Shawn E Kotermanski
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:2774-9. 2009
    ....
  4. pmc A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction
    BETH SIEGLER RETCHLESS
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 15:406-13, S1-2. 2012
    ..We conclude that a single GluN2 subunit residue couples with the pore-forming loop of the GluN1 subunit to create naturally occurring variations in NMDAR properties that are critical to synaptic plasticity and learning...
  5. pmc Voltage-dependent gating of NR1/2B NMDA receptors
    Richard J Clarke
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 586:5727-41. 2008
    ..We propose that voltage-dependent gating of NR1/2B receptors confers enhanced voltage and time dependence on NMDAR-mediated signalling...
  6. pmc Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock
    Richard J Clarke
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 33:4140-50. 2013
    ..Therefore, the residue at the GluN2 S/L site governs the expression of both slow Mg(o)(2+) unblock and inherent voltage dependence...
  7. ncbi request reprint Amantadine inhibits NMDA receptors by accelerating channel closure during channel block
    Thomas A Blanpied
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 25:3312-22. 2005
    ..The surprising variation in the clinical utility of NMDA channel blockers may in part derive from their diverse effects on channel gating...
  8. pmc Comparison of behavioral effects of the NMDA receptor channel blockers memantine and ketamine in rats
    Shawn E Kotermanski
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Pharmacol Biochem Behav 109:67-76. 2013
    ..Our results suggest that the divergence of memantine's and ketamine's behavioral consequences is likely to result from differences in mechanisms of NMDA receptor antagonism or actions at other targets...
  9. ncbi request reprint Permeant ion effects on external Mg2+ block of NR1/2D NMDA receptors
    Anqi Qian
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:10899-910. 2006
    ..Differences in the Mg2+(o) blocking site, and particularly in the selectivity filter and internal channel entrance, are principally responsible for the subunit dependence of Mg2+(o) block...
  10. ncbi request reprint NMDA receptor NR2 subunit dependence of the slow component of magnesium unblock
    Richard J Clarke
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:5825-34. 2006
    ..These NR2 subunit differences in the kinetics of Mg(o)2+ unblock are likely to help determine the contribution of each NMDA receptor subtype to current flow during synaptic activity...
  11. pmc NR2 subunit-dependence of NMDA receptor channel block by external Mg2+
    Anqi Qian
    Department of Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 562:319-31. 2005
    ..4) Mg(2+)(o) inhibits NR1/2D receptors less effectively than cortical receptors chiefly because Mg(2+)(o) unbinds much more rapidly from NR1/2D receptors...
  12. pmc HSV delivery of a ligand-regulated endogenous ion channel gene to sensory neurons results in pain control following channel activation
    James R Goss
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    Mol Ther 19:500-6. 2011
    ..Use of an endogenous inhibitory receptor not normally present on sensory neurons both minimizes immunogenicity and maximizes therapeutic selectivity...
  13. pmc Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons
    Nadezhda V Povysheva
    Department of Neuroscience and Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurophysiol 107:2232-43. 2012
    ..We found that the magnitude of tonic NMDAR current is similar in pyramidal cells and fast-spiking interneurons, and that quantal release of glutamate does not significantly impact tonic NMDAR current...
  14. ncbi request reprint Acid tests of N-methyl-D-aspartate receptor gating basics
    Jon W Johnson
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Mol Pharmacol 63:1199-201. 2003
  15. ncbi request reprint Channel gating of NMDA receptors
    Anqi Qian
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:577-82. 2002
    ..Information is drawn from studies of NMDA receptors themselves, of other types of glutamate receptors, and of more distantly related potassium channels...
  16. pmc Modulation by permeant ions of Mg(2+) inhibition of NMDA-activated whole-cell currents in rat cortical neurons
    Anqi Qian
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Physiol 538:65-77. 2002
    ..This similarity implies that Mg(2+)(o) does not affect gating while blocking the channel...

Research Grants3

  1. MECHANISMS OF BLOCK OF NMDA ACTIVATED CHANNELS
    Jon Johnson; Fiscal Year: 2003
    ..The knowledge gained should help provide insight into the mechanisms that underlie the wide variety of physiological processes and brain disorders in which glutamate receptors are involved. ..
  2. Interaction of Ions with NMDA Receptors
    Jon Johnson; Fiscal Year: 2006
    ..The results of the proposed research will extend our understanding of the structure and operation of NMDA receptors, and thus provide insight into their operation in nervous system physiology and disease. ..
  3. Interaction of Permeant and Blocking Ions with NMDA Receptors
    Jon Johnson; Fiscal Year: 2007
    ..The improved understanding of NMDA receptors that will be provided by the proposed research has enormous potential to help prevent, and ameliorate the consequences of, many forms of brain dysfunction. ..