Jeffrey Johnson

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration
    Jeffrey A Johnson
    Division of Pharmaceutical Sciences, University of Wisconsin, Madison, WI 53705, USA
    Ann N Y Acad Sci 1147:61-9. 2008
  2. pmc The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases
    Gururaj Joshi
    Division of Pharmaceutical Sciences, School of Pharmacy, 6125 Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, WI 53705, USA
    Recent Pat CNS Drug Discov 7:218-29. 2012
  3. pmc The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
    Christine R Swanson
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA
    J Neuroinflammation 8:91. 2011
  4. ncbi request reprint Dissecting tBHQ induced ARE-driven gene expression through long and short oligonucleotide arrays
    Jiang Li
    School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin 53705 2222, USA
    Physiol Genomics 21:43-58. 2005
  5. ncbi request reprint Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction
    Tracy L Hagemann
    Wisman Center, University of Wisconsin, Madison, WI 53705, USA
    Hum Mol Genet 14:2443-58. 2005
  6. ncbi request reprint Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element
    Andrew D Kraft
    University of Wisconsin, Madison, WI, USA
    J Neurochem 98:1852-65. 2006
  7. pmc Activation of the Nrf2-ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1
    Andrew D Kraft
    Division of Pharmaceutical Sciences, Madison, WI, USA
    Exp Neurol 207:107-17. 2007
  8. ncbi request reprint Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
    Jiang Li
    School of Pharmacy, University of Wisconsin, Madison 53705 2222, USA
    Physiol Genomics 18:261-72. 2004
  9. pmc Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
    Marcelo R Vargas
    Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, Wisconsin 53705 2222, USA
    J Neurosci 28:13574-81. 2008
  10. ncbi request reprint Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    Jong Min Lee
    School of Pharmacy, Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 278:12029-38. 2003

Research Grants

Collaborators

  • Jong Min Lee
  • A Messing
  • Tracy L Hagemann
  • Clive N Svendsen
  • Gary M Diffee
  • REGINA MURPHY
  • T H Murphy
  • Sic L Chan
  • Jonathan T Kern
  • Mark A Smith
  • Richard Smeyne
  • Lin Liu
  • M A Caldwell
  • Li Gan
  • Woosung Cho
  • M P Mattson
  • John R Walker
  • Delinda A Johnson
  • Jiang Li
  • Marcus J Calkins
  • Andrew D Kraft
  • Marcelo R Vargas
  • Thor D Stein
  • Rebekah J Jakel
  • Jessica A Townsend
  • Yuet Wai Kan
  • Gururaj Joshi
  • Christine R Swanson
  • Lynda S Wright
  • Pei Chun Chen
  • Melinda S Yates
  • Yanxia Liu
  • Dean T Eurich
  • Maria L Spletter
  • Althaf I Hussain
  • Andy Y Shih
  • Heather A Simmons
  • Viktoriya Bondarenko
  • Valerie Joers
  • Marina E Emborg
  • Joseph W Kemnitz
  • Kevin Brunner
  • Toni E Ziegler
  • Zsuszanna Fabry
  • Charlotte Ward
  • Sara Amirahmadi
  • Tracy P Williamson
  • James A Dowell
  • Amar K Pani
  • Daniel W Sirkis
  • Kathleen C Flanders
  • Masafumi Tauchi
  • Thomas W Kensler
  • Karen T Liby
  • Jon M Resch
  • Gordon W Gribble
  • Michael B Sporn
  • Hendrik Luesch
  • Fumiki Katsuoka
  • Neal C Burton
  • Tomas R Guilarte
  • Masayuki Yamamoto
  • Peter G Schultz
  • Tadashi Honda
  • Kimberly J Reid
  • John A Spertus
  • Kaimin Chan
  • Lynda Wright
  • Delinda Johnson
  • Marcus Calkins
  • Nicholas J Anders
  • Charles DeCarli
  • Kyle Wallace
  • Lei Jiang
  • Marcos da Silva Freire
  • Walid Heneine
  • Gloria Wong
  • Heidi Erb
  • Matthew Pankratz

Detail Information

Publications43

  1. pmc The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration
    Jeffrey A Johnson
    Division of Pharmaceutical Sciences, University of Wisconsin, Madison, WI 53705, USA
    Ann N Y Acad Sci 1147:61-9. 2008
    ..This procedure led to dramatic protection against malonate-induced neurotoxicity. Translating this to other chemical and genetic models of neurodegeneration will be discussed...
  2. pmc The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases
    Gururaj Joshi
    Division of Pharmaceutical Sciences, School of Pharmacy, 6125 Rennebohm Hall, 777 Highland Avenue, University of Wisconsin, Madison, WI 53705, USA
    Recent Pat CNS Drug Discov 7:218-29. 2012
    ..This review primarily focuses on recent patents that target Nrf2 overexpression as a promising therapeutic strategy for the treatment of neurodegenerative disorders...
  3. pmc The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
    Christine R Swanson
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA
    J Neuroinflammation 8:91. 2011
    ..Here we report preclinical data on the use of the PPAR-γ agonist pioglitazone (Actos®; Takeda Pharmaceuticals Ltd.) in a paradigm resembling early PD in nonhuman primates...
  4. ncbi request reprint Dissecting tBHQ induced ARE-driven gene expression through long and short oligonucleotide arrays
    Jiang Li
    School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin 53705 2222, USA
    Physiol Genomics 21:43-58. 2005
    ..Integration of the gene expression profiles from different array platforms may not only help for cross-validation but also provide a more complete view of the transcriptional scenario...
  5. ncbi request reprint Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction
    Tracy L Hagemann
    Wisman Center, University of Wisconsin, Madison, WI 53705, USA
    Hum Mol Genet 14:2443-58. 2005
    ..Together, these data implicate an initial stress response by astrocytes, which results in the activation of microglia and compromised neuronal function...
  6. ncbi request reprint Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element
    Andrew D Kraft
    University of Wisconsin, Madison, WI, USA
    J Neurochem 98:1852-65. 2006
    ..These results combine to support a role for Nrf2 in the neural cell defense response of the adult brain...
  7. pmc Activation of the Nrf2-ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1
    Andrew D Kraft
    Division of Pharmaceutical Sciences, Madison, WI, USA
    Exp Neurol 207:107-17. 2007
    ..Subsequently, Nrf2-ARE activation appears to progress in a retrograde fashion along the motor pathway. These data provide timely information concerning the contributions of the Nrf2-ARE pathway in ALS disease progression...
  8. ncbi request reprint Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
    Jiang Li
    School of Pharmacy, University of Wisconsin, Madison 53705 2222, USA
    Physiol Genomics 18:261-72. 2004
    ..These data strongly suggest that a deficiency in detoxification and increased oxidative stress can result in the development of a systemic autoimmune disease...
  9. pmc Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
    Marcelo R Vargas
    Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, Wisconsin 53705 2222, USA
    J Neurosci 28:13574-81. 2008
    ..Over-expression of Nrf2 in astrocytes significantly delayed onset and extended survival. These findings demonstrate that Nrf2 activation in astrocytes is a viable therapeutic target to prevent chronic neurodegeneration...
  10. ncbi request reprint Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    Jong Min Lee
    School of Pharmacy, Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 278:12029-38. 2003
    ....
  11. ncbi request reprint Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
    ..Strikingly, the change in neuronal gene expression after tBHQ treatment was dependent on Nrf2 activity in the astrocytes. This suggests that Nrf2-dependent genetic changes alter neuron-glia interactions resulting in neuroprotection...
  12. pmc Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia
    Jong Min Lee
    School of Pharmacy, Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 101:9751-6. 2004
    ....
  13. pmc Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
    Pei Chun Chen
    School of Pharmacy, Molecular and Environmental Toxicology Center, Waisman Center, and Center of Neuroscience, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 106:2933-8. 2009
    ....
  14. pmc Keap1-Nrf2 activation in the presence and absence of DJ-1
    Li Gan
    School of Pharmacy, 6125 Rennebohm Hall, University of Wisconsin Madison, Madison, WI 53705 2222, USA
    Eur J Neurosci 31:967-77. 2010
    ..These findings indicate that activation of the Nrf2-ARE pathway is independent of DJ-1, and Nrf2 activation is a potential therapeutic target to prevent neurodegeneration in sporadic and DJ-1 familial Parkinson's disease...
  15. ncbi request reprint Differential gene expression patterns revealed by oligonucleotide versus long cDNA arrays
    Jiang Li
    School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53706, USA
    Toxicol Sci 69:383-90. 2002
    ..According to our results, the data generated from oligonucleotide microarrays is more reliable for interrogating changes in gene expression than data from long cDNA microarrays...
  16. ncbi request reprint Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles
    Gary M Diffee
    Department of Kinesiology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Am J Physiol Heart Circ Physiol 284:H830-7. 2003
    ..These results suggest that increased expression of aMLC-1 in response to training may be responsible, at least in part, for previously observed training-induced enhancement of contractile function...
  17. pmc The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
    Delinda A Johnson
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    Toxicol Sci 114:237-46. 2010
    ....
  18. ncbi request reprint Gene expression in human neural stem cells: effects of leukemia inhibitory factor
    Lynda S Wright
    The Waisman Center Stem Cell Research Program and Department of Anatomy, University of Wisconsin, 53705, USA
    J Neurochem 86:179-95. 2003
    ..This study provides the first molecular profile of human ltNSCctx cultures capable of long-term self renewal, and reveals specific sets of genes that are directly or indirectly regulated by LIF...
  19. doi request reprint The Nrf2-ARE cytoprotective pathway in astrocytes
    Marcelo R Vargas
    Division of Pharmaceutical Sciences, University of Wisconsin, Madison, WI 53705, USA
    Expert Rev Mol Med 11:e17. 2009
    ..Here, we review the current data supporting Nrf2 activation in astrocytes as a viable therapeutic approach, not only in acute neuronal damage, but also in chronic neurodegeneration related to oxidative stress...
  20. pmc Dual transgenic reporter mice as a tool for monitoring expression of glial fibrillary acidic protein
    Woosung Cho
    Waisman Center and Department of Comparative Biosciences, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Neurochem 110:343-51. 2009
    ..In knock-in mice expressing the R236H Alexander disease mutant, GFAP promoter activity is only transiently elevated and may not entirely account for the accumulation of GFAP protein that takes place...
  21. pmc Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition
    Marcus J Calkins
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    Toxicol Sci 115:557-68. 2010
    ..Overall, these data establish that enhanced astrocytic Nrf2 response and Nrf2 preconditioning are both sufficient to protect from acute lesions from mitochondrial complex II inhibition...
  22. ncbi request reprint Role of Nrf2-dependent ARE-driven antioxidant pathway in neuroprotection
    Jiang Li
    School of Pharmacy, University of Wisconsin, Madison, USA
    Methods Mol Biol 399:67-78. 2007
    ..The details for generating Nrf2-overexpressing astrocytes and grafting them onto the lesion model are described in this chapter...
  23. pmc Nrf2-mediated protection against 6-hydroxydopamine
    Rebekah J Jakel
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, WI 53705, USA
    Brain Res 1144:192-201. 2007
    ..This suggests that the Nrf2-ARE pathway is a promising target for therapeutics aimed at reducing or preventing cell death in PD...
  24. ncbi request reprint NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
    Jong Min Lee
    School of Pharmacy, University of Wisconsin, Madison 53705 2222, USA
    J Biol Chem 278:37948-56. 2003
    ..Taken together, these findings suggest that Nrf2 plays an important role in protecting neurons from toxic insult...
  25. ncbi request reprint Genetic programming by the proteolytic fragments of the amyloid precursor protein: somewhere between confusion and clarity
    Thor D Stein
    Neuroscience Training Program, University of Wisconsin, Madison, WI 53705 2222, USA
    Rev Neurosci 14:317-41. 2003
    ..In fact, the gene expression changes driven by sAPPalpha, such as increases in transthyretin and insulin-like growth factor 2, may protect these mice from high levels of Abeta...
  26. ncbi request reprint Antioxidant responsive element activation by quinones: antioxidant responsive element target genes, role of PI3 kinase in activation
    Jiang Li
    University of Wisconsin Madison, School of Pharmacy, Madison, Wisconsin 53705 2222, USA
    Methods Enzymol 378:238-58. 2004
  27. ncbi request reprint Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis
    Thor D Stein
    Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:7707-17. 2004
    ..Therefore, the elevated expression of transthyretin is mediated by sAPPalpha and protects APP(Sw) mice from developing many of the neuropathologies observed in AD...
  28. ncbi request reprint Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
    Jiang Li
    School of Pharmacy, University of Wisconsin at Madison, Madison, Wisconsin 53705, USA
    Toxicol Sci 83:313-28. 2005
    ..Nrf2 stabilization by pharmacological modulation or adenovirus-mediated Nrf2 overexpression, therefore, might be viable strategies to prevent a wide-spectrum of oxidative stress-related neuronal cell injuries...
  29. ncbi request reprint Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 cells
    Jiang Li
    School of Pharmacy, Environmental Toxicology Center, Waisman Center, Center for Neuroscience, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Biol Chem 277:388-94. 2002
    ..These data are the first to show a set of programmed cell life genes involved in conferring protection from an oxidative stress-induced apoptosis...
  30. pmc Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
    Marcus J Calkins
    School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 102:244-9. 2005
    ..These data also introduce Nrf2-mediated ARE transcription as a potential target of preventative therapy in neurodegenerative disorders such as Huntington's disease...
  31. ncbi request reprint Time-dependent changes in ARE-driven gene expression by use of a noise-filtering process for microarray data
    Jiang Li
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA
    Physiol Genomics 9:137-44. 2002
    ..The noise-filtering process applied to these microarray data, therefore, has proven to be very useful in identification of the time-dependent changes in ARE-drive gene expression...
  32. ncbi request reprint Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro
    Rebekah J Jakel
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Toxicol Sci 87:176-86. 2005
    ..Further induction of this endogenous defense mechanism may suggest a novel therapeutic venue in Parkinson's disease...
  33. pmc Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription
    Marcus J Calkins
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, USA
    Exp Neurol 224:307-17. 2010
    ..Therefore, these findings provide strong evidence that Nrf2 signaling may be an effective target for prevention of neurodegeneration...
  34. ncbi request reprint Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways
    Thor D Stein
    Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 22:7380-8. 2002
    ....
  35. ncbi request reprint Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element
    Jong Min Lee
    School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, USA
    Biochim Biophys Acta 1629:92-101. 2003
    ..Taken together, these observations suggest that 4-hydroxyestradiol activates the ARE by a PI3-kinase-Nrf2 dependent mechanism, not involving ER...
  36. pmc Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity
    Lin Liu
    Department of Chemical and Biological Engineering, University of Wisconsin, 1415 Engineering Drive, Madison, WI 53706, USA
    Protein Eng Des Sel 22:479-88. 2009
    ..However, pTTR differed from rTTR in the extent and nature of modification at Cys10. We hypothesize that differential modification at Cys10 regulates TTR's effect on Abeta aggregation and toxicity...
  37. ncbi request reprint Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells
    Jiang Li
    School of Pharmacy, University of Wisconsin at Madison, 777 Highland Avenue, Madison, WI 53705 2222, USA
    J Neurochem 92:462-76. 2005
    ..Intracellular ATP levels may play an important role in determining whether neural progenitors or their differentiated cells follow a caspase 9/3-dependent or -independent pathway in response to acute insults from neuronal toxicants...
  38. pmc The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease
    Marcus J Calkins
    Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    Antioxid Redox Signal 11:497-508. 2009
    ..Herein, we review the current literature that suggests that Nrf2 may be a valuable therapeutic target for neurodegenerative disease, as well as experiments that illustrate potential mechanisms of protection...
  39. pmc Identification and characterization of avian retroviruses in chicken embryo-derived yellow fever vaccines: investigation of transmission to vaccine recipients
    Althaf I Hussain
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 77:1105-11. 2003
    ..The absence of evidence of infection with ALV-E or EAV in 43 YF vaccine recipients suggests low risks for transmission of these viruses, further supporting the safety of these vaccines...
  40. ncbi request reprint Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress
    Andy Y Shih
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Neurosci 23:3394-406. 2003
    ..Neuroprotection was not limited to overexpression of Nrf2, because activation of endogenous glial Nrf2 by the small molecule ARE inducer, tert-butylhydroquinone, also protected against oxidative glutamate toxicity...
  41. pmc Assessing responsiveness of generic and specific health related quality of life measures in heart failure
    Dean T Eurich
    Institute of Health Economics, Edmonton, Alberta, Canada
    Health Qual Life Outcomes 4:89. 2006
    ..We compared the relative responsiveness of generic and heart failure specific HRQL instruments, as measured both by common psychometric indices and by external clinical criteria...
  42. ncbi request reprint Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
    Melinda S Yates
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Mol Cancer Ther 6:154-62. 2007
    ..This pharmacodynamic characterization highlights the chemopreventive promise of several synthetic triterpenoids in multiple target organs...
  43. pmc A genomic screen for activators of the antioxidant response element
    Yanxia Liu
    Department of Medicinal Chemistry, University of Florida, 1600 Southwest Archer Road, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 104:5205-10. 2007
    ..This work and other such studies may provide mechanisms for activating the ARE in the absence of general oxidative stress and a yet-unexploited therapeutic approach to degenerative diseases and aging...

Research Grants18

  1. The Nrf2-ARE Pathway in Amyotrophic Lateral Sclerosis
    Jeffrey Johnson; Fiscal Year: 2009
    ..The hope is to gain a greater understanding of the disease process and discover ways to treat ALS that will stop or at least slow disease progression. ..
  2. The Nrf2-ARE pathway in modulating Parkinson's Disease
    Jeffrey A Johnson; Fiscal Year: 2010
    ..Specific Aim 3. Determine that transplantation of Nrf2 overexpressing neural stem cells and/or astrocytes confers protection from 6-OHDA or MPTP-induced nigrostriatal lesions and loss of DA neurons. ..
  3. The Nrf2-ARE pathway in modulating Parkinson's Disease
    Jeffrey Johnson; Fiscal Year: 2007
    ..Specific Aim 3. Determine that transplantation of Nrf2 overexpressing neural stem cells and/or astrocytes confers protection from 6-OHDA or MPTP-induced nigrostriatal lesions and loss of DA neurons. ..
  4. Transcriptional Control of Antioxidant Genes in Brain
    Jeffrey Johnson; Fiscal Year: 2006
    ..abstract_text> ..
  5. ANTIOXIDANT/ELECTROPHILE RESPONSE GENES IN NEUROTOXICITY
    Jeffrey Johnson; Fiscal Year: 2005
    ..Elucidating the molecular mechanisms (s) regulating ARE genes in brain, therefore, may be crucial for developing therapeutic approaches to mitigate, or prevent, neurotoxicity. ..
  6. The Nrf2-ARE Pathway in Amyotrophic Lateral Sclerosis
    Jeffrey A Johnson; Fiscal Year: 2010
    ..The hope is to gain a greater understanding of the disease process and discover ways to treat ALS that will stop or at least slow disease progression. ..