J K Johnson
Affiliation: University of California
- Clinical and pathological evidence for a frontal variant of Alzheimer diseaseJ K Johnson
Institute for Brain Aging and Dementia, University of California at Irvine, 92697 4285, USA
Arch Neurol 56:1233-9. 1999..We hypothesized that these patients would exhibit a greater degree of either neurofibrillary tangle (NFT) or senile plaque pathology in the frontal lobes than would patients with typical AD...
- Initiation and propagation stages of beta-amyloid are associated with distinctive apolipoprotein E, age, and gender profilesJ K Johnson
Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4285, USA
Brain Res 798:18-24. 1998..In contrast, once Abeta deposition has been initiated, the presence of an epsilon2 allele is associated with slower rates of accumulation, with males benefiting from the protective effect more than females...
- Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndromeE Head
Institute for Brain Aging and Dementia, University of California, Irvine, California, 92697-4540, USA
Neurobiol Dis 8:792-806. 2001..Oxidatively modified Abeta may reflect the efforts of microglial cells to take up and degrade Abeta. Oxidative modification of Abeta may be an early event in Abeta pathogenesis and may be important for plaque biogenesis...
- Sensory cortical interactions in aging, mild cognitive impairment, and Alzheimer's diseaseE J Golob
Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, CA, USA
Neurobiol Aging 22:755-63. 2001..These findings are compatible with progressive declines in corticocortical processing in aging, MCI, and AD...
- Auditory event-related potentials during target detection are abnormal in mild cognitive impairmentEdward J Golob
Institute for Brain Aging and Dementia and Department of Neurology, 154 Med Surge I, University of California, Irvine, Irvine, CA 92627, USA
Clin Neurophysiol 113:151-61. 2002..To define brain activity and behavioral changes in mild cognitive impairment (MCI), an isolated memory deficit in the elderly that is a major risk factor for Alzheimer's disease...
- Frontotemporal dementia progresses to death faster than Alzheimer diseaseE D Roberson
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
Neurology 65:719-25. 2005..Frontotemporal lobar degeneration (FTLD) is a common cause of non-Alzheimer dementia, but its natural history and the factors related to mortality in affected patients are not well understood...
- Cognitive and motor assessment in autopsy-proven corticobasal degenerationR Murray
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neurology 68:1274-83. 2007..To investigate the clinical features of autopsy-proven corticobasal degeneration (CBD)...
- Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degenerationG D Rabinovici
Memory and Aging Center, University of California, San Francisco, California 94143, USA
Am J Alzheimers Dis Other Demen 22:474-88. 2007..001, uncorrected). These findings suggest that AD and FTLD are anatomically distinct, with degeneration of a posterior parietal network in AD and degeneration of a paralimbic fronto-insular-striatal network in FTLD...