B A Johnson

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint The role of serotonergic agents as treatments for alcoholism
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Drugs Today (Barc) 39:665-72. 2003
  2. ncbi request reprint Dose-ranging kinetics and behavioral pharmacology of naltrexone and acamprosate, both alone and combined, in alcohol-dependent subjects
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229 3900, USA
    J Clin Psychopharmacol 23:281-93. 2003
  3. ncbi request reprint Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individuals
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Alcohol Clin Exp Res 27:1773-9. 2003
  4. ncbi request reprint Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepileptics
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Clin Exp Res 28:295-301. 2004
  5. ncbi request reprint Effects of isradipine on cocaine-induced subjective mood
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Clin Psychopharmacol 24:180-91. 2004
  6. ncbi request reprint Progress in the development of topiramate for treating alcohol dependence: from a hypothesis to a proof-of-concept study
    Bankole A Johnson
    Department of Psychiatry, Division of Alcohol and Drug Addiction, The University of Texas Health Science Center at San Antonio, South Texas Addiction Research and Technology START Center, San Antonio, Texas, USA
    Alcohol Clin Exp Res 28:1137-44. 2004
  7. ncbi request reprint An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependence
    Bankole A Johnson
    Department of Psychiatry, Division of Alcohol and Drug Addiction, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
    Expert Opin Pharmacother 5:1943-55. 2004
  8. ncbi request reprint Topiramate-induced neuromodulation of cortico-mesolimbic dopamine function: a new vista for the treatment of comorbid alcohol and nicotine dependence?
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, South Texas Addiction Research and Technology START Center, San Antonio, TX 78229 3900, USA
    Addict Behav 29:1465-79. 2004
  9. ncbi request reprint Oral topiramate reduces the consequences of drinking and improves the quality of life of alcohol-dependent individuals: a randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Arch Gen Psychiatry 61:905-12. 2004
  10. ncbi request reprint A pilot evaluation of the safety and tolerability of repeat dose administration of long-acting injectable naltrexone (Vivitrex) in patients with alcohol dependence
    Bankole A Johnson
    University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Clin Exp Res 28:1356-61. 2004

Detail Information

Publications69

  1. ncbi request reprint The role of serotonergic agents as treatments for alcoholism
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Drugs Today (Barc) 39:665-72. 2003
    ..This type of understanding could develop our ability to make reasonable predictions as to what alcoholic subtype would respond best to a particular serotonergic agent, which could then be provided...
  2. ncbi request reprint Dose-ranging kinetics and behavioral pharmacology of naltrexone and acamprosate, both alone and combined, in alcohol-dependent subjects
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229 3900, USA
    J Clin Psychopharmacol 23:281-93. 2003
    ..More side effects were noted with the combination of medications than with either medication alone. Naltrexone administration significantly increased plasma acamprosate levels...
  3. ncbi request reprint Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individuals
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Alcohol Clin Exp Res 27:1773-9. 2003
    ....
  4. ncbi request reprint Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepileptics
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Clin Exp Res 28:295-301. 2004
    ..DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr...
  5. ncbi request reprint Effects of isradipine on cocaine-induced subjective mood
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Clin Psychopharmacol 24:180-91. 2004
    ..Also, isradipine-mediated inhibition of mesolimbic DA release may be an ineffective treatment of cocaine dependence...
  6. ncbi request reprint Progress in the development of topiramate for treating alcohol dependence: from a hypothesis to a proof-of-concept study
    Bankole A Johnson
    Department of Psychiatry, Division of Alcohol and Drug Addiction, The University of Texas Health Science Center at San Antonio, South Texas Addiction Research and Technology START Center, San Antonio, Texas, USA
    Alcohol Clin Exp Res 28:1137-44. 2004
    ..This commentary highlights the scientific concepts and clinical evidence for the development of topiramate in the treatment of alcohol dependence...
  7. ncbi request reprint An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependence
    Bankole A Johnson
    Department of Psychiatry, Division of Alcohol and Drug Addiction, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
    Expert Opin Pharmacother 5:1943-55. 2004
    ..Both ondansetron and sertraline appear to have some efficacy in treating different subgroups of alcoholic...
  8. ncbi request reprint Topiramate-induced neuromodulation of cortico-mesolimbic dopamine function: a new vista for the treatment of comorbid alcohol and nicotine dependence?
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, South Texas Addiction Research and Technology START Center, San Antonio, TX 78229 3900, USA
    Addict Behav 29:1465-79. 2004
    ..Further studies are ongoing to establish and extend topiramate's efficacy in the treatment of each and both disorders...
  9. ncbi request reprint Oral topiramate reduces the consequences of drinking and improves the quality of life of alcohol-dependent individuals: a randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Arch Gen Psychiatry 61:905-12. 2004
    ..Topiramate, a fructopyranose derivative, was superior to placebo at improving the drinking outcomes of alcohol-dependent individuals...
  10. ncbi request reprint A pilot evaluation of the safety and tolerability of repeat dose administration of long-acting injectable naltrexone (Vivitrex) in patients with alcohol dependence
    Bankole A Johnson
    University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Clin Exp Res 28:1356-61. 2004
    ..A long-acting injectable naltrexone formulation (Vivitrex) was designed to facilitate patient adherence by providing an extended duration of therapeutic naltrexone over 1 month, thereby eliminating the need for daily dosing...
  11. ncbi request reprint Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 178:296-302. 2005
    ..Yet, isradipine's effects on cognitive performance in methamphetamine-dependent individuals are not known...
  12. ncbi request reprint Uses of topiramate in the treatment of alcohol dependence
    Bankole A Johnson
    Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
    Expert Rev Neurother 4:751-8. 2004
    ..This drug profile highlights the scientific concepts and clinical evidence in the development of topiramate for treating alcohol dependence...
  13. ncbi request reprint Oral topiramate for treatment of alcohol dependence: a randomised controlled trial
    Bankole A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Lancet 361:1677-85. 2003
    ..We aimed to see whether topiramate was more effective than placebo as a treatment for alcohol dependence...
  14. ncbi request reprint Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trial
    B A Johnson
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Dr, Mail Stop 7792, San Antonio, TX 78229 3900, USA
    JAMA 284:963-71. 2000
    ..Thus, individuals with early-onset alcoholism may be responsive to treatment with a selective serotonergic agent...
  15. ncbi request reprint Isradipine, a dihydropyridine-class calcium channel antagonist, attenuates some of d-methamphetamine's positive subjective effects: a preliminary study
    B A Johnson
    University of Texas, Health Science Center at San Antonio, 78284 7792, USA
    Psychopharmacology (Berl) 144:295-300. 1999
    ..This is the first experiment to test the hypothesis that the rewarding effects of d-methamphetamine, like other psychostimulants, can be reduced by isradipine...
  16. ncbi request reprint Ondansetron reduces the craving of biologically predisposed alcoholics
    Bankole A Johnson
    Department of Psychiatry, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229 3900, USA
    Psychopharmacology (Berl) 160:408-13. 2002
    ..Proximate motivational drives such as craving could have determined drinking behavior. We therefore investigated whether ondansetron treatment would reduce alcohol craving significantly among EOA...
  17. ncbi request reprint Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced reduction in hunger
    B A Johnson
    Division of Alcohol and Drug Addiction, University of Texas, Health Science Center at San Antonio, USA
    Prog Neuropsychopharmacol Biol Psychiatry 23:1227-34. 1999
    ..Additionally, isradipine pretreatment did not significantly alter d-methamphetamine's anorexic effects. 4. Isradipine may, therefore, not significantly modify the control of hunger in humans...
  18. ncbi request reprint Treatment advances for cocaine-induced ischemic stroke: focus on dihydropyridine-class calcium channel antagonists
    B A Johnson
    Department of Psychiatry and Pharmacology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    Am J Psychiatry 158:1191-8. 2001
    ..The authors reviewed the pathogenesis of cocaine-related cerebral ischemia, appraised current knowledge of its sequelae, and assessed the role of putative therapeutic agents, particularly dihydropyridine-class calcium channel antagonists...
  19. ncbi request reprint Combining ondansetron and naltrexone effectively treats biologically predisposed alcoholics: from hypotheses to preliminary clinical evidence
    B A Johnson
    Department of Psychiatry, University of Texas, San Antonio, USA
    Alcohol Clin Exp Res 24:737-42. 2000
    ....
  20. ncbi request reprint Neuropharmacological treatments for alcoholism: scientific basis and clinical findings
    B A Johnson
    Department of Psychiatry, University of Texas, Health Sciences Center at San Antonio 78212, USA
    Psychopharmacology (Berl) 149:327-44. 2000
    ..The coming decade promises more powerful tools for characterizing drug effects on alcohol drinking, thereby closing the gap between animal models of addiction and the human condition...
  21. ncbi request reprint Combining ondansetron and naltrexone treats biological alcoholics: corroboration of self-reported drinking by serum carbohydrate deficient transferrin, a biomarker
    N Ait-Daoud
    Department of Psychiatry and the Southwest Texas Addiction Research and Technology START Center, University of Texas Health Science Center at San Antonio, San Antonio 78229 3900, Texas, USA
    Alcohol Clin Exp Res 25:847-9. 2001
    ....
  22. ncbi request reprint Combining ondansetron and naltrexone reduces craving among biologically predisposed alcoholics: preliminary clinical evidence
    N Ait-Daoud
    Treatment Research Center, Department of Psychiatry, University of Texas, Health Science Center at San Antonio, 78229 3900, USA
    Psychopharmacology (Berl) 154:23-7. 2001
    ..We now hypothesize further that an important mechanism by which the combination diminishes alcohol consumption is through a reduction in craving...
  23. ncbi request reprint Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on D-methamphetamine-induced cognitive and physiological changes in humans
    B A Johnson
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7792, USA
    Neuropsychopharmacology 22:504-12. 2000
    ..Isradipine increased the false responding rate but was without significant effect on any other attentional task, or on reasoning ability, or performance. Isradipine does not appear to enhance cognitive function in healthy humans...
  24. ncbi request reprint Age of onset as a discriminator between alcoholic subtypes in a treatment-seeking outpatient population
    B A Johnson
    Department of Psychiatry, University of Texas, San Antonio 78284 7792, USA
    Am J Addict 9:17-27. 2000
    ..Yet, this clinical characterization would be clinically important if specific age of onset levels were found to be differentially sensitive to pharmacological and/or psychological treatments...
  25. ncbi request reprint Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effects
    Bankole A Johnson
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Int J Neuropsychopharmacol 8:203-13. 2005
    ..Depending upon conditioning status, isradipine can reduce some methamphetamine-induced positive subjective and reinforcing effects associated with its abuse liability in methamphetamine addicts...
  26. ncbi request reprint Kinetic and cardiovascular comparison of immediate-release isradipine and sustained-release isradipine among non-treatment-seeking, cocaine-dependent individuals
    Bankole A Johnson
    South Texas Addiction Research and Technology Center, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:15-20. 2005
    ..The more favorable cardiovascular profile of SR isradipine would, however, make it more appropriate as an investigational medication for the treatment of stimulant dependence and related neurovascular disorders...
  27. ncbi request reprint Effects of repeated-dose isradipine on the abuse liability of cocaine
    John D Roache
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, 78229, USA
    Exp Clin Psychopharmacol 13:319-26. 2005
    ..Isradipine enhanced, rather than antagonized, subjective effects, indicating that isradipine does not antagonize cocaine's abuse liability in dependent research volunteers...
  28. ncbi request reprint Topiramate reduces the harm of excessive drinking: implications for public health and primary care
    Jennie Z Ma
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Addiction 101:1561-8. 2006
    ....
  29. pmc Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholics
    Martin A Javors
    South Texas Addiction Research and Technology START Center, and Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:7-13. 2005
    ..Our findings in currently drinking alcoholics support the hypothesis that those with the LL genotype of the 5'-HTTLPR region of the 5-HTT gene have reduced 5-HTT function...
  30. ncbi request reprint A prospective, open-label trial of ondansetron in adolescents with alcohol dependence
    Michael A Dawes
    START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio UTHSCSA, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
    Addict Behav 30:1077-85. 2005
    ..Findings of decreased drinking underscore the need for future double-blind, placebo-controlled studies in this adolescent population...
  31. ncbi request reprint Current status of carbohydrate deficient transferrin, total serum sialic acid, sialic acid index of apolipoprotein J and serum beta-hexosaminidase as markers for alcohol consumption
    Martin A Javors
    Department of Psychiatry, The University of Texas HSC, San Antonio, Texas 78229, USA
    Addiction 98:45-50. 2003
    ....
  32. ncbi request reprint Pharmacotherapeutic trials in adolescent alcohol use disorders: opportunities and challenges
    Michael A Dawes
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Alcohol Alcohol 39:166-77. 2004
    ....
  33. pmc Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporter
    Michael A Dawes
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Stud Alcohol Drugs 70:899-907. 2009
    ..Specifically, we wanted to examine the relationships between the following: platelet 5-HTT and 5-HTT genotype; platelet 5-HTT parameters and age at onset, as well as duration of drinking; and 5-HTT genotype and impulse control...
  34. pmc Prediction of serotonergic treatment efficacy using age of onset and Type A/B typologies of alcoholism
    John D Roache
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mailstop 7792, San Antonio, Texas 78229, USA
    Alcohol Clin Exp Res 32:1502-12. 2008
    ..Randomized participants underwent 11 weeks of treatment with ondansetron (1, 4, or 16 microg/kg twice daily; n = 67, 77, and 71, respectively) or identical placebo (n = 56), plus weekly standardized group cognitive behavioral therapy...
  35. ncbi request reprint Cue reactivity in cocaine-dependent subjects: effects of cue type and cue modality
    B A Johnson
    Department of Psychiatry, University of Texas, Houston 77030, USA
    Addict Behav 23:7-15. 1998
    ..The relative sensitivities of the cue modalities in decreasing order was manual, audio, and visual. We suggest that a modified conditioned-cue paradigm could be a useful tool in the repeated assessment of craving during a clinical study...
  36. ncbi request reprint Reductions in and relations between "craving" and drinking in a prospective, open-label trial of ondansetron in adolescents with alcohol dependence
    Michael A Dawes
    START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, The South Texas Addiction Research and Technology Center, San Antonio, TX 78229 3900, USA
    Addict Behav 30:1630-7. 2005
    ..These preliminary results suggest that the A-OCDS can be useful as an outcome measure in clinical studies of adolescents with alcohol dependence...
  37. ncbi request reprint Relative bioavailability of an extemporaneous ondansetron 4-mg capsule formulation versus solution
    Y W Francis Lam
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Pharmacotherapy 24:477-81. 2004
    ..To compare the relative bioavailability of an extemporaneous ondansetron capsule formulation with that of an identical dose of the commercially available solution formulation...
  38. ncbi request reprint The role of anxiety in predicting drinking behaviour
    Tracy B Sloan
    University of Texas Health Science Center, START Center, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229, USA
    Alcohol Alcohol 38:360-3. 2003
    ..We investigated whether reduced anxiety predicted improved drinking outcomes over and above age of onset and ondansetron treatment among alcoholics enrolled in a clinical trial...
  39. ncbi request reprint New weapon to curb smoking: no more excuses to delay treatment
    Bankole A Johnson
    Arch Intern Med 166:1547-50. 2006
  40. pmc Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:123-30. 2007
    ..Topiramate's complicated cognitive effects among methamphetamine addicts need more comprehensive examination...
  41. pmc Kinetic and cardiovascular effects of acute topiramate dosing among non-treatment-seeking, methamphetamine-dependent individuals
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:455-61. 2007
    ..Larger laboratory studies with chronic dosing regimens are needed to establish whether or not there is a kinetic interaction between topiramate and methamphetamine...
  42. ncbi request reprint Treating smoking dependence in depressed alcoholics
    Nassima Ait-Daoud
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
    Alcohol Res Health 29:213-20. 2006
    ..Additional treatment strategies targeting dually dependent individuals with comorbid psychiatric disorders, including special populations such as women and adolescents, await further investigation...
  43. ncbi request reprint A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of methamphetamine dependence
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Int J Neuropsychopharmacol 11:1-14. 2008
    ..These findings should be viewed in light of the possibility that a less intensive cognitive behavioural therapy regimen might have yielded more positive results in this initial phase II trial exploring for the efficacy of ondansetron...
  44. ncbi request reprint Evaluating readiness and treatment seeking effects in a pharmacotherapy trial for alcohol dependence
    J Kim Penberthy
    Center for Addiction Research and Education, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, Charlottesville, Virginia 22908 0623, USA
    Alcohol Clin Exp Res 31:1538-44. 2007
    ..Our goal was to evaluate drinking behavior before initiating a randomized, double-blind pharmacotherapy clinical trial for alcohol dependence...
  45. pmc Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Biochem Pharmacol 75:34-56. 2008
    ..As neuroscientific research progresses, other promising medications, as well as medication combinations, for treating alcohol dependence continue to be explored...
  46. ncbi request reprint Topiramate for treating alcohol dependence: a randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908, USA
    JAMA 298:1641-51. 2007
    ....
  47. pmc Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:209-16. 2008
    ..Thus, 5-HTT expression varies with current and lifetime drinking in L-carriers alone...
  48. doi request reprint World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: Alcoholism
    Michael Soyka
    Psychiatric Hospital Meiringen, Meiringen, Switzerland
    World J Biol Psychiatry 9:6-23. 2008
    ..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...
  49. doi request reprint Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Arch Intern Med 168:1188-99. 2008
    ..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being...
  50. ncbi request reprint Genetics of alcoholism using intermediate phenotypes
    MARY ANNE ENOCH
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
    Alcohol Clin Exp Res 27:169-76. 2003
    ..Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson...
  51. pmc Cost and cost-effectiveness of the COMBINE study in alcohol-dependent patients
    Gary A Zarkin
    RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC 27709, USA
    Arch Gen Psychiatry 65:1214-21. 2008
    ..The costs and cost-effectiveness of these combinations are unknown and of interest to clinicians and policy makers...
  52. ncbi request reprint Emerging biomarkers: new directions and clinical applications
    Friedrich M Wurst
    Psychiatric University Hospital, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
    Alcohol Clin Exp Res 29:465-73. 2005
    ....
  53. ncbi request reprint Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial
    Raymond F Anton
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
    JAMA 295:2003-17. 2006
    ..Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings...
  54. ncbi request reprint Effects of isradipine on cocaine-induced changes in cognitive performance in recently abstinent cocaine-dependent individuals
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
    Int J Neuropsychopharmacol 8:549-56. 2005
    ..Hence, cocaine-taking by cocaine-dependent individuals produces little improvement in cognitive performance and attention in either the presence or absence of isradipine...
  55. ncbi request reprint Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment
    Bankole A Johnson
    University of Virginia Health System, Charlottesville, Virginia 22908 0623, USA
    CNS Drugs 18:1105-18. 2004
    ..Such an understanding could enable us to make comfortable predictions as to which alcoholic subtype might respond best to a particular serotonergic agent, which could then be provided...
  56. ncbi request reprint Isradipine decreases the hemodynamic response of cocaine and methamphetamine results from two human laboratory studies: results from two human laboratory studies
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
    Am J Hypertens 18:813-22. 2005
    ..We therefore examined, in two separate experiments of similar design conducted contemporaneously, the hemodynamic effects of cocaine or methamphetamine in the presence and absence of isradipine...
  57. ncbi request reprint Use of oral topiramate to promote smoking abstinence among alcohol-dependent smokers: a randomized controlled trial
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Arch Intern Med 165:1600-5. 2005
    ..Herein, we extend that proof-of-concept study by determining whether cigarette-smoking, alcohol-dependent individuals from the earlier study also experienced improved smoking outcomes...
  58. ncbi request reprint Challenges and opportunities for medications development in alcoholism: an international perspective on collaborations between academia and industry
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Alcohol Clin Exp Res 29:1528-40. 2005
    ..Swift, MD, PhD; (4) A European Perspective on Medications Development, by Otto M. Lesch, MD, PhD, and (5) A Scandinavian Perspective on Evidence-Based Addiction Treatment, by Mats Berglund, MD...
  59. ncbi request reprint Comorbid alcohol and nicotine dependence: from the biomolecular basis to clinical consequences
    Nassima Ait-Daoud
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Alcohol Clin Exp Res 29:1541-9. 2005
    ..Lesch, MD, PhD; and (5) Pharmacotherapy for Promotion of Abstinence from Nicotine Among Alcohol-Dependent Individuals, by Bankole A. Johnson, DSc, MD, PhD...
  60. ncbi request reprint Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate function
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908, USA
    CNS Drugs 19:873-96. 2005
    ....
  61. ncbi request reprint Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism
    William J McBride
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 28:257-67. 2004
    ..Rodd and James M. Murphy; and (4) Ondansetron as a treatment for "biological" alcoholism, by John D. Roache and Bankole A. Johnson...
  62. ncbi request reprint Effects of acute topiramate dosing on methamphetamine-induced subjective mood
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
    Int J Neuropsychopharmacol 10:85-98. 2007
    ..Thus, testing chronically administered or higher doses, or both, of topiramate would be necessary to determine conclusively whether or not it can attenuate the positive subjective and reinforcing effects of methamphetamine...
  63. ncbi request reprint An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsants
    Nassima Ait-Daoud
    Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Addict Behav 31:1628-49. 2006
    ..Furthermore, as a class of medication, there appears to be a growing interest in investigating the utility of novel anticonvulsants such as topiramate for the treatment of alcohol dependence...
  64. ncbi request reprint Understanding and treating alcohol dependence
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
    Alcohol Clin Exp Res 30:567-84. 2006
    ..Johnson, DSc, MD, PhD; and (5) Differential Effects of Pharmacological Agents on Craving, by Nassima Ait-Daoud, MD...
  65. ncbi request reprint A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Drug Alcohol Depend 84:256-63. 2006
    ..04). These results suggest the possibility of a non-linear dose-response function, with evidence supporting efficacy for the 4.0 mg group...
  66. ncbi request reprint A synopsis of the pharmacological rationale, properties and therapeutic effects of depot preparations of naltrexone for treating alcohol dependence
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, PO Box 800623, Charlottesville, VA 22908 0623, USA
    Expert Opin Pharmacother 7:1065-73. 2006
    ..Naltrel helped reduce relapse and promote abstinence in two samples of alcohol-dependent individuals. Additional efficacy studies are warranted...
  67. ncbi request reprint Acute intravenous low- and high-dose cocaine reduces quantitative global and regional cerebral blood flow in recently abstinent subjects with cocaine use disorder
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
    J Cereb Blood Flow Metab 25:928-36. 2005
    ..Increasingly larger doses of cocaine may be associated with greater risk for ischemic stroke...
  68. ncbi request reprint Pills for speedballing or cocaine dependence
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Lancet 367:1714-6. 2006
  69. ncbi request reprint Safety and efficacy of GABAergic medications for treating alcoholism
    Bankole A Johnson
    Department of Psychiatric Medicine, The University of Virginia, Charlottesville, Virginia 22908 0623, USA
    Alcohol Clin Exp Res 29:248-54. 2005
    ..Johnson; (5) Evaluating the Risk of Benzodiazepine Prescription to Alcohol-Dependent Individuals, by Domenic A. Ciraulo; and (6) Safety and Efficacy of GABAergic Agents in Treating Alcoholics: Discussion, by Robert M. Swift...