Research Topics
Genomes and GenesSpecies | B A JohnsonSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
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Publications
The role of serotonergic agents as treatments for alcoholismBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Drugs Today (Barc) 39:665-72. 2003..This type of understanding could develop our ability to make reasonable predictions as to what alcoholic subtype would respond best to a particular serotonergic agent, which could then be provided...- Dose-ranging kinetics and behavioral pharmacology of naltrexone and acamprosate, both alone and combined, in alcohol-dependent subjectsBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229 3900, USA
J Clin Psychopharmacol 23:281-93. 2003..More side effects were noted with the combination of medications than with either medication alone. Naltrexone administration significantly increased plasma acamprosate levels... - Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individualsBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
Alcohol Clin Exp Res 27:1773-9. 2003.... - Development of novel pharmacotherapies for the treatment of alcohol dependence: focus on antiepilepticsBankole A Johnson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Alcohol Clin Exp Res 28:295-301. 2004..DiClemente; (5) Synopsis of promising medications to treat alcoholism, by Robert M. Swift; and (6) New knowledge on the development of antiepileptic medications for the treatment of alcoholism, by Robert J. Malcolm, Jr... - Effects of isradipine on cocaine-induced subjective moodBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Clin Psychopharmacol 24:180-91. 2004..Also, isradipine-mediated inhibition of mesolimbic DA release may be an ineffective treatment of cocaine dependence... - Progress in the development of topiramate for treating alcohol dependence: from a hypothesis to a proof-of-concept studyBankole A Johnson
Department of Psychiatry, Division of Alcohol and Drug Addiction, The University of Texas Health Science Center at San Antonio, South Texas Addiction Research and Technology START Center, San Antonio, Texas, USA
Alcohol Clin Exp Res 28:1137-44. 2004..This commentary highlights the scientific concepts and clinical evidence for the development of topiramate in the treatment of alcohol dependence... - An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependenceBankole A Johnson
Department of Psychiatry, Division of Alcohol and Drug Addiction, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
Expert Opin Pharmacother 5:1943-55. 2004..Both ondansetron and sertraline appear to have some efficacy in treating different subgroups of alcoholic... - Topiramate-induced neuromodulation of cortico-mesolimbic dopamine function: a new vista for the treatment of comorbid alcohol and nicotine dependence?Bankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, South Texas Addiction Research and Technology START Center, San Antonio, TX 78229 3900, USA
Addict Behav 29:1465-79. 2004..Further studies are ongoing to establish and extend topiramate's efficacy in the treatment of each and both disorders... - Oral topiramate reduces the consequences of drinking and improves the quality of life of alcohol-dependent individuals: a randomized controlled trialBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
Arch Gen Psychiatry 61:905-12. 2004..Topiramate, a fructopyranose derivative, was superior to placebo at improving the drinking outcomes of alcohol-dependent individuals... - A pilot evaluation of the safety and tolerability of repeat dose administration of long-acting injectable naltrexone (Vivitrex) in patients with alcohol dependenceBankole A Johnson
University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Alcohol Clin Exp Res 28:1356-61. 2004..A long-acting injectable naltrexone formulation (Vivitrex) was designed to facilitate patient adherence by providing an extended duration of therapeutic naltrexone over 1 month, thereby eliminating the need for daily dosing... - Effects of isradipine on methamphetamine-induced changes in attentional and perceptual-motor skills of cognitionBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Psychopharmacology (Berl) 178:296-302. 2005..Yet, isradipine's effects on cognitive performance in methamphetamine-dependent individuals are not known... - Uses of topiramate in the treatment of alcohol dependenceBankole A Johnson
Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
Expert Rev Neurother 4:751-8. 2004..This drug profile highlights the scientific concepts and clinical evidence in the development of topiramate for treating alcohol dependence... - Oral topiramate for treatment of alcohol dependence: a randomised controlled trialBankole A Johnson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
Lancet 361:1677-85. 2003..We aimed to see whether topiramate was more effective than placebo as a treatment for alcohol dependence... - Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: A randomized controlled trialB A Johnson
Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Dr, Mail Stop 7792, San Antonio, TX 78229 3900, USA
JAMA 284:963-71. 2000..Thus, individuals with early-onset alcoholism may be responsive to treatment with a selective serotonergic agent... - Isradipine, a dihydropyridine-class calcium channel antagonist, attenuates some of d-methamphetamine's positive subjective effects: a preliminary studyB A Johnson
University of Texas, Health Science Center at San Antonio, 78284 7792, USA
Psychopharmacology (Berl) 144:295-300. 1999..This is the first experiment to test the hypothesis that the rewarding effects of d-methamphetamine, like other psychostimulants, can be reduced by isradipine... - Ondansetron reduces the craving of biologically predisposed alcoholicsBankole A Johnson
Department of Psychiatry, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229 3900, USA
Psychopharmacology (Berl) 160:408-13. 2002..Proximate motivational drives such as craving could have determined drinking behavior. We therefore investigated whether ondansetron treatment would reduce alcohol craving significantly among EOA... - Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on d-methamphetamine-induced reduction in hungerB A Johnson
Division of Alcohol and Drug Addiction, University of Texas, Health Science Center at San Antonio, USA
Prog Neuropsychopharmacol Biol Psychiatry 23:1227-34. 1999..Additionally, isradipine pretreatment did not significantly alter d-methamphetamine's anorexic effects. 4. Isradipine may, therefore, not significantly modify the control of hunger in humans... - Treatment advances for cocaine-induced ischemic stroke: focus on dihydropyridine-class calcium channel antagonistsB A Johnson
Department of Psychiatry and Pharmacology, University of Texas Health Science Center at San Antonio, TX 78229, USA
Am J Psychiatry 158:1191-8. 2001..The authors reviewed the pathogenesis of cocaine-related cerebral ischemia, appraised current knowledge of its sequelae, and assessed the role of putative therapeutic agents, particularly dihydropyridine-class calcium channel antagonists... - Combining ondansetron and naltrexone effectively treats biologically predisposed alcoholics: from hypotheses to preliminary clinical evidenceB A Johnson
Department of Psychiatry, University of Texas, San Antonio, USA
Alcohol Clin Exp Res 24:737-42. 2000.... - Neuropharmacological treatments for alcoholism: scientific basis and clinical findingsB A Johnson
Department of Psychiatry, University of Texas, Health Sciences Center at San Antonio 78212, USA
Psychopharmacology (Berl) 149:327-44. 2000..The coming decade promises more powerful tools for characterizing drug effects on alcohol drinking, thereby closing the gap between animal models of addiction and the human condition... - Combining ondansetron and naltrexone treats biological alcoholics: corroboration of self-reported drinking by serum carbohydrate deficient transferrin, a biomarkerN Ait-Daoud
Department of Psychiatry and the Southwest Texas Addiction Research and Technology START Center, University of Texas Health Science Center at San Antonio, San Antonio 78229 3900, Texas, USA
Alcohol Clin Exp Res 25:847-9. 2001.... - Combining ondansetron and naltrexone reduces craving among biologically predisposed alcoholics: preliminary clinical evidenceN Ait-Daoud
Treatment Research Center, Department of Psychiatry, University of Texas, Health Science Center at San Antonio, 78229 3900, USA
Psychopharmacology (Berl) 154:23-7. 2001..We now hypothesize further that an important mechanism by which the combination diminishes alcohol consumption is through a reduction in craving... - Effects of isradipine, a dihydropyridine-class calcium channel antagonist, on D-methamphetamine-induced cognitive and physiological changes in humansB A Johnson
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284 7792, USA
Neuropsychopharmacology 22:504-12. 2000..Isradipine increased the false responding rate but was without significant effect on any other attentional task, or on reasoning ability, or performance. Isradipine does not appear to enhance cognitive function in healthy humans... - Age of onset as a discriminator between alcoholic subtypes in a treatment-seeking outpatient populationB A Johnson
Department of Psychiatry, University of Texas, San Antonio 78284 7792, USA
Am J Addict 9:17-27. 2000..Yet, this clinical characterization would be clinically important if specific age of onset levels were found to be differentially sensitive to pharmacological and/or psychological treatments... - Effects of isradipine, a dihydropyridine-class calcium-channel antagonist, on d-methamphetamine's subjective and reinforcing effectsBankole A Johnson
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Int J Neuropsychopharmacol 8:203-13. 2005..Depending upon conditioning status, isradipine can reduce some methamphetamine-induced positive subjective and reinforcing effects associated with its abuse liability in methamphetamine addicts... - Kinetic and cardiovascular comparison of immediate-release isradipine and sustained-release isradipine among non-treatment-seeking, cocaine-dependent individualsBankole A Johnson
South Texas Addiction Research and Technology Center, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:15-20. 2005..The more favorable cardiovascular profile of SR isradipine would, however, make it more appropriate as an investigational medication for the treatment of stimulant dependence and related neurovascular disorders... - Effects of repeated-dose isradipine on the abuse liability of cocaineJohn D Roache
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, 78229, USA
Exp Clin Psychopharmacol 13:319-26. 2005..Isradipine enhanced, rather than antagonized, subjective effects, indicating that isradipine does not antagonize cocaine's abuse liability in dependent research volunteers... - Topiramate reduces the harm of excessive drinking: implications for public health and primary careJennie Z Ma
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Addiction 101:1561-8. 2006..Topiramate's potential to decrease the public health consequences of hazardous drinking needs to be established in future long-term studies... 
Platelet serotonin uptake and paroxetine binding among allelic genotypes of the serotonin transporter in alcoholicsMartin A Javors
South Texas Addiction Research and Technology START Center, and Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:7-13. 2005..Our findings in currently drinking alcoholics support the hypothesis that those with the LL genotype of the 5'-HTTLPR region of the 5-HTT gene have reduced 5-HTT function...- A prospective, open-label trial of ondansetron in adolescents with alcohol dependenceMichael A Dawes
START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio UTHSCSA, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
Addict Behav 30:1077-85. 2005..Findings of decreased drinking underscore the need for future double-blind, placebo-controlled studies in this adolescent population... - Current status of carbohydrate deficient transferrin, total serum sialic acid, sialic acid index of apolipoprotein J and serum beta-hexosaminidase as markers for alcohol consumptionMartin A Javors
Department of Psychiatry, The University of Texas HSC, San Antonio, Texas 78229, USA
Addiction 98:45-50. 2003.... - Pharmacotherapeutic trials in adolescent alcohol use disorders: opportunities and challengesMichael A Dawes
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
Alcohol Alcohol 39:166-77. 2004.... - Drinking histories in alcohol-use-disordered youth: preliminary findings on relationships to platelet serotonin transporter expression with genotypes of the serotonin transporterMichael A Dawes
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
J Stud Alcohol Drugs 70:899-907. 2009..Specifically, we wanted to examine the relationships between the following: platelet 5-HTT and 5-HTT genotype; platelet 5-HTT parameters and age at onset, as well as duration of drinking; and 5-HTT genotype and impulse control... - Prediction of serotonergic treatment efficacy using age of onset and Type A/B typologies of alcoholismJohn D Roache
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mailstop 7792, San Antonio, Texas 78229, USA
Alcohol Clin Exp Res 32:1502-12. 2008..Randomized participants underwent 11 weeks of treatment with ondansetron (1, 4, or 16 microg/kg twice daily; n = 67, 77, and 71, respectively) or identical placebo (n = 56), plus weekly standardized group cognitive behavioral therapy... - Cue reactivity in cocaine-dependent subjects: effects of cue type and cue modalityB A Johnson
Department of Psychiatry, University of Texas, Houston 77030, USA
Addict Behav 23:7-15. 1998..The relative sensitivities of the cue modalities in decreasing order was manual, audio, and visual. We suggest that a modified conditioned-cue paradigm could be a useful tool in the repeated assessment of craving during a clinical study... - Reductions in and relations between "craving" and drinking in a prospective, open-label trial of ondansetron in adolescents with alcohol dependenceMichael A Dawes
START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, The South Texas Addiction Research and Technology Center, San Antonio, TX 78229 3900, USA
Addict Behav 30:1630-7. 2005..These preliminary results suggest that the A-OCDS can be useful as an outcome measure in clinical studies of adolescents with alcohol dependence... - Relative bioavailability of an extemporaneous ondansetron 4-mg capsule formulation versus solutionY W Francis Lam
Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229-3900, USA
Pharmacotherapy 24:477-81. 2004..The commercially available solution would be a useful alternative formulation for administration of low-dose ondansetron in research and clinical settings... - The role of anxiety in predicting drinking behaviourTracy B Sloan
University of Texas Health Science Center, START Center, 7703 Floyd Curl Drive, Mail Stop 7792, San Antonio, TX 78229, USA
Alcohol Alcohol 38:360-3. 2003..Those who experienced decreases in anxiety during the treatment reported fewer drinks per day at their last visit compared with those who reported increases in anxiety... - New weapon to curb smoking: no more excuses to delay treatmentBankole A Johnson
Arch Intern Med 166:1547-50. 2006 - Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individualsBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:123-30. 2007..Topiramate's complicated cognitive effects among methamphetamine addicts need more comprehensive examination... - Kinetic and cardiovascular effects of acute topiramate dosing among non-treatment-seeking, methamphetamine-dependent individualsBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:455-61. 2007..Larger laboratory studies with chronic dosing regimens are needed to establish whether or not there is a kinetic interaction between topiramate and methamphetamine... - Treating smoking dependence in depressed alcoholicsNassima Ait-Daoud
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
Alcohol Res Health 29:213-20. 2006..Additional treatment strategies targeting dually dependent individuals with comorbid psychiatric disorders, including special populations such as women and adolescents, await further investigation... - A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of methamphetamine dependenceBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Int J Neuropsychopharmacol 11:1-14. 2008..These findings should be viewed in light of the possibility that a less intensive cognitive behavioural therapy regimen might have yielded more positive results in this initial phase II trial exploring for the efficacy of ondansetron... - Evaluating readiness and treatment seeking effects in a pharmacotherapy trial for alcohol dependenceJ Kim Penberthy
Center for Addiction Research and Education, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, Charlottesville, Virginia 22908 0623, USA
Alcohol Clin Exp Res 31:1538-44. 2007..Our goal was to evaluate drinking behavior before initiating a randomized, double-blind pharmacotherapy clinical trial for alcohol dependence... - Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findingsBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Biochem Pharmacol 75:34-56. 2008..As neuroscientific research progresses, other promising medications, as well as medication combinations, for treating alcohol dependence continue to be explored... - Topiramate for treating alcohol dependence: a randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908, USA
JAMA 298:1641-51. 2007.... - Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?Bankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:209-16. 2008..Thus, 5-HTT expression varies with current and lifetime drinking in L-carriers alone... 
World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Substance Use and Related Disorders, Part 1: AlcoholismMichael Soyka
Psychiatric Hospital Meiringen, Meiringen, Switzerland
World J Biol Psychiatry 9:6-23. 2008..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...- Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trialBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Arch Intern Med 168:1188-99. 2008..We sought to determine whether topiramate's antidrinking effects are bolstered by improvements in physical and psychosocial well-being... - Genetics of alcoholism using intermediate phenotypesMARY ANNE ENOCH
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892 8110, USA
Alcohol Clin Exp Res 27:169-76. 2003..Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson... - Cost and cost-effectiveness of the COMBINE study in alcohol-dependent patientsGary A Zarkin
RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC 27709, USA
Arch Gen Psychiatry 65:1214-21. 2008..The costs and cost-effectiveness of these combinations are unknown and of interest to clinicians and policy makers... - Emerging biomarkers: new directions and clinical applicationsFriedrich M Wurst
Psychiatric University Hospital, Wilhelm Klein Strasse 27, CH 4025 Basel, Switzerland
Alcohol Clin Exp Res 29:465-73. 2005.... - Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trialRaymond F Anton
Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
JAMA 295:2003-17. 2006..Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings... - Effects of isradipine on cocaine-induced changes in cognitive performance in recently abstinent cocaine-dependent individualsBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
Int J Neuropsychopharmacol 8:549-56. 2005..Hence, cocaine-taking by cocaine-dependent individuals produces little improvement in cognitive performance and attention in either the presence or absence of isradipine... - Role of the serotonergic system in the neurobiology of alcoholism: implications for treatmentBankole A Johnson
University of Virginia Health System, Charlottesville, Virginia 22908 0623, USA
CNS Drugs 18:1105-18. 2004..Such an understanding could enable us to make comfortable predictions as to which alcoholic subtype might respond best to a particular serotonergic agent, which could then be provided... - Isradipine decreases the hemodynamic response of cocaine and methamphetamine results from two human laboratory studies: results from two human laboratory studiesBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
Am J Hypertens 18:813-22. 2005..We therefore examined, in two separate experiments of similar design conducted contemporaneously, the hemodynamic effects of cocaine or methamphetamine in the presence and absence of isradipine... - Use of oral topiramate to promote smoking abstinence among alcohol-dependent smokers: a randomized controlled trialBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
Arch Intern Med 165:1600-5. 2005..Herein, we extend that proof-of-concept study by determining whether cigarette-smoking, alcohol-dependent individuals from the earlier study also experienced improved smoking outcomes... - Challenges and opportunities for medications development in alcoholism: an international perspective on collaborations between academia and industryBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
Alcohol Clin Exp Res 29:1528-40. 2005..Swift, MD, PhD; (4) A European Perspective on Medications Development, by Otto M. Lesch, MD, PhD, and (5) A Scandinavian Perspective on Evidence-Based Addiction Treatment, by Mats Berglund, MD... - Comorbid alcohol and nicotine dependence: from the biomolecular basis to clinical consequencesNassima Ait-Daoud
Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
Alcohol Clin Exp Res 29:1541-9. 2005..Lesch, MD, PhD; and (5) Pharmacotherapy for Promotion of Abstinence from Nicotine Among Alcohol-Dependent Individuals, by Bankole A. Johnson, DSc, MD, PhD... - Recent advances in the development of treatments for alcohol and cocaine dependence: focus on topiramate and other modulators of GABA or glutamate functionBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908, USA
CNS Drugs 19:873-96. 2005.... - Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholismWilliam J McBride
Indiana University School of Medicine, Indianapolis, Indiana, USA
Alcohol Clin Exp Res 28:257-67. 2004..Rodd and James M. Murphy; and (4) Ondansetron as a treatment for "biological" alcoholism, by John D. Roache and Bankole A. Johnson... - Effects of acute topiramate dosing on methamphetamine-induced subjective moodBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
Int J Neuropsychopharmacol 10:85-98. 2007..Thus, testing chronically administered or higher doses, or both, of topiramate would be necessary to determine conclusively whether or not it can attenuate the positive subjective and reinforcing effects of methamphetamine... - An overview of medications for the treatment of alcohol withdrawal and alcohol dependence with an emphasis on the use of older and newer anticonvulsantsNassima Ait-Daoud
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Addict Behav 31:1628-49. 2006..Furthermore, as a class of medication, there appears to be a growing interest in investigating the utility of novel anticonvulsants such as topiramate for the treatment of alcohol dependence... - Understanding and treating alcohol dependenceBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
Alcohol Clin Exp Res 30:567-84. 2006..Johnson, DSc, MD, PhD; and (5) Differential Effects of Pharmacological Agents on Craving, by Nassima Ait-Daoud, MD... - A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependenceBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Drug Alcohol Depend 84:256-63. 2006..04). These results suggest the possibility of a non-linear dose-response function, with evidence supporting efficacy for the 4.0 mg group... - A synopsis of the pharmacological rationale, properties and therapeutic effects of depot preparations of naltrexone for treating alcohol dependenceBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, PO Box 800623, Charlottesville, VA 22908 0623, USA
Expert Opin Pharmacother 7:1065-73. 2006..Naltrel helped reduce relapse and promote abstinence in two samples of alcohol-dependent individuals. Additional efficacy studies are warranted... - Acute intravenous low- and high-dose cocaine reduces quantitative global and regional cerebral blood flow in recently abstinent subjects with cocaine use disorderBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
J Cereb Blood Flow Metab 25:928-36. 2005..Increasingly larger doses of cocaine may be associated with greater risk for ischemic stroke... - Pills for speedballing or cocaine dependenceBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908, USA
Lancet 367:1714-6. 2006 - Safety and efficacy of GABAergic medications for treating alcoholismBankole A Johnson
Department of Psychiatric Medicine, The University of Virginia, Charlottesville, Virginia 22908 0623, USA
Alcohol Clin Exp Res 29:248-54. 2005..Johnson; (5) Evaluating the Risk of Benzodiazepine Prescription to Alcohol-Dependent Individuals, by Domenic A. Ciraulo; and (6) Safety and Efficacy of GABAergic Agents in Treating Alcoholics: Discussion, by Robert M. Swift...