Alan L Johnson

Summary

Affiliation: University of Notre Dame
Country: USA

Publications

  1. ncbi request reprint Susceptibility of avian ovarian granulosa cells to apoptosis is dependent upon stage of follicle development and is related to endogenous levels of bcl-xlong gene expression
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Indiana 46556, USA
    Endocrinology 137:2059-66. 1996
  2. doi request reprint Role for inhibitor of differentiation/deoxyribonucleic acid-binding (Id) proteins in granulosa cell differentiation
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Endocrinology 149:3187-95. 2008
  3. ncbi request reprint Tumor necrosis factor-related apoptosis inducing ligand expression and activity in hen granulosa cells
    A L Johnson
    Department of Biological Sciences and Walther Cancer Institute, The University of Notre Dame, PO Box 369, Notre Dame, Indiana 46556, USA
    Reproduction 133:609-16. 2007
  4. ncbi request reprint Cellular mechanisms and modulation of activin A- and transforming growth factor beta-mediated differentiation in cultured hen granulosa cells
    A L Johnson
    Department of Biological Sciences and Walther Cancer Center, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 71:1844-51. 2004
  5. ncbi request reprint Relationship between steroidogenic acute regulatory protein expression and progesterone production in hen granulosa cells during follicle development
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, Indiana 46556, USA
    Biol Reprod 67:1313-20. 2002
  6. ncbi request reprint Survivin as a cell cycle-related and antiapoptotic protein in granulosa cells
    A L Johnson
    Department of Biological Sciences and the Walther Cancer Research Center, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Endocrinology 143:3405-13. 2002
  7. ncbi request reprint Caspase-mediated apoptosis in the vertebrate ovary
    Alan L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Reproduction 124:19-27. 2002
  8. ncbi request reprint Regulation of steroidogenic acute regulatory protein and luteinizing hormone receptor messenger ribonucleic acid in hen granulosa cells
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Endocrinology 142:3116-24. 2001
  9. ncbi request reprint Activation of the Akt/protein kinase B signaling pathway is associated with granulosa cell survival
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 64:1566-74. 2001
  10. ncbi request reprint Granulosa cell apoptosis: conservation of cell signaling in an avian ovarian model system
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre IN 46556, USA
    Biol Signals Recept 9:96-101. 2000

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Susceptibility of avian ovarian granulosa cells to apoptosis is dependent upon stage of follicle development and is related to endogenous levels of bcl-xlong gene expression
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Indiana 46556, USA
    Endocrinology 137:2059-66. 1996
    ....
  2. doi request reprint Role for inhibitor of differentiation/deoxyribonucleic acid-binding (Id) proteins in granulosa cell differentiation
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Endocrinology 149:3187-95. 2008
    ....
  3. ncbi request reprint Tumor necrosis factor-related apoptosis inducing ligand expression and activity in hen granulosa cells
    A L Johnson
    Department of Biological Sciences and Walther Cancer Institute, The University of Notre Dame, PO Box 369, Notre Dame, Indiana 46556, USA
    Reproduction 133:609-16. 2007
    ....
  4. ncbi request reprint Cellular mechanisms and modulation of activin A- and transforming growth factor beta-mediated differentiation in cultured hen granulosa cells
    A L Johnson
    Department of Biological Sciences and Walther Cancer Center, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 71:1844-51. 2004
    ..Significantly, the finding that TGFbeta signaling is negatively regulated by MAP kinase signaling is proposed to represent a mechanism that prevents premature differentiation of granulosa cells...
  5. ncbi request reprint Relationship between steroidogenic acute regulatory protein expression and progesterone production in hen granulosa cells during follicle development
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, Indiana 46556, USA
    Biol Reprod 67:1313-20. 2002
    ..Furthermore, subsequent to follicle selection into the preovulatory hierarchy, StAR transcription and translation is necessary but not sufficient for the full potentiation of the preovulatory surge of serum progesterone...
  6. ncbi request reprint Survivin as a cell cycle-related and antiapoptotic protein in granulosa cells
    A L Johnson
    Department of Biological Sciences and the Walther Cancer Research Center, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Endocrinology 143:3405-13. 2002
    ..Taken together, these data provide evidence for Survivin in granulosa cells acting as a bifunctional protein associated with regulation of the cell cycle and the inhibition of apoptosis...
  7. ncbi request reprint Caspase-mediated apoptosis in the vertebrate ovary
    Alan L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Reproduction 124:19-27. 2002
    ....
  8. ncbi request reprint Regulation of steroidogenic acute regulatory protein and luteinizing hormone receptor messenger ribonucleic acid in hen granulosa cells
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Endocrinology 142:3116-24. 2001
    ..Finally, these results fail to support a role for MAP kinase signaling in acutely modulating LH-mediated StAR expression or progesterone production in hierarchal follicles, such as occurs during the preovulatory surge of progesterone...
  9. ncbi request reprint Activation of the Akt/protein kinase B signaling pathway is associated with granulosa cell survival
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 64:1566-74. 2001
    ..In addition, the data indicate the importance of an alternative survival pathway mediated via gonadotropins and protein kinase A independent of Akt signaling...
  10. ncbi request reprint Granulosa cell apoptosis: conservation of cell signaling in an avian ovarian model system
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Notre IN 46556, USA
    Biol Signals Recept 9:96-101. 2000
    ..The following review will discuss evidence for the conservation of cellular processes that regulate the fate of granulosa cells from the avian, versus mammalian, ovary during follicle development...
  11. doi request reprint Dynamics of avian ovarian follicle development: cellular mechanisms of granulosa cell differentiation
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, P O Box 369, Notre Dame, IN 46556, USA
    Gen Comp Endocrinol 163:12-7. 2009
    ....
  12. ncbi request reprint Expression of avian urokinase and tissue-type plasminogen activator messenger ribonucleic acid during follicle development and atresia
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Indiana 46556, USA
    Biol Reprod 56:581-8. 1997
    ....
  13. ncbi request reprint Expression of the inhibitor of T-cell apoptosis (ita) gene in hen ovarian follicles during development
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, Indiana 46556, USA
    Biol Reprod 58:414-20. 1998
    ....
  14. ncbi request reprint Characterization of the chicken interleukin-1beta converting enzyme (caspase-1) cDNA and expression of caspase-1 mRNA in the hen
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, Notre Dame, IN 46556, USA
    Gene 219:55-62. 1998
    ..However, the pattern of mRNA expression is consistent with a requirement for caspase-1 mediated IL-1beta production in chicken immune tissues...
  15. ncbi request reprint Characterization of the avian Ich-1 cDNA and expression of Ich-1L mRNA in the hen ovary
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, IN 46556, USA
    Gene 192:227-33. 1997
    ..The deduced amino acid (aa) sequence of ICH-1L is 70.8% identical to human ICH-1L and contains the conserved QACRG peptide active catalytic sequence characteristic of many ICE-related family of cysteine proteases...
  16. ncbi request reprint Bcl-X(LONG) protein expression and phosphorylation in granulosa cells
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, Indiana 46556, USA
    Endocrinology 140:4521-9. 1999
    ....
  17. ncbi request reprint Characterization of a chicken luteinizing hormone receptor (cLH-R) complementary deoxyribonucleic acid, and expression of cLH-R messenger ribonucleic acid in the ovary
    A L Johnson
    Department of Biological Sciences, University of Notre Dame, Indiana 46556, USA
    Biol Reprod 55:304-9. 1996
    ....
  18. ncbi request reprint Caspase-3 and -6 expression and enzyme activity in hen granulosa cells
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 62:589-98. 2000
    ....
  19. ncbi request reprint Protein kinase C activity mediates LH-induced ErbB/Erk signaling in differentiated hen granulosa cells
    Dori C Woods
    Department of Biological Sciences, The University of Notre Dame, PO Box 369, Notre Dame, Indiana 46556, USA
    Reproduction 133:733-41. 2007
    ....
  20. ncbi request reprint Phosphatase activation by epidermal growth factor family ligands regulates extracellular regulated kinase signaling in undifferentiated hen granulosa cells
    Dori C Woods
    Department of Biological Sciences, University of Notre Dame, Indiana 46556, USA
    Endocrinology 147:4931-40. 2006
    ..These data provide direct evidence for ERK-mediated negative feedback due to regulation of phosphatase activity in undifferentiated granulosa cells...
  21. ncbi request reprint Regulation of follicle-stimulating hormone-receptor messenger RNA in hen granulosa cells relative to follicle selection
    Dori C Woods
    Department of Biological Sciences, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 72:643-50. 2005
    ..At the time of follicle selection, a release from inhibitory MAP kinase signaling is proposed to occur, which enables the full potentiation of FSH-R expression mediated by intrafollicular factors...
  22. ncbi request reprint Expression and regulation of Fas antigen and tumor necrosis factor receptor type I in hen granulosa cells
    J T Bridgham
    Department of Biological Sciences, The University of Notre Dame, Notre Dame, IN 46556, USA
    Biol Reprod 65:733-9. 2001
    ..In addition, data provided demonstrate the presence of multiple death domain-containing TNFR family members simultaneously expressed within hen granulosa cells, each of which may be regulated by separate signaling pathways...
  23. ncbi request reprint Actions of epidermal growth factor receptor/mitogen-activated protein kinase and protein kinase C signaling in granulosa cells from Gallus gallus are dependent upon stage of differentiation
    Dori C Woods
    Department of Biological Sciences and the Walther Cancer Institute, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 77:61-70. 2007
    ....
  24. ncbi request reprint Avian TVB (DR5-like) death receptor expression in hen ovarian follicles
    Jamie T Bridgham
    Department of Biological Sciences and Walther Cancer Research Center, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biochem Biophys Res Commun 291:226-32. 2002
    ..These results provide evidence that TVB receptor signaling in the ovary may function in a capacity other than solely to mediate granulosa cell death and follicle atresia...
  25. ncbi request reprint Characterization of chicken TNFR superfamily decoy receptors, DcR3 and osteoprotegerin
    Jamie T Bridgham
    Department of Biological Sciences, The University of Notre Dame, P O Box 369, Notre Dame, IN 46556, USA
    Biochem Biophys Res Commun 307:956-61. 2003
    ..Finally, characterization of these chicken receptors further contributes to understanding the evolutionary divergence of TNFR superfamily members among vertebrate species...
  26. ncbi request reprint Expression and function of brain-derived neurotrophin factor and its receptor, TrkB, in ovarian follicles from the domestic hen (Gallus gallus domesticus)
    T Jensen
    Department of Biological Sciences, PO Box 369, The University of Notre Dame, Notre Dame, IN 46556, USA
    J Exp Biol 204:2087-95. 2001
    ..These results support the proposals that BDNF functions as a paracrine signal in hen granulosa cells and that its physiological functions may include the modulation of steroidogenesis...
  27. ncbi request reprint Conservation of steroidogenic acute regulatory (StAR) protein structure and expression in vertebrates
    M P Bauer
    Department of Biological Sciences, University of Notre Dame, PO Box 369, Notre Dame IN 46556, USA
    Mol Cell Endocrinol 168:119-25. 2000
    ..The conserved deduced protein sequence and expression pattern of StAR transcripts in chicken and zebrafish tissues, strongly suggest that StAR is also involved in the regulation of steroidogenesis in nonmammalian vertebrates...
  28. ncbi request reprint Expression of bcl-2 and nr-13 in hen ovarian follicles during development
    A L Johnson
    Department of Biological Sciences, The University of Notre Dame, Indiana 46556, USA
    Biol Reprod 57:1096-103. 1997
    ..Thus, it is proposed that nr-13 and bcl-2 play more of a supportive role in regulating additional aspects of ovarian cell function such as cell proliferation and/or differentiation...
  29. ncbi request reprint Opposing actions of TGFbeta and MAP kinase signaling in undifferentiated hen granulosa cells
    Dori C Woods
    Department of Biological Sciences, The University of Notre Dame, P O Box 369, Notre Dame, IN 46556, USA
    Biochem Biophys Res Commun 336:450-7. 2005
    ....
  30. ncbi request reprint Intracellular mechanisms regulating cell survival in ovarian follicles
    A L Johnson
    Department of Biological Sciences and the Walther Cancer Research Center, The University of Notre Dame, P O Box 369, Notre Dame, IN 46556, USA
    Anim Reprod Sci 78:185-201. 2003
    ....
  31. ncbi request reprint Alternatively spliced variants of Gallus gallus TNFRSF23 are expressed in the ovary and differentially regulated by cell signaling pathways
    J T Bridgham
    Department of Biological Sciences and the Walther Cancer Research Center, The University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biol Reprod 70:972-9. 2004
    ....
  32. ncbi request reprint Inhibition of proteasome activity sensitizes human granulosa tumor cells to TRAIL-induced cell death
    Dori C Woods
    Department of Biological Sciences and the Walther Cancer Research Center, The University of Notre Dame, Notre Dame, IN 46556, USA
    Cancer Lett 260:20-7. 2008
    ..These studies underscore the potential to develop targeted treatments for GCTs using established cell lines...
  33. ncbi request reprint Conservation of death receptor-6 in avian and piscine vertebrates
    J T Bridgham
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Biochem Biophys Res Commun 284:1109-15. 2001
    ..We conclude that DR6 is a highly conserved and widely expressed death-domain-containing receptor and may be implicated in regulating follicle atresia within the vertebrate ovary...
  34. ncbi request reprint All in the family: evolutionary and functional relationships among death receptors
    J T Bridgham
    Department of Biological Sciences and Walther Cancer Center, University of Notre Dame, IN 46556, USA
    Cell Death Differ 10:19-25. 2003
    ..The following represents an evolutionary approach towards an understanding of the complex relationship among death receptors and their proposed physiological functions in vertebrate species...
  35. ncbi request reprint Protein Kinase C- alpha/betaII, delta, and zeta/lambda involvement in ethanol-induced MAPK expression in vascular smooth muscle cells
    A L Johnson
    Department of Biological Sciences, Tennessee State University, Nashville, TN 37209, USA
    Cell Mol Biol (Noisy-le-grand) 53:38-44. 2007
    ..These results demonstrate also that classical, novel, and atypical PKCs respond to ethanol during the initial phase of activation of ERK 1 & 2...