JOSEPHINE JOHNS

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Effects of chronic and intermittent cocaine treatment on dominance, aggression, and oxytocin levels in post-lactational rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina, 430 Taylor Hall, CB 7096, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 211:175-85. 2010
  2. pmc Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7096, USA
    Neurotoxicol Teratol 29:634-41. 2007
  3. pmc Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Behav Neurosci 119:1605-18. 2005
  4. pmc The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat
    J M Johns
    Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Pharmacol Biochem Behav 81:769-85. 2005
  5. pmc Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams
    Josephine M Johns
    Department of Psychiatry, The University of North Carolina at Chapel Hill, 424 Taylor Hall, CB 7096, Chapel Hill, NC 27599 7096, USA
    Int J Dev Neurosci 22:321-8. 2004
  6. pmc Developmental effects of prenatal cocaine exposure on 5-HT1A receptors in male and female rat offspring
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7096, USA
    Dev Neurosci 24:522-30. 2002
  7. pmc An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior
    Deborah A Lubin
    Department of Psychology, University of North Carolina at Chapel Hill, 27599, USA
    Behav Neurosci 117:195-201. 2003
  8. pmc Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy
    Kathleen C Light
    Department of Psychiatry, School of Medicine, University of North Carolina, CB 7175 Medical Building A, Chapel Hill 27599 7175, USA
    Addict Behav 29:1541-64. 2004
  9. pmc Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats
    Sarah K Williams
    Curriculum in Neurobiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 31:291-302. 2009
  10. pmc Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine
    Paul E M Phillips
    Department of Chemistry, Venable Hall CB3290, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Brain Res 961:63-72. 2003

Research Grants

Detail Information

Publications10

  1. pmc Effects of chronic and intermittent cocaine treatment on dominance, aggression, and oxytocin levels in post-lactational rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina, 430 Taylor Hall, CB 7096, Chapel Hill, NC 27599, USA
    Psychopharmacology (Berl) 211:175-85. 2010
    ..Little is known about mechanisms underlying female rodent aggression during the late postpartum period with no pups present. Studies of aggression, dominance, and oxytocin (OT) response in cocaine-treated females are sparse...
  2. pmc Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7096, USA
    Neurotoxicol Teratol 29:634-41. 2007
    ..We now report disruptions in pup-induced maternal behavior in both 28 and 60 day old first generation offspring attributable to rearing condition and prenatal cocaine exposure...
  3. pmc Cocaine treatment and prenatal environment interact to disrupt intergenerational maternal behavior in rats
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Behav Neurosci 119:1605-18. 2005
    ..The authors report disruptions in MB in dams and their 1st-generation offspring, attributable to main and interaction effects of maternal treatment, litter PDE, and rearing experience...
  4. pmc The effects of dopaminergic/serotonergic reuptake inhibition on maternal behavior, maternal aggression, and oxytocin in the rat
    J M Johns
    Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Pharmacol Biochem Behav 81:769-85. 2005
    ..Dopamine uptake inhibition appears to have a strong effect on hippocampal oxytocin levels, while receptor dynamics may be more strongly affected by serotonin uptake inhibition...
  5. pmc Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams
    Josephine M Johns
    Department of Psychiatry, The University of North Carolina at Chapel Hill, 424 Taylor Hall, CB 7096, Chapel Hill, NC 27599 7096, USA
    Int J Dev Neurosci 22:321-8. 2004
    ..Results of the present study support previous data indicating that alterations in oxytocinergic and perhaps serotonergic system dynamics in the amygdala may play a role in cocaine-induced postpartum aggression...
  6. pmc Developmental effects of prenatal cocaine exposure on 5-HT1A receptors in male and female rat offspring
    Josephine M Johns
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7096, USA
    Dev Neurosci 24:522-30. 2002
    ..This study also demonstrates gender-specific development of serotonin (5-HT(1A)) receptors across postnatal ages, demonstrating a fundamentally different pattern of development of 5-HT(1A) receptors between males and females...
  7. pmc An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior
    Deborah A Lubin
    Department of Psychology, University of North Carolina at Chapel Hill, 27599, USA
    Behav Neurosci 117:195-201. 2003
    ..OTA did not affect other behaviors, suggesting that disruption of oxytocin activity in the CNA may be sufficient to selectively alter maternal aggressive behavior...
  8. pmc Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy
    Kathleen C Light
    Department of Psychiatry, School of Medicine, University of North Carolina, CB 7175 Medical Building A, Chapel Hill 27599 7175, USA
    Addict Behav 29:1541-64. 2004
    ..Although they tended to hold their babies less often at home, baby holding in the laboratory led to decreased BP in cocaine mothers who then did not differ from no-drug mothers in BP or observed affect...
  9. pmc Simultaneous prenatal ethanol and nicotine exposure affect ethanol consumption, ethanol preference and oxytocin receptor binding in adolescent and adult rats
    Sarah K Williams
    Curriculum in Neurobiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 31:291-302. 2009
    ..Prenatal exposure to these drugs sex-specifically decreased ethanol preference behavior in offspring unlike reports for either drug separately. The possible role of oxytocin in reduction of ethanol consumption behavior is highlighted...
  10. pmc Presynaptic dopaminergic function is largely unaltered in mesolimbic and mesostriatal terminals of adult rats that were prenatally exposed to cocaine
    Paul E M Phillips
    Department of Chemistry, Venable Hall CB3290, University of North Carolina, Chapel Hill, NC 27599 3290, USA
    Brain Res 961:63-72. 2003
    ..We conclude, therefore, that behavioral changes that have previously been observed in rats that were prenatally exposed to cocaine are not mediated through alteration of presynaptic dopaminergic mechanisms in these brain regions...

Research Grants10

  1. COCAINE & MATERNAL AGGRESSION--OXYTOCINERGIC MECHANISMS
    JOSEPHINE JOHNS; Fiscal Year: 2005
    ..OXY levels in the amygdala will be assessed following the behavioral testing. ..
  2. COCAINE AND MATERNAL NEGLECT: INTERGENERATIONAL EFFECTS
    JOSEPHINE JOHNS; Fiscal Year: 2003
    ....