Chandy John

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens
    Bartholomew N Ondigo
    Department of Biomedical Science and Technology, Maseno University, Maseno, Kenya
    Malar J 11:427. 2012
  2. pmc Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study
    Jennifer A Greene
    Case Western Reserve University, Wolstein Research Building, 2103 Cornell Rd, Cleveland, OH 44106, USA
    Malar J 11:47. 2012
  3. pmc Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial
    Michael Hawkes
    Institute of Medical Sciences, University of Toronto, Canada
    Trials 12:176. 2011
  4. pmc Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviour
    Paul Bangirana
    Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda
    Malar J 10:334. 2011
  5. pmc Malaria treatment-seeking behaviour and recovery from malaria in a highland area of Kenya
    Peter O Sumba
    Center for Global Pediatrics and Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Malar J 7:245. 2008
  6. pmc Local topographic wetness indices predict household malaria risk better than land-use and land-cover in the western Kenya highlands
    Justin M Cohen
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Malar J 9:328. 2010
  7. pmc Topography-derived wetness indices are associated with household-level malaria risk in two communities in the western Kenyan highlands
    Justin M Cohen
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Malar J 7:40. 2008
  8. pmc Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals
    Thanh V Nguyen
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Malar J 8:235. 2009
  9. pmc Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors
    Kacey C Ernst
    University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Malar J 5:78. 2006
  10. pmc Reliability of the Luganda version of the Child Behaviour Checklist in measuring behavioural problems after cerebral malaria
    Paul Bangirana
    Department of Psychiatry, Makerere University School of Medicine, Kampala, Uganda
    Child Adolesc Psychiatry Ment Health 3:38. 2009

Collaborators

Detail Information

Publications40

  1. pmc Standardization and validation of a cytometric bead assay to assess antibodies to multiple Plasmodium falciparum recombinant antigens
    Bartholomew N Ondigo
    Department of Biomedical Science and Technology, Maseno University, Maseno, Kenya
    Malar J 11:427. 2012
    ..The present study was set to determine optimal parameters for multiplex testing of antibodies to P. falciparum antigens, and to compare results of multiplex CBA to ELISA...
  2. pmc Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study
    Jennifer A Greene
    Case Western Reserve University, Wolstein Research Building, 2103 Cornell Rd, Cleveland, OH 44106, USA
    Malar J 11:47. 2012
    ..There are two common polymorphisms in the 5' un-translated region (UTR) of TLR2, a 22 base pair deletion in the first unstranslated exon (Δ22), and a GT dinucleotide repeat in the second intron (GTn)...
  3. pmc Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial
    Michael Hawkes
    Institute of Medical Sciences, University of Toronto, Canada
    Trials 12:176. 2011
    ..Low-flow inhaled nitric oxide (iNO) gas is a US FDA-approved treatment for hypoxic respiratory failure in neonates...
  4. pmc Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviour
    Paul Bangirana
    Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda
    Malar J 10:334. 2011
    ..This study investigated the effect of malaria with neurological involvement on cognitive ability, behaviour and academic achievement...
  5. pmc Malaria treatment-seeking behaviour and recovery from malaria in a highland area of Kenya
    Peter O Sumba
    Center for Global Pediatrics and Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Malar J 7:245. 2008
    ..Malaria epidemics in highland areas of Kenya cause significant morbidity and mortality...
  6. pmc Local topographic wetness indices predict household malaria risk better than land-use and land-cover in the western Kenya highlands
    Justin M Cohen
    Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
    Malar J 9:328. 2010
    ..This study examined whether environmental factors like land-cover, land-use, and urban density improved malaria risk prediction based solely on the topographically-determined context, as measured by the topographic wetness index...
  7. pmc Topography-derived wetness indices are associated with household-level malaria risk in two communities in the western Kenyan highlands
    Justin M Cohen
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Malar J 7:40. 2008
    ..Understanding these local topographic effects may permit prediction of regions at high risk of malaria within the highlands at small spatial scales...
  8. pmc Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals
    Thanh V Nguyen
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Malar J 8:235. 2009
    ..falciparum infected irradiated mosquitoes. The anti-MB2 antibody response may be part of a robust protective response against the sporozoite...
  9. pmc Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factors
    Kacey C Ernst
    University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    Malar J 5:78. 2006
    ....
  10. pmc Reliability of the Luganda version of the Child Behaviour Checklist in measuring behavioural problems after cerebral malaria
    Paul Bangirana
    Department of Psychiatry, Makerere University School of Medicine, Kampala, Uganda
    Child Adolesc Psychiatry Ment Health 3:38. 2009
    ..Depressive and thought problems are likely behavioural outcomes of cerebral malaria in children. Further work in children with psychiatric diagnoses is required to test its validity in a clinical setting...
  11. pmc Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial
    Paul Bangirana
    Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda
    BMC Neurol 11:96. 2011
    ..We designed a study in which children who had suffered from severe malaria three months earlier were enrolled into a cognitive intervention program and assessed for the immediate benefit in cognitive, academic and behavioral outcomes...
  12. pmc Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan children
    Chandy C John
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Infect Dis 197:519-26. 2008
    ..IgG antibodies to pre-erythrocytic antigens are involved in prevention of infection and disease in animal models of malaria but have not been associated with protection against disease in human malaria...
  13. pmc Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease
    Chandy C John
    Global Pediatrics Program and Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street, SE, 850 Mayo, MMC 296, Minneapolis, MN 55455, USA
    Cytokine 41:204-8. 2008
    ..216, P=0.03) but not IL-8 (76 vs. 62, P=NS). Elevated IL-1ra levels are associated with increased disease severity in children with malaria, and very elevated levels of IL-1ra, G-CSF and MCP-1 are seen in children who die of CM...
  14. pmc Cerebral malaria in children is associated with long-term cognitive impairment
    Chandy C John
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Pediatrics 122:e92-9. 2008
    ..This study was conducted to determine the long-term effects of cerebral malaria on the cognitive function of these children...
  15. pmc Possible interruption of malaria transmission, highland Kenya, 2007-2008
    Chandy C John
    Global Pediatrics Program, University of Minnesota Medical School, 420 Delaware St SE, 850 Mayo, MMC 296, Minneapolis, MN 55455, USA
    Emerg Infect Dis 15:1917-24. 2009
    ..Our findings show that in such areas, interruption and eventual elimination of malaria transmission may be achievable with widespread annual indoor residual spraying of households and artemisinin combination therapy...
  16. pmc Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malaria
    Chandy C John
    Center for Global Pediatrics, 717 Delaware Street SE, Room 363, Minneapolis, MN 55455, USA
    Expert Rev Anti Infect Ther 8:997-1008. 2010
    ..g., levamisole), immune modulators (e.g., rosiglitazone), agents that increase nitric oxide levels (e.g., arginine) and neuroprotective agents (e.g., erythropoietin)...
  17. pmc Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria
    Chandy C John
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Am J Trop Med Hyg 78:198-205. 2008
    ..34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-alpha production is associated with subsequent neurologic and cognitive morbidity...
  18. pmc Cerebral malaria pathogenesis: what can we learn from microarray analysis?
    Chandy C John
    Dept of Pediatrics, University of Minnesota Medical School, 420 Delaware St, SE, 850 Mayo, MMC 296, Minneapolis, MN 55455, USA
    Am J Pathol 171:1729-32. 2007
  19. ncbi request reprint Low levels of RANTES are associated with mortality in children with cerebral malaria
    Chandy C John
    University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Infect Dis 194:837-45. 2006
    ..In children with cerebral malaria (CM), serum chemokine levels and associated morbidity and mortality have not been characterized...
  20. ncbi request reprint Therapies and vaccines for emerging bacterial infections: learning from methicillin-resistant Staphylococcus aureus
    Chandy C John
    Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Pediatr Clin North Am 53:699-713. 2006
    ..This article outlines the molecular biology of MRSA, how molecular biology has contributed to the understanding of MRSA infections, current therapy and prevention of MRSA, and the prospects for a vaccine against S aureus...
  21. pmc Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmission
    Gregory S Noland
    University of Minnesota, Minneapolis, MN 55455, USA
    Infect Immun 76:5721-8. 2008
    ..Suboptimal immunity to malaria in areas of unstable malaria transmission may relate in part to infrequent high-level antibodies to preerythrocytic antigens and AMA-1...
  22. pmc Microscopy underestimates the frequency of Plasmodium falciparum infection in symptomatic individuals in a low transmission highland area
    David M Menge
    Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Trop Med Hyg 79:173-7. 2008
    ..P. falciparum infection appears to resolve without treatment in most LDR-FMA-positive, microscopy-negative individuals, but is persistent in a subset of these individuals and requires treatment...
  23. doi request reprint Development of a competency-based curriculum in global child health
    Cynthia R Howard
    Pediatric Global Health Education Program, University of Minnesota, Minneapolis, Minnesota 55414, USA
    Acad Med 86:521-8. 2011
    ....
  24. pmc Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity
    Chandy C John
    Department of 1Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Clin Infect Dis 49:1893-6. 2009
    ..The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on preexisting T cell hypersensitivity amplified by superantigenicity...
  25. pmc TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria
    Nadia A Sam-Agudu
    University of Minnesota, Minneapolis, MN, USA
    Am J Trop Med Hyg 82:548-55. 2010
    ..We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection...
  26. ncbi request reprint A family cluster of five cases of group A streptococcal pneumonia
    Sumita Roy
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Pediatrics 112:e61-5. 2003
    ..7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease...
  27. ncbi request reprint Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa
    Chandy C John
    Center for Global Health and Diseases, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
    J Immunol 173:666-72. 2004
    ..falciparum infection, and suggest that the measurement of MSP-1(19) specific inhibitory Abs may serve as an accurate correlate of protection in clinical trials of MSP-1-based vaccines...
  28. pmc Antibodies to the Plasmodium falciparum antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver-stage antigen 1 vary by ages of subjects and by season in a highland area of Kenya
    Chandy C John
    Center for Global Health and Disease and Division of Pediatric Infectious Disease, Case Western Reserve University School of Medicine and Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
    Infect Immun 71:4320-5. 2003
    ..falciparum antigens vary in subjects by age and season, and the protective effects of these antibodies against infection may be different in adults and children...
  29. pmc Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malaria
    Chandy C John
    Center for Global Health and Diseases, Case Western Researve University, Cleveland, OH, USA
    Infect Immun 72:5135-42. 2004
    ..IFN-gamma responses to LSA-1 appear to require repeated P. falciparum exposure and/or increased age and, as measured by ELISA, are associated with protection against clinical malaria and anemia...
  30. ncbi request reprint Lymphocyte proliferation and antibody responses to Plasmodium falciparum liver-stage antigen-1 in a highland area of Kenya with seasonal variation in malaria transmission
    Chandy C John
    Division of Geographic Medicine, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio 44106 4983, USA
    Am J Trop Med Hyg 66:372-8. 2002
    ..These data indicate that age and transmission intensity independently affect IgG antibody responses to LSA-1 but do not influence lymphocyte proliferation in this highland area where malaria transmission is highly variable...
  31. ncbi request reprint Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area
    Ann M Moormann
    Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
    Am J Trop Med Hyg 74:585-90. 2006
    ..This suggests that cytokine responses to LSA-1 and TRAP are transient under natural exposure conditions...
  32. ncbi request reprint Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infection
    Chandy C John
    Center for Global Health and Diseases, Rainbow Center for International Child Health, Division of Pediatric Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Trop Med Hyg 73:222-8. 2005
    ..High levels of IgG antibodies to CSP, LSA-1, and TRAP may be useful immune correlates of protection against P. falciparum infection in malaria-endemic populations...
  33. ncbi request reprint Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of Kenya
    Chandy C John
    Rainbow Babies and Children s Hospital, RCICH, RBC 487, MS6008, Cleveland, OH 44106, USA
    Trans R Soc Trop Med Hyg 99:780-6. 2005
    ..3%. In this epidemic-prone highland area, inter-epidemic periods are characterized by low frequencies of asymptomatically infected individuals. Increases in gametocyte prevalence may be an early indicator of impending outbreaks...
  34. ncbi request reprint Antibodies to Plasmodium falciparum antigens vary by age and antigen in children in a malaria-holoendemic area of Kenya
    Kiprotich Chelimo
    Kenya Medical Research Institute, Kisian, Kenya
    Pediatr Infect Dis J 24:680-4. 2005
    ..Antibodies are important in protection against infection and disease caused by Plasmodium falciparum, but the frequencies of antibodies to multiple P. falciparum antigens in children are not well-characterized...
  35. pmc Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malaria
    Robert O Opoka
    Department of Paediatrics and Child Health, Mulago Hospital Makerere University Medical School, Kampala, Uganda
    Pediatr Infect Dis J 27:319-24. 2008
    ..Differences in mortality in children who are tested by microscopy for Plasmodium falciparum infection as compared with those not tested are not well characterized...
  36. ncbi request reprint Rehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitations
    Paul Bangirana
    Department of Mental Health and Community Psychology, Makerere University Institute of Psychology, Kampala, Uganda
    Trop Med Int Health 11:1341-9. 2006
    ..The limitations of implementing these interventions and solutions are discussed in light of the limited human resources and infrastructure of the developing countries that are malaria endemic...
  37. ncbi request reprint Drug treatment of malaria in children
    Chandy C John
    Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH, USA
    Pediatr Infect Dis J 22:649-51. 2003
  38. ncbi request reprint Clinical manifestations of severe malaria in the highlands of southwestern Uganda
    Richard Idro
    Department of Pediatrics and Child Health, Makerere University Medical School Mulago Hospital, Kampala, Uganda
    Am J Trop Med Hyg 72:561-7. 2005
    ..quot;Typical" signs like splenomegaly are frequently absent, prostration is the major manifestation, and other manifestations vary in frequency according to age...
  39. ncbi request reprint Risk of Plasmodium falciparum infection during a malaria epidemic in highland Kenya, 1997
    Chandy C John
    Rainbow Center for International Child Health, Rainbow Babies and Children s Hospital, Case Western Reserve University, RBC 487, 11100 Euclid Avenue, MS6008, Cleveland, OH 44106, USA
    Acta Trop 92:55-61. 2004
    ....
  40. pmc Cognitive impairment after cerebral malaria in children: a prospective study
    Michael J Boivin
    International Neurologic and Psychiatric Epidemiology Program, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
    Pediatrics 119:e360-6. 2007
    ..This study was conducted to assess prospectively the frequency of cognitive deficits in children with cerebral malaria...

Research Grants7

  1. IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYA
    Chandy John; Fiscal Year: 2002
    Candidate Immediate and Long-term Research Goals: Chandy John is currently a fellow in Pediatric Infectious Diseases/Geographic Medicine at Case Western Reserve University...
  2. Malaria transmission and immunity in highland Kenya
    Chandy John; Fiscal Year: 2007
    ..We anticipate that our findings will generate strategies for vaccine induction of robust immune responses against multiple antigenic variants in vulnerable populations experiencing malaria epidemics. ..
  3. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy John; Fiscal Year: 2009
    ..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
  4. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2010
    ..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
  5. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2010
    ..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..