Research Topics
| Chandy JohnSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control studyJennifer A Greene
Case Western Reserve University, Wolstein Research Building, 2103 Cornell Rd, Cleveland, OH 44106, USA
Malar J 11:47. 2012..There are two common polymorphisms in the 5' un-translated region (UTR) of TLR2, a 22 base pair deletion in the first unstranslated exon (Δ22), and a GT dinucleotide repeat in the second intron (GTn)...- Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trialMichael Hawkes
Institute of Medical Sciences, University of Toronto, Canada
Trials 12:176. 2011..Low-flow inhaled nitric oxide (iNO) gas is a US FDA-approved treatment for hypoxic respiratory failure in neonates... - Malaria with neurological involvement in Ugandan children: effect on cognitive ability, academic achievement and behaviourPaul Bangirana
Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda
Malar J 10:334. 2011..This study investigated the effect of malaria with neurological involvement on cognitive ability, behaviour and academic achievement... - Malaria treatment-seeking behaviour and recovery from malaria in a highland area of KenyaPeter O Sumba
Center for Global Pediatrics and Division of Pediatric Infectious Diseases, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Malar J 7:245. 2008..Malaria epidemics in highland areas of Kenya cause significant morbidity and mortality... - Local topographic wetness indices predict household malaria risk better than land-use and land-cover in the western Kenya highlandsJustin M Cohen
Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA
Malar J 9:328. 2010..This study examined whether environmental factors like land-cover, land-use, and urban density improved malaria risk prediction based solely on the topographically-determined context, as measured by the topographic wetness index... - Topography-derived wetness indices are associated with household-level malaria risk in two communities in the western Kenyan highlandsJustin M Cohen
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
Malar J 7:40. 2008..Understanding these local topographic effects may permit prediction of regions at high risk of malaria within the highlands at small spatial scales... - Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individualsThanh V Nguyen
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
Malar J 8:235. 2009..falciparum infected irradiated mosquitoes. The anti-MB2 antibody response may be part of a robust protective response against the sporozoite... - Malaria hotspot areas in a highland Kenya site are consistent in epidemic and non-epidemic years and are associated with ecological factorsKacey C Ernst
University of Michigan School of Public Health, Ann Arbor, Michigan, USA
Malar J 5:78. 2006.... - Reliability of the Luganda version of the Child Behaviour Checklist in measuring behavioural problems after cerebral malariaPaul Bangirana
Department of Psychiatry, Makerere University School of Medicine, Kampala, Uganda
Child Adolesc Psychiatry Ment Health 3:38. 2009..Depressive and thought problems are likely behavioural outcomes of cerebral malaria in children. Further work in children with psychiatric diagnoses is required to test its validity in a clinical setting... - Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trialPaul Bangirana
Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda
BMC Neurol 11:96. 2011..We designed a study in which children who had suffered from severe malaria three months earlier were enrolled into a cognitive intervention program and assessed for the immediate benefit in cognitive, academic and behavioral outcomes... - Possible interruption of malaria transmission, highland Kenya, 2007-2008Chandy C John
Global Pediatrics Program, University of Minnesota Medical School, 420 Delaware St SE, 850 Mayo, MMC 296, Minneapolis, MN 55455, USA
Emerg Infect Dis 15:1917-24. 2009..Our findings show that in such areas, interruption and eventual elimination of malaria transmission may be achievable with widespread annual indoor residual spraying of households and artemisinin combination therapy... - Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malariaChandy C John
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Trop Med Hyg 78:198-205. 2008..34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-alpha production is associated with subsequent neurologic and cognitive morbidity... - Antibodies to pre-erythrocytic Plasmodium falciparum antigens and risk of clinical malaria in Kenyan childrenChandy C John
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
J Infect Dis 197:519-26. 2008..IgG antibodies to pre-erythrocytic antigens are involved in prevention of infection and disease in animal models of malaria but have not been associated with protection against disease in human malaria... - Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of diseaseChandy C John
Global Pediatrics Program and Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street, SE, 850 Mayo, MMC 296, Minneapolis, MN 55455, USA
Cytokine 41:204-8. 2008..216, P=0.03) but not IL-8 (76 vs. 62, P=NS). Elevated IL-1ra levels are associated with increased disease severity in children with malaria, and very elevated levels of IL-1ra, G-CSF and MCP-1 are seen in children who die of CM... - Cerebral malaria in children is associated with long-term cognitive impairmentChandy C John
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Pediatrics 122:e92-9. 2008..This study was conducted to determine the long-term effects of cerebral malaria on the cognitive function of these children... - Adjunctive therapy for cerebral malaria and other severe forms of Plasmodium falciparum malariaChandy C John
Center for Global Pediatrics, 717 Delaware Street SE, Room 363, Minneapolis, MN 55455, USA
Expert Rev Anti Infect Ther 8:997-1008. 2010..g., levamisole), immune modulators (e.g., rosiglitazone), agents that increase nitric oxide levels (e.g., arginine) and neuroprotective agents (e.g., erythropoietin)... - Cerebral malaria pathogenesis: what can we learn from microarray analysis?Chandy C John
Dept of Pediatrics, University of Minnesota Medical School, 420 Delaware St, SE, 850 Mayo, MMC 296, Minneapolis, MN 55455, USA
Am J Pathol 171:1729-32. 2007 
Low levels of RANTES are associated with mortality in children with cerebral malariaChandy C John
University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Infect Dis 194:837-45. 2006..In children with cerebral malaria (CM), serum chemokine levels and associated morbidity and mortality have not been characterized...- Therapies and vaccines for emerging bacterial infections: learning from methicillin-resistant Staphylococcus aureusChandy C John
Department of Pediatrics, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Pediatr Clin North Am 53:699-713. 2006..This article outlines the molecular biology of MRSA, how molecular biology has contributed to the understanding of MRSA infections, current therapy and prevention of MRSA, and the prospects for a vaccine against S aureus... - Low prevalence of antibodies to preerythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable malaria transmission compared to prevalence in an area of stable malaria transmissionGregory S Noland
University of Minnesota, Minneapolis, MN 55455, USA
Infect Immun 76:5721-8. 2008..Suboptimal immunity to malaria in areas of unstable malaria transmission may relate in part to infrequent high-level antibodies to preerythrocytic antigens and AMA-1... 
Development of a competency-based curriculum in global child healthCynthia R Howard
Pediatric Global Health Education Program, University of Minnesota, Minneapolis, Minnesota 55414, USA
Acad Med 86:521-8. 2011....- Microscopy underestimates the frequency of Plasmodium falciparum infection in symptomatic individuals in a low transmission highland areaDavid M Menge
Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Trop Med Hyg 79:173-7. 2008..P. falciparum infection appears to resolve without treatment in most LDR-FMA-positive, microscopy-negative individuals, but is persistent in a subset of these individuals and requires treatment... - TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malariaNadia A Sam-Agudu
University of Minnesota, Minneapolis, MN, USA
Am J Trop Med Hyg 82:548-55. 2010..We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection... - Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivityChandy C John
Department of 1Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Clin Infect Dis 49:1893-6. 2009..The associated staphylococcal superantigen was enterotoxin B. We demonstrate that erythroderma depends on preexisting T cell hypersensitivity amplified by superantigenicity... - A family cluster of five cases of group A streptococcal pneumoniaSumita Roy
Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Pediatrics 112:e61-5. 2003..7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease... - Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of AfricaChandy C John
Center for Global Health and Diseases, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
J Immunol 173:666-72. 2004..falciparum infection, and suggest that the measurement of MSP-1(19) specific inhibitory Abs may serve as an accurate correlate of protection in clinical trials of MSP-1-based vaccines... - Antibodies to the Plasmodium falciparum antigens circumsporozoite protein, thrombospondin-related adhesive protein, and liver-stage antigen 1 vary by ages of subjects and by season in a highland area of KenyaChandy C John
Center for Global Health and Disease and Division of Pediatric Infectious Disease, Case Western Reserve University School of Medicine and Rainbow Babies and Children s Hospital, Cleveland, Ohio 44106, USA
Infect Immun 71:4320-5. 2003..falciparum antigens vary in subjects by age and season, and the protective effects of these antibodies against infection may be different in adults and children... - Gamma interferon responses to Plasmodium falciparum liver-stage antigen 1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity, and protection against malariaChandy C John
Center for Global Health and Diseases, Case Western Researve University, Cleveland, OH, USA
Infect Immun 72:5135-42. 2004..IFN-gamma responses to LSA-1 appear to require repeated P. falciparum exposure and/or increased age and, as measured by ELISA, are associated with protection against clinical malaria and anemia... - Lymphocyte proliferation and antibody responses to Plasmodium falciparum liver-stage antigen-1 in a highland area of Kenya with seasonal variation in malaria transmissionChandy C John
Division of Geographic Medicine, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio 44106 4983, USA
Am J Trop Med Hyg 66:372-8. 2002..These data indicate that age and transmission intensity independently affect IgG antibody responses to LSA-1 but do not influence lymphocyte proliferation in this highland area where malaria transmission is highly variable... - Inpatient mortality in children with clinically diagnosed malaria as compared with microscopically confirmed malariaRobert O Opoka
Department of Paediatrics and Child Health, Mulago Hospital Makerere University Medical School, Kampala, Uganda
Pediatr Infect Dis J 27:319-24. 2008..Differences in mortality in children who are tested by microscopy for Plasmodium falciparum infection as compared with those not tested are not well characterized... - Correlation of high levels of antibodies to multiple pre-erythrocytic Plasmodium falciparum antigens and protection from infectionChandy C John
Center for Global Health and Diseases, Rainbow Center for International Child Health, Division of Pediatric Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, USA
Am J Trop Med Hyg 73:222-8. 2005..High levels of IgG antibodies to CSP, LSA-1, and TRAP may be useful immune correlates of protection against P. falciparum infection in malaria-endemic populations... - Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of KenyaChandy C John
Rainbow Babies and Children s Hospital, RCICH, RBC 487, MS6008, Cleveland, OH 44106, USA
Trans R Soc Trop Med Hyg 99:780-6. 2005..3%. In this epidemic-prone highland area, inter-epidemic periods are characterized by low frequencies of asymptomatically infected individuals. Increases in gametocyte prevalence may be an early indicator of impending outbreaks... - Antibodies to Plasmodium falciparum antigens vary by age and antigen in children in a malaria-holoendemic area of KenyaKiprotich Chelimo
Kenya Medical Research Institute, Kisian, Kenya
Pediatr Infect Dis J 24:680-4. 2005..falciparum antigens is infrequent in the first 4 months of life but increases with age and increased exposure. The pattern of age-related IgG response frequencies to P. falciparum antigens varies significantly by antigen... - Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic areaAnn M Moormann
Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 7286, USA
Am J Trop Med Hyg 74:585-90. 2006..This suggests that cytokine responses to LSA-1 and TRAP are transient under natural exposure conditions... - Rehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitationsPaul Bangirana
Department of Mental Health and Community Psychology, Makerere University Institute of Psychology, Kampala, Uganda
Trop Med Int Health 11:1341-9. 2006..The limitations of implementing these interventions and solutions are discussed in light of the limited human resources and infrastructure of the developing countries that are malaria endemic... - Drug treatment of malaria in childrenChandy C John
Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA
Pediatr Infect Dis J 22:649-51. 2003 - Clinical manifestations of severe malaria in the highlands of southwestern UgandaRichard Idro
Department of Pediatrics and Child Health, Makerere University Medical School/Mulago Hospital, Kampala, Uganda
Am J Trop Med Hyg 72:561-7. 2005..quot;Typical" signs like splenomegaly are frequently absent, prostration is the major manifestation, and other manifestations vary in frequency according to age... - Risk of Plasmodium falciparum infection during a malaria epidemic in highland Kenya, 1997Chandy C John
Rainbow Center for International Child Health, Rainbow Babies and Children s Hospital, Case Western Reserve University, RBC 487, 11100 Euclid Avenue, MS6008, Cleveland, OH 44106, USA
Acta Trop 92:55-61. 2004.... - Cognitive impairment after cerebral malaria in children: a prospective studyMichael J Boivin
International Neurologic and Psychiatric Epidemiology Program, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
Pediatrics 119:e360-6. 2007..This study was conducted to assess prospectively the frequency of cognitive deficits in children with cerebral malaria...
Research Grants
- IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYAChandy John; Fiscal Year: 2002Candidate Immediate and Long-term Research Goals: Chandy John is currently a fellow in Pediatric Infectious Diseases/Geographic Medicine at Case Western Reserve University...
- Malaria transmission and immunity in highland KenyaChandy John; Fiscal Year: 2007..We anticipate that our findings will generate strategies for vaccine induction of robust immune responses against multiple antigenic variants in vulnerable populations experiencing malaria epidemics. ..
- Pathogenesis of cognitive/neurologic deficits in central nervous system malariaChandy John; Fiscal Year: 2009..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
- Pathogenesis of cognitive/neurologic deficits in central nervous system malariaChandy C John; Fiscal Year: 2010..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
- Pathogenesis of cognitive/neurologic deficits in central nervous system malariaChandy C John; Fiscal Year: 2010..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..