Bina Joe

Summary

Affiliation: University of Toledo
Country: USA

Publications

  1. doi request reprint Blood pressure and proteinuria effects of multiple quantitative trait loci on rat chromosome 9 that differentiate the spontaneously hypertensive rat from the Dahl salt-sensitive rat
    Edward J Toland
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614 5804, USA
    J Hypertens 26:2134-41. 2008
  2. pmc Positional identification of variants of Adamts16 linked to inherited hypertension
    Bina Joe
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614 2598, USA
    Hum Mol Genet 18:2825-38. 2009
  3. pmc Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension
    Kathirvel Gopalakrishnan
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Ave, Toledo, OH 43614 2598, USA
    Hypertension 57:764-71. 2011
  4. ncbi request reprint Quest for arthritis-causative genetic factors in the rat
    Bina Joe
    Physiological Genomics Laboratory, Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, University of Ohio Health Science Campus, Toledo, Ohio 43614 5804, USA
    Physiol Genomics 27:1-11. 2006
  5. pmc Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models
    Sivarajan Kumarasamy
    Physiological Genomics Laboratory, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA
    Hypertens Res 34:1263-70. 2011
  6. pmc Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model
    George T Cicila
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Ave, Mail Stop 1008, Toledo, OH 43614, USA
    Hypertension 53:725-32. 2009
  7. ncbi request reprint Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure
    Yasser Saad
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3035 Arlington Ave, Ohio 43614 5804, USA
    Hypertension 50:891-8. 2007
  8. pmc Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10
    Yasser Saad
    Department of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo, Health Science Campus, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
    Genomics 89:343-53. 2007
  9. doi request reprint Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain
    Yasser Saad
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3035 Arlington Avenue, Toledo, Ohio, 43614 5804, USA
    Mamm Genome 19:85-91. 2008
  10. doi request reprint Closely linked non-additive blood pressure quantitative trait loci
    Edward J Toland
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3035 Arlington Avenue, Toledo, OH 43614, USA
    Mamm Genome 19:209-18. 2008

Research Grants

Collaborators

Detail Information

Publications31

  1. doi request reprint Blood pressure and proteinuria effects of multiple quantitative trait loci on rat chromosome 9 that differentiate the spontaneously hypertensive rat from the Dahl salt-sensitive rat
    Edward J Toland
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614 5804, USA
    J Hypertens 26:2134-41. 2008
    ....
  2. pmc Positional identification of variants of Adamts16 linked to inherited hypertension
    Bina Joe
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614 2598, USA
    Hum Mol Genet 18:2825-38. 2009
    ..Overall, our report represents a high resolution positional cloning and translational study for Adamts16 as a candidate gene controlling BP...
  3. pmc Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension
    Kathirvel Gopalakrishnan
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Ave, Toledo, OH 43614 2598, USA
    Hypertension 57:764-71. 2011
    ..001). Taken together, our study provides evidence to suggest that early perturbations in endocytic recycling caused by the overexpression of Rffl is a novel physiological mechanism potentially underlying the development of hypertension...
  4. ncbi request reprint Quest for arthritis-causative genetic factors in the rat
    Bina Joe
    Physiological Genomics Laboratory, Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, University of Ohio Health Science Campus, Toledo, Ohio 43614 5804, USA
    Physiol Genomics 27:1-11. 2006
    ..This review catalogs some of the recent advances made in QTL discovery projects of experimentally induced rat models of arthritis...
  5. pmc Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models
    Sivarajan Kumarasamy
    Physiological Genomics Laboratory, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA
    Hypertens Res 34:1263-70. 2011
    ..Tmeff2 is known to be upregulated in patients from multiple cohorts with cardiac hypertrophy. Taken together, Tmeff2 can be prioritized as a candidate gene for hypertension and associated cardiac hypertrophy in both rats and in humans...
  6. pmc Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model
    George T Cicila
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Ave, Mail Stop 1008, Toledo, OH 43614, USA
    Hypertension 53:725-32. 2009
    ..This is the first report of simultaneous detection of independent and epistatic loci dictating, in part, longevity in a hypertensive rat strain...
  7. ncbi request reprint Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure
    Yasser Saad
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3035 Arlington Ave, Ohio 43614 5804, USA
    Hypertension 50:891-8. 2007
    ..Because all of these genetic elements are located within a 1.06-Mb region of RNO10, our study has revealed a remarkable insight into a genomic module comprising very closely-linked, opposing genetic determinants of BP...
  8. pmc Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10
    Yasser Saad
    Department of Physiology, Pharmacology, Metabolism, and Cardiovascular Sciences, University of Toledo, Health Science Campus, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
    Genomics 89:343-53. 2007
    ..Therefore, the present work defines a novel blood pressure QTL with three potential quantitative trait nucleotides...
  9. doi request reprint Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain
    Yasser Saad
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3035 Arlington Avenue, Toledo, Ohio, 43614 5804, USA
    Mamm Genome 19:85-91. 2008
    ..LEW BP QTL region. Identification of the same QTL affecting BP in multiple rat strains will provide further support for the QTL's involvement and importance in human essential hypertension...
  10. doi request reprint Closely linked non-additive blood pressure quantitative trait loci
    Edward J Toland
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3035 Arlington Avenue, Toledo, OH 43614, USA
    Mamm Genome 19:209-18. 2008
    ..Overall, this study represents an intermediary yet obligatory progression towards the identification of genetic elements controlling BP...
  11. pmc Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria
    Sivarajan Kumarasamy
    Program in Physiological Genomics, Center for Hypertension and Personalized Medicine, Department of Physiology qaand Pharmacology, University of Toledo College of Medicine and Life Sciences, 3000 Arlington Ave, Toledo, OH 43614 2598, USA
    Am J Physiol Heart Circ Physiol 304:H22-32. 2013
    ..These novel conplastic strains serve as invaluable tools to further dissect the relationship between heart function, aerobic fitness, cardiovascular disease progression, and mortality...
  12. pmc Isolation and high-throughput sequencing of two closely linked epistatic hypertension susceptibility loci with a panel of bicongenic strains
    Resmi Pillai
    Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, USA
    Physiol Genomics 45:729-36. 2013
    ..77 and 4.18 Mb containing 7,360 and 2,753 candidate variants, respectively. The current study demonstrates definitive evidence for epistasis and provides genetic tools for further dissection of the isolated epistatic BP loci. ..
  13. ncbi request reprint Transcriptional profiling with a blood pressure QTL interval-specific oligonucleotide array
    Bina Joe
    Department of Physiology and Cardiovascular Genomics, Medical University of Ohio, Toledo, Ohio 43614 5804, USA
    Physiol Genomics 23:318-26. 2005
    ..These results demonstrate the importance of using a saturated oligonucleotide array for identifying and prioritizing differentially expressed positional candidate genes of a BP QTL...
  14. pmc Neointimal hyperplasia and vasoreactivity are controlled by genetic elements on rat chromosome 3
    Andrea L Nestor Kalinoski
    Department of Surgery and University of Toledo Advanced Microscopy and Imaging Center, University of Toledo, Toledo, Ohio 43614 5804, USA
    Hypertension 55:555-61. 2010
    ..In summary, these results confirm that the RNO3 NIH QTL carries the gene(s) contributing to postinjury NIH formation...
  15. pmc Targeted disruption of Adamts16 gene in a rat genetic model of hypertension
    Kathirvel Gopalakrishnan
    Center for Hypertension and Personalized Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA
    Proc Natl Acad Sci U S A 109:20555-9. 2012
    ..Taken together, these physiological observations functionally link Adamts16 to BP regulation and suggest the vasculature as the potential site of action of Adamts16 to lower BP...
  16. pmc Mitochondrial polymorphisms in rat genetic models of hypertension
    Sivarajan Kumarasamy
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614 5804, USA
    Mamm Genome 21:299-306. 2010
    ..The variations detected among the various hypertensive strains provides the basis to construct conplastic strains and further evaluate the effects of these variants on hypertension and associated phenotypes...
  17. ncbi request reprint Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains
    Michael R Garrett
    Department of Physiology and Cardiovascular Genomics, Medical University of Ohio, Toledo, Ohio 43614 5804, USA
    Physiol Genomics 25:39-49. 2006
    ..These congenic strains demonstrated large and significant effects on UAE compared with the S rat, proving that QTL for UAE reside on these chromosomes...
  18. pmc Substitution mapping in dahl rats identifies two distinct blood pressure quantitative trait loci within 1.12- and 1.25-mb intervals on chromosome 3
    Soon Jin Lee
    Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    Genetics 174:2203-13. 2006
    ..25 Mb, respectively. Also important was our difficulty in fine mapping and marker placement in this portion of the rat genome (and thus candidate gene identification) using the available genomic data, including the rat genome sequence...
  19. pmc Use of contiguous congenic strains in analyzing compound QTLs
    John P Rapp
    Program in Physiological Genomics, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614, USA
    Physiol Genomics 44:117-20. 2012
    ..Examples from the literature where this strategy would be helpful, as well as a case where it would be potentially counterproductive, are given...
  20. pmc Dysglycemia induces abnormal circadian blood pressure variability
    Sivarajan Kumarasamy
    Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA
    Cardiovasc Diabetol 10:104. 2011
    ..Prediabetes (PreDM) in asymptomatic adults is associated with abnormal circadian blood pressure variability (abnormal CBPV)...
  21. doi request reprint Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation
    Wissam A AbouAlaiwi
    Department of Pharmacology W A A, S M N, Department of Medicinal and Biological Chemistry B S M, S M N, Department of Medicine S R, S M N, Center for Hypertension and Personalized Medicine B J, S M N, Department of Biochemistry and Cancer Biology L L, and Department of Pathology R L B, University of Toledo, Toledo, OH Department of Emergency and Intensive Care, ProMedica Sponsored Research, Toledo, OH I R Departments of Medicine B S H and Medical and Molecular Genetics R L B, Indiana University School of Medicine, Indianapolis UCL Institute of Ophthalmology, University College London, London, UK M F Ontario Cancer Institute, University Health Network, Toronto, ON, Canada T W M and Department of Medicine, Brigham and Women s Hospital, Boston, MA J Z
    Circulation 129:660-72. 2014
    ..The present studies aim to examine whether and how cilia function (Pkd1 or Pkd2) and structure (Tg737) play a role in cystic kidney and aneurysm through survivin downregulation...
  22. ncbi request reprint Substitution mapping of a blood pressure quantitative trait locus to a 2.73 Mb region on rat chromosome 1
    Bina Joe
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, OH 43614, USA
    J Hypertens 21:2077-84. 2003
    ..To improve the localization of a blood pressure quantitative trait locus (BP QTL) on rat chromosome (RNO) 1...
  23. pmc Impairment of Na/K-ATPase signaling in renal proximal tubule contributes to Dahl salt-sensitive hypertension
    Jiang Liu
    Department of Medicine, University of Toledo College of Medicine, Toledo, Ohio 43614, USA
    J Biol Chem 286:22806-13. 2011
    ..Our data suggested that impairment of Na/K-ATPase signaling and consequent regulation of Na/K-ATPase and NHE3 in renal proximal tubule may contribute to salt-induced hypertension in the Dahl S rat...
  24. ncbi request reprint Evaluation of quantitative trait loci regulating severity of mycobacterial adjuvant-induced arthritis in monocongenic and polycongenic rats: identification of a new regulatory locus on rat chromosome 10 and evidence of overlap with rheumatoid arthritis su
    Bina Joe
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 46:1075-85. 2002
    ..To evaluate the regulatory potential of genetic loci controlling Mycobacterium butyricum adjuvant-induced arthritis (Mbt-AIA) using mono- and polycongenic rats...
  25. ncbi request reprint The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis
    Max Brenner
    Laboratory of Experimental Rheumatology, Robert S Boas Center for Genomics and Human Genetics and Graduate School of Molecular Medicine, North Shore Long Island Jewish LIJ Research Institute, Manhasset, NY 11030, USA
    J Immunol 174:7894-903. 2005
    ..These loci are syntenic to regions on human chromosomes 17q and 5q implicated in the susceptibility to rheumatoid arthritis, suggesting that the identification of these genes will be relevant to human disease...
  26. ncbi request reprint Cross-talk of expression quantitative trait loci within 2 interacting blood pressure quantitative trait loci
    Norman H Lee
    Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA
    Hypertension 50:1126-33. 2007
    ..A network of transcription factors potentially affecting blood pressure could be traced, lending support to our hypothesis...
  27. ncbi request reprint Genomic regions controlling corticosterone levels in rats
    Marc N Potenza
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 55:634-41. 2004
    ..The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness...
  28. ncbi request reprint Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment
    Harold G Klemcke
    US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Shock 29:748-53. 2008
    ..Identification of inbred strains divergent in survival time to hemorrhage provides the opportunity for future use of these strains to identify genes associated with this complex response...
  29. ncbi request reprint Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains
    Michael R Garrett
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614, USA
    J Hypertens 20:2399-406. 2002
    ..To describe genetic loci that differentiate blood pressures in two genetically hypertensive strains, the Dahl salt-sensitive (S) rat and the Albino Surgery (AS) rat...
  30. ncbi request reprint Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland20892, USA
    Arthritis Rheum 46:2225-34. 2002
    ..In the present study, we sought to characterize the independent arthritis-modulating effects of these 5 QTLs...
  31. ncbi request reprint Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: substitution mapping and renal expression analysis
    Michael R Garrett
    Department of Physiology and Cardiovascular Genomics, Medical College of Ohio, Toledo 43614 5804, USA
    Hypertension 45:451-9. 2005
    ..Together, these results demonstrate that a BP QTL independent of Resp18 exists within the newly defined 117-kb QTL region on RNO9...

Research Grants14

  1. Genetic Elements Controlling Blood Pressure
    Bina Joe; Fiscal Year: 2010
    ..Knowledge gained through successful completion of the work described is expected to identify genetic factors that have not been previously suspected to cause hypertension. ..
  2. Functional genomic dissection of rat blood pressure QTL
    Bina Joe; Fiscal Year: 2007
    ..Question 2 will be addressed by using an already available rat genome chip, to identify the genes whose mRNA expression levels are affected by the causative gene. ..
  3. BIOCHEMISTRY AND GENETICS OF HYPERTENSION
    Bina Joe; Fiscal Year: 2007
    ..Such genes are likely to provide targets for therapeutic intervention in human hypertension. ..
  4. GENETICS OF HYPERTENSION
    Bina Joe; Fiscal Year: 2010
    ..Knowledge gained through successful completion of the work described is expected to pin-point at least one genetic factor that has not been previously suspected to cause hypertension. ..