Umesh K Jinwal

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein
    Umesh K Jinwal
    Department of Pharmaceutical Sciences, University of South Florida Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 287:24814-20. 2012
  2. pmc The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics
    Umesh K Jinwal
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 286:16976-83. 2011
  3. pmc Hsc70 rapidly engages tau after microtubule destabilization
    Umesh K Jinwal
    Department of Molecular Medicine, University of South Florida, Johnnie B Byrd Sr Alzheimer s Research Institute, Tampa, Florida 33613, USA
    J Biol Chem 285:16798-805. 2010
  4. pmc Imbalance of Hsp70 family variants fosters tau accumulation
    Umesh K Jinwal
    Department of Pharmaceutical Sciences, University of South Florida Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    FASEB J 27:1450-9. 2013
  5. pmc Facilitating Akt clearance via manipulation of Hsp70 activity and levels
    John Koren
    Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 285:2498-505. 2010
  6. pmc Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism
    Amirthaa Suntharalingam
    Department of Molecular Medicine and Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
    J Biol Chem 287:40661-9. 2012
  7. pmc Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau
    Jose Abisambra
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, 33613, USA
    Biol Psychiatry 74:367-74. 2013
  8. pmc DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau
    Jose F Abisambra
    Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
    J Mol Biol 421:653-61. 2012
  9. pmc Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice
    Jose F Abisambra
    Department of Molecular Medicine, University of South Florida Health Byrd Alzheimer s Institute, Tampa, Florida 33613, USA
    J Neurosci 30:15374-82. 2010
  10. pmc The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau
    Jeffrey R Jones
    Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, United States
    J Nat Prod 74:38-44. 2011

Collaborators

Detail Information

Publications24

  1. pmc Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein
    Umesh K Jinwal
    Department of Pharmaceutical Sciences, University of South Florida Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 287:24814-20. 2012
    ..But when tau accumulation is occurring, cleaved TDP-43 can no longer be cleared, perhaps explaining the emergence of these co-pathologies...
  2. pmc The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics
    Umesh K Jinwal
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 286:16976-83. 2011
    ..We propose that changes in the neuronal levels or activity of Cdc37 could dramatically alter the kinome, leading to profound changes in the tau phosphorylation signature, altering its proteotoxicity and stability...
  3. pmc Hsc70 rapidly engages tau after microtubule destabilization
    Umesh K Jinwal
    Department of Molecular Medicine, University of South Florida, Johnnie B Byrd Sr Alzheimer s Research Institute, Tampa, Florida 33613, USA
    J Biol Chem 285:16798-805. 2010
    ..Thus, under normal circumstances, MC1 formation may be a protective conformation facilitated by Hsc70. However, in a diseased environment, Hsc70 may preserve Tau in a more unstructured state, perhaps facilitating its pathogenicity...
  4. pmc Imbalance of Hsp70 family variants fosters tau accumulation
    Umesh K Jinwal
    Department of Pharmaceutical Sciences, University of South Florida Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    FASEB J 27:1450-9. 2013
    ..Thus, efforts to promote Hsp72 expression and inhibit Hsc70 could be therapeutically relevant for tauopathies...
  5. pmc Facilitating Akt clearance via manipulation of Hsp70 activity and levels
    John Koren
    Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Biol Chem 285:2498-505. 2010
    ..Thus, increasing Hsp70 levels combined with inhibiting its ATPase function may serve to dramatically reduce Akt levels and facilitate cell death in certain types of cancer...
  6. pmc Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism
    Amirthaa Suntharalingam
    Department of Molecular Medicine and Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
    J Biol Chem 287:40661-9. 2012
    ..Mutant myocilin accumulates in the endoplasmic reticulum for unknown reasons...
  7. pmc Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau
    Jose Abisambra
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, 33613, USA
    Biol Psychiatry 74:367-74. 2013
    ..One way to treat these disorders may be to reduce abnormal tau levels through chaperone manipulation, thus subverting synaptic plasticity defects caused by tau's toxic accretion...
  8. pmc DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau
    Jose F Abisambra
    Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
    J Mol Biol 421:653-61. 2012
    ..Further investigations could provide new insights about triage decisions that facilitate or prevent amyloidogenesis of tau and other proteins associated with neurodegenerative disease...
  9. pmc Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice
    Jose F Abisambra
    Department of Molecular Medicine, University of South Florida Health Byrd Alzheimer s Institute, Tampa, Florida 33613, USA
    J Neurosci 30:15374-82. 2010
    ....
  10. pmc The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau
    Jeffrey R Jones
    Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, United States
    J Nat Prod 74:38-44. 2011
    ..Myricanol may represent a novel scaffold for drug development efforts targeting tau turnover in AD...
  11. pmc The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules
    Umesh K Jinwal
    Johnnie B Byrd Sr Alzheimer s Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 30:591-9. 2010
    ..Based on these new findings, we propose that FKBP51 can use the Hsp90 complex to isomerize tau, altering its phosphorylation pattern and stabilizing microtubules...
  12. pmc Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
    John C O'Leary
    Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, FL 33613, USA
    Mol Neurodegener 5:45. 2010
    ..Thus, efforts to discover therapeutics for tauopathies emphasize soluble tau reductions as well as neuroprotection...
  13. pmc Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance
    John Koren
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, College of Medicine, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 7:e35566. 2012
    ..Thus, modifications to the rhodocyanine scaffold could potentially be made to improve efficacy and pharmacokinetic properties. Moreover, the impact on tamoxifen sensitivity could be a new utility for this compound family...
  14. pmc Chemical manipulation of hsp70 ATPase activity regulates tau stability
    Umesh K Jinwal
    Departments of Molecular Medicine, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 29:12079-88. 2009
    ..These findings reveal an entirely novel path toward therapeutic intervention of tauopathies by inhibition of the previously untargeted ATPase activity of Hsp70...
  15. pmc Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies
    John Koren
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    Mol Neurobiol 44:65-70. 2011
    ..This, combined with compelling evidence that the prolyl isomerase Pin1 regulates tau stability and phosphorylation dynamics, suggests an emerging role for isomerization in tau pathogenesis...
  16. pmc Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics
    Jose F Abisambra
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, Tampa, FL 33613, USA
    Curr Neuropharmacol 9:623-31. 2011
    ..It will particularly focus on the pharmacological targeting of the Hsp70/90 system and the value of manipulating Hsp27 for treating Alzheimer's disease...
  17. pmc A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51
    John C O'Leary
    Department of Molecular Medicine, Byrd Alzheimer s Research Institute, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 6:e24840. 2011
    ..Age-dependent anxiety was also modulated by FKBP5 deletion. Therefore, drug discovery efforts focused on depleting FKBP51 levels may yield novel antidepressant therapies...
  18. pmc Natural products as a rich source of tau-targeting drugs for Alzheimer's disease
    Laurent Calcul
    Department of Chemistry and Center for Drug Discovery and Innovation, University of South Florida, FL, USA
    Future Med Chem 4:1751-61. 2012
    ..The overlooked approach of clearing tau aggregation will most likely be the next objective for AD drug discovery...
  19. pmc Chaperone signalling complexes in Alzheimer's disease
    John Koren
    Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Department of Molecular Medicine, University of South Florida, Tampa, USA
    J Cell Mol Med 13:619-30. 2009
    ..Here, we present the current understandings of chaperone biology and examine the literature investigating these proteins in the context of AD...
  20. pmc ApoER2 function in the establishment and maintenance of retinal synaptic connectivity
    Justin H Trotter
    Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 31:14413-23. 2011
    ..Interestingly, age-related reductions in rod and cone function were observed in both ApoER2 and VLDLR KOs. These results support a pivotal role for ApoER2 in the establishment and maintenance of normal retinal synaptic connectivity...
  21. pmc Reconstructing the Hsp90/Tau Machine
    Umesh K Jinwal
    Department of Molecular Medicine, USF Health Byrd Alzheimer s Institute, Tampa, Florida 33613
    Curr Enzym Inhib 9:41-45. 2013
    ..We propose that each of these proteins may be novel therapeutic targets. While targeting Hsp90 directly may be deleterious at the organismal level, perhaps targeting individual co-chaperone activities will be more tolerable...
  22. pmc Akt and CHIP coregulate tau degradation through coordinated interactions
    Chad A Dickey
    Department of Molecular Pharmacology and Physiology and H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Proc Natl Acad Sci U S A 105:3622-7. 2008
    ..Hence, Akt serves as a major regulator of tau biology by manipulating both tau kinases and protein quality control, providing a link to several common pathways that have demonstrated dysfunction in Alzheimer's disease...
  23. doi request reprint Cell-based assays for regulators of tau biology
    Umesh K Jinwal
    Department of Molecular Medicine, Byrd Alzheimer s Institute, University of South Florida, Tampa, FL, USA
    Methods Mol Biol 670:93-108. 2011
    ..We provide some tips on where mistakes are most likely to occur, and we interpret our standard Western data, providing some estimation as to the composition of the banding pattern that is typical for this enigmatic protein...
  24. ncbi request reprint Preparation and Characterization of Methylene blue Nanoparticles for Alzheimer's Disease and Other Tauopathies
    Umesh K Jinwal
    Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USA
    Curr Drug Deliv 11:541-50. 2014
    ..05). The proposed MB loaded nanoparticles could provide a more effective treatment option for AD and many other related disorders. ..