Zheng Gen Jin

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis
    Chang Hoon Ha
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
    J Biol Chem 283:14590-9. 2008
  2. ncbi request reprint Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 280:12305-9. 2005
  3. ncbi request reprint Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 93:354-63. 2003
  4. ncbi request reprint Cyclophilin A is a proinflammatory cytokine that activates endothelial cells
    Zheng Gen Jin
    Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 24:1186-91. 2004
  5. ncbi request reprint Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae
    Andreea O Lungu
    Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, New York 14642, USA
    J Biol Chem 279:48794-800. 2004
  6. ncbi request reprint Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)
    Tatsuo Tanimoto
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:42997-3001. 2002
  7. ncbi request reprint Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor
    Chelsea Wong
    Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 280:33262-9. 2005
  8. pmc Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antioxid Redox Signal 12:1355-69. 2010
  9. pmc VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis
    Chang Hoon Ha
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 28:1782-8. 2008
  10. pmc Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS
    Weiye Wang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Blood 115:2971-9. 2010

Research Grants

  1. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
  2. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009

Collaborators

Detail Information

Publications25

  1. pmc Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis
    Chang Hoon Ha
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
    J Biol Chem 283:14590-9. 2008
    ..These findings suggest that the PKD-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis...
  2. ncbi request reprint Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 280:12305-9. 2005
    ..Finally, knockdown of endogenous Gab1 by small interference RNA abrogated flow activation of Akt and eNOS. These data demonstrate a critical role of Gab1 in flow-stimulated PI3K/Akt/eNOS signal pathway in endothelial cells...
  3. ncbi request reprint Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase
    Zheng Gen Jin
    Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circ Res 93:354-63. 2003
    ..Finally, we show that inhibiting VEGFR2 kinase significantly reduces flow-mediated NO-dependent arteriolar dilation in vivo. These data identify VEGFR2 as a key mechanotransducer that activates eNOS in response to blood flow...
  4. ncbi request reprint Cyclophilin A is a proinflammatory cytokine that activates endothelial cells
    Zheng Gen Jin
    Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 24:1186-91. 2004
    ..We therefore studied the proinflammatory effects of CyPA on vascular endothelium...
  5. ncbi request reprint Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae
    Andreea O Lungu
    Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, New York 14642, USA
    J Biol Chem 279:48794-800. 2004
    ..These data suggest that decreasing cholesterol content in caveolae by CsA is a potentially important pathogenic mechanism for CsA-induced endothelial dysfunction and hypertension...
  6. ncbi request reprint Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)
    Tatsuo Tanimoto
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:42997-3001. 2002
    ..These data are the first to establish a critical role of Flk-1/KDR in S1P-stimulated eNOS phosphorylation and activation...
  7. ncbi request reprint Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor
    Chelsea Wong
    Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 280:33262-9. 2005
    ..Taken together, our results demonstrated for the first time that VEGF activates PKD via the VEGFR2/PLCgamma/PKCalpha pathway and revealed a critical role of PKD in VEGF-induced ERK signaling and endothelial cell proliferation...
  8. pmc Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    Antioxid Redox Signal 12:1355-69. 2010
    ....
  9. pmc VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis
    Chang Hoon Ha
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arterioscler Thromb Vasc Biol 28:1782-8. 2008
    ..However, whether HDAC7 is involved in the processes of vascular endothelial signaling and angiogenesis remains unclear. Here, we investigated the role of HDAC7 in vascular endothelial growth factor (VEGF) signaling and angiogenesis...
  10. pmc Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS
    Weiye Wang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Blood 115:2971-9. 2010
    ....
  11. pmc Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis
    Jinjing Zhao
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 31:1016-23. 2011
    ..The study was designed to investigate the role of endothelial Gab1 in angiogenesis and its underlying molecular mechanisms...
  12. ncbi request reprint Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells
    Jun Suzuki
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY 14642, USA
    Circ Res 98:811-7. 2006
    ..Our findings define a novel VSMC vesicular secretory pathway for CyPA that involves actin remodeling and myosin II activation via RhoA-, Cdc42-, and Rho kinase-dependent signaling events...
  13. doi request reprint Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1
    Bong Sook Jhun
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Circ Res 110:59-70. 2012
    ..ObjecTIVE: To determine if Rem1 function is physiologically regulated by adrenergic signaling and thus impacts voltage-gated L-type calcium channel (VLCC) activity in the heart...
  14. pmc PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy
    Chang Hoon Ha
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 107:15467-72. 2010
    ..This pathway may represent a mechanism by which cAMP/PKA signaling modulates a wide range of biological functions and human diseases such as cardiomyopathy...
  15. ncbi request reprint Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2
    Lung Kuo Tai
    Cardiovascular Research Institute and Department of Medicine, University of Rochester, New York 14642, USA
    J Biol Chem 280:29620-4. 2005
    ..These results establish Tie2 transactivation via PECAM1 as an early event in flow-mediated mechanotransduction and suggest an important role for a PECAM1-SHP2-Tie2 pathway in flow-mediated signal transduction...
  16. ncbi request reprint Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy
    Xiangbin Xu
    Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine, NY 14642, USA
    Arterioscler Thromb Vasc Biol 27:2355-62. 2007
    ..In this study, we tested the hypothesis that histone deacetylases 5 (HDAC5) and its signal pathway play a role in Ang II-induced VSMC hypertrophy...
  17. pmc Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation
    Xiangbin Xu
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 679, Rochester, New York 14642, USA
    Endocrinology 149:4183-92. 2008
    ....
  18. doi request reprint A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor
    Chang Hoon Ha
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
    J Biol Chem 283:7261-70. 2008
    ..These findings reveal a novel role for VE-cadherin in modulating c-Src activation in VEGF signaling, thus providing new insights into the importance of VE-cadherin in VEGF signaling and vascular function...
  19. ncbi request reprint Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt
    Matthew G Melaragno
    Center for Cardiovascular Research, Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Box MED, Rochester, NY 14642, USA
    J Mol Cell Cardiol 37:881-7. 2004
    ..These findings establish the Gas6-Axl-PI3K-Akt pathway as an anti-apoptotic mechanism for VSMC that may be important in the response to vascular injury...
  20. doi request reprint VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction
    Indika Edirisinghe
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    FASEB J 22:2297-310. 2008
    ..This explains the mechanism of endothelial dysfunction in smokers and has implications in understanding the pathogenesis of pulmonary and cardiovascular diseases...
  21. pmc Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation
    Kimio Satoh
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circulation 117:3088-98. 2008
    ....
  22. pmc VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism
    Qian Zhang
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:13491-9. 2008
    ....
  23. ncbi request reprint Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarction
    Craig R Narins
    Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 94:1285-7. 2004
    ....
  24. doi request reprint Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis
    Chang Hoon Ha
    The Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mol Cells 28:1-5. 2009
    ..This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis...
  25. ncbi request reprint Where is endothelial nitric oxide synthase more critical: plasma membrane or Golgi?
    Zheng Gen Jin
    Arterioscler Thromb Vasc Biol 26:959-61. 2006

Research Grants6

  1. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
    ..In this pathway, VEGFR2 may emerge as a central mediator for laminar flow atheroprotective effects, which will provide new insight into the prevention of atherosclerotic vascular disease. ..
  2. Receptor Tyrosine Kinases in Mechanotransduction
    Zheng Gen Jin; Fiscal Year: 2009
    ..In this pathway, VEGFR2 may emerge as a central mediator for laminar flow atheroprotective effects, which will provide new insight into the prevention of atherosclerotic vascular disease. ..