Research Topics
Genomes and Genes
| Zheng Gen JinSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesisChang Hoon Ha
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14586, USA
J Biol Chem 283:14590-9. 2008..These findings suggest that the PKD-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis...
Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthaseZheng Gen Jin
Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Circ Res 93:354-63. 2003..Finally, we show that inhibiting VEGFR2 kinase significantly reduces flow-mediated NO-dependent arteriolar dilation in vivo. These data identify VEGFR2 as a key mechanotransducer that activates eNOS in response to blood flow...- Cyclophilin A is a proinflammatory cytokine that activates endothelial cellsZheng Gen Jin
Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 24:1186-91. 2004..We therefore studied the proinflammatory effects of CyPA on vascular endothelium... - Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cellsZheng Gen Jin
Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 280:12305-9. 2005..Finally, knockdown of endogenous Gab1 by small interference RNA abrogated flow activation of Akt and eNOS. These data demonstrate a critical role of Gab1 in flow-stimulated PI3K/Akt/eNOS signal pathway in endothelial cells... - Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolaeAndreea O Lungu
Department of Medicine and Center for Cardiovascular Research, University of Rochester School of Medicine and Dentistry, Aab Institute of Biomedical Sciences, Rochester, New York 14642, USA
J Biol Chem 279:48794-800. 2004..These data suggest that decreasing cholesterol content in caveolae by CsA is a potentially important pathogenic mechanism for CsA-induced endothelial dysfunction and hypertension... - Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)Tatsuo Tanimoto
Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 277:42997-3001. 2002..These data are the first to establish a critical role of Flk-1/KDR in S1P-stimulated eNOS phosphorylation and activation... - Protein kinase C-dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factorChelsea Wong
Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 280:33262-9. 2005..Taken together, our results demonstrated for the first time that VEGF activates PKD via the VEGFR2/PLCgamma/PKCalpha pathway and revealed a critical role of PKD in VEGF-induced ERK signaling and endothelial cell proliferation... - VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesisChang Hoon Ha
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester Medical Center, Rochester, New York 14642, USA
Arterioscler Thromb Vasc Biol 28:1782-8. 2008..However, whether HDAC7 is involved in the processes of vascular endothelial signaling and angiogenesis remains unclear. Here, we investigated the role of HDAC7 in vascular endothelial growth factor (VEGF) signaling and angiogenesis... - Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOSWeiye Wang
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Blood 115:2971-9. 2010.... - Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cellsIndika Edirisinghe
Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
Antioxid Redox Signal 12:1355-69. 2010.... - Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesisJinjing Zhao
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
Arterioscler Thromb Vasc Biol 31:1016-23. 2011..The study was designed to investigate the role of endothelial Gab1 in angiogenesis and its underlying molecular mechanisms... 
Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1Bong Sook Jhun
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
Circ Res 110:59-70. 2012..ObjecTIVE: To determine if Rem1 function is physiologically regulated by adrenergic signaling and thus impacts voltage-gated L-type calcium channel (VLCC) activity in the heart...- PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophyChang Hoon Ha
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 107:15467-72. 2010..This pathway may represent a mechanism by which cAMP/PKA signaling modulates a wide range of biological functions and human diseases such as cardiomyopathy... - Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2Lung Kuo Tai
Cardiovascular Research Institute and Department of Medicine, University of Rochester, New York 14642, USA
J Biol Chem 280:29620-4. 2005..These results establish Tie2 transactivation via PECAM1 as an early event in flow-mediated mechanotransduction and suggest an important role for a PECAM1-SHP2-Tie2 pathway in flow-mediated signal transduction... - Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophyXiangbin Xu
Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine, NY 14642, USA
Arterioscler Thromb Vasc Biol 27:2355-62. 2007..In this study, we tested the hypothesis that histone deacetylases 5 (HDAC5) and its signal pathway play a role in Ang II-induced VSMC hypertrophy... - Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and AktMatthew G Melaragno
Center for Cardiovascular Research, Department of Medicine, Aab Institute for Biomedical Sciences, University of Rochester, Box MED, Rochester, NY 14642, USA
J Mol Cell Cardiol 37:881-7. 2004..These findings establish the Gas6-Axl-PI3K-Akt pathway as an anti-apoptotic mechanism for VSMC that may be important in the response to vascular injury... - A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factorChang Hoon Ha
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14586, USA
J Biol Chem 283:7261-70. 2008..These findings reveal a novel role for VE-cadherin in modulating c-Src activation in VEGF signaling, thus providing new insights into the importance of VE-cadherin in VEGF signaling and vascular function... - Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activationXiangbin Xu
Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 679, Rochester, New York 14642, USA
Endocrinology 149:4183-92. 2008.... - Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferationKimio Satoh
Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
Circulation 117:3088-98. 2008.... - VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunctionIndika Edirisinghe
Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
FASEB J 22:2297-310. 2008..This explains the mechanism of endothelial dysfunction in smokers and has implications in understanding the pathogenesis of pulmonary and cardiovascular diseases... - VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanismQian Zhang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 283:13491-9. 2008.... - Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarctionCraig R Narins
Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Am J Cardiol 94:1285-7. 2004.... - Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cellsJun Suzuki
Cardiovascular Research Institute, Department of Medicine, University of Rochester, NY 14642, USA
Circ Res 98:811-7. 2006..Our findings define a novel VSMC vesicular secretory pathway for CyPA that involves actin remodeling and myosin II activation via RhoA-, Cdc42-, and Rho kinase-dependent signaling events... - Protein kinase D1, a new molecular player in VEGF signaling and angiogenesisChang Hoon Ha
The Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Mol Cells 28:1-5. 2009..This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis... - Where is endothelial nitric oxide synthase more critical: plasma membrane or Golgi?Zheng Gen Jin
Arterioscler Thromb Vasc Biol 26:959-61. 2006
Research Grants
- Receptor Tyrosine Kinases in MechanotransductionZheng Gen Jin; Fiscal Year: 2009..In this pathway, VEGFR2 may emerge as a central mediator for laminar flow atheroprotective effects, which will provide new insight into the prevention of atherosclerotic vascular disease. ..
- Receptor Tyrosine Kinases in MechanotransductionZheng Gen Jin; Fiscal Year: 2009..In this pathway, VEGFR2 may emerge as a central mediator for laminar flow atheroprotective effects, which will provide new insight into the prevention of atherosclerotic vascular disease. ..