Xia Jin

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults
    Xia Jin
    Infectious Diseases Division, University of Rochester Medical Center, Rochester, NY 14642, United States xia
    Vaccine 27:7080-6. 2009
  2. ncbi request reprint An automated Dengue virus microneutralization plaque assay performed in human Fc{gamma} receptor-expressing CV-1 cells
    W W Shanaka I Rodrigo
    Departments of Pathology and Laboratory Medicine, Microbiology and Immunology, and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Trop Med Hyg 80:61-5. 2009
  3. pmc Dengue virus neutralization is modulated by IgG antibody subclass and Fcgamma receptor subtype
    W W Shanaka I Rodrigo
    Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA
    Virology 394:175-82. 2009
  4. pmc 9G4+ Antibodies Isolated from HIV-Infected Patients Neutralize HIV-1 and Have Distinct Autoreactivity Profiles
    Danielle C Alcena
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 8:e85098. 2013
  5. doi request reprint Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes
    Zhihua Kou
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Virology 410:240-7. 2011
  6. ncbi request reprint Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells
    Zhihua Kou
    Department of Medicine, Infectious Diseases Division, University of Rochester, Rochester, New York 14642, USA
    J Med Virol 80:134-46. 2008
  7. pmc Evaluation of multitype mathematical models for CFSE-labeling experiment data
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
    Bull Math Biol 74:300-26. 2012
  8. ncbi request reprint Statistical determination of threshold for cellular division in the CFSE-labeling assay
    Dacheng Liu
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, NY 14642, USA
    J Immunol Methods 312:126-36. 2006
  9. pmc Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture
    Carrie Dykes
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Clin Microbiol 44:1930-43. 2006
  10. pmc Human immunodeficiency virus type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypes
    Xia Jin
    Infectious Disease Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
    J Virol 76:12603-10. 2002

Detail Information

Publications19

  1. pmc A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults
    Xia Jin
    Infectious Diseases Division, University of Rochester Medical Center, Rochester, NY 14642, United States xia
    Vaccine 27:7080-6. 2009
    ..The responding CD4+ T cells made various combinations of IL-2, IL-4, IFN-gamma, and TNF-alpha. The study demonstrated that the EP-1043 vaccine is safe, well-tolerated, and immunogenic...
  2. ncbi request reprint An automated Dengue virus microneutralization plaque assay performed in human Fc{gamma} receptor-expressing CV-1 cells
    W W Shanaka I Rodrigo
    Departments of Pathology and Laboratory Medicine, Microbiology and Immunology, and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Trop Med Hyg 80:61-5. 2009
    ....
  3. pmc Dengue virus neutralization is modulated by IgG antibody subclass and Fcgamma receptor subtype
    W W Shanaka I Rodrigo
    Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA
    Virology 394:175-82. 2009
    ..Thus, the IgG antibody subclass profile generated by DENV infection or vaccination may independently influence the magnitude of the neutralizing response...
  4. pmc 9G4+ Antibodies Isolated from HIV-Infected Patients Neutralize HIV-1 and Have Distinct Autoreactivity Profiles
    Danielle C Alcena
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, United States of America Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 8:e85098. 2013
    ..Further studies of 9G4+ B cells may shed light on the regulation of B cell tolerance and interface between the generation of specific autoreactivities and the induction of antiviral immunity in persons living with HIV. ..
  5. doi request reprint Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes
    Zhihua Kou
    Department of Medicine, University of Rochester, Rochester, NY 14642, USA
    Virology 410:240-7. 2011
    ..These results demonstrate that the regulation of virus production in ADE infection of primary human monocytes is more complex than previously appreciated...
  6. ncbi request reprint Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells
    Zhihua Kou
    Department of Medicine, Infectious Diseases Division, University of Rochester, Rochester, New York 14642, USA
    J Med Virol 80:134-46. 2008
    ..They also demonstrate that using modern experimental technology, DV infection, and neutralization and enhancement of DV infection can be easily assessed simultaneously in multiple cell types...
  7. pmc Evaluation of multitype mathematical models for CFSE-labeling experiment data
    Hongyu Miao
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA
    Bull Math Biol 74:300-26. 2012
    ..This model was then employed to understand the proliferation pattern of CD4+ and CD8+ T cells under polyclonal stimulation...
  8. ncbi request reprint Statistical determination of threshold for cellular division in the CFSE-labeling assay
    Dacheng Liu
    Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, NY 14642, USA
    J Immunol Methods 312:126-36. 2006
    ..071% (95% confidence) and 0.114% (99% confidence) of total CFSE-labeled cells under our laboratory conditions. We offer our methods presented here for other investigators to calculate a threshold in their own CFSE-labeling experiments...
  9. pmc Evaluation of a multiple-cycle, recombinant virus, growth competition assay that uses flow cytometry to measure replication efficiency of human immunodeficiency virus type 1 in cell culture
    Carrie Dykes
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Clin Microbiol 44:1930-43. 2006
    ..This flow cytometry-based growth competition assay offers advantages over current assays for HIV replication efficiency and should prove useful for the evaluation of patient samples in clinical trials...
  10. pmc Human immunodeficiency virus type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypes
    Xia Jin
    Infectious Disease Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
    J Virol 76:12603-10. 2002
    ..05). The data are consistent with the hypothesis that higher levels of virus-specific CTL contribute to protection against HIV disease progression in infected individuals with B*35-PY, but not in those with B*35-Px...
  11. pmc APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremia
    Xia Jin
    Department of Medicine, University of Rochester, NY 14682, USA
    J Virol 79:11513-6. 2005
    ..00012) in these patients. Furthermore, we discovered that the order of hA3G mRNA levels is LTNPs > HIV-uninfected subjects > progressors...
  12. pmc The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children
    Mary T Caserta
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Brain Behav Immun 22:933-40. 2008
    ....
  13. pmc 9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activity
    James J Kobie
    Division of Allergy, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS ONE 7:e35356. 2012
    ..Our results suggest that the development of HIV BNAbs is not merely a consequence of a general breakdown in tolerance, but rather a more intricate expansion of selective autoreactive B cells and antibodies...
  14. pmc Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32)
    W W Shanaka I Rodrigo
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Crittenden Avenue, Rochester, NY 14642, USA
    J Virol 80:10128-38. 2006
    ....
  15. doi request reprint Dengue vaccine development and dengue viral neutralization and enhancement assays
    Xia Jin
    Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Antivir Ther 14:739-49. 2009
    ..We conclude that modification of current neutralization assays is required to improve the correlation between neutralization end point determinations and protection against secondary heterotypic dengue infections...
  16. ncbi request reprint HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses
    Jennifer E Snyder-Cappione
    David H Smith Center for Vaccine Biology and Immunology, and Department of Microbiology and Immunology, University of Rochester Medical Center, NY 14642, USA
    J Immunol 176:2662-8. 2006
    ..Analysis of the frequency of directly cytotoxic HIV-specific T cells may be of considerable value in the assessment of disease progression and the potential efficacy of HIV vaccines...
  17. pmc A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects
    Michael C Keefer
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA michael
    Vaccine 29:1948-58. 2011
    ..Thus, a heterologous poxvirus vector prime-boost regimen can induce HIV-specific CD8+ T-cell and CD4+ T-cell responses, which may be an important feature of an optimal regimen for preventive HIV vaccination...
  18. ncbi request reprint Establishment of an alternative intracellular cytokine staining assay for HIV/AIDS clinical studies
    Huiyuan Chen
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, NY 14642, USA
    J Virol Methods 123:131-40. 2005
    ..The results suggest that this ICS assay format is sensitive and specific, and is amenable to standardization for screening for HIV-specific CD8+ T cells in clinical trials...
  19. ncbi request reprint Association of family stress with natural killer cell activity and the frequency of illnesses in children
    Peter A Wyman
    Department of Psychiatry, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arch Pediatr Adolesc Med 161:228-34. 2007
    ..To examine prospective associations between chronic stress in the parent-child and family systems and subsequent rates of illnesses and the activity of natural killer (NK) cells in children...