Lee Way Jin

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death
    Lee Way Jin
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    J Mol Neurosci 19:57-61. 2002
  2. pmc Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis
    L W Jin
    Department of Pathology, University of Washington, Seattle 98195 6480, USA
    Am J Pathol 153:1679-86. 1998
  3. pmc Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities
    Lee Way Jin
    Department of Pathology, University of Washington, Seattle, Washington 98104 2499, USA
    Am J Pathol 164:975-85. 2004
  4. ncbi request reprint Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Pathol Int 52:551-4. 2002
  5. ncbi request reprint Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice
    Feng Shiun Shie
    Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195 7490, USA
    Neuroreport 14:123-9. 2003
  6. ncbi request reprint Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice
    Feng Shiun Shie
    Nutritional Sciences Interdisciplinary Program and Department of Pathology, Box 353410, Raitt Hall, Room 305, University of Washington, Seattle, WA 98195, USA
    Neuroreport 13:455-9. 2002
  7. ncbi request reprint Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease
    Simona Vuletic
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 44:1113-23. 2003
  8. ncbi request reprint Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurochem 91:1312-21. 2004
  9. pmc Imaging linear birefringence and dichroism in cerebral amyloid pathologies
    Lee Way Jin
    Departments of Chemistry and Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:15294-8. 2003
  10. ncbi request reprint Isoform-specific knockout of FE65 leads to impaired learning and memory
    Baiping Wang
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci Res 75:12-24. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death
    Lee Way Jin
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    J Mol Neurosci 19:57-61. 2002
    ..Lead compounds will now be selected for their abilities to ameliorate A beta/CTF-mediated pathology in transgenic mice. Our hope is that these compounds may eventually prove beneficial for the prevention and treatment of AD...
  2. pmc Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis
    L W Jin
    Department of Pathology, University of Washington, Seattle 98195 6480, USA
    Am J Pathol 153:1679-86. 1998
    ..The expression of IBM-like lesions was age dependent. These transgenic mice provide a model for the study of IBM and for the peripheral expression of a key element in the pathogenesis of Alzheimer disease...
  3. pmc Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities
    Lee Way Jin
    Department of Pathology, University of Washington, Seattle, Washington 98104 2499, USA
    Am J Pathol 164:975-85. 2004
    ..Our results suggest that endosomal abnormalities related to abnormal lipid trafficking in NPC may contribute to abnormal APP processing and Abeta42/C99/APP-CTF deposition...
  4. ncbi request reprint Alterations of chaperone protein expression in presenilin mutant neurons in response to glutamate excitotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Pathol Int 52:551-4. 2002
    ..These findings suggest that PS1 mutations may, in part, contribute to the development of DAT via altered expression of chaperone proteins...
  5. ncbi request reprint Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice
    Feng Shiun Shie
    Department of Pathology, University of Washington, School of Medicine, Seattle, WA 98195 7490, USA
    Neuroreport 14:123-9. 2003
    ..Our results are consistent with the notion that the earliest Abeta deposition occurs intraneuronally, prior to extracellular amyloid plaque formation...
  6. ncbi request reprint Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice
    Feng Shiun Shie
    Nutritional Sciences Interdisciplinary Program and Department of Pathology, Box 353410, Raitt Hall, Room 305, University of Washington, Seattle, WA 98195, USA
    Neuroreport 13:455-9. 2002
    ..Overall, plasma lipoproteins may be an important factor in induction of AD-like plaques in mice. The lowering of plasma lipids may be therapeutic for AD patients...
  7. ncbi request reprint Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease
    Simona Vuletic
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 44:1113-23. 2003
    ..Comparison between brain tissues from patients with Alzheimer's disease (AD) and nonAD subjects revealed a significant increase (P = 0.02) in PLTP levels in brain tissue homogenates and increased PLTP immunostaining in AD...
  8. ncbi request reprint Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity
    Izumi Maezawa
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Neurochem 91:1312-21. 2004
    ....
  9. pmc Imaging linear birefringence and dichroism in cerebral amyloid pathologies
    Lee Way Jin
    Departments of Chemistry and Pathology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:15294-8. 2003
    ..This investigation illustrates that the latest methods for the optical analysis of heterogeneous substances are useful for in situ study of amyloid...
  10. ncbi request reprint Isoform-specific knockout of FE65 leads to impaired learning and memory
    Baiping Wang
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci Res 75:12-24. 2004
    ..Reduced secretion of Abeta peptides was observed in primary neuronal cultures of hybrids of p97FE65(-/-)/betaPP transgenic (Tg2576) mice. These studies suggest an important and novel function of FE65 in learning and memory...
  11. doi request reprint Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate
    Izumi Maezawa
    Department of Pathology, Laboratory Medicine, Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Neurosci 30:5346-56. 2010
    ..Our results suggest that microglia may influence the onset and progression of RTT and that microglia glutamate synthesis or release could be a therapeutic target for RTT...
  12. pmc Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
    David G Cook
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Pathol 162:313-9. 2003
    ..These findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Abeta metabolism...
  13. ncbi request reprint Niemann-Pick disease type C yields possible clue for why cerebellar neurons do not form neurofibrillary tangles
    Bitao Bu
    Department of Pathology, University of Washington, Seattle, 98195, USA
    Neurobiol Dis 11:285-97. 2002
    ..Even without NFT, cerebellar neurodegeneration may be triggered by the inappropriate activation of the cell cycle cdc2 kinase, and the npc-1 murine model provides an opportunity to test this hypothesis...
  14. ncbi request reprint A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes
    Izumi Maezawa
    MIND Institute and Department of Pathology, University of California Davis, Sacramento, California, USA
    J Neurochem 98:57-67. 2006
    ..CP2 analogs represent a new class of promising compounds for the amelioration of Abeta toxicities within both intracellular and extracellular sites...
  15. ncbi request reprint Characterization of radioiodinated ligand binding to amyloid beta plaques
    Mei Ping Kung
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19014, USA
    J Mol Neurosci 20:249-54. 2003
    ....
  16. ncbi request reprint Congo red and thioflavin-T analogs detect Abeta oligomers
    Izumi Maezawa
    M I N D Institute and Department of Pathology, University of California Davis, Sacramento, California 95817, USA
    J Neurochem 104:457-68. 2008
    ..We propose that by improving the binding affinity of current ligands, in vivo imaging of AbetaO is feasible by a 'signal subtraction' procedure. This approach may facilitate the identification of individuals with early AD...
  17. ncbi request reprint Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease
    Erin M Ramos
    Institute for Public Health Genetics, Department of Medicine, University of Washington, Seattle, WA, USA
    Arch Neurol 63:1165-9. 2006
    ..Functional polymorphisms in tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) can affect immune response, inflammation, tissue injury, and possibly the susceptibility to Alzheimer disease (AD)...
  18. ncbi request reprint Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro
    Simona Vuletic
    Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington 98109 4517, USA
    J Neurosci Res 80:406-13. 2005
    ..The findings of reduced PLTP activity in AD CSF, and the observation that PLTP can influence apoE secretion in astrocytes suggest a potential link between alterations in the brain lipid metabolism and AD pathogenesis...
  19. ncbi request reprint Polarimetric imaging of amyloid
    Werner Kaminksy
    Department of Chemistry, University of Washington, Box 351700, Seattle, Washington, USA
    Micron 37:324-38. 2006
    ..The application of polarimetric imaging as demonstrated here can be extended to broader pathological practice since polarimetric measurements are sensitive to transformations in tissues that are specific disease signatures...
  20. pmc Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity
    Hyun Seok Hong
    M I N D Institute and Department of Pathology, UC Davis Cancer Center, University of California Davis, Sacramento, CA 95817, USA
    Brain Res 1130:223-34. 2007
    ..Both assays are simple, suitable for rapid screening of a large number of medicinal libraries, and amenable for automation...
  21. ncbi request reprint Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients
    Michael J House
    School of Physics, University of Western Australia, Perth, Australia
    Magn Reson Med 57:172-80. 2007
    ..High-field MRI may therefore be a useful research tool for assessing brain iron changes associated with AD...
  22. ncbi request reprint New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques
    Rajesh Chandra
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Med Chem 50:2415-23. 2007
    ..These preliminary results suggest that the novel diphenylacetylenes may be potentially useful for imaging of Abeta plaques in the brain of patients with Alzheimer's disease...
  23. pmc Radioiodinated aza-diphenylacetylenes as potential SPECT imaging agents for beta-amyloid plaque detection
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Bioorg Med Chem Lett 17:3581-4. 2007
    ..Taken together, these preliminary results strongly suggest that these novel iodinated aza-diphenylacetylenes may be potentially useful for imaging Abeta plaques in the living human brain...
  24. pmc Mapping the structural transition in an amyloidogenic apolipoprotein A-I
    Jens O Lagerstedt
    Department of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA
    Biochemistry 46:9693-9. 2007
    ....
  25. ncbi request reprint Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
    Jin Xu
    Department of Neurology, Harvard Medical School and Division of Neuroscience, The Children s Hospital, Boston, Massachusetts, USA
    Nat Med 8:600-6. 2002
    ..Thus, accumulation of soluble alpha-synuclein protein complexes can render endogenous dopamine toxic, suggesting a potential mechanism for the selectivity of neuronal loss in PD...
  26. ncbi request reprint Genetic modulation of tau phosphorylation in the mouse
    Jochen Brich
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 23:187-92. 2003
    ..Dab1 mutant mice provide an animal model for studying the relationships between ApoE receptors, tau hyperphosphorylation, and Alzheimer's disease...