Research Topics
| Glen C JicklingSummaryAffiliation: University of California Country: USA Publications
| Collaborators |
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Publications
Genome response to tissue plasminogen activator in experimental ischemic strokeGlen C Jickling
Department of Neurology and M, I, N, d, Institute, University of California at Davis, Sacramento, California 95817, USA
BMC Genomics 11:254. 2010..To further delineate tPA functions in the blood, we examined the gene expression profiles induced by tPA in a rat model of ischemic stroke...- Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct locationGlen C Jickling
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, CA 95817, USA
Stroke 43:2036-41. 2012..We demonstrate how gene expression profiles in blood can be used in conjunction with a measure of infarct location on neuroimaging to predict a probable cause in cryptogenic stroke... - Ischemic transient neurological events identified by immune response to cerebral ischemiaGlen C Jickling
University of California at Davis, MIND Institute, 2805 50th Street, Sacramento, CA 95817, USA
Stroke 43:1006-12. 2012..Ischemia of cerebral tissue elicits an immune response in stroke and transient ischemic attack (TIA). This response, as detected by RNA expressed in immune cells, could potentially distinguish ischemic from nonischemic TNE... - Profiles of lacunar and nonlacunar strokeGlen C Jickling
Department of Neurology and the MIND Institute, University of California at Davis, Sacramento, CA 95817, USA
Ann Neurol 70:477-85. 2011..We sought to distinguish lacunar from nonlacunar causes of SDIs using a gene expression profile... - Blood biomarkers of ischemic strokeGlen C Jickling
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, CA 95817, USA
Neurotherapeutics 8:349-60. 2011..With further well designed study and careful validation, the development of blood biomarkers to improve the care of patients with ischemic stroke may be achieved... - Signatures of cardioembolic and large-vessel ischemic strokeGlen C Jickling
Department of Neurology and the MIND Institute, University of California at Davis, Sacramento, CA 95817, USA
Ann Neurol 68:681-92. 2010..We sought to determine whether gene expression signatures in blood can distinguish between cardioembolic and large-vessel causes of stroke, and whether these profiles can predict stroke etiology in the cryptogenic group... - Effects of gender on gene expression in the blood of ischemic stroke patientsYingfang Tian
Department of Neurology, The MIND Institute, University of California at Davis, Sacramento, CA, USA
J Cereb Blood Flow Metab 32:780-91. 2012..Gender affects gene expression in the blood of IS patients, which likely implies gender differences in immune, inflammatory, and cell death responses to stroke... 
GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: a pilot studyYingfang Tian
University of California at Davis, M I N D, Institute and Department of Neurology, USA
Brain Res 1381:228-36. 2011..This pilot study suggests that at least some of these GABA- and ACh-related genes observed in blood that correlate with tics or are alternatively spliced are involved in the pathophysiology of TS and tics...- Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in Tourette syndrome: a pilot studyYingfang Tian
MIND Institute and Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
BMC Med Genomics 5:49. 2012..This study determined if gene expression in blood correlated significantly with IA and/or HI rating scale scores in participants with TS... - Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controlsYingfang Tian
Department of Neurology and the MIND Institute, University of California at Davis, Sacramento, California 95817, USA
Gend Med 9:68-75.e3. 2012.... - RNA expression profiles from blood for the diagnosis of stroke and its causesFrank R Sharp
Department of Neurology, University of California at Davis, Sacramento, CA, USA
J Child Neurol 26:1131-6. 2011..These profiles will be useful for predicting the causes of cryptogenic stroke. The results in adults suggest that similar diagnostic tools could be developed for children... - Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humansFrank R Sharp
Department of Neurology, MIND Institute, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 31:1513-31. 2011..New techniques to measure all coding and noncoding RNAs along with alternatively spliced transcripts will markedly advance molecular studies of human stroke... - Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjectsYingfang Tian
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, CA 95817, United States
J Neuroimmunol 230:124-9. 2011..However, given that multiple comparisons were performed on a very small sample, these preliminary findings require confirmation using a much larger independent cohort... - Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cellsDa Zhi Liu
Department of Neurology and the M I N D Institute, University of California at Davis, Sacramento, CA 95817, USA
Gene 495:120-7. 2012..g., miR-370, miR-9, miR-672) in NBCs are associated with cancer pathways. These results provide a library of negative mRNAmiRNA networks that are likely involved in the cellular processes of differentiation and division... - Genome wide differences of gene expression associated with HLA-DRB1 genotype in multiple sclerosis: A pilot studyMichelle L Apperson
Department of Neurology and the M I N D Institute, University of California at Davis, Sacramento, CA 95817, United States Department of Neurology, VA Northern California Health System, Mather, CA 95655, United States Electronic address
J Neuroimmunol 257:90-6. 2013..Different risk alleles appear to be associated with different patterns of gene expression that may reflect differences in pathophysiology of these two MS subtypes. These preliminary data will need to be confirmed in future studies... - Exon expression and alternatively spliced genes in Tourette SyndromeYingfang Tian
M I N D Institute, Department of Neurology, University of California at Davis, Sacramento, 95817, USA
Am J Med Genet B Neuropsychiatr Genet 156:72-8. 2011..However, the findings are tempered by the small sample size and multiple comparisons and require confirmation using PCR or deep RNA sequencing and a much larger patient population...