G A Jicha

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Attention-deficit/hyperactivity disorder in childhood is associated with cognitive test profiles in the geriatric population but not with mild cognitive impairment or Alzheimer's disease
    N Ivanchak
    Sanders Brown Center on Aging and the University of Kentucky Alzheimer s Disease Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Aging Res 2011:729801. 2011
  2. pmc Is passive immunization for Alzheimer's disease 'alive and well' or 'dead and buried'?
    Gregory A Jicha
    University of Kentucky College of Medicine, Sanders Brown Center on Aging, Alzheimer s Disease Center, Department of Neurology, 800 South Limestone Street, Lexington, KY 40536 0230, USA
    Expert Opin Biol Ther 9:481-91. 2009
  3. pmc Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 31:1805-13. 2010
  4. pmc Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials
    Sarah A Carr
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Alzheimer Dis Assoc Disord 24:165-70. 2010
  5. pmc Conceptual evolution in Alzheimer's disease: implications for understanding the clinical phenotype of progressive neurodegenerative disease
    Gregory A Jicha
    Department of Neurology and Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 19:253-72. 2010
  6. pmc Clinical features of mild cognitive impairment differ in the research and tertiary clinic settings
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
    Dement Geriatr Cogn Disord 26:187-92. 2008
  7. pmc Omega-3 fatty acids: potential role in the management of early Alzheimer's disease
    Gregory A Jicha
    University of Kentucky, Alzheimer s Disease Center and the Sanders Brown Center on Aging University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
    Clin Interv Aging 5:45-61. 2010
  8. pmc Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies
    Gregory A Jicha
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Room 223, 800 South Limestone Street, Lexington, KY 40536, USA
    J Mol Neurosci 45:713-23. 2011
  9. ncbi request reprint Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment
    Gregory A Jicha
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 65:602-9. 2006
  10. ncbi request reprint Neuropathologic features of amnestic mild cognitive impairment
    Ronald C Petersen
    Alzheimer s Disease Research Center and Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 63:665-72. 2006

Detail Information

Publications28

  1. pmc Attention-deficit/hyperactivity disorder in childhood is associated with cognitive test profiles in the geriatric population but not with mild cognitive impairment or Alzheimer's disease
    N Ivanchak
    Sanders Brown Center on Aging and the University of Kentucky Alzheimer s Disease Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    J Aging Res 2011:729801. 2011
    ....
  2. pmc Is passive immunization for Alzheimer's disease 'alive and well' or 'dead and buried'?
    Gregory A Jicha
    University of Kentucky College of Medicine, Sanders Brown Center on Aging, Alzheimer s Disease Center, Department of Neurology, 800 South Limestone Street, Lexington, KY 40536 0230, USA
    Expert Opin Biol Ther 9:481-91. 2009
    ..Current approaches, based on data demonstrating behavioral improvement and reduced pathology in transgenic animal models, have focused exclusively on immune targeting of beta-amyloid. Objective: To examine immunization strategies for AD...
  3. pmc Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Neurobiol Aging 31:1805-13. 2010
    ....
  4. pmc Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials
    Sarah A Carr
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Alzheimer Dis Assoc Disord 24:165-70. 2010
    ..Our results suggest that outreach efforts directed at the potential study subject/caregiver are not only cost-effective but are able to easily accomplish the desired result of direct recruitment into clinical research studies...
  5. pmc Conceptual evolution in Alzheimer's disease: implications for understanding the clinical phenotype of progressive neurodegenerative disease
    Gregory A Jicha
    Department of Neurology and Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 19:253-72. 2010
    ....
  6. pmc Clinical features of mild cognitive impairment differ in the research and tertiary clinic settings
    G A Jicha
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
    Dement Geriatr Cogn Disord 26:187-92. 2008
    ..Comparative analysis of subjects with mild cognitive impairment (MCI) diagnosed in a primary research setting and those seen in a tertiary care memory disorders clinic...
  7. pmc Omega-3 fatty acids: potential role in the management of early Alzheimer's disease
    Gregory A Jicha
    University of Kentucky, Alzheimer s Disease Center and the Sanders Brown Center on Aging University of Kentucky College of Medicine, Lexington, KY 40536 0230, USA
    Clin Interv Aging 5:45-61. 2010
    ..However, these trials produced intriguing data suggesting that the beneficial effects of omega-3 fatty acid supplementation may depend on the stage of disease, other dietary mediators, and apolipoprotein E status...
  8. pmc Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies
    Gregory A Jicha
    Sanders Brown Center on Aging, University of Kentucky College of Medicine, Room 223, 800 South Limestone Street, Lexington, KY 40536, USA
    J Mol Neurosci 45:713-23. 2011
    ..This manuscript highlights the importance of establishing an effective therapeutic partnership between the physician and caregiver in the medical management of the person suffering from FTD...
  9. ncbi request reprint Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment
    Gregory A Jicha
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Neuropathol Exp Neurol 65:602-9. 2006
    ..AGD is a common pathologic finding in subjects who have been diagnosed with amnestic MCI...
  10. ncbi request reprint Neuropathologic features of amnestic mild cognitive impairment
    Ronald C Petersen
    Alzheimer s Disease Research Center and Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 63:665-72. 2006
    ..The neuropathologic substrate of amnestic mild cognitive impairment (aMCI) is not known...
  11. pmc Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies
    P T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, 800 S Limestone, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurology 73:1127-33. 2009
    ..Recent studies raised questions about the severity of cognitive impairment associated with dementia with Lewy bodies (DLB). However, there have been few analyses of large, multicenter data registries for clinical-pathologic correlation...
  12. ncbi request reprint Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia
    Gregory A Jicha
    Alzheimer s Disease Research Center and Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 63:674-81. 2006
    ..The pathologic outcome of patients diagnosed with mild cognitive impairment (MCI) following progression to dementia is poorly understood...
  13. ncbi request reprint Brain structural alterations before mild cognitive impairment
    C D Smith
    MRISC, Room 62, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536
    Neurology 68:1268-73. 2007
    ..To determine whether alterations of brain structure in normal aged individuals precede the development of mild cognitive impairment (MCI) or Alzheimer disease (AD)...
  14. pmc Differential reports of pain and depression differentiate mild cognitive impairment from cognitively intact elderly participants
    T M Kruger
    Graduate Center for Gerontology, University of Kentucky, Lexington, KY, USA
    J Geriatr Psychiatry Neurol 25:107-12. 2012
    ....
  15. pmc Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB
    Peter T Nelson
    Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY, USA
    J Alzheimers Dis 16:29-34. 2009
    ..In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline...
  16. pmc Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 66:1136-46. 2007
    ..Our data show that there are many important contributory causes to cognitive decline in older persons. However, NFTs and NPs should not be dismissed as irrelevant in AD based on clinicopathologic correlation...
  17. pmc Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies
    Peter T Nelson
    Department of Pathology, University of Kentucky, Lexington, KY 40536 0230, USA
    Acta Neuropathol 121:571-87. 2011
    ..In conclusion, it may be most fruitful to focus attention on specific pathways involved in AD rather than attributing it to an inevitable consequence of aging...
  18. pmc Association between male gender and cortical Lewy body pathology in large autopsy series
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, Sanders Brown Center on Aging, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:1875-81. 2010
    ..05 for both). Males are far more likely than females to die with neocortical LB pathology. This phenomenon may help guide medical practice including clinical trial study design...
  19. pmc Human cerebral neuropathology of Type 2 diabetes mellitus
    Peter T Nelson
    Department of Pathology, Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
    Biochim Biophys Acta 1792:454-69. 2009
    ..These preliminary, correlative, and descriptive studies may help develop new hypotheses about CNDM2. We conclude that more work should be performed on human material in the context of CNDM2...
  20. pmc Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 450:336-9. 2009
    ..Our results are not consistent with the idea that the precuneus is involved in a special way with plaques or tangles relative to other areas of neocortex...
  21. pmc Low sensitivity in clinical diagnoses of dementia with Lewy bodies
    Peter T Nelson
    Division of Neuropathology, Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Rm 311, Sanders Brown Building, 800 S Limestone, Lexington, KY 40536 0230, USA
    J Neurol 257:359-66. 2010
    ..Our data suggest that further work is needed to refine our ability to identify specific aging-related brain disease mechanisms, especially in DLB...
  22. pmc Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, University of Kentucky Medical Center, Sanders Brown Center on Aging and Alzheimer s Disease Center, University of Kentucky, Lexington, KY, USA
    Brain Pathol 20:66-79. 2010
    ..There was no support for independent association between CILA severity and most evaluated indices including diffuse plaques, argyrophilic grains, heart disease, education level, apolipoprotein E alleles or diabetes...
  23. pmc Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease
    Peter T Nelson
    Department of Pathology and Division of Neuropathology, Univerisity of Kentucky, Lexington, Kentucky 40536 0230, USA
    J Neuropathol Exp Neurol 68:774-84. 2009
    ..We conclude that NFT+/NP- cases comprise approximately 5% of aged individuals in multiple data sets; these cases are not necessarily within the spectrum of AD...
  24. pmc Lewy body pathology in normal elderly subjects
    William R Markesbery
    Alzheimer s Disease Center and the Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    J Neuropathol Exp Neurol 68:816-22. 2009
    ..Overall, our findings support the concept that incidental Lewy body disease most likely represents preclinical or presymptomatic Parkinson disease, Parkinson disease with dementia, or dementia with Lewy bodies...
  25. pmc Age and apoE associations with complex pathologic features in Alzheimer's disease
    Gregory A Jicha
    Department of Neurology, Mayo Clinic, Rochester, MN, Jacksonville, FL, United States
    J Neurol Sci 273:34-9. 2008
    ....
  26. ncbi request reprint Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: a prospective cohort study
    Yonas E Geda
    Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Arch Neurol 63:435-40. 2006
    ..It remains unknown whether depression and apolipoprotein E genotype are risk factors for incident mild cognitive impairment (MCI)...
  27. doi request reprint Primary diffuse leptomeningeal gliomatosis
    Gregory A Jicha
    Department of Neurology and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA
    Eur Neurol 62:16-22. 2009
    ..Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare presentation of a primary central nervous system glial tumor...
  28. ncbi request reprint Pseudotumor cerebri reversed by cardiac septal defect repair
    Gregory A Jicha
    Mayo Clinic, Department of Neurology, Rochester, MN 55905, USA
    Neurology 60:2016-7. 2003