Research Topics
Genomes and Genes | Zhong JiangSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective studyZhong Jiang
University of Massachusetts Medical Center, Department of Pathology, Worcester, MA, USA
Lancet Oncol 7:556-64. 2006..We aimed to investigate whether IMP3, an oncofetal RNA-binding protein, can be used as a biomarker to predict metastasis and prognosis of renal-cell carcinoma...
Combination of quantitative IMP3 and tumor stage: a new system to predict metastasis for patients with localized renal cell carcinomasZhong Jiang
Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusettes, USA
Clin Cancer Res 14:5579-84. 2008..To create an easily applicable system based on a combination of the quantitative level of IMP3 (an oncofetal protein) and tumor stage to more accurately predict postoperative metastasis of localized renal cell carcinoma...- P504S: a new molecular marker for the detection of prostate carcinomaZ Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Am J Surg Pathol 25:1397-404. 2001..Our findings indicate that P504S is a highly sensitive and specific positive marker for prostate carcinoma... - Prognostic biomarkers in renal cell carcinomaZhong Jiang
University of Massachusetts Medical School, Department of Pathology, Three Biotech, Worcester, MA 01605, USA
Expert Rev Mol Diagn 7:293-307. 2007.... - [Alpha-methylacyl-CoA racemase: a useful marker for diagnosis of prostatic carcinoma.]Zhong Jiang
Department of Pathology, University of Massachusetts Medical School, MA 01655, USA
Zhonghua Bing Li Xue Za Zhi 33:401-3. 2004 - A dietary enzyme: alpha-methylacyl-CoA racemase/P504S is overexpressed in colon carcinomaZhong Jiang
Department of Pathology, University of Massachusetts Medical School, Room H2 436, 55 Lake Avenue, Worcester, MA 01655, USA
Cancer Detect Prev 27:422-6. 2003..AMACR may also serve as a molecular marker for colon cancers and its precursor lesions... - Diagnostic utility of alpha-methylacyl CoA racemase (P504S) on prostate needle biopsyZhong Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Adv Anat Pathol 11:316-21. 2004..We also discuss the potential pitfalls and caveats in the interpretation of immunostaining results... 
Oncofetal protein IMP3: a novel molecular marker that predicts metastasis of papillary and chromophobe renal cell carcinomasZhong Jiang
Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
Cancer 112:2676-82. 2008..Whether an oncofetal protein, IMP3, can serve as a prognostic biomarker to predict metastasis for patients with localized papillary and chromophobe subtypes of renal cell carcinomas (RCCs) was investigated...- An oncofetal protein IMP3: a new molecular marker for the detection of esophageal adenocarcinoma and high-grade dysplasiaDi Lu
Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA
Am J Surg Pathol 33:521-5. 2009..The data also suggest that IMP3, an oncofetal protein, may play an important role in malignant transformation in esophageal adenocarcinoma... - P504S/alpha-methylacyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsyZhong Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts General Hospital, Boston, Massachusetts 01655, USA
Am J Surg Pathol 26:1169-74. 2002..Using a combination of P504S and 34betaE12 can help the diagnosis of limited prostatic adenocarcinoma on needle biopsy... - IMP3 predicts aggressive superficial urothelial carcinoma of the bladderLioudmila Sitnikova
Department of Urology, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
Clin Cancer Res 14:1701-6. 2008..In this study, we investigated whether an oncofetal protein, IMP3, can serve as a new biomarker to predict progression and metastasis of early-stage urothelial carcinoma of the bladder... - P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimensZhong Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester, USA
Am J Clin Pathol 121:99-107. 2004..Thus, the consensus diagnosis rate improved from poor to good after supplementing 34 beta E12 immunostaining with P504S... - Expression of alpha-Methylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostateXiming J Yang
Department of Pathology, University of Chicago, Illinois, USA
Am J Surg Pathol 26:921-5. 2002..Because most cases of AAH are negative for P504S, immunostaining of P504S is also of diagnostic value in distinguishing the majority of AAHs from prostatic adenocarcinoma... - IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expressionCuizhen Li
Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA
Mod Pathol 20:242-7. 2007.... - Analysis of alpha-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasiaChin-Lee Wu
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Hum Pathol 35:1008-13. 2004..This study provides additional evidence to link high-grade PIN as a precursor lesion to prostatic adenocarcinoma... - IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancerDi Lu
Department of Pathology, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical Center, Worcester, USA
Am J Surg Pathol 35:1638-45. 2011..IMP3 plays a critical role in the development of invasive SCC from cervical dysplasia. IMP3 can be used at the time of initial diagnosis of CIN to identify a group of patients with an increased chance of developing invasive cancer... - Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S)Zhong Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
Am J Clin Pathol 122:275-89. 2004.... - Expression of alpha-methylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: astudy of 761 casesZhong Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Hum Pathol 34:792-6. 2003..Our data provide important baseline information for using AMACR in clinical practice and also are valuable in furthering understanding of the pathogenic role of AMACR in malignant neoplasms... - Using an AMACR (P504S)/34betaE12/p63 cocktail for the detection of small focal prostate carcinoma in needle biopsy specimensZhong Jiang
Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA
Am J Clin Pathol 123:231-6. 2005.... - Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancerIrwin Leav
Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
Am J Pathol 176:393-401. 2010..Targeting this pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer... - The oncofetal protein IMP3: a novel biomarker for endometrial serous carcinomaWenxin Zheng
Department of Pathology, University of Arizona Medical College, Tucson, AZ 85724, USA
Am J Surg Pathol 32:304-15. 2008..Although the significance of the latter finding remains unclear, the differential diagnosis between decidual changes and endometrial serous carcinoma is rarely problematic... - Overlapping features between dedifferentiated liposarcoma and undifferentiated high-grade pleomorphic sarcomaLawrance Chung
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 33:1594-600. 2009.... - Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistryWanda M P Coston
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Am J Surg Pathol 32:433-44. 2008..GPC3 immunoreactivity, in combination with a complete CD34 immunostaining pattern, greatly facilitates the accuracy of distinguishing between malignant hepatic lesions and benign mimickers... - Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesisYuet Kin Leung
Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
Cancer Res 65:3726-34. 2005..Collectively, these data provided the first evidence that CYP1A1 overexpression and alternative splicing could contribute to ovarian cancer initiation and progression... - Estrogen receptor-beta expression in human testicular germ cell tumorsVernon Pais
Division of Urology, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Clin Cancer Res 9:4475-82. 2003..For completeness, expression of androgen and progesterone receptors was also investigated... - Detection of alpha-methylacyl-coenzyme A racemase in postradiation prostatic adenocarcinomaXiming J Yang
Department of Pathology, University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA
Urology 62:282-6. 2003..AMACR immunostaining facilitates the challenging differentiation between prostatic adenocarcinoma and radiation-induced atypia in benign prostatic epithelium and may be of exceptional value in limited needle biopsies... - Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zoneIrwin Leav
Department of Pathology, Division of Urology, University of Massachusetts Medical School, Worcester, MA, USA
Hum Pathol 34:228-33. 2003.... - Oncofetal protein IMP3, a new diagnostic biomarker to distinguish malignant mesothelioma from reactive mesothelial proliferationMin Shi
Department of Pathology, University of Massachusetts Medical Center, One Innovation Drive, Worcester, MA 01605, USA
Am J Surg Pathol 35:878-82. 2011..IMP3 immunohistochemical staining can be used as an adjunct tool in the distinction of malignant mesothelioma from reactive mesothelial proliferations... - The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningiomaSuyang Hao
Department of Pathology, University of Massachusetts Medical Center, Worcester, USA
Arch Pathol Lab Med 135:1032-6. 2011..One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors... - Sensitivity of P504S/alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry for the detection of prostate carcinoma on stored needle biopsiesVijay K Vanguri
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Appl Immunohistochem Mol Morphol 14:365-8. 2006.... - Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1Hira Lal Goel
Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Cancer Res 69:5374-82. 2009..In conclusion, our novel findings indicate that expression of the beta(1C) integrin variant in prostate glands prevents cancer progression by up-regulation of TSP1 levels and inhibition of angiogenesis... - Myopericytoma of the kidneySean K Lau
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
Hum Pathol 41:1500-4. 2010..The present case serves to expand the anatomical distribution of myopericytoma and also broadens the spectrum of primary mesenchymal neoplasms that may be encountered in the kidney... - Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitroJames A Mobley
Department of Surgery, Division of Urology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Cancer Epidemiol Biomarkers Prev 12:775-83. 2003..Our findings therefore provide a link between the consumption of dietary fatty acids and the enhanced expression of AMACR, an enzyme that may play an important role in genesis and progression of CaP... - Intestinal type of mucinous borderline tumor arising from mixed epithelial and stromal tumor of kidneyPeiguo G Chu
Department of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
Virchows Arch 455:389-94. 2009..There was no invasive mucinous tumor identified. We believe that this case represents the first reported example of mucinous borderline tumor arising from a MESTK... - Oncofetal protein IMP3: a useful diagnostic biomarker for leiomyosarcomaKristine Cornejo
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Hum Pathol 43:1567-72. 2012.... - Prostate cancer regulatory networksDario C Altieri
Department of Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
J Cell Biochem 107:845-52. 2009.... - Tumor immunotherapy by converting tumor cells to MHC class II-positive, Ii protein-negative phenotypeXueqing Lu
Antigen Express, 100 Barber Avenue, Worcester, MA 01606, USA
Cancer Immunol Immunother 52:592-8. 2003..Our method provides an effective immunotherapy warranting further development for human cancers... - Hepatocyte antigen as a marker of intestinal metaplasiaPeiguo G Chu
Department of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
Am J Surg Pathol 27:952-9. 2003..The specificity and sensitivity of Hep for intestinal metaplasia were higher than that of keratin 7 and keratin 20, or MUC2. We conclude that Hep may be used as a single diagnostic marker for intestinal metaplasia... - Expression and diagnostic utility of alpha-methylacyl-CoA-racemase (P504S) in foamy gland and pseudohyperplastic prostate cancerMing Zhou
Department of Pathology, John Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Am J Surg Pathol 27:772-8. 2003..The major caveat in the interpretation of positive staining is that high-grade prostatic intraepithelial neoplasia cannot be in the differential diagnosis... - Intercellular adhesion molecules (ICAM-1, VCAM-1, and LFA-1) in adenocarcinoma of lung. Technical aspectsArmando E Fraire
Department of Pathology, University of Massachusetts Memorial Medical Center, Worcester, MA, USA
Methods Mol Med 74:243-9. 2003 - Expression of alpha-methylacyl-coenzyme A racemase in nephrogenic adenomaAnita Gupta
Department of Pathology, Northwestern Memorial Hospital Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Am J Surg Pathol 28:1224-9. 2004..These findings could be explained by possible renal tubular origin or renal differentiation, at least in a subset, of nephrogenic adenomas... - A novel diagnostic test for prostate cancer emerges from the determination of alpha-methylacyl-coenzyme a racemase in prostatic secretionsP J Zielie
Departments of Surgery (Division of Urology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-2324, USA
J Urol 172:1130-3. 2004..Furthermore, early results demonstrate a trend toward excluding patients with clinically insignificant disease that may not yet require aggressive treatment due to a low cancer burden... - Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancerAndrew H Fischer
Department of Pathology, University of Massachusetts UMMHC, Worcester, Massachusetts 01655, USA
J Cell Biochem 91:170-84. 2004..NE irregularity could also promote chromosomal instability because it leads to chromosomal asymmetry in metaphase. Finally, NE irregularity could impact replication competence, transcriptional programming and nuclear pore function... - Alpha-methylacyl-CoA racemase: a multi-institutional study of a new prostate cancer markerZ Jiang
University of Massachusetts Medical School, Worcester, MA, USA
Histopathology 45:218-25. 2004..To test whether alpha-methylacyl-CoA racemase (AMACR) is a sensitive and specific marker of prostate cancer... - Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinomaC L Campbell
Cytokine Cytokine Receptor Laboratory, LINK Laboratories, University of Massachusetts Cancer Center, University of Massachusetts Medical School, Worcester 01655, USA
Am J Pathol 158:25-32. 2001..Thus, the IL-11 receptor system is up-regulated in prostate carcinoma, and may be one part of a cytokine network that maintains STAT3 in its activated form in these tissues... - Detection of prostate cancer by alpha-methylacyl CoA racemase (P504S) in needle biopsy specimens previously reported as negative for malignancyB M Carswell
Department of Surgery, Urology Division, University of Massachusetts Medical School, Worcester, MA 01655, USA
Histopathology 48:668-73. 2006.... - p53: a good diagnostic marker for intratubular germ cell neoplasia, unclassifiedB E Moore
Department of Pathology, University of Massachusetts Memorial Medical Center, Worcester 01655, USA
Appl Immunohistochem Mol Morphol 9:203-6. 2001..The current findings also suggest that p53 may be involved as an early step in the malignant progression of most germ cell neoplasias... - Alpha-methylacyl coenzyme A racemase as a marker for prostate cancerZhong Jiang
JAMA 287:3080-1; author reply 3081. 2002 - Florid basal cell hyperplasia of the prostate: a histological, ultrastructural, and immunohistochemical analysisXiming J Yang
Department of Pathology and Surgery, University of Chicago, Chicago, IL 60611, USA
Hum Pathol 34:462-70. 2003.... - Expression of a novel oncofetal mRNA-binding protein IMP3 in endometrial carcinomas: diagnostic significance and clinicopathologic correlationsCuizhen Li
Riverside Methodist Hospital, 3535 Olentangy River Road, Columbus, OH 43214, USA
Mod Pathol 20:1263-8. 2007..In addition, expression of IMP3 in endometrioid adenocarcinoma correlates with higher nuclear and architecture grades of the tumor (P=0.0000 and P=0.0002, respectively)... - External validation of IMP3 expression as an independent prognostic marker for metastatic progression and death for patients with clear cell renal cell carcinomaNathan E Hoffmann
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer 112:1471-9. 2008.... - Alpha-methylacyl-CoA racemase (P504S)/34betaE12/p63 triple cocktail stain in prostatic adenocarcinoma after hormonal therapyMing Tse Sung
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Hum Pathol 38:332-41. 2007..A triple cocktail stain using AMACR, 34betaE12, and p63 can be helpful in evaluating prostate specimens for the presence of residual or recurrent carcinoma after hormonal therapy for cancer... - Laparoscopic radical prostatectomy: initial 70 cases at a U.S. university medical centerDouglas M Dahl
Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Urology 60:859-63. 2002..The morbidity of this operation is significantly less than that of radical retropubic prostatectomy. The laparoscopic approach shows significant promise for reducing surgical morbidity and improving the anatomic radical prostatectomy... - Epidermal growth factor receptor (EGFR) expression in prostatic adenocarcinoma after hormonal therapy: a fluorescence in situ hybridization and immunohistochemical analysisRebecca A Marks
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
Prostate 68:919-23. 2008..Activation of epidermal growth factor receptor (EGFR) has been implicated in prostate cancer cell growth... - Protein expression profiling of breast cancer cells by dissociable antibody microarray (DAMA) stainingX Cynthia Song
Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
Mol Cell Proteomics 7:163-9. 2008..These proteins could be potential biomarkers for the diagnosis of breast cancer...