Research Topics
Genomes and Genes | Xiangning JiangSummaryAffiliation: University of California Country: USA Publications
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Publications
Developmental localization of NMDA receptors, Src and MAP kinases in mouse brainXiangning Jiang
Department of Neurology, University of California, San Francisco, CA 94143, United States
Neurosci Lett 503:215-9. 2011....
Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemiaXiangning Jiang
Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
Ann Neurol 63:632-41. 2008....- HIF-1 alpha-deficient mice have increased brain injury after neonatal hypoxia-ischemiaR Ann Sheldon
Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
Dev Neurosci 31:452-8. 2009..05) and was more severe in the cortex. Genetic reduction of neuronal HIF-1 alpha results in a worsening of injury after neonatal HI, with a region-specific role for HIF-1 alpha in the setting of neonatal brain injury... 
Differential vulnerability of immature murine neurons to oxygen-glucose deprivationXiangning Jiang
Department of Neurology, University of California-San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143-0663, USA
Exp Neurol 190:224-32. 2004....- A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotectionShannon Elise Goldsmith Hamrick
Department of Pediatrics, University of California San Francisco, 521 Parnassus Avenue, C 215, San Francisco, CA 94143-0663, USA
Neurosci Lett 379:96-100. 2005..006). This protection was diminished with transfection of antiHIF-1alpha (p = 0.049). Blocking HIF-1alpha reduces DFO protection suggesting that DFO protects through iron chelation and HIF-1alpha induction... - Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neuronsShengjun Chang
Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
Neurosci Lett 441:134-8. 2008..For both preconditioning paradigms, HIF-1alpha expression level declined to baseline at 72 h. Our results suggest that low levels of H(2)O(2) may up-regulate HIF-1alpha protein and thereby mediate H/I preconditioning protection... - Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayersBrandon Davis
Department of Neurology, University of California, San Francisco, CA 94143, USA
Int J Dev Neurosci 28:423-8. 2010..We also found that VASP at tight junctions was co-localized with ZO-1 in cell-cell contacts. Our findings show that VASP phosphorylation is affected by hypoxia and VEGFR2 inhibition suggesting a role for VASP in BBB permeability... - Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke modelDezhi Mu
Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
Neurobiol Dis 14:524-34. 2003..The presence of HIF-1alpha and VEGF after moderate ischemia-reperfusion injury suggests potential avenues to exploit for neuroprotection... - Manipulation of antioxidant pathways in neonatal murine brainR Ann Sheldon
Department of Neurology, University of California San Francisco, San Francisco, California 94143
Pediatr Res 56:656-62. 2004..008). These findings support the hypothesis that the immature brain has limited GPX activity and is more susceptible to oxidative damage and may explain the paradoxical effect seen in ischemic neonatal brain when SOD1 is overexpressed... - Neonatal hypoxia-ischemia differentially upregulates MAGUKs and associated proteins in PSD-93-deficient mouse brainXiangning Jiang
Department of Neurology, University of California, San Francisco 94143-0663, USA
Stroke 34:2958-63. 2003..Deletion of PSD-93 alone does not provide neuroprotection after neonatal HI, possibly a result, in part, of upregulation of PSD-95. MAGUKs may substitute for one another, allowing normal NMDAR function in the postnatal period... - Enhanced NMDA receptor tyrosine phosphorylation and increased brain injury following neonatal hypoxia-ischemia in mice with neuronal Fyn overexpressionRenatta Knox
Department of Neurology, University of California, San Francisco, CA 94158, USA
Neurobiol Dis 51:113-9. 2013..Our findings suggest a role for Fyn kinase in neuronal death after neonatal HI, possibly via up-regulation of NMDA receptor tyrosine phosphorylation... - Expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal strokeMeng Mao
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Neurosci Lett 403:227-32. 2006..Our findings suggest that TNFalpha expression increases after neonatal stroke and is associated with neuronal apoptosis after transient focal cerebral ischemia... - Expression of Nogo-A and NgR in the developing rat brain after hypoxia-ischemiaHua Wang
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Brain Res 1114:212-20. 2006..Our findings of upregulation of neurite growth inhibitor Nogo-A and its receptor NgR in ischemic cortex suggest that Nogo-A and NgR may participate in the pathology seen after HI in neonatal rats...