Affiliation: University of California
Jiang Q, Isquith J, Zipeto M, Diep R, Pham J, Delos Santos N, et al
. Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation. Cancer Cell. 2019;35:81-94.e7 pubmed publisher
..These data reveal a dual mechanism governing malignant transformation of progenitors that is predicated on hyper-editing of cell-cycle-regulatory miRNAs and the 3' UTR binding site of tumor suppressor miRNAs. ..
Crews L, Jiang Q, Zipeto M, Lazzari E, Court A, Ali S, et al
. An RNA editing fingerprint of cancer stem cell reprogramming. J Transl Med. 2015;13:52 pubmed publisher
..RNA editing quantification enables rapid detection of malignant progenitors signifying cancer progression and therapeutic resistance, and will aid future RNA editing inhibitor development efforts. ..
Zipeto M, Court A, Sadarangani A, Delos Santos N, Balaian L, Chun H, et al
. ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis. Cell Stem Cell. 2016;19:177-191 pubmed publisher
..A small-molecule tool compound antagonizes ADAR1's effect on LSC self-renewal in stromal co-cultures and restores let-7 biogenesis. Thus, ADAR1 activation represents a unique therapeutic vulnerability in LSCs with active JAK2 signaling. ..