Qi Jiang

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitors
    V McNeil Coffield
    Lineberger Comprehensive Cancer Center, Dept of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    J Exp Med 200:1315-24. 2004
  2. pmc Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP
    Qi Jiang
    Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Immunol 7:6. 2006
  3. pmc TSLP is involved in expansion of early thymocyte progenitors
    Qi Jiang
    Lineberger Comprehensive Cancer Center, School of Medicine, UNC at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Immunol 8:11. 2007
  4. ncbi request reprint Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L
    Yuki Okada
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Nat Cell Biol 8:1017-24. 2006
  5. pmc Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse model
    William L Ince
    Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Virol 84:2740-52. 2010
  6. pmc Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis
    Derek Holmes
    Department of Microbiology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Immunol Res 41:248-66. 2008
  7. pmc FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
    Qi Jiang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Blood 112:2858-68. 2008
  8. pmc Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
    Søren M Johnson
    Department of Genetics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 120:2528-36. 2010
  9. pmc Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease
    Christian A Wysocki
    Department of Medicine, Lineberger Comprehensive Cancer Center, Campus Box No 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Blood 106:3300-7. 2005
  10. ncbi request reprint hDOT1L links histone methylation to leukemogenesis
    Yuki Okada
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cell 121:167-78. 2005

Collaborators

Detail Information

Publications12

  1. pmc Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitors
    V McNeil Coffield
    Lineberger Comprehensive Cancer Center, Dept of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    J Exp Med 200:1315-24. 2004
    ..Overexpression of the antiapoptotic gene Bcl2 rescued the defect in DN3 cells and partially rescued T cell development. Therefore, Galpha13-mediated signaling is necessary in early thymocyte proliferation and survival...
  2. pmc Delayed functional maturation of natural regulatory T cells in the medulla of postnatal thymus: role of TSLP
    Qi Jiang
    Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA
    BMC Immunol 7:6. 2006
    ..It has therefore, been proposed that functional FoxP3+ Treg cells are not made in the neonatal thymus; however, it remains unclear when and where functional (FoxP3+)(CD4+)(CD8-)CD25+ thymocytes are generated in postnatal thymus...
  3. pmc TSLP is involved in expansion of early thymocyte progenitors
    Qi Jiang
    Lineberger Comprehensive Cancer Center, School of Medicine, UNC at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Immunol 8:11. 2007
    ..Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear...
  4. ncbi request reprint Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L
    Yuki Okada
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Nat Cell Biol 8:1017-24. 2006
    ..Thus, our study establishes CALM-AF10 fusion as a cause of leukaemia and reveals that mistargeting of hDOT1L and upregulation of Hoxa5 through H3K79 methylation is the underlying mechanism behind leukaemia caused by CALM-AF10 fusion...
  5. pmc Evolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse model
    William L Ince
    Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Virol 84:2740-52. 2010
    ..Thus, humanized mice offer a useful model for studying evolutionary processes of HIV-1 in a complex host environment...
  6. pmc Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis
    Derek Holmes
    Department of Microbiology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Immunol Res 41:248-66. 2008
    ..Based on recent findings from SIV/monkey and HIV/humanized mouse models, a model of the dual role of Treg cells in HIV-1 infection and immuno-pathogenesis is discussed...
  7. pmc FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
    Qi Jiang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Blood 112:2858-68. 2008
    ..The DKO-hu HSC mouse will be a valuable model to study human Treg functions and their role in HIV-1 pathogenesis in vivo...
  8. pmc Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
    Søren M Johnson
    Department of Genetics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 120:2528-36. 2010
    ..These results demonstrate an effective method to mitigate the hematopoietic toxicity of IR in mammals, which may be potentially useful after radiological disaster or as an adjuvant to anticancer therapy...
  9. pmc Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease
    Christian A Wysocki
    Department of Medicine, Lineberger Comprehensive Cancer Center, Campus Box No 7295, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Blood 106:3300-7. 2005
    ....
  10. ncbi request reprint hDOT1L links histone methylation to leukemogenesis
    Yuki Okada
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cell 121:167-78. 2005
    ..Our studies thus establish that mistargeting of hDOT1L to Hoxa9 plays an important role in MLL-AF10-mediated leukemogenesis and suggests that the enzymatic activity of hDOT1L may provide a potential target for therapeutic intervention...
  11. ncbi request reprint A genetic approach to inactivating chemokine receptors using a modified viral protein
    V McNeil Coffield
    Curriculum in Genetics and Molecular Biology, and 22 048 Lineberger Cancer Center, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Nat Biotechnol 21:1321-7. 2003
    ..Thus the degrakine provides an effective genetic tool to dissect receptor functions in a number of biological systems in vitro and in vivo...
  12. pmc The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis
    Xing Chang
    Division of Cancer Immunology, Department of Pathology and Comprehensive Cancer Center, Ohio State University Medical Center, Columbus, OH 43210, USA
    J Exp Med 202:1141-51. 2005
    ....