Meisheng Jiang

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells
    Zhanwei Wang
    Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
    Cell Commun Signal 12:10. 2014
  2. pmc Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer
    Keejong Chang
    BioAgri Corporation Taiwan Branch, Fl 8 8, no 8, Song Chiang Rd, Taipei, Taiwan
    BMC Biotechnol 2:5. 2002
  3. pmc Molecular mechanisms of go signaling
    Meisheng Jiang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurosignals 17:23-41. 2009
  4. pmc Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells
    Guanghua Tang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:2636-41. 2012
  5. pmc Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins
    Ying Wang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:1693-8. 2011
  6. pmc Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation
    Alejandra Young
    Jules Stein Eye Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Invest Ophthalmol Vis Sci 49:3245-52. 2008
  7. pmc Phenotype of transgenic mice overexpressed with inducible nitric oxide synthase in the retina
    Guey Shuang Wu
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    PLoS ONE 7:e43089. 2012
  8. doi request reprint c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface
    Masaya Ueno
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 27:373-86. 2013
  9. pmc Regulated expression of the Ras effector Rin1 in forebrain neurons
    Bartholomew Dzudzor
    Department of Biological Chemistry, Molecular Biology Institute and Jonsson Cancer Center, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive, 34609 BSRB, Los Angeles, CA 90095 1737, USA
    Mol Cell Neurosci 43:108-16. 2010
  10. pmc A constitutively active Gαi3 protein corrects the abnormal retinal pigment epithelium phenotype of Oa1-/- mice
    Alejandra Young
    Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States of America Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e76240. 2013

Research Grants

  1. Modulation of Insulin Secretion via Go2 G-Protein
    Meisheng Jiang; Fiscal Year: 2009

Collaborators

Detail Information

Publications15

  1. doi request reprint Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells
    Zhanwei Wang
    Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
    Cell Commun Signal 12:10. 2014
    ..Additionally, a role of these Giα proteins in breast cancer remains to be elucidated...
  2. pmc Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer
    Keejong Chang
    BioAgri Corporation Taiwan Branch, Fl 8 8, no 8, Song Chiang Rd, Taipei, Taiwan
    BMC Biotechnol 2:5. 2002
    ..Here, we report a linker based sperm-mediated gene transfer method (LB-SMGT) that greatly improves the production efficiency of large transgenic animals...
  3. pmc Molecular mechanisms of go signaling
    Meisheng Jiang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurosignals 17:23-41. 2009
    ..This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go...
  4. pmc Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells
    Guanghua Tang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:2636-41. 2012
    ..Our findings provide insight into galanin's action in glucose homeostasis. The results may also be relevant to the understanding of galanin signaling in other biological systems, especially the central nervous system...
  5. pmc Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins
    Ying Wang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 108:1693-8. 2011
    ..We thus provide unique genetic evidence that the G(o2) protein is a transducer in an inhibitory pathway that prevents damaging oversecretion of insulin...
  6. pmc Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation
    Alejandra Young
    Jules Stein Eye Institute, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Invest Ophthalmol Vis Sci 49:3245-52. 2008
    ..This study was undertaken to test whether one of the G alpha i proteins, G alpha i3, signals in the same pathway as OA1 to regulate melanosome biogenesis and axonal growth through the optic chiasm...
  7. pmc Phenotype of transgenic mice overexpressed with inducible nitric oxide synthase in the retina
    Guey Shuang Wu
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    PLoS ONE 7:e43089. 2012
    ..In this study, we constructed transgenic mice overexpressing iNOS in the retina to evaluate the effect of sustained, intense iNOS generation in the photoreceptor damage...
  8. doi request reprint c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface
    Masaya Ueno
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 27:373-86. 2013
    ..Identification of this c-Met-dependent multipotent LaTP provides a landmark in the poorly defined placental stem/progenitor cell hierarchy and may help us understand pregnancy complications caused by a defective placental exchange. ..
  9. pmc Regulated expression of the Ras effector Rin1 in forebrain neurons
    Bartholomew Dzudzor
    Department of Biological Chemistry, Molecular Biology Institute and Jonsson Cancer Center, David Geffen School of Medicine at UCLA, 615 Charles E Young Drive, 34609 BSRB, Los Angeles, CA 90095 1737, USA
    Mol Cell Neurosci 43:108-16. 2010
    ..These results provide insight into regulated expression of a neuronal Ras effector, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons...
  10. pmc A constitutively active Gαi3 protein corrects the abnormal retinal pigment epithelium phenotype of Oa1-/- mice
    Alejandra Young
    Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, United States of America Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e76240. 2013
    ..To test this hypothesis, we have generated transgenic mice that carry the constitutively active Gαi3 (Q204L) protein in the RPE of Oa1-/- mice and are now reporting the effects that the transgene produced on the Oa1-/- RPE phenotype...
  11. pmc Decreased blastocyst production in mice exposed to increased rack noise
    Bernadette M Zamora
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Am Assoc Lab Anim Sci 48:486-91. 2009
    ..These results support the earlier observation that decreased blastocyst count occurs following housing of bred C57BL/6 donor mice in ventilated cages...
  12. pmc Dynamic intracellular distribution of Eaf2 and its potential involvement in UV-Induced DNA damage response
    Fengfeng Zhuang
    Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    DNA Cell Biol 27:649-56. 2008
    ..Following UV irradiation, Eaf2 is relocalized to the nucleolus, suggesting a possible functional involvement of Eaf2 in DNA damage response...
  13. ncbi request reprint Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins
    Meisheng Jiang
    Department of Anesthesiology, School of Medicine, University of California, Los Angeles, California 90095, USA
    Methods Enzymol 344:277-98. 2002
  14. ncbi request reprint Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis
    Kathy K Niakan
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Mol Genet Metab 88:261-71. 2006
    ..Our results further suggest that the failure of conventional murine Nr0b1 knockout attempts may be due to disregulated differentiation...
  15. doi request reprint Purification of BAC DNA for high-efficiency transgenesis
    Rajendra K Gangalum
    Jules Stein Eye Institute, UCLA, University of California, Los Angeles, CA 90095 700019, USA
    Biotechniques 51:335-6, 338. 2011
    ....

Research Grants4

  1. Modulation of Insulin Secretion via Go2 G-Protein
    Meisheng Jiang; Fiscal Year: 2009
    ..The results of these experiments will unequivocally prove the role of Go2 G protein in insulin secretion, thereby setting the stage for designing future interventional strategies in managing diabetes. ..