Research Topics
Genomes and Genes | Lily I JiangSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammationLily I Jiang
Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390 9041, United States Electronic address
Mol Immunol 54:14-22. 2013..This would also help explain a well documented phenomenon, that the ability of zymosan to stimulate inflammatory cytokine responses via TLR2 appears to be weaker than other stimuli of TLR2...- Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathwayLily I Jiang
Department of Pharmacology, Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9196, USA
J Biol Chem 282:10576-84. 2007..Thus in these macrophage cells, all four major classes of G proteins can regulate intracellular cAMP... - Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VIILily I Jiang
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 283:23429-39. 2008..Our results demonstrate that AC7 is a specific downstream effector of the G(12/13) pathway... - Distinct roles of adenylyl cyclase VII in regulating the immune responses in miceBiyan Duan
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Immunol 185:335-44. 2010..These results are the first to ascribe specific functions to an AC isoform in the immune system and emphasize the importance of cAMP synthesis by this isoform in shaping the immune responses... - Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEFZhe Chen
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Protein Sci 20:107-17. 2011..It is possible that Gα subunits activate p115 in part by relieving autoinhibition imposed by the linker region... - Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulationZhe Chen
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Biol Chem 285:21070-81. 2010..PH bound to both forms of RhoA can be isolated by size-exclusion chromatography. This novel interaction between activated RhoA and PH could play a key role in regulation of RhoGEF activity in vivo... 
Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEFZhe Chen
Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 278:9912-9. 2003..This suggests that the rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13)...- Functional characterization of p115 RhoGEFClark Wells
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Methods Enzymol 345:371-82. 2002 - Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activatorZhe Chen
Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Nat Struct Mol Biol 12:191-7. 2005..The interface between the RGS module of rgRGS and Galpha is similar to that of a Galpha-effector complex, suggesting a role for the rgRGS domain in the stimulation of the GEF activity of p115RhoGEF by Galpha13... - Regions on adenylyl cyclase VII required for selective regulation by the G13 pathwayLily I Jiang
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA 74390 9041, USA
Mol Pharmacol 83:587-93. 2013..A mutagenesis screen identified more specific regions of AC7 that differentially mediate its regulation by distinct pathways... - A global analysis of cross-talk in a mammalian cellular signalling networkMadhusudan Natarajan
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9050, USA
Nat Cell Biol 8:571-80. 2006..A global analysis of cross-talk suggests that many external stimuli converge on a relatively small number of interaction mechanisms to provide for context-dependent signalling... - Ribozyme- and siRNA-mediated suppression of RGS-containing RhoGEF proteinsQin Wang
Department of Pharmacology, University of Michigan, Ann Arbor 48109, USA
Methods Enzymol 389:244-65. 2004..Also, the three siRNAs targeting LARG, PDZ-RhoGEF, and p115-RhoGEF are able to discriminate the closely related sequences within this RGS-RhoGEF gene family... - Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105Estelle A Wall
Alliance for Cellular Signaling, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Sci Signal 2:ra28. 2009..These data suggest that crosstalk between the TLR4 and cAMP pathways in macrophages can be coordinated through PKA-dependent scaffolds that localize specific pools of the kinase to distinct substrates... - Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calciumTamara I A Roach
Alliance for Cellular Signaling, Northern California Institute for Research and Education, San Francisco, California 94121, USA
J Biol Chem 283:17351-61. 2008..PLCbeta3 may thus provide a selective target for inhibiting Ca(2+) responses to mediators of inflammation, including C5a, UDP, PAF, and LPA... - Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cellsQin Wang
Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 279:28831-4. 2004..Suppression of p115rhoGEF had no effect. Thus different rhoGEFs (LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and LPA receptors... - Deciphering signaling outcomes from a system of complex networksRobert C Hsueh
University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
Sci Signal 2:ra22. 2009..This suggests that most potential interactions are not realized and that unique cellular responses are limited to discrete subsets of ligands and pathways that enhance specific cellular functions... - Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEFZhe Chen
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Structure 16:1532-43. 2008..Replacement of key residues in this motif with their counterparts in p115RhoGEF confers GAP activity... - Mechanisms for reversible regulation between G13 and Rho exchange factorsClark D Wells
Department of Pharmacology, University of Texas, Southwestern Medical Center at Dallas, Texas 75390-9041, USA
J Biol Chem 277:1174-81. 2002..These results suggest a mechanism for activation of the nucleotide exchange activity of p115 RhoGEF that involves direct and coordinate interaction of Galpha(13) to both its RGS and DH domains... - Regulation of Rho guanine nucleotide exchange factors by G proteinsPaul C Sternweis
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Adv Protein Chem 74:189-228. 2007..An overview of identified interactions with other signaling proteins suggests the growing spectrum of their involvement in numerous signaling pathways... - RhoA binds to the amino terminus of MEKK1 and regulates its kinase activityEwen D Gallagher
Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9041, USA
J Biol Chem 279:1872-7. 2004..In summary, we have characterized a novel point at which Rho GTPases impinge upon the regulation and function of MEKK1... - p115 Rho GTPase activating protein interacts with MEKK1Lori B Christerson
Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
J Cell Physiol 192:200-8. 2002..Here we have identified an MEKK1 binding partner that offers a connection between this protein kinase and the machinery regulating cytoskeletal reorganization... - Assays and characterization of mammalian phosphatidylinositol 4,5-bisphosphate-sensitive phospholipase DXuejun Jiang
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Methods Enzymol 345:328-34. 2002 - Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system developmentRobert E Palmer
Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Dev Biol 252:202-13. 2002..Two mutant alleles of cog-1 differentially affect alternative transcripts and cause different phenotypes, suggesting that the two forms of cog-1 have distinct functions in C. elegans...
Research Grants
- Regulation of adenylyl cyclase VII and its function in the immune systemPaul C Sternweis; Fiscal Year: 2010..Results from these studies will help identify novel targets for selective therapeutic intervention in immune diseases. ..
- Regulation of adenylyl cyclase VII and its function in the immune systemLi Jiang; Fiscal Year: 2009..Results from these studies will help identify novel targets for selective therapeutic intervention in immune diseases. ..