Jin Jiang


Affiliation: University of Texas Southwestern Medical Center
Country: USA


  1. request reprint
    Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, et al. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell. 2005;9:819-30 pubmed
    ..We propose that phosphorylation of Ci by CKI creates multiple Slimb/beta-TRCP binding sites that act cooperatively to recruit SCF(Slimb/beta-TRCP). ..
  2. Li S, Cho Y, Wang B, Li S, Jiang J. Regulation of Smoothened ubiquitylation and cell surface expression through a Cul4-DDB1-G? E3 ubiquitin ligase complex. J Cell Sci. 2018;131: pubmed publisher
    ..Taken together, our study identifies an E3 ubiquitin ligase complex targeting Smo for ubiquitylation and provides new insight into how Hh signaling regulates Smo trafficking and cell surface expression. ..
  3. Jiang J. Misshapen Connects Food, Mechanosensing, and Intestinal Growth. Dev Cell. 2018;45:417-418 pubmed publisher
    ..In this issue of Developmental Cell, Li et al. (2018) demonstrate that gut epithelium stretching caused by food ingestion drives Drosophila intestinal growth via Hippo pathway regulation. ..
  4. Han Y, Shi Q, Jiang J. Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction. Proc Natl Acad Sci U S A. 2015;112:6383-8 pubmed publisher
    ..Hence, our study identifies a previously unidentified and conserved Sufu-binding motif in the C-terminal region of Ci/Gli and provides mechanistic insight into how Sufu inhibits Ci/Gli activity in the nucleus. ..
  5. Cho Y, Zhu J, Li S, Wang B, Han Y, Jiang J. Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K. Nat Commun. 2018;9:1657 pubmed publisher
    ..Our study unravels an unanticipated layer of Hpo pathway regulation and suggests that PRP4K-mediated Yki/Yap phosphorylation in the nucleus provides a fail-safe mechanism to restrict aberrant pathway activation. ..
  6. Li S, Li S, Wang B, Jiang J. Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases. Sci Signal. 2018;11: pubmed publisher
    ..Our study identifies the E3 ubiquitin ligases that target Smo and provides insight into how Hh regulates the reciprocal trafficking of its receptor and signal transducer. ..
  7. Jiang J, Hui C. Hedgehog signaling in development and cancer. Dev Cell. 2008;15:801-12 pubmed publisher
    ..We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning. ..
  8. Tian A, Wang B, Jiang J. Injury-stimulated and self-restrained BMP signaling dynamically regulates stem cell pool size during Drosophila midgut regeneration. Proc Natl Acad Sci U S A. 2017;114:E2699-E2708 pubmed publisher
    ..Our study suggests that dynamic BMP signaling controls ISC population size during midgut regeneration and reveals mechanisms that precisely control stem cell number in response to tissue needs. ..
  9. Jiang J. CK1 in Developmental Signaling: Hedgehog and Wnt. Curr Top Dev Biol. 2017;123:303-329 pubmed publisher
    ..I will highlight this feature in the context of Hh signaling and draw interesting parallels between the Hh and Wnt pathways. ..

More Information


  1. Jiang H, Tian A, Jiang J. Intestinal stem cell response to injury: lessons from Drosophila. Cell Mol Life Sci. 2016;73:3337-49 pubmed publisher
  2. Zhou Z, Yao X, Li S, Xiong Y, Dong X, Zhao Y, et al. Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Dev Cell. 2015;34:58-72 pubmed publisher
    ..Our findings reveal a conserved mechanism by which Ci/Gli is stabilized by a deubiquitination enzyme and identify Usp7/HUASP as a critical regulator of Hh signaling and potential therapeutic target for Hh-related cancers. ..
  3. Chen P, Zhou Z, Yao X, Pang S, Liu M, Jiang W, et al. Capping Enzyme mRNA-cap/RNGTT Regulates Hedgehog Pathway Activity by Antagonizing Protein Kinase A. Sci Rep. 2017;7:2891 pubmed publisher
    ..Our study makes an unexpected link between the mRNA capping machinery and the Hh signaling pathway, unveils a new facet of Hh signaling regulation, and reveals a potential drug target for modulating Hh signaling activity. ..
  4. request reprint
    Jiang J. Degrading Ci: who is Cul-pable?. Genes Dev. 2002;16:2315-21 pubmed
  5. Tian A, Shi Q, Jiang A, Li S, Wang B, Jiang J. Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells. J Cell Biol. 2015;208:807-19 pubmed publisher
    ..Hence, our study uncovers a JNK-Hh-JAK-STAT signaling axis in the regulation of regenerative stem cell proliferation. ..
  6. Shi Q, Li S, Li S, Jiang A, Chen Y, Jiang J. Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci U S A. 2014;111:E5651-60 pubmed publisher
  7. Li S, Ma G, Wang B, Jiang J. Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation. Sci Signal. 2014;7:ra62 pubmed publisher
    ..Thus, our study uncovers a previously uncharacterized mechanism for regulation of PKA activity and demonstrates that the signal-regulated formation of kinase-substrate complexes plays a central role in Hh signal transduction. ..
  8. Jia J, Tong C, Jiang J. Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev. 2003;17:2709-20 pubmed
    ..Taken together, our results suggest that Smo transduces the Hh signal by physically interacting with the Cos2/Fu protein complex. ..
  9. Ma G, Li S, Han Y, Li S, Yue T, Wang B, et al. Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway. Dev Cell. 2016;39:438-451 pubmed publisher
    ..Our findings reveal a conserved mechanism whereby the SUMO pathway promotes Hh signaling by regulating Smo subcellular localization and shed light on how sumoylation regulates membrane protein trafficking. ..
  10. request reprint
    Jia J, Tong C, Wang B, Luo L, Jiang J. Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature. 2004;432:1045-50 pubmed
    ..Our data indicate that Hh induces progressive Smo phosphorylation by PKA and CKI, leading to elevation of Smo cell-surface levels and signalling activity. ..
  11. Jia J, Zhang W, Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 2003;17:2514-9 pubmed
    ..dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that they act in common pathways. ..