Jin Jiang

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 9:819-30. 2005
  2. ncbi request reprint Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors
    Chan Yen Ou
    Taiwan International Graduate Program, Graduate Institute of Life Science, National Defense Medical Center and Academia Sinica, Taipei, Taiwan
    Dev Biol 308:106-19. 2007
  3. pmc Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
    Shuang Li
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Biol 10:e1001239. 2012
  4. pmc Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened
    Yongbin Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, United States of America
    PLoS Biol 9:e1001083. 2011
  5. ncbi request reprint Hedgehog signaling in development and cancer
    Jin Jiang
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Dev Cell 15:801-12. 2008
  6. ncbi request reprint Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 432:1045-50. 2004
  7. pmc Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 17:2709-20. 2003
  8. pmc The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis
    Jianhang Jia
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 17:2514-9. 2003
  9. ncbi request reprint Regulation of Hh/Gli signaling by dual ubiquitin pathways
    Jin Jiang
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cell Cycle 5:2457-63. 2006
  10. ncbi request reprint Degrading Ci: who is Cul-pable?
    Jin Jiang
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 16:2315-21. 2002

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 9:819-30. 2005
    ..We propose that phosphorylation of Ci by CKI creates multiple Slimb/beta-TRCP binding sites that act cooperatively to recruit SCF(Slimb/beta-TRCP)...
  2. ncbi request reprint Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors
    Chan Yen Ou
    Taiwan International Graduate Program, Graduate Institute of Life Science, National Defense Medical Center and Academia Sinica, Taipei, Taiwan
    Dev Biol 308:106-19. 2007
    ..Taken together, these results suggest that Cul3 downregulates Ci levels to modulate Hh signaling activity, thus ensuring proper cell proliferation during retinal development...
  3. pmc Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
    Shuang Li
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS Biol 10:e1001239. 2012
    ....
  4. pmc Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened
    Yongbin Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, United States of America
    PLoS Biol 9:e1001083. 2011
    ..Hence, despite divergence in their primary sequences and their subcellular trafficking, mSmo and dSmo employ analogous mechanisms for their activation...
  5. ncbi request reprint Hedgehog signaling in development and cancer
    Jin Jiang
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Dev Cell 15:801-12. 2008
    ..We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning...
  6. ncbi request reprint Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 432:1045-50. 2004
    ..Our data indicate that Hh induces progressive Smo phosphorylation by PKA and CKI, leading to elevation of Smo cell-surface levels and signalling activity...
  7. pmc Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 17:2709-20. 2003
    ..Taken together, our results suggest that Smo transduces the Hh signal by physically interacting with the Cos2/Fu protein complex...
  8. pmc The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis
    Jianhang Jia
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 17:2514-9. 2003
    ..dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that they act in common pathways...
  9. ncbi request reprint Regulation of Hh/Gli signaling by dual ubiquitin pathways
    Jin Jiang
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cell Cycle 5:2457-63. 2006
    ..Tissue- and developmental stage-specific expression of HIB and its homologs in vertebrates may provide a conserved mechanism for ensuring precision in spatial and temporal control of Hh signaling...
  10. ncbi request reprint Degrading Ci: who is Cul-pable?
    Jin Jiang
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Genes Dev 16:2315-21. 2002
  11. ncbi request reprint Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus
    Wensheng Zhang
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Dev Cell 8:267-78. 2005
    ..We propose that Cos2 recruits multiple kinases to efficiently phosphorylate Ci and that Hh inhibits Ci phosphorylation by specifically interfering with kinase recruitment...
  12. ncbi request reprint A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
    Qing Zhang
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 10:719-29. 2006
    ..We provide evidence that HIB prevents aberrant Hh signaling posterior to the morphogenic furrow, which is essential for normal eye development...
  13. pmc The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    Lei Zhang
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 14:377-87. 2008
    ..Finally, Sd recruits Yki to the enhancer of the pathway-responsive gene diap1, suggesting that diap1 is a direct transcriptional target of the Hpo pathway...
  14. pmc The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway
    Tao Yue
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Dev Cell 22:255-67. 2012
    ..Overexpression of Sav or dimerized Ed cytoplasmic domain suppressed loss-of-Ed phenotypes. We propose that Ed may link cell-cell contact to Hpo signaling through binding and stabilizing Sav, thus modulating the Hpo kinase activity...
  15. pmc Regulation of wingless signaling by the CKI family in Drosophila limb development
    Lei Zhang
    Center for Developmental Biology, Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Biol 299:221-37. 2006
    ..Finally, we provide evidence that several CKI isoforms including CKIalpha and Gish/CKIgamma can phosphorylate the Wg coreceptor Arrow (Arr), which may account, at least in part, for their positive roles in the Wg pathway...
  16. pmc The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
    Qing Shi
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Development 138:4219-31. 2011
    ....
  17. pmc Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Biol 337:303-12. 2010
    ..Finally, we provided evidence that Hpo signaling restricted Yki nuclear localization depending on CRM1-mediated nuclear export...
  18. ncbi request reprint Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus
    Jianhang Jia
    Center for Developmental Biology and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9133, USA
    Nature 416:548-52. 2002
    ..We propose that Sgg/GSK3 acts in conjunction with PKA to cause hyperphosphorylation of Ci, which targets it for proteolytic processing, and that Hh opposes Ci proteolysis by promoting its dephosphorylation...
  19. pmc Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
    Qing Zhang
    Departments of Developmental Biology and Pharmacology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:21191-6. 2009
    ..Our results provide a mechanistic insight into how HIB/SPOP recognizes its substrates and have important implications for the genome-wide prediction of substrates for Cul3-based E3 ligases...
  20. ncbi request reprint Transducing the Hedgehog signal across the plasma membrane
    Yun Zhao
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Fly (Austin) 1:333-6. 2007
    ..We discuss how Smo conformational change regulates the intracellular signaling complex and how Smo transduces the graded Hh signaling activities through different conformational states...
  21. ncbi request reprint Hedgehog regulates smoothened activity by inducing a conformational switch
    Yun Zhao
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 450:252-8. 2007
    ..Hence, by employing multiple Arg clusters as inhibitory elements counteracted by differential phosphorylation, SMO acts as a rheostat to translate graded HH signals into distinct responses...
  22. pmc Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cell Res 23:1133-46. 2013
    ..Finally, we show that a basal level of dMyc expression is required for ISC maintenance, proliferation and lineage differentiation during normal tissue homeostasis...
  23. pmc Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:21064-9. 2010
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS...
  24. ncbi request reprint Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms
    Gelin Wang
    Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Dev Biol 268:493-505. 2004
    ..In addition, we find that adding a nuclear localization signal (NLS) to exposed regions of Ci155 greatly facilitates its nuclear translocation, suggesting that the cytoplasmic retention of Ci155 may also depend on NLS masking...
  25. pmc G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
    Yongbin Chen
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Genes Dev 24:2054-67. 2010
    ..Thus, Gprk2 forms a positive feedback loop and acts downstream from PKA and CK1 to facilitate high-level Hh signaling by promoting the active state of Smo through direct phosphorylation and molecular scaffolding...
  26. ncbi request reprint Direct contact between enamel matrix derivative (EMD) and osteoblasts is not required for EMD-induced cell proliferation
    Jianing He
    Department of Endodontics, Baylor College of Dentistry, Dallas, Tex, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:370-5. 2004
    ..The purpose of this study was to determine whether the effect of enamel matrix derivative (EMD) on osteoblast proliferation is dependent on direct contact between EMD and the cells...
  27. ncbi request reprint Enamel matrix derivative inhibits TNF-alpha-induced apoptosis in osteoblastic MC3T3-E1 cells
    Jianing He
    Department of Endodontics, Baylor College of Dentistry, Dallas, Tex, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:761-7. 2005
    ..The purpose of this study was to examine the effect of enamel matrix derivative (EMD) on TNF-alpha-induced apoptosis in osteoblastic MC3T3-E1 cells...
  28. doi request reprint A rapid nondestructive method for root dentin moisture measurements: in vitro pilot study
    Takashi Komabayashi
    Department of Endodontics, Texas A and M Health Science Center Baylor College of Dentistry, Dallas, TX 75246, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:e107-11. 2009
    ....
  29. ncbi request reprint Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation
    Shuang Li
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Sci Signal 7:ra62. 2014
    ..Thus, our study uncovers a previously uncharacterized mechanism for regulation of PKA activity and demonstrates that the signal-regulated formation of kinase-substrate complexes plays a central role in Hh signal transduction. ..
  30. ncbi request reprint Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression
    Jianing He
    Department of Endodontics, Baylor College of Dentistry, Waco, Texas, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:239-45. 2004
    ....
  31. pmc Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization
    Yuxiao Wang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75063, USA
    Sci Signal 5:ra6. 2012
    ..Together, these findings define a pathway for plexin signaling and provide insights into the mechanism for semaphorin-induced activation of plexins...
  32. pmc Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase
    Sheu Fen Lee
    Department of Neuroscience, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 286:27447-53. 2011
    ..The sequential and regulated proteolysis by γ-secretase and MIPEP suggests a new means by which Notch function can be modulated...
  33. doi request reprint Apical infection spreading to adjacent teeth: a case report
    Takashi Komabayashi
    Department of Endodontics, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, TX 75246, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:e15-20. 2011
    ....
  34. pmc Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling
    Qing Shi
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9133, USA
    J Cell Sci 127:1092-103. 2014
    ..Our study not only provides a mechanistic insight into how Sufu regulates Hh signaling and the subcellular localization of Ci/Gli, but also reveals a role for Trn/Kapβ2 in developmental regulation. ..
  35. ncbi request reprint Drosophila WntD is a target and an inhibitor of the Dorsal/Twist/Snail network in the gastrulating embryo
    Atish Ganguly
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Development 132:3419-29. 2005
    ..Thus, these results together demonstrate that WntD is regulated by the Dorsal/Twist/Snail network, and is an inhibitor of Dorsal nuclear localization and function...
  36. pmc Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila
    Trudy Correia
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 100:6404-9. 2003
    ..Other missense mutations map to amino acids that are conserved among Fringe proteins, but not among other glycosyltransferases, and thus may identify structural motifs that are required for unique aspects of Fringe activity...
  37. ncbi request reprint Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
    Hyuk Wan Ko
    Graduate Program in Physiology and Neurobiology, Rutgers University, Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Nature 420:673-8. 2002
    ..Our findings suggest that hyperphosphorylated Per is targeted to the proteasome by interactions with Slimb...
  38. pmc Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation
    Yajuan Liu
    Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Genes Dev 21:1949-63. 2007
    ..Our data suggest that Cos2-Smo interaction blocks Hh-induced Smo phosphorylation, and that Fu promotes Smo phosphorylation by antagonizing Cos2...
  39. ncbi request reprint Transgenic mice with osteoblast-targeted insulin-like growth factor-I show increased bone remodeling
    Jin Jiang
    Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 39:494-504. 2006
    ..Thus, broad overexpression of IGF-I in cells of the osteoblast lineage increased indices of bone formation and resorption...

Research Grants20

  1. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2000
    ..Knowledge gained from the proposed study may provide new avenues for diagnosis and therapeutic intervention of cancers caused by mis-regulation of Hh signaling activity. ..
  2. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2007
    ..As unconstrained elevation of Smo activity contributes to many human cancers including skin, lung, pancreas, and prostate cancers, our study may provide new avenues for improving diagnosis and therapeutics of these cancers. ..
  3. Complex regulation of Ci/Gli proteins in Hedgehog signal transduction
    Jin Jiang; Fiscal Year: 2007
    ....
  4. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2009
    ..abstract_text> ..
  5. Complex regulation of Ci/Gli proteins in Hedgehog signal transduction
    Jin Jiang; Fiscal Year: 2009
    ....
  6. Complex regulation of Ci/Gli proteins in Hedgehog signal transduction
    Jin Jiang; Fiscal Year: 2010
    ....
  7. Mechanism of Hedgehog Signal transduction across the plasma membrane
    Jin Jiang; Fiscal Year: 2010
    ..Hence, understanding the Hh signaling mechanisms, as proposed by this project, may provide new avenues for improving diagnosis and therapeutics of cancer. ..
  8. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2006
    ..As unconstrained elevation of Smo activity contributes to many human cancers including skin, lung, pancreas, and prostate cancers, our study may provide new avenues for improving diagnosis and therapeutics of these cancers. ..
  9. Regulation of Hh/Ci signaling by Cos2 and its partners
    Jin Jiang; Fiscal Year: 2006
    ..abstract_text> ..
  10. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2001
    ..Knowledge gained from the proposed study may provide new avenues for diagnosis and therapeutic intervention of cancers caused by mis-regulation of Hh signaling activity. ..
  11. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2002
    ..Knowledge gained from the proposed study may provide new avenues for diagnosis and therapeutic intervention of cancers caused by mis-regulation of Hh signaling activity. ..
  12. Regulation of Hh/Ci signaling by Cos2 and its partners
    Jin Jiang; Fiscal Year: 2003
    ..abstract_text> ..
  13. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2003
    ..Knowledge gained from the proposed study may provide new avenues for diagnosis and therapeutic intervention of cancers caused by mis-regulation of Hh signaling activity. ..
  14. REGULATION OF HEDGEHOG SIGNALING IN DROSOPHILA
    Jin Jiang; Fiscal Year: 2004
    ..Knowledge gained from the proposed study may provide new avenues for diagnosis and therapeutic intervention of cancers caused by mis-regulation of Hh signaling activity. ..
  15. Role of PI3 Kinase p110alpha in Osteoclasts
    Jin Jiang; Fiscal Year: 2004
    ..These studies could lead to the development of new, specific, bone active pharmaceuticals with the potential to improve dental health. ..
  16. Complex regulation of Ci/Gli proteins in Hedgehog signal transduction
    Jin Jiang; Fiscal Year: 2010
    ....