Jean Xin Jiang


Affiliation: University of Texas Health Science Center
Country: USA


  1. Graham S, Jiang J, Mesnil M. Connexins and Pannexins: Important Players in Tumorigenesis, Metastasis and Potential Therapeutics. Int J Mol Sci. 2018;19: pubmed publisher
    ..In this review, the involvements of connexins and pannexins in these different topics (cancer cell growth, invasion/metastasis process, possible cancer therapeutic targets) are discussed. ..
  2. Jiang J, Cherian P. Hemichannels formed by connexin 43 play an important role in the release of prostaglandin E(2) by osteocytes in response to mechanical strain. Cell Commun Adhes. 2003;10:259-64 pubmed
    ..Our results suggest that hemichannels formed by Cx43, instead of intercellular channels, are likely to play a predominant role in the release of intracellular PGE(2) in response to FFSS. ..
  3. Riquelme M, Kar R, Gu S, Jiang J. Antibodies targeting extracellular domain of connexins for studies of hemichannels. Neuropharmacology. 2013;75:525-32 pubmed publisher
    ..This article is part of the Special Issue Section entitled 'Current Pharmacology of Gap Junction Channels and Hemichannels'. ..
  4. Riquelme M, Burra S, Kar R, Lampe P, Jiang J. Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E2 Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress. J Biol Chem. 2015;290:28321-8 pubmed publisher
  5. Shi Q, Gu S, Yu X, White T, Banks E, Jiang J. Connexin Controls Cell-Cycle Exit and Cell Differentiation by Directly Promoting Cytosolic Localization and Degradation of E3 Ligase Skp2. Dev Cell. 2015;35:483-96 pubmed publisher
    ..Therefore, this study identifies a role for connexins in regulating cell-cycle modulators and, consequently, cell growth and differentiation. ..
  6. Shi W, Riquelme M, Gu S, Jiang J. Connexin hemichannels mediate glutathione transport and protect lens fiber cells from oxidative stress. J Cell Sci. 2018;131: pubmed publisher
    ..Taken together, these results show that oxidative stress activates connexin hemichannels in the lens fiber cells and that hemichannels likely protect lens cell against oxidative damage through transporting extracellular reductants. ..
  7. Jiang J. Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development. Curr Mol Med. 2010;10:851-63 pubmed
    ..Recent advances in basic research of lens connexins and the discoveries of clinical disorders as a result of lens connexin dysfunctions are summarized and discussed here. ..
  8. Hu Z, Riquelme M, Wang B, Bugay V, Brenner R, Gu S, et al. Cataract-associated connexin 46 mutation alters its interaction with calmodulin and function of hemichannels. J Biol Chem. 2018;293:2573-2585 pubmed publisher
    ..The data suggest that the G143R-induced enhancement of the CaM-Cx46 interaction results in altered hemichannel activities and might be related to cataract formation. ..
  9. Callaway D, Riquelme M, Sharma R, Lopez Cruzan M, Herman B, Jiang J. Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress. Bone. 2015;76:40-8 pubmed publisher
    ..In conclusion, our results indicate a novel role of Casp-2 in the osteoclast as a modulator of total and mitochondrial ROS and osteoclast differentiation. ..

More Information


  1. Zhou J, Jiang J. Gap junction and hemichannel-independent actions of connexins on cell and tissue functions--an update. FEBS Lett. 2014;588:1186-92 pubmed publisher
    ..In this review, we provide an updated overview on the current knowledge of gap junction- and hemichannel-independent functions of connexins, in particular, their effects on tumorigenesis, neurogenesis and disease development. ..
  2. Hu Z, Shi W, Riquelme M, Shi Q, Biswas S, Lo W, et al. Connexin 50 Functions as an Adhesive Molecule and Promotes Lens Cell Differentiation. Sci Rep. 2017;7:5298 pubmed publisher
    ..Together, these results suggest that in addition to forming gap junction channels, Cx50 acts as an adhesive molecule that is critical in maintaining lens fiber integrity and epithelial-fiber differentiation. ..