Genomes and Genes

Species

Jean Xin Jiang

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. Jiang J. Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development. Curr Mol Med. 2010;10:851-63 pubmed
    ..Recent advances in basic research of lens connexins and the discoveries of clinical disorders as a result of lens connexin dysfunctions are summarized and discussed here. ..
  2. Hu Z, Riquelme M, Wang B, Bugay V, Brenner R, Gu S, et al. Cataract-associated connexin 46 mutation alters its interaction with calmodulin and function of hemichannels. J Biol Chem. 2018;293:2573-2585 pubmed publisher
    ..The data suggest that the G143R-induced enhancement of the CaM-Cx46 interaction results in altered hemichannel activities and might be related to cataract formation. ..
  3. Callaway D, Riquelme M, Sharma R, Lopez Cruzan M, Herman B, Jiang J. Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress. Bone. 2015;76:40-8 pubmed publisher
    ..In conclusion, our results indicate a novel role of Casp-2 in the osteoclast as a modulator of total and mitochondrial ROS and osteoclast differentiation. ..
  4. Zhou J, Jiang J. Gap junction and hemichannel-independent actions of connexins on cell and tissue functions--an update. FEBS Lett. 2014;588:1186-92 pubmed publisher
    ..In this review, we provide an updated overview on the current knowledge of gap junction- and hemichannel-independent functions of connexins, in particular, their effects on tumorigenesis, neurogenesis and disease development. ..
  5. Hu Z, Shi W, Riquelme M, Shi Q, Biswas S, Lo W, et al. Connexin 50 Functions as an Adhesive Molecule and Promotes Lens Cell Differentiation. Sci Rep. 2017;7:5298 pubmed publisher
    ..Together, these results suggest that in addition to forming gap junction channels, Cx50 acts as an adhesive molecule that is critical in maintaining lens fiber integrity and epithelial-fiber differentiation. ..

Detail Information

Publications5

  1. Jiang J. Gap junctions or hemichannel-dependent and independent roles of connexins in cataractogenesis and lens development. Curr Mol Med. 2010;10:851-63 pubmed
    ..Recent advances in basic research of lens connexins and the discoveries of clinical disorders as a result of lens connexin dysfunctions are summarized and discussed here. ..
  2. Hu Z, Riquelme M, Wang B, Bugay V, Brenner R, Gu S, et al. Cataract-associated connexin 46 mutation alters its interaction with calmodulin and function of hemichannels. J Biol Chem. 2018;293:2573-2585 pubmed publisher
    ..The data suggest that the G143R-induced enhancement of the CaM-Cx46 interaction results in altered hemichannel activities and might be related to cataract formation. ..
  3. Callaway D, Riquelme M, Sharma R, Lopez Cruzan M, Herman B, Jiang J. Caspase-2 modulates osteoclastogenesis through down-regulating oxidative stress. Bone. 2015;76:40-8 pubmed publisher
    ..In conclusion, our results indicate a novel role of Casp-2 in the osteoclast as a modulator of total and mitochondrial ROS and osteoclast differentiation. ..
  4. Zhou J, Jiang J. Gap junction and hemichannel-independent actions of connexins on cell and tissue functions--an update. FEBS Lett. 2014;588:1186-92 pubmed publisher
    ..In this review, we provide an updated overview on the current knowledge of gap junction- and hemichannel-independent functions of connexins, in particular, their effects on tumorigenesis, neurogenesis and disease development. ..
  5. Hu Z, Shi W, Riquelme M, Shi Q, Biswas S, Lo W, et al. Connexin 50 Functions as an Adhesive Molecule and Promotes Lens Cell Differentiation. Sci Rep. 2017;7:5298 pubmed publisher
    ..Together, these results suggest that in addition to forming gap junction channels, Cx50 acts as an adhesive molecule that is critical in maintaining lens fiber integrity and epithelial-fiber differentiation. ..