Huabei Jiang

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Three-dimensional diffuse optical tomography of bones and joints
    Yong Xu
    Clemson University, Biomedical Optics Laboratory, Department of Physics and Astronomy, Clemson, South Carolina 29634 0978, USA
    J Biomed Opt 7:88-92. 2002
  2. doi request reprint Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography
    Qizhi Zhang
    The J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 53:1921-31. 2008
  3. ncbi request reprint Multispectral diffuse optical tomography with absorption and scattering spectral constraints
    Changqing Li
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    Appl Opt 46:8229-36. 2007
  4. ncbi request reprint Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements
    Lu Yin
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Opt Lett 32:2556-8. 2007
  5. ncbi request reprint Image reconstruction scheme that combines modified Newton method and efficient initial guess estimation for optical tomography of finger joints
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, FL 32611 6131, USA
    Appl Opt 46:2757-68. 2007
  6. pmc Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning mirror
    Hao Yang
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Biomed Opt Express 4:427-32. 2013
  7. pmc Photoacoustic image reconstruction from few-detector and limited-angle data
    Lei Yao
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Biomed Opt Express 2:2649-54. 2011
  8. pmc Noninvasive evaluation of nuclear morphometry in breast lesions using multispectral diffuse optical tomography
    Mohammad Reza Hajihashemi
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
    PLoS ONE 7:e45714. 2012
  9. pmc Cortical neurovascular coupling driven by stimulation of channelrhodopsin-2
    Lijun Ji
    The J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e46607. 2012
  10. pmc 4-D photoacoustic tomography
    Liangzhong Xiang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Sci Rep 3:1113. 2013

Research Grants

  1. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2006
  2. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2003
  3. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2002
  4. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2007
  5. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2005
  6. Noninvasive Functional and Cellular Imaging of Epilepsy
    Huabei Jiang; Fiscal Year: 2010
  7. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2005
  8. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2004
  9. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2004
  10. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2006

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Three-dimensional diffuse optical tomography of bones and joints
    Yong Xu
    Clemson University, Biomedical Optics Laboratory, Department of Physics and Astronomy, Clemson, South Carolina 29634 0978, USA
    J Biomed Opt 7:88-92. 2002
    ..Our results show that 3D imaging methods can provide details of the joint structure/composition that would be impossible from two-dimensional imaging methods...
  2. doi request reprint Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography
    Qizhi Zhang
    The J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 53:1921-31. 2008
    ....
  3. ncbi request reprint Multispectral diffuse optical tomography with absorption and scattering spectral constraints
    Changqing Li
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    Appl Opt 46:8229-36. 2007
    ..The initial clinical results indicate that the volume fraction of scattering particles in a malignant tumor is higher than that in a benign tumor...
  4. ncbi request reprint Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements
    Lu Yin
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Opt Lett 32:2556-8. 2007
    ..The experimental results show that targets as small as 0.5 mm in diameter with optical absorption contrasts as low as 1.5 relative to a 50 mm diameter scattering background medium can be clearly detected...
  5. ncbi request reprint Image reconstruction scheme that combines modified Newton method and efficient initial guess estimation for optical tomography of finger joints
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, FL 32611 6131, USA
    Appl Opt 46:2757-68. 2007
    ..The recovered results suggest that the improved approach is able to provide quantitatively better images than our previous algorithm for optical tomography reconstruction...
  6. pmc Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning mirror
    Hao Yang
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Biomed Opt Express 4:427-32. 2013
    ..We validate this dual-modal DOT/PAI approach using extensive phantom experiments, and demonstrate its application for tumor imaging using tumor-bearing mice systematically injected with targeted contrast agents...
  7. pmc Photoacoustic image reconstruction from few-detector and limited-angle data
    Lei Yao
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Biomed Opt Express 2:2649-54. 2011
    ..The enhancement is confirmed and evaluated using several phantom experiments...
  8. pmc Noninvasive evaluation of nuclear morphometry in breast lesions using multispectral diffuse optical tomography
    Mohammad Reza Hajihashemi
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
    PLoS ONE 7:e45714. 2012
    ..This pilot study demonstrates the potential of multispectral DOT as a cellular imaging method for accurate determination of breast cancer...
  9. pmc Cortical neurovascular coupling driven by stimulation of channelrhodopsin-2
    Lijun Ji
    The J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e46607. 2012
    ..Our results also indicate that strong nonlinearity exists in neurovascular coupling...
  10. pmc 4-D photoacoustic tomography
    Liangzhong Xiang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Sci Rep 3:1113. 2013
    ..We also use this technique to monitor 1) fast hemodynamic changes during inter-ictal epileptic seizures and 2) temperature variations during tumor thermal therapy...
  11. pmc Integrated diffuse optical tomography and photoacoustic tomography: phantom validations
    Xiaoqi Li
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Biomed Opt Express 2:2348-53. 2011
    ..Here we describe this integrated platform along with initial tissue phantom validations...
  12. pmc Quantitative photoacoustic tomography
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Philos Trans A Math Phys Eng Sci 367:3043-54. 2009
    ..Simulation and in vivo experiments are used to demonstrate the effectiveness of the reconstruction algorithms presented...
  13. pmc Pre-seizure state identified by diffuse optical tomography
    Tao Zhang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida Gainesville, FL 32611, USA
    Sci Rep 4:3798. 2014
    ..Together, these findings suggest DOT represents a powerful tool for mapping early seizure onset and propagation pathways. ..
  14. ncbi request reprint Ultrasound-guided microwave imaging of breast cancer: tissue phantom and pilot clinical experiments
    Huabei Jiang
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Med Phys 32:2528-35. 2005
    ..The pilot clinical studies on two cases suggest that breast tumors can be much more accurately detected by the multimodality method...
  15. ncbi request reprint Spatially varying optical and acoustic property reconstruction using finite-element-based photoacoustic tomography
    Huabei Jiang
    Department of Biomedical Engineering, University of Florida, Gainesville 32611, USA
    J Opt Soc Am A Opt Image Sci Vis 23:878-88. 2006
    ..The effect of acoustic heterogeneity on conventional pure optical absorption reconstruction is also studied...
  16. ncbi request reprint Phase-contrast diffuse optical tomography pilot results in the breast
    Xiaoping Liang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 130 BME Building PO Box 116131, Gainesville, FL 32611
    Acad Radiol 15:859-66. 2008
    ....
  17. pmc High-resolution x-ray guided three-dimensional diffuse optical tomography of joint tissues in hand osteoarthritis: morphological and functional assessments
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, 32611, USA
    Med Phys 37:4343-54. 2010
    ..The aim of this study was to investigate the potential use of multimodality functional imaging techniques to identify the quantitative optical findings that can be used to distinguish between osteoarthritic and normal finger joints...
  18. pmc Noninvasive in vivo tomographic optical imaging of cellular morphology in the breast: possible convergence of microscopic pathology and macroscopic radiology
    Changqing Li
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Med Phys 35:2493-501. 2008
    ..38 and 2.63. These initial results suggest that cellular mean size and volume fraction may be two new criteria that could be used to differentiate malignant from benign lesions...
  19. ncbi request reprint Phase-contrast diffuse optical tomography for in vivo breast imaging: a two-step method
    Ruixin Jiang
    The J Crayton Pruitt Family, Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 48:4749-55. 2009
    ..The sensitivity and specificity from these 42 cases are both 81% when RI is used as an imaging parameter for distinguishing between malignant and benign lesions...
  20. ncbi request reprint Imaging of small nanoparticle-containing objects by finite-element-based photoacoustic tomography
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville 32611, USA
    Opt Lett 30:3054-6. 2005
    ..The results obtained show that millimeter-size nanoparticle-containing objects can be clearly detected in terms of position, size, and relative optical properties...
  21. ncbi request reprint Quantitative bioluminescence tomography guided by diffuse optical tomography
    Qizhi Zhang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Opt Express 16:1481-6. 2008
    ....
  22. ncbi request reprint Three-dimensional finite-element-based photoacoustic tomography: reconstruction algorithm and simulations
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Med Phys 34:538-46. 2007
    ..The results show that the algorithm is able to reconstruct photoacoustic images quantitatively in terms of the location, size, optical and acoustic properties of the target, and background media for various examples examined...
  23. ncbi request reprint Finite-element-based photoacoustic tomography: phantom and chicken bone experiments
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville 32611 6131, USA
    Appl Opt 45:3177-83. 2006
    ..The results obtained show that millimeter-sized phantom objects and chicken bones and/or joints can be clearly detected using our finite-element-based photoacoustic tomography method...
  24. ncbi request reprint Model-based ultrasound tomography: tissue phantom experiments
    Hongzhi Zhao
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Med Phys 32:2659-64. 2005
    ..We also demonstrate that a high contrast target as small as 3 mm in diameter can be quantitatively resolved with our acoustic speed and attenuation images...
  25. ncbi request reprint DOT guided fluorescence molecular tomography of arbitrarily shaped objects
    Yiyong Tan
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Med Phys 35:5703-7. 2008
    ..In particular, the absolute value of mu(a(x-->m)) from their DOT guided FMT is quantitatively consistent with that obtained with spectroscopic methods...
  26. pmc Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study
    Yao Sun
    University of Florida, Department of Biomedical Engineering, 130 BME Building, P O Box 116131, Gainesville, Florida 32611, USA
    J Biomed Opt 14:064002. 2009
    ..This in vivo study suggests that the 3-D PAT method described has the potential to be used for early diagnosis of joint diseases such as osteoarthritis and rheumatoid arthritis...
  27. pmc Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis
    Zhen Yuan
    University of Florida, Department of Biomedical Engineering, 130 BME Building, P O Box 116131, Gainesville, Florida 32611 6131, USA
    J Biomed Opt 14:054013. 2009
    ..The results show that the reconstruction error between these two models is about 15 and 4%, respectively, for stand-alone and image-guided frameworks...
  28. doi request reprint A higher order diffusion model for three-dimensional photon migration and image reconstruction in optical tomography
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 54:65-88. 2009
    ..We conclude that the developed higher order diffusion model is able to accurately describe light propagation in biological tissues and to offer improved image reconstruction...
  29. ncbi request reprint Quantitative photoacoustic tomography based on the radiative transfer equation
    Lei Yao
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Opt Lett 34:1765-7. 2009
    ..The method and associated finite element reconstruction algorithm are validated using a series of tissuelike phantom experiments...
  30. ncbi request reprint Visualizing localized dynamic changes during epileptic seizure onset in vivo with diffuse optical tomography
    Qiang Wang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Med Phys 35:216-24. 2008
    ....
  31. ncbi request reprint Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system
    Changqing Li
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Med Phys 33:627-36. 2006
    ..From the in vivo clinic experiment, functional images including deoxyhemoglobin, oxyhemoglobin, and water concentration are recovered and tumors are detected with correct size and position compared with the mammography...
  32. doi request reprint Transport-based quantitative photoacoustic tomography: simulations and experiments
    Lei Yao
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 55:1917-34. 2010
    ....
  33. ncbi request reprint Two-dimensional bioluminescence tomography: numerical simulations and phantom experiments
    Senhu Li
    Department of Biomedical Engineering, University of Florida, Gainesville, USA
    Appl Opt 45:3390-4. 2006
    ..The method is tested with numerical simulations and further confirmed with several phantom experiments...
  34. ncbi request reprint Three-dimensional diffuse optical tomography of osteoarthritis: initial results in the finger joints
    Zhen Yuan
    University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611 6131, USA
    J Biomed Opt 12:034001. 2007
    ..The results of this pilot study show potential for quantitative imaging and diagnosis of early OA by DOT...
  35. doi request reprint Tomographic x-ray-guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints
    Zhen Yuan
    University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611 6131, USA
    J Biomed Opt 13:044006. 2008
    ..In particular, the improved quantitative capability of imaging absorption and scattering coefficients of the joint tissues allows for more accurate diagnosis of osteoarthritis over x-ray radiography or DOT alone...
  36. pmc Morphologic tomography of nonspherical particles using multispectral diffusing light measurements
    Mohammad Reza Hajihashemi
    University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611 6131, USA
    J Biomed Opt 16:116014. 2011
    ..Diffusely scattered light at several wavelengths along the boundary of the phantom are collected and analyzed to allow for simultaneous extraction of the size, concentration, and aspect ratio of the spheroidal particles...
  37. doi request reprint Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection
    Lei Xi
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Med Phys 39:2584-94. 2012
    ..The combined PAT/DOT system takes full advantages of two different modalities to provide complementary information and most accurate recovery of tissue optical properties...
  38. doi request reprint Quantitative three-dimensional photoacoustic tomography of the finger joints: phantom studies in a spherical scanning geometry
    Yao Sun
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 54:5457-67. 2009
    ..015 to 0.04 mm(-1). The phantom images shown in this paper suggest that 3D photoacoustic tomography in a spherical scanning geometry has the potential to image a realistic human joint...
  39. ncbi request reprint Diffuse optical tomography guided quantitative fluorescence molecular tomography
    Yiyong Tan
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 47:2011-6. 2008
    ..In particular absolute value of mu(a(x-->m) ) from our DOT guided FMT are quantitatively consistent with that obtained using spectroscopic methods...
  40. doi request reprint Photoacoustic tomography for imaging nanoparticles
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 624:309-24. 2010
    ..In this chapter, we described in detail photoacoustic reconstruction methods and imaging systems. We also review the recent advances in nanoparticles and their in vivo applications in the field of photoacoustic imaging...
  41. doi request reprint Design and evaluation of a miniature probe integrating diffuse optical tomography and electroencephalographic source localization
    Hao Yang
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 52:5036-41. 2013
    ..The results obtained from extensive phantom experiments show that this dual-modal approach is suitable for imaging seizure focus in the study of epilepsy. ..
  42. doi request reprint Miniature probe combining optical-resolution photoacoustic microscopy and optical coherence tomography for in vivo microcirculation study
    Lei Xi
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 52:1928-31. 2013
    ..The combined system yields a lateral resolution of 15 μm for both ORPAM and OCT...
  43. pmc DOT corrected fluorescence molecular tomography using targeted contrast agents for small animal tumor imaging
    Yiyong Tan
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    J Xray Sci Technol 21:43-52. 2013
    ..To demonstrate diffuse optical tomography (DOT) corrected fluorescence molecular tomography (FMT) for quantitatively imaging tumor-targeted contrast agents in a 4T1 mouse mammary tumor model...
  44. doi request reprint Impact of inhomogeneous optical scattering coefficient distribution on recovery of optical absorption coefficient maps using tomographic photoacoustic data
    Xiaoqi Li
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 58:999-1011. 2013
    ..Results from extensive simulations show that photoacoustic recovery of absorption coefficient maps can be improved considerably with a priori scattering information from DOT...
  45. pmc Microelectromechanical systems scanning-mirror-based handheld probe for fluorescence molecular tomography
    Bin He
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 51:4678-83. 2012
    ..Tumor-bearing mice with systematically injected tumor-targeted NIR fluorescent probes were scanned to further demonstrate the ability of this MEMS-based FMT for imaging small animals...
  46. pmc First assessment of three-dimensional quantitative photoacoustic tomography for in vivo detection of osteoarthritis in the finger joints
    Yao Sun
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Med Phys 38:4009-17. 2011
    ..The purpose of this pilot clinical study is to assess three-dimensional (3-D) quantitative photoacoustic tomography (qPAT) for in vivo detection of osteoarthritis (OA) in the finger joints...
  47. ncbi request reprint Simultaneous recovery of tissue physiological and acoustic properties and the criteria for wavelength selection in multispectral photoacoustic tomography
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Opt Lett 34:1714-6. 2009
    ..We found that the image quality and the separation between acoustic velocity and different chromophore concentrations strongly depend on the measurement wavelengths of incident laser source...
  48. pmc Fast multispectral diffuse optical tomography system for in vivo three-dimensional imaging of seizure dynamics
    Jianjun Yang
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 51:3461-9. 2012
    ..The system is validated using both static and dynamic tissue-like phantoms. An initial in vivo experiment using a rat model of seizure is also demonstrated...
  49. pmc Molecular photoacoustic tomography of breast cancer using receptor targeted magnetic iron oxide nanoparticles as contrast agents
    Lei Xi
    Department of Biomedical Engineering, University of Florida, College of Engineering JG56 BMS Bldg, Gainesville, FL 32611 6131, USA
    J Biophotonics 7:401-9. 2014
    ..Our study indicates the potential of the combination of photoacoustic tomography and receptor-targeted NIR830-ATF-IONP as a clinical tool that can provide improved specificity and sensitivity for breast cancer detection...
  50. ncbi request reprint Reconstruction of optical absorption coefficient maps of heterogeneous media by photoacoustic tomography coupled with diffusion equation based regularized Newton method
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Opt Express 15:18076-81. 2007
    ..The reconstruction results show that the optical absorption coefficient images obtained are quantitative in terms of the shape, size, location and optical property values of the heterogeneities examined...
  51. ncbi request reprint Quantitative microwave-induced thermoacoustic tomography
    Lei Yao
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Med Phys 37:3752-9. 2010
    ..Here the authors describe a method for quantitative MI-TAT and obtain the distribution of dielectric property which directly correlates with tissue structural and functional information...
  52. ncbi request reprint Quantitative reconstruction of refractive index distribution and imaging of glucose concentration by using diffusing light
    Xiaoping Liang
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville 32611, USA
    Appl Opt 45:8360-5. 2006
    ..The results show that the relative error of the reconstructed refractive index is reduced from 20% to within 1.5%. We also demonstrate the possibility of PCDOT for recovering glucose concentration using these phantom experiments...
  53. ncbi request reprint Liquid acoustic lens for photoacoustic tomography
    Chaolong Song
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Opt Lett 38:2930-3. 2013
    ..Phantom experiments have been carried out to demonstrate the improvement of using such a liquid lens over using a bare transducer for PA tomography. ..
  54. doi request reprint Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging
    Lei Xi
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Opt Express 20:8726-31. 2012
    ..The MEMS imaging probe is small and has the potential to be conveniently used to guide surgical resection of tumors in the breast...
  55. doi request reprint Photoacoustic tomography and fluorescence molecular tomography: a comparative study based on indocyanine green
    Bo Wang
    Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Med Phys 39:2512-7. 2012
    ..The goal of this work is to comparatively evaluate the performance of reflection-mode PAT and FMT in common phantom when indocyanine green (ICG) was used as a contrast agent...
  56. doi request reprint In vivo monitoring of stem cells in Drosophila pupae using the radiative transfer equation-based fluorescence molecular tomography
    Yiyong Tan
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Mol Imaging Biol 13:868-73. 2011
    ..The aim of this study is to realize in vivo monitoring of DSRed-expressing cell distribution in Drosophila pupae using fluorescence molecular tomography (FMT)...
  57. pmc Tomographic reconstruction of tissue properties and temperature increase for high-intensity focused ultrasound applications
    Lu Yin
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Ultrasound Med Biol 39:1760-70. 2013
    ..The method was initially conducted in ex vivo experiments in which time-dependent temperature on a tissue surface was measured using high-resolution, non-invasive infrared thermography...
  58. pmc HER-2/neu targeted delivery of a nanoprobe enables dual photoacoustic and fluorescence tomography of ovarian cancer
    Lei Xi
    Department of Biomedical Engineering, University of Florida, Gainesville, FL
    Nanomedicine 10:669-77. 2014
    ..This study demonstrated the potential of the application of HER-2/neu-targeted PAT/FMT approach for non-invasive or intraoperative imaging of ovarian cancer...
  59. ncbi request reprint Photoacoustic and fluorescence image-guided surgery using a multifunctional targeted nanoprobe
    Lei Xi
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
    Ann Surg Oncol 21:1602-9. 2014
    ..We hypothesized that image-guided surgery using nanoparticle-enhanced photoacoustic and fluorescence imaging could significantly reduce the rate of local recurrence...
  60. ncbi request reprint Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo
    Zhijuan Chen
    Department of Anatomy and Cell Biology, University of Florida, 1600 SW Archer Road, Gainesville, FL, USA
    Breast Cancer Res Treat 145:45-59. 2014
    ..Our findings provide 'proof-of-concept' for the development of highly specific structure-based alternative targeted therapy for the prevention and/or treatment of TNBC. ..
  61. ncbi request reprint Emerging implications of nanotechnology on cancer diagnostics and therapeutics
    Alex G Cuenca
    Division of Surgical Oncology, Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Cancer 107:459-66. 2006
    ..A widespread understanding of these new technologies is important, because they currently are being integrated into the clinical practice of oncology...
  62. pmc T-matrix-based inverse algorithm for morphologic characterization of nonspherical particles using multispectral diffuse optical tomography
    M Reza Hajihashemi
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    Appl Opt 50:3896-906. 2011
    ..Different statistical models are assumed for the suspended nonspherical particles and the performance of the inverse algorithm is tested using noise-corrupted data up to 50% noise added to the observed scattering spectra...
  63. ncbi request reprint Photoacoustic tomography can detect cerebral hemodynamic alterations in a neonatal rodent model of hypoxia-ischemia
    Craig B Sussman
    Department of Pediatrics, University of Florida, Gainesville and Jacksonville, Florida, USA
    Acta Neurobiol Exp (Wars) 72:253-63. 2012
    ..This is the first study described in the literature utilizing a neonatal rat model of HIE to demonstrate in vivo alterations in cerebral hemodynamics in a non-invasive and near real-time fashion...
  64. pmc A calibration-free, one-step method for quantitative photoacoustic tomography
    Zhen Yuan
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
    Med Phys 39:6895-9. 2012
    ..The purpose of this study is to develop a new algorithm for the reconstruction of optical absorption coefficient that does not depend on these initial parameters...
  65. pmc An inverse light scattering technique for morphological characterization of irregular particles based on the Gaussian-random-sphere model
    M Reza Hajihashemi
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA
    J Opt Soc Am A Opt Image Sci Vis 29:1124-31. 2012
    ..The performance of the inverse algorithm is tested using noise-corrupted data, in which up to 50% noise may be added to the observed scattering spectra...
  66. ncbi request reprint A practical method for three-dimensional reconstruction of joints using a C-arm system and shift-and-add algorithm
    Senhu Li
    Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611 6131, USA
    Med Phys 32:1491-9. 2005
    ..The proposed method has been tested and evaluated on simulated cylinders, a chicken bone phantom with known structure, and an in vivo human index finger. The results are demonstrated and discussed...
  67. pmc Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development
    Qing Ruan
    Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
    Cancer Lett 332:120-9. 2013
    ..PA imaging showed that knockdown of UPR proteins greatly reduced tumor angiogenesis in vivo in breast cancer models...
  68. ncbi request reprint Looking at and listening to cancer cells
    Stephen R Grobmyer
    Department of Surgery, University of Florida, 1600 SW Archer Road, Room 6164 Box 100109, Gainesville, FL 32609 0109 USA
    Chembiochem 13:1401-3. 2012
    ..This novel approach for imaging cancer cells opens the door to unprecedented insight into cancer progression in vivo...
  69. pmc A handheld fluorescence molecular tomography system for intraoperative optical imaging of tumor margins
    Qing Zhao
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Med Phys 38:5873-8. 2011
    ....
  70. ncbi request reprint Near-infrared optical imaging of the breast with model-based reconstruction
    Huabei Jiang
    Department of Physics and Astronomy, Clemson University, SC 29634 0978, USA
    Acad Radiol 9:186-94. 2002
    ..The authors report quantitative absorption and scattering images of the human breast with model-based reconstruction methods using near-infrared continuous-wave tomographic data...
  71. ncbi request reprint Absorption and scattering images of heterogeneous scattering media can be simultaneously reconstructed by use of dc data
    Yong Xu
    Department of Physics and Astronomy, Clemson University, South Carolina 29634, USA
    Appl Opt 41:5427-37. 2002
    ..Finally, we discuss our results in light of recent theoretical findings on nonuniqueness for dc image reconstruction...
  72. ncbi request reprint Measurement of particle-size distribution and concentration in heterogeneous turbid media with multispectral diffuse optical tomography
    Changqing Li
    Department of Physics and Astronomy, Clemson University, 118 Kinard Lab, Clemson, South Carolina 29634, USA
    Appl Opt 44:1838-44. 2005
    ....
  73. ncbi request reprint Phase-contrast imaging of tissue using near-infrared diffusing light
    Huabei Jiang
    Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634 0978, USA
    Med Phys 30:1048-51. 2003
    ..The imaging method is validated using several tissue-like phantom experiments. Initial in vivo imaging of breast tissue is also presented, demonstrating the ability of this new imaging method for tumor detection...
  74. ncbi request reprint Differentiation of cysts from solid tumors in the breast with diffuse optical tomography
    Xuejun Gu
    Department of Physics and Astronomy, Clemson University, Clemson, SC 29634 0978, USA
    Acad Radiol 11:53-60. 2004
    ..Thus far, the clinical evaluation of DOT has been largely limited to solid tumors. A pilot clinical study focused on DOT imaging of breasts with cysts is presented...
  75. ncbi request reprint Model-based microwave image reconstruction: simulations and experiments
    Razvan Ciocan
    Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, USA
    Med Phys 31:3231-41. 2004
    ....
  76. ncbi request reprint In vivo breast imaging with diffuse optical tomography based on higher-order diffusion equations
    Yong Xu
    Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, USA
    Appl Opt 42:3163-9. 2003
    ..Pilot clinical results from female volunteers indicate that enhanced diffuse optical tomography can quantitatively image findings such as breast cysts or implants in which the absorption and scattering coefficients are usually low...
  77. ncbi request reprint Measurement of particle size distribution in multilayered skin phantoms using polarized light spectroscopy
    Matthew Bartlett
    Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 65:031906. 2002
    ..In this paper we also study the effect of the thickness of the top layer on the ability to reconstruct the polystyrene size distribution...
  78. ncbi request reprint Measurement of particle size distribution in mammalian cells in vitro by use of polarized light spectroscopy
    Matthew Bartlett
    Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, USA
    Appl Opt 43:1296-307. 2004
    ..Other subcellular structures, such as the nucleoli and the nucleus, may also contribute significantly. We reconstruct the PSD of the mitochondria, as verified by optical microscopy. We also demonstrate the angle dependence of the PSD...

Research Grants11

  1. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2006
    ....
  2. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2003
    ....
  3. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2002
    ....
  4. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2007
    ....
  5. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2005
    ....
  6. Noninvasive Functional and Cellular Imaging of Epilepsy
    Huabei Jiang; Fiscal Year: 2010
    ..Both technological development and in vivo animal studies are proposed in this application. ..
  7. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2005
    ....
  8. Optical Imaging of Breast Cancer
    Huabei Jiang; Fiscal Year: 2004
    ....
  9. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2004
    ....
  10. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2006
    ....
  11. Diffuse Optical Tomography of Osteoarthritis
    Huabei Jiang; Fiscal Year: 2003
    ....