Feng Jiang

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers
    Lingxiao Xing
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
    Mod Pathol 23:1157-64. 2010
  2. doi A panel of sputum-based genomic marker for early detection of lung cancer
    Feng Jiang
    Department of Pathology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cancer Prev Res (Phila) 3:1571-8. 2010
  3. pmc Combined genetic analysis of sputum and computed tomography for noninvasive diagnosis of non-small-cell lung cancer
    Feng Jiang
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
    Lung Cancer 66:58-63. 2009
  4. doi Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer
    Feng Jiang
    Department of Pathology, Greenbaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
    Mol Cancer Res 7:330-8. 2009
  5. pmc Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers
    Lei Yu
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
    Int J Cancer 127:2870-8. 2010
  6. ncbi Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target
    Tao Fan
    Department of Pathology, University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
    Cancer Res 67:7901-6. 2007
  7. ncbi Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer
    RuiYun Li
    Department of Surgery, The University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
    Clin Cancer Res 13:482-7. 2007
  8. pmc Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer
    Ying Xie
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    Lung Cancer 67:170-6. 2010
  9. pmc Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers
    Jun Shen
    Department of Pathology, University of Maryland School of Medicine, 10 S, Pine St, Baltimore, MD 21201, USA
    BMC Cancer 11:374. 2011
  10. pmc Genetically abnormal circulating cells in lung cancer patients: an antigen-independent fluorescence in situ hybridization-based case-control study
    Ruth L Katz
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 16:3976-87. 2010

Research Grants

Collaborators

Detail Information

Publications37

  1. doi Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers
    Lingxiao Xing
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
    Mod Pathol 23:1157-64. 2010
    ..The sputum markers showed the potential to improve the early detection of lung squamous cell carcinomas...
  2. doi A panel of sputum-based genomic marker for early detection of lung cancer
    Feng Jiang
    Department of Pathology, The University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cancer Prev Res (Phila) 3:1571-8. 2010
    ..The gene panel could provide sputum-based markers that have the potential to improve early detection of lung SCCs...
  3. pmc Combined genetic analysis of sputum and computed tomography for noninvasive diagnosis of non-small-cell lung cancer
    Feng Jiang
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
    Lung Cancer 66:58-63. 2009
    ..05). The integration of the genetic assay with CT led to improvements in noninvasive diagnosis of stage I NSCLCs, especially central tumors...
  4. doi Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer
    Feng Jiang
    Department of Pathology, Greenbaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
    Mol Cancer Res 7:330-8. 2009
    ..These findings offer an important new tool for the study of lung CSCs and provide a potential prognostic factor and therapeutic target for treatment of the patients with lung cancer...
  5. pmc Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers
    Lei Yu
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
    Int J Cancer 127:2870-8. 2010
    ..The sputum markers demonstrated the potential of translation to laboratory settings for improving the early detection of lung adenocarcinoma...
  6. ncbi Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target
    Tao Fan
    Department of Pathology, University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
    Cancer Res 67:7901-6. 2007
    ..008). Our results suggest that 14-3-3zeta is a potential target for developing a prognostic biomarker and therapeutics that can enhance the antitumor activity of cisplatin for NSCLC...
  7. ncbi Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer
    RuiYun Li
    Department of Surgery, The University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
    Clin Cancer Res 13:482-7. 2007
    ..The aim of this study was to determine whether the genetic changes can be used as markers in sputum specimen for the early detection of lung cancer...
  8. pmc Altered miRNA expression in sputum for diagnosis of non-small cell lung cancer
    Ying Xie
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    Lung Cancer 67:170-6. 2010
    ..82% sensitivity and 100.00% specificity by sputum cytology. The measurement of altered miRNA expression in sputum could be a useful noninvasive approach for the diagnosis of lung cancer...
  9. pmc Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers
    Jun Shen
    Department of Pathology, University of Maryland School of Medicine, 10 S, Pine St, Baltimore, MD 21201, USA
    BMC Cancer 11:374. 2011
    ..We previously demonstrated that microRNAs (miRNAs) could be used as biomarkers for lung cancer diagnosis. Here we investigate whether plasma microRNAs are useful in identifying lung cancer among individuals with CT-detected SPNs...
  10. pmc Genetically abnormal circulating cells in lung cancer patients: an antigen-independent fluorescence in situ hybridization-based case-control study
    Ruth L Katz
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 16:3976-87. 2010
    ....
  11. ncbi Surfactant protein A gene deletion and prognostics for patients with stage I non-small cell lung cancer
    Feng Jiang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:5417-24. 2005
    ..The present study was conducted to determine clinical relevance of surfactant protein A (SP-A) genetic aberrations in early-stage non-small cell lung cancer (NSCLC)...
  12. pmc Plasma microRNAs as potential biomarkers for non-small-cell lung cancer
    Jun Shen
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 1192, USA
    Lab Invest 91:579-87. 2011
    ..67%) in diagnosis of lung adenocarcinomas compared with squamous cell carcinomas (82.35%) (P<0.05). Altered expressions of the miRNAs in plasma would provide potential blood-based biomarkers for NSCLC...
  13. doi Magnetic enrichment of bronchial epithelial cells from sputum for lung cancer diagnosis
    Qi Qiu
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine St, MSTF 7th Fl, Baltimore, MD 21201 1192, USA
    Cancer 114:275-83. 2008
    ..We propose to obtain concentrated and purified bronchial epithelial cells to improve early detection of lung cancer in sputum samples...
  14. pmc Genomic profiles in stage I primary non small cell lung cancer using comparative genomic hybridization analysis of cDNA microarrays
    Feng Jiang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Neoplasia 6:623-35. 2004
    ..The identified genomic aberrations may be involved in the initiation and progression of lung tumorigenesis and, most importantly, may be developed as new biomarkers for the early detection and classification of lung cancer...
  15. ncbi Induction of ovarian cancer cell apoptosis by 1,25-dihydroxyvitamin D3 through the down-regulation of telomerase
    Feng Jiang
    Department of Pathology, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612 4799, USA
    J Biol Chem 279:53213-21. 2004
    ..Overall, the study suggests that the down-regulation of telomerase activity by 1,25(OH)(2)VD(3) and the resulting cell death are important components of the response of OCa cells to 1,25(OH)(2)VD(3)-induced growth suppression...
  16. pmc Automated detection of genetic abnormalities combined with cytology in sputum is a sensitive predictor of lung cancer
    Ruth L Katz
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Mod Pathol 21:950-60. 2008
    ..For diagnosing lung cancer in sputum, a combination of molecular and cytologic variables was superior to using conventional cytology alone...
  17. ncbi RNA silencing of S-phase kinase-interacting protein 2 inhibits proliferation and centrosome amplification in lung cancer cells
    Feng Jiang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 24:3409-18. 2005
    ..These results imply that SKP2 plays an oncogenic role in lung cancer and that SKP2 silencing may be useful in the treatment of lung cancer...
  18. ncbi Overexpression of S100A2 protein as a prognostic marker for patients with stage I non small cell lung cancer
    Huijun Wang
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 116:285-90. 2005
    ..Our results suggested that the expression of the S100A2 protein in stage I NSCLC indicates poor prognosis and may be used to identify patients with early-stage NSCLC who might benefit from adjuvant treatment...
  19. pmc Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer
    Jipei Liao
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    Mol Cancer 9:198. 2010
    ....
  20. ncbi A novel multiple FISH array for the detection of genetic aberrations in cancer
    RuiYun Li
    Department of Surgery, The University of Maryland School of Medicine, Baltimore, 21201 1192, USA
    Lab Invest 86:619-27. 2006
    ..The technique may thus be a powerful laboratory strategy for cancer prevention and early detection and for improved patient management...
  21. ncbi Comparison of molecular abnormalities in bronchial brushings and tumor touch preparations
    Guliz A Barkan
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 105:35-43. 2005
    ..The authors performed a pilot study to evaluate the use of DNA fluorescence in situ hybridization (FISH) probes to ascertain whether these biomarkers can predict nonsmall cell lung carcinoma (NSCLC)...
  22. pmc ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome
    Ting Li
    Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201 1192, USA
    Lab Invest 90:234-44. 2010
    ..00093 and 0.00017, respectively). ALDH1A1 could be a prostate CSC-related marker. Measuring its expression might provide a potential approach to study tumorigenesis of PCa and predict outcome of the disease...
  23. pmc Kernel based methods for accelerated failure time model with ultra-high dimensional data
    Zhenqiu Liu
    University of Maryland Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA
    BMC Bioinformatics 11:606. 2010
    ..This two-step procedure may introduce bias and inaccuracy and lead us to miss biologically important genes...
  24. pmc Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65
    Junying Bao
    Department of Pathology, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612 4799, USA
    Mol Cell Biol 27:1321-33. 2007
    ..Our studies reveal a novel mechanism of estrogen action, which may explain the well-known neuroprotective functions of estrogens as well as the complex role of this female hormone in the pathogenesis of neuronal degeneration diseases...
  25. doi Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapy
    Merry Y Zhao
    Department of Pathology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland 21201, USA
    Clin Cancer Res 15:1708-20. 2009
    ..This study aimed to identify and evaluate molecular targets for the development of a novel combination chemotherapy to treat refractory and recurrent diffuse large B-cell lymphoma (DLBCL)...
  26. doi Analysis of MicroRNAs in Sputum to Improve Computed Tomography for Lung Cancer Diagnosis
    Jun Shen
    Department of Pathology and Division of Biostatistics, The University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland
    J Thorac Oncol 9:33-40. 2014
    ..However, CT has relatively low specificity, presenting a challenge in clinical settings. We previously identified 12 microRNAs (miRNAs) whose expressions in tumor tissues were associated with lung cancer...
  27. ncbi Gene identification and survival prediction with Lp Cox regression and novel similarity measure
    Zhenqiu Liu
    University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA
    Int J Data Min Bioinform 3:398-408. 2009
    ....
  28. pmc Regularized F-measure maximization for feature selection and classification
    Zhenqiu Liu
    Division of Biostatistics, University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA
    J Biomed Biotechnol 2009:617946. 2009
    ..Our experiments with the benchmark, methylation, and high dimensional microarray data show that the performance of proposed algorithm is better or equivalent compared with the other popular classifiers in limited experiments...
  29. pmc Gene and pathway identification with Lp penalized Bayesian logistic regression
    Zhenqiu Liu
    Division of Biostatistics, University of Maryland Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA
    BMC Bioinformatics 9:412. 2008
    ..Usually this parameter must be carefully tuned through cross-validation, which is time consuming...
  30. pmc Fluorescent metal nanoshell probe to detect single miRNA in lung cancer cell
    Jian Zhang
    Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, Maryland 21201, USA
    Anal Chem 82:4464-71. 2010
    ..The results may reflect a genomic signal change and provide a reference to lung cancer early diagnosis as well as other diseases...
  31. ncbi Evaluation of peripheral blood involvement of mantle cell lymphoma by fluorescence in situ hybridization in comparison with immunophenotypic and morphologic findings
    Jun Gu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 17:553-60. 2004
    ....
  32. ncbi Detecting genomic aberrations by fluorescence in situ hybridization with quantum dots-labeled probes
    Zhengran Jiang
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Nanosci Nanotechnol 7:4254-9. 2007
    ..These results suggest that the QD-FISH probes may offer an effective approach to analyze cancer-related genomic aberrations in basic research and clinical applications...
  33. pmc MicroRNAs as potential biomarkers in human solid tumors
    Jun Shen
    Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
    Cancer Lett 329:125-36. 2013
    ..Here we review the progress of analysis of microRNAs as a potential approach for diagnosis and prognosis of solid cancer. We will also discuss obstacles in developing miRNAs as circulating biomarkers...
  34. doi Digital PCR quantification of miRNAs in sputum for diagnosis of lung cancer
    Ning Li
    Department of Pathology, The University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, 10 South Pine Street, MSTF 7th floor, Baltimore, MD, 21201 1192, USA
    J Cancer Res Clin Oncol 140:145-50. 2014
    ..The objective of the study was to investigate whether digital PCR could be used to quantify miRNAs in sputum for lung cancer diagnosis...
  35. pmc Small nucleolar RNAs in cancer
    Kaiissar Mannoor
    Department of Pathology, University of Maryland School of Medicine, 10 S Pine St, Baltimore, MD 21201 1192, USA
    Biochim Biophys Acta 1826:121-8. 2012
    ..In this review, we will describe current studies that have shed new light on the functions of snoRNAs in carcinogenesis and the potential applications for cancer diagnosis and therapy...
  36. ncbi Centrosomal abnormality is common in and a potential biomarker for bladder cancer
    Feng Jiang
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 106:661-5. 2003
    ..Centrosomal abnormalities appear to be intrinsic to aneuploidy and tumorigenesis and may be potential markers for early detection of bladder cancer...
  37. ncbi G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer
    Feng Jiang
    Department of Pathology, University of South Florida College of Medicine and the Program of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 4799, USA
    J Biol Chem 278:48030-40. 2003
    ..Taken together, these results identify GADD45 as an important mediator for the tumor-suppressing activity of 1,25-dihydroxyvitamin D3 in human ovarian cancer cells...

Research Grants4

  1. New Diagnostic Assay for Early Detection of Lung Cancer
    Feng Jiang; Fiscal Year: 2005
    ..This project will be multidisciplinary, incorporating epidemiology, molecular biology, cytogenetics, pathology, bioinformatics, and statistics. ..