I Jialal

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Increased Expression of Fc-γ Receptors on Monocytes in Patients With Nascent Metabolic Syndrome
    Sridevi Devaraj
    MD, PhD, Laboratory of Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 S Avenue, Research I Building, Room 3000, Sacramento, California 95817 2218
    J Clin Endocrinol Metab 98:E1510-5. 2013
  2. doi request reprint Increased chemerin and decreased omentin-1 in both adipose tissue and plasma in nascent metabolic syndrome
    Ishwarlal Jialal
    MD, PhD, University of California Davis Medical Center, 4635 Second Avenue, Research I Building, Room 3005, Sacramento, California 95817 2218
    J Clin Endocrinol Metab 98:E514-7. 2013
  3. pmc Human C-reactive protein accentuates macrophage activity in biobreeding diabetic rats
    Ishwarlal Jialal
    Laboratory of Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California at Davis, Sacramento, CA, USA
    J Diabetes Complications 27:23-8. 2013
  4. pmc Hyperglycemia induces Toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy
    Harmeet Kaur
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, Universityof California Sacramento, 4635 Second Ave, Sacramento, CA 95817, USA
    Am J Physiol Renal Physiol 303:F1145-50. 2012
  5. pmc Antisense to protein kinase C-alpha and p47phox attenuates the pro-inflammatory effects of human C-reactive protein in macrophages of biobreeding diabetic rats
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Diab Vasc Dis Res 9:315-9. 2012
  6. ncbi request reprint Pharmacotherapy for the metabolic syndrome
    Arthur L M Swislocki
    VA Medical Center, Mather, CA, USA
    Curr Vasc Pharmacol 10:187-205. 2012
  7. pmc Statin therapy in metabolic syndrome and hypertension post-JUPITER: what is the value of CRP?
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Avenue, Research 1 Building, Room 3000, Sacramento, CA 95817, USA
    Curr Atheroscler Rep 13:31-42. 2011
  8. pmc Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome
    Sridevi Devaraj
    University of California Davis Medical Center, Sacramento, CA 95817, USA
    Curr Atheroscler Rep 12:110-8. 2010
  9. pmc Concomitant reduction in low-density lipoprotein cholesterol and glycated hemoglobin with colesevelam hydrochloride in patients with type 2 diabetes: a pooled analysis
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, California 95817, USA
    Metab Syndr Relat Disord 7:255-8. 2009
  10. pmc Management of hypertriglyceridemia in the diabetic patient
    Ishwarlal Jialal
    VA Medical Center and Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Internal Medicine, UC Davis Medical Center, 4635 Second Avenue, Research 1 Building, Room 3000, Sacramento, CA 95817, USA
    Curr Diab Rep 10:316-20. 2010

Research Grants

  1. CLINICAL STUDIES IN NUTRITION AND METABOLISM
    Ishwarlal Jialal; Fiscal Year: 2007
  2. C-Reactive Protein And Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2007
  3. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
  4. EFFECT OF HIGH DOSE VITAMIN E ON CAROTID ATHERSCLEROSIS
    Ishwarlal Jialal; Fiscal Year: 2001
  5. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010

Detail Information

Publications104 found, 100 shown here

  1. doi request reprint Increased Expression of Fc-γ Receptors on Monocytes in Patients With Nascent Metabolic Syndrome
    Sridevi Devaraj
    MD, PhD, Laboratory of Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 S Avenue, Research I Building, Room 3000, Sacramento, California 95817 2218
    J Clin Endocrinol Metab 98:E1510-5. 2013
    ..Conclusions: We provide novel evidence of increased FcgR expression and activity in monocytes of patients with MetS that correlates with the number of features of MetS and with high-sensitivity CRP. ..
  2. doi request reprint Increased chemerin and decreased omentin-1 in both adipose tissue and plasma in nascent metabolic syndrome
    Ishwarlal Jialal
    MD, PhD, University of California Davis Medical Center, 4635 Second Avenue, Research I Building, Room 3005, Sacramento, California 95817 2218
    J Clin Endocrinol Metab 98:E514-7. 2013
    ..Conclusions: We make the novel observation of abnormal circulating and gluteal SAT-secreted chemerin and omentin-1 levels in nascent MetS, which could confer a higher risk for diabetes and cardiovascular disease...
  3. pmc Human C-reactive protein accentuates macrophage activity in biobreeding diabetic rats
    Ishwarlal Jialal
    Laboratory of Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California at Davis, Sacramento, CA, USA
    J Diabetes Complications 27:23-8. 2013
    ..However, there is a paucity of data examining the role of CRP in promoting the pro-inflammatory state of diabetes. Thus, we examined the pro-inflammatory effects of human CRP using spontaneously diabetic bio-breeding (BB) rats...
  4. pmc Hyperglycemia induces Toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy
    Harmeet Kaur
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, Universityof California Sacramento, 4635 Second Ave, Sacramento, CA 95817, USA
    Am J Physiol Renal Physiol 303:F1145-50. 2012
    ..05). Collectively, these data suggest that hyperglycemia activates TLR4 expression and activity in MC and could contribute to DN...
  5. pmc Antisense to protein kinase C-alpha and p47phox attenuates the pro-inflammatory effects of human C-reactive protein in macrophages of biobreeding diabetic rats
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Diab Vasc Dis Res 9:315-9. 2012
    ..In this report, we tested the effects of molecular inhibition of CRP effects on MO activity using antisense oligonucleotide (ASO) to both PKC-α and p47phox...
  6. ncbi request reprint Pharmacotherapy for the metabolic syndrome
    Arthur L M Swislocki
    VA Medical Center, Mather, CA, USA
    Curr Vasc Pharmacol 10:187-205. 2012
    ..Metformin therapy has been shown to prevent new onset MetS. Modulating the incretin axis can prove very fruitful. A drug targeting all 3 disorders would be ideal but to date does not exist...
  7. pmc Statin therapy in metabolic syndrome and hypertension post-JUPITER: what is the value of CRP?
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Avenue, Research 1 Building, Room 3000, Sacramento, CA 95817, USA
    Curr Atheroscler Rep 13:31-42. 2011
    ....
  8. pmc Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome
    Sridevi Devaraj
    University of California Davis Medical Center, Sacramento, CA 95817, USA
    Curr Atheroscler Rep 12:110-8. 2010
    ..This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes...
  9. pmc Concomitant reduction in low-density lipoprotein cholesterol and glycated hemoglobin with colesevelam hydrochloride in patients with type 2 diabetes: a pooled analysis
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, California 95817, USA
    Metab Syndr Relat Disord 7:255-8. 2009
    ..In conclusion, COL represents a novel therapeutic option by significantly lowering both LDL-C and HbA1c in patients with T2DM, two important treatment goals to forestall vascular complications...
  10. pmc Management of hypertriglyceridemia in the diabetic patient
    Ishwarlal Jialal
    VA Medical Center and Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Internal Medicine, UC Davis Medical Center, 4635 Second Avenue, Research 1 Building, Room 3000, Sacramento, CA 95817, USA
    Curr Diab Rep 10:316-20. 2010
    ..The data about the combination of fibrate therapy with statin therapy are disappointing...
  11. ncbi request reprint Oxidative stress, inflammation, and diabetic vasculopathies: the role of alpha tocopherol therapy
    I Jialal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA, USA
    Free Radic Res 36:1331-6. 2002
    ..Thus, it appears that, in diabetes, alpha tocopherol therapy could emerge as an additional therapeutic modality...
  12. ncbi request reprint Scientific evidence to support a vitamin E and heart disease health claim: research needs
    I Jialal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, University of California Davis, Sacramento, CA, USA
    J Nutr 135:348-53. 2005
    ..In this review, we critically appraise the various clinical trials and provide recommendations for future research...
  13. pmc Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 92:3136-40. 2007
    ..TIDM is a proinflammatory state. Whereas there is consensus on lipid management in type 2 diabetes, there is a lack of data in type 1 diabetes. In addition to benefits on the lipid profile, statin therapy is antiinflammatory...
  14. ncbi request reprint Role of C-reactive protein in the assessment of cardiovascular risk
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    Am J Cardiol 91:200-2. 2003
  15. pmc Circulating levels of endothelial progenitor cell mobilizing factors in the metabolic syndrome
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center and the VA Medical Center, Sacramento, California, USA
    Am J Cardiol 106:1606-8. 2010
    ....
  16. ncbi request reprint C-reactive protein: risk marker or mediator in atherothrombosis?
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Ave, Res 1 Bldg, Rm 3000, Sacramento, Calif 95817, USA
    Hypertension 44:6-11. 2004
    ..In conclusion, CRP is a risk marker for cardiovascular disease and, based on future studies, could emerge as a mediator in atherogenesis...
  17. ncbi request reprint Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center and Veterans Affairs Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 91:4489-96. 2006
    ..Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) reduce cardiovascular events in MS patients. There is a paucity of data examining the effect of statins on inflammation in MS...
  18. ncbi request reprint Vitamin E, oxidative stress, and inflammation
    U Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    Annu Rev Nutr 25:151-74. 2005
    ..Based on its antioxidant and anti-inflammatory activities, AT (at the appropriate dose and form) could have beneficial effects on cardiovascular disease in a high-risk population...
  19. ncbi request reprint The effect of alpha-tocopherol on monocyte proatherogenic activity
    I Jialal
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    J Nutr 131:389S-94S. 2001
    ....
  20. ncbi request reprint Inflammation and atherosclerosis: the value of the high-sensitivity C-reactive protein assay as a risk marker
    I Jialal
    Department of Pathology, UT Southwestern Medical Center at Dallas, TX 75390-9073, USA
    Am J Clin Pathol 116:S108-15. 2001
    ..Weight loss, statin drugs, aspirin, and high-dose alpha tocopherol therapy could affect hsCRP. It has its greatest validity as an adjunctive measure in the primary prevention of cardiovascular disease...
  21. pmc A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Avenue, Sacramento, CA 95817, USA
    J Am Coll Nutr 27:267-73. 2008
    ..Thus, we tested the effects of different doses of purified lycopene supplementation on biomarkers of oxidative stress in healthy volunteers...
  22. pmc Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome
    Uma Singh
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California, USA
    Am J Cardiol 102:321-5. 2008
    ..In conclusion, this randomized trial of subjects with MS showed the superiority of atorvastatin 80 mg compared with its 10-mg dose in decreasing oxidized LDL, hs-CRP, matrix metalloproteinase-9, and NF-kB activity...
  23. pmc Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes
    S Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Diabetologia 52:1665-8. 2009
    ..Thus, the aim of this study was to examine circulating levels of exogenous/endogenous ligands of TLR2 and TLR4 in type 1 diabetic patients and to compare these with the levels in matched healthy controls...
  24. pmc High glucose induces toll-like receptor expression in human monocytes: mechanism of activation
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes 57:3090-8. 2008
    ..Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions...
  25. ncbi request reprint alpha-Tocopherol supplementation decreases plasminogen activator inhibitor-1 and P-selectin levels in type 2 diabetic patients
    Sridevi Devaraj
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    Diabetes Care 25:524-9. 2002
    ....
  26. pmc Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats
    U Singh
    Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA
    J Lipid Res 49:1015-23. 2008
    ..Because OxLDL uptake by macrophages contributes to foam cell formation and MMP release contributes to plaque instability, this study provides novel in vivo evidence for the role of CRP in atherosclerosis...
  27. ncbi request reprint Alpha-tocopherol decreases CD36 expression in human monocyte-derived macrophages
    S Devaraj
    Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Lipid Res 42:521-7. 2001
    ..In conclusion, AT decreases both CD36 and SR-A expression and cholesteryl ester accumulation in human macrophages. This provides additional scientific support for the antiatherogenic properties of AT...
  28. pmc Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: implications for increased cardiovascular risk
    I Jialal
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Atherosclerosis 211:297-302. 2010
    ..We aimed to enumerate and functionally characterize EPCs in subjects with MetS in comparison to healthy controls...
  29. ncbi request reprint Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Diabetes 55:774-9. 2006
    ..These results have a major implication on our understanding of the role of inflammation in vasculopathies in type 1 diabetes...
  30. pmc Simvastatin reduces circulating plasminogen activator inhibitor 1 activity in volunteers with the metabolic syndrome
    Long Wang
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA, USA
    Metab Syndr Relat Disord 6:149-52. 2008
    ..Their levels are increased in the MS. The current study was to investigate the effects of simvastatin on PAI-1, sP-selectin, and sCD40 ligand...
  31. ncbi request reprint The effect of weight loss on a stable biomarker of inflammation, C-reactive protein
    Marion Dietrich
    School of Public Health, University of California, Berkeley, CA, USA
    Nutr Rev 63:22-8. 2005
    ..Reducing inflammation through weight loss could therefore be associated with reduced risk for cardiovascular disease and other obesity-associated chronic diseases...
  32. ncbi request reprint The biological effects of CRP are not attributable to endotoxin contamination: evidence from TLR4 knockdown human aortic endothelial cells
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
    J Lipid Res 48:509-12. 2007
    ..This is the first study to positively authenticate the significance of earlier in vitro reports on CRP biological effects...
  33. ncbi request reprint Alpha-tocopherol and atherosclerosis
    N Kaul
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390-9073, USA
    Exp Biol Med (Maywood) 226:5-12. 2001
    ....
  34. ncbi request reprint CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, 4635 II Ave, Res 1 Bldg, Rm 3000, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Physiol Heart Circ Physiol 291:H1170-6. 2006
    ..Thus, in HAEC, CRP upregulates monocyte-endothelial adhesion by activation of NF-kappaB through engaging the Fcgamma receptors CD32 and CD64...
  35. ncbi request reprint Dietary factors that promote or retard inflammation
    Arpita Basu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 26:995-1001. 2006
    ..Much further research is needed to define the role of individual dietary factors on the biomarkers of inflammation and the mechanism of the anti-inflammatory effects of weight loss...
  36. ncbi request reprint Failure of vitamin E in clinical trials: is gamma-tocopherol the answer?
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, USA
    Nutr Rev 63:290-3. 2005
    ..Thus, studies using pure GT, alone or in conjunction with AT, will elucidate its utility in cardiovascular disease prevention...
  37. ncbi request reprint Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults
    Dawn J O'Byrne
    Center for Human Nutrition and the Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Clin Nutr 76:1367-74. 2002
    ..Concord grape juice (CGJ) is a rich source of flavonoids, which have greater antioxidant efficacy in vitro than does alpha-tocopherol; however, the efficacies of flavonoids and alpha-tocopherol in vivo have not been compared...
  38. ncbi request reprint Effect of C-reactive protein on chemokine expression in human aortic endothelial cells
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California, Davis Medical Center, 4635 Second Avenue, Research 1 Building, Rm 3000, Sacramento, CA 95817, USA
    J Mol Cell Cardiol 36:405-10. 2004
    ..01). In conclusion, this study makes the novel observation that CRP induces IL-8 synthesis and secretion in HAEC via upregulation of NF-kappa B activity...
  39. ncbi request reprint RRR-alpha-tocopherol decreases the expression of the major scavenger receptor, CD36, in human macrophages via inhibition of tyrosine kinase (Tyk2)
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California Davis Medical Center, 4635, 2nd Avenue, Room 3000, Research Building 1, Sacramento, CA 95817, USA
    Atherosclerosis 175:213-20. 2004
    ..In conclusion, this study demonstrates an additional direct cellular effect of AT, i.e. inhibition of CD36 expression via inhibition of tyrosine kinase (Tyk2)...
  40. doi request reprint Effects of epigallocatechin gallate on regulatory T cell number and function in obese v. lean volunteers
    Jung Mi Yun
    Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA, USA
    Br J Nutr 103:1771-7. 2010
    ..05) in both groups. Thus, in part, EGCG enhances the functionality of Tregs, i.e. IL-10 production and number by suppressing the NF-kappaB signalling pathway via inducing epigenetic changes...
  41. ncbi request reprint Anti-inflammatory effects of alpha-tocopherol
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 Second Avenue, Res 1 Building, Room 3000, Sacramento, CA 95817, USA
    Ann N Y Acad Sci 1031:195-203. 2004
    ..In this review, our focus will be on anti-inflammatory effects of alpha-tocopherol reported in in vivo studies...
  42. ncbi request reprint Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, California 95817, USA
    Diabetes 51:3049-54. 2002
    ....
  43. pmc Macrophage conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: potential for paracrine/autocrine effects
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California Medical Center, Sacramento, CA 95817, USA
    Am J Pathol 166:1265-71. 2005
    ....
  44. ncbi request reprint Antioxidants and vitamins to reduce cardiovascular disease
    S Devaraj
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Curr Atheroscler Rep 2:342-51. 2000
    ..This will have to await results of ongoing clinical trials...
  45. ncbi request reprint Divergence between LDL oxidative susceptibility and urinary F(2)-isoprostanes as measures of oxidative stress in type 2 diabetes
    S Devaraj
    Division of Clinical Biochemistry and Human Metabolism and the Center for Human Nutrition, Department of Pathology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9073, USA
    Clin Chem 47:1974-9. 2001
    ..g., LDL oxidative susceptibility, in type 2 diabetes...
  46. pmc Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 93:578-83. 2008
    ..TLR2 and TLR4 are important in atherosclerosis. However, there is a paucity of data examining TLR2 and TLR4 expression in T1DM and examining its contribution to the proinflammatory state...
  47. pmc Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Free Radic Biol Med 44:1203-8. 2008
    ....
  48. pmc Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications
    Sridevi Devaraj
    Department of Pathology, Laboratory for Atherosclerosis and Metabolic Research, UCDavis Medical Center, Sacramento, CA 95817, USA
    Diabetes 56:2790-6. 2007
    ....
  49. pmc CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1
    R Michael Gower
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Arterioscler Thromb Vasc Biol 31:160-6. 2011
    ..Involvement of β(2)-integrin CD11c/CD18 in atherogenesis was recently shown in dyslipidemic mice, which motivates our study of its inflammatory function during hypertriglyceridemia in humans...
  50. pmc Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Physiol Endocrinol Metab 300:E145-54. 2011
    ..We conclude that FFA exacerbates HG-induced TLR expression and activity in monocytic cells with excess superoxide release, enhanced NF-κB activity, and induced proinflammatory factor release...
  51. pmc C-reactive protein stimulates myeloperoxidase release from polymorphonuclear cells and monocytes: implications for acute coronary syndromes
    Uma Singh
    Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Clin Chem 55:361-4. 2009
    ..Because MPO and CRP concentrations are increased in acute coronary syndrome (ACS) patients and predict poor outcomes, we tested the effect of CRP on MPO release from PMNs and monocytes...
  52. pmc Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Diabetes Care 33:861-8. 2010
    ..Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression, their ligands, and signaling in monocytes of recently diagnosed type 2 diabetic patients...
  53. pmc Validation of the circulating monocyte being representative of the cholesterol-loaded macrophage: biomediator activity
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arch Pathol Lab Med 132:1432-5. 2008
    ..However, there is a paucity of data comparing circulating monocytes to cholesterol-laden macrophages (foam cells), with regard to their atherogenic properties, especially in subjects with established risk factors such as hyperlipidemia...
  54. pmc Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    Endocrinology 150:3457-64. 2009
    ..Data suggest that Pam- and LPS-induced TLR2 and TLR4 expression are inhibited by PIO in human monocytes and db/db mice. Thus, we define a novel pathway by which PIO could induce antiinflammatory effects...
  55. pmc C-reactive protein impairs the endothelial glycocalyx resulting in endothelial dysfunction
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA
    Cardiovasc Res 84:479-84. 2009
    ..The glycocalyx decorates the luminal surface and affords critical protection of the endothelium. Thus, the aim of the study was to examine the effect of C-reactive protein on the endothelial glycocalyx...
  56. pmc C-reactive protein induces M-CSF release and macrophage proliferation
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA 95817, USA
    J Leukoc Biol 85:262-7. 2009
    ..These effects appear to be mediated via activation of NF-kappaB via CD32 and CD64. These studies provide further evidence for a proatherogenic role for CRP...
  57. pmc CRP and adiponectin and its oligomers in the metabolic syndrome: evaluation of new laboratory-based biomarkers
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Am J Clin Pathol 129:815-22. 2008
    ..5; 95% CI, 1.3-4.5), its oligomers, or the adiponectin/ hsCRP ratio (OR, 2.6; 95% CI, 1.5, 4.8). Thus, measurements of CRP, adiponectin, or its oligomers provide robust biomarkers for predicting MetS...
  58. ncbi request reprint Effects of colesevelam hydrochloride (WelChol) on biomarkers of inflammation in patients with mild hypercholesterolemia
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California, USA
    Am J Cardiol 98:641-3. 2006
    ..No correlation was found between LDL cholesterol lowering and hs-CRP lowering (r = 0.3). In conclusion, our results show that colesevelam HCl monotherapy significantly lowered hs-CRP levels in a double-blind, placebo-controlled study...
  59. ncbi request reprint Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease
    Sonia Vega-Lopez
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    J Investig Med 52:24-32. 2004
    ..Thus, it appears that, in diabetes, antioxidant therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic modality...
  60. ncbi request reprint Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Curr Opin Nephrol Hypertens 14:33-7. 2005
    ..Recent evidence from different cell types suggests that CRP is not only a risk marker but may also be a participant in atherogenesis. This review will focus on the effects of CRP on different cells involved in atherosclerosis...
  61. ncbi request reprint The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology, UC Davis Medical Center, Sacramento, California 95817, USA
    Nutr Rev 64:348-54. 2006
    ..Present evidence is accumulating to promote their use for lowering LDL cholesterol levels, as a first line of therapy (as well as adjunctive therapy) in patients on statin therapy...
  62. ncbi request reprint C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 26:2469-75. 2006
    ..IL-10 deficiency results in increased lesion formation, whereas IL-10 delivery attenuates lesions. We tested the effect of CRP on lipopolysaccharide (LPS)-induced IL-10 secretion in human monocyte-derived macrophages (HMDMs)...
  63. ncbi request reprint Supplementation with omega3 polyunsaturated fatty acids and all-rac alpha-tocopherol alone and in combination failed to exert an anti-inflammatory effect in human volunteers
    Sonia Vega-Lopez
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA, USA
    Metabolism 53:236-40. 2004
    ..In conclusion, supplementation with n3PUFA and all-rac AT at these doses is not anti-inflammatory...
  64. ncbi request reprint Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Free Radic Biol Med 38:1212-20. 2005
    ..Furthermore, AT and the 5-LO inhibitor decreased NFkappab-binding activity. Thus, in activated human monocytes, AT appears to inhibit TNF mRNA and protein by inhibition of 5-LO...
  65. ncbi request reprint Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research and General Clinical Research Center, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Clin Nutr 84:756-61. 2006
    ..High-sensitivity C-reactive protein (hs-CRP), the prototypic marker of inflammation, is a cardiovascular disease risk marker; however, there is a paucity of data on the effect of plant sterols on CRP concentrations...
  66. ncbi request reprint Defining the proinflammatory phenotype using high sensitive C-reactive protein levels as the biomarker
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Avenue, Sacramento, California 95817, USA
    J Clin Endocrinol Metab 90:4549-54. 2005
    ..Inflammation is pivotal in atherosclerosis. The prototypic marker of inflammation is C-reactive protein (CRP). Numerous studies have confirmed that high CRP levels in normal volunteers predict cardiovascular events...
  67. ncbi request reprint Autoantibodies to oxidized low-density lipoprotein in patients with type 2 diabetes mellitus
    Rebecca M Hsu
    Department of Pathology, Division of Clinical Biochemistry and Human Metabolism, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9073, USA
    Clin Chim Acta 317:145-50. 2002
    ..Our aim was to evaluate an ELISA for Ab against Ox-LDL in Type 2 diabetes, a condition with increased oxidative stress...
  68. ncbi request reprint Modulation of monocyte-macrophage function with alpha-tocopherol: implications for atherosclerosis
    Sridevi Devaraj
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    Nutr Rev 60:8-14. 2002
    ..Further clinical trials are required, however, before a definitive recommendation can be made for primary and secondary prevention of heart disease...
  69. pmc Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, CA 95817, USA
    Metabolism 60:256-9. 2011
    ..005). Thus, we make the novel observation that TLR2 and TLR4 expression and signaling are increased in T1DM-MV compared with T1DM and may contribute to the accentuated proinflammatory state and complications of T1DM...
  70. doi request reprint Low vitamin D levels in Northern American adults with the metabolic syndrome
    S Devaraj
    Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Horm Metab Res 43:72-4. 2011
    ..29, p=0.04) and HOMA (r=-0.34, p=0.04). Future studies of vitamin D supplementation in these subjects on subsequent risk of diabetes will prove instructive with respect to potential health claims in these high risk patients with MetS...
  71. ncbi request reprint Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California Davis Medical Center, 4635 Second Avenue, Res 1 Building, Room 3000, Sacramento CA 95817, USA
    Arterioscler Thromb Vasc Biol 24:e25-8. 2004
    ..Their effectiveness in nonfat moieties is not yet established. The aim of this study was to examine if phytosterols alter the plasma lipoprotein profile when incorporated into nonfat orange juice...
  72. pmc Increased secretion of IP-10 from monocytes under hyperglycemia is via the TLR2 and TLR4 pathway
    Sridevi Devaraj
    Department of Medical Pathology and Laboratory Medicine, Laboratory for Atherosclerosis and Metabolic Research, Robert E Stowell Endowed Chair in Experimental Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Cytokine 47:6-10. 2009
    ..Thus, we demonstrate increased circulating and monocytic IP-10 in T1DM. Down-regulation of TLR2 and TLR4 abrogates HG-induced IP-10 release via NF-kappaB inhibition...
  73. ncbi request reprint Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, The University of California Davis Medical Center, 4635, II Ave, Res 1 Bldg, Rm 3000, Sacramento, CA 95817, USA
    Diabetes 54:85-91. 2005
    ..Thus, inhibition of PKC-alpha and -beta can ameliorate the proinflammatory state of diabetes...
  74. pmc The evolving role of C-reactive protein in atherothrombosis
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA, USA
    Clin Chem 55:229-38. 2009
    ..In addition to being a risk marker, there is much evidence indicating that CRP may indeed participate in atherogenesis...
  75. ncbi request reprint Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, Calif 95817, USA
    Circulation 106:1439-41. 2002
    ..C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis...
  76. ncbi request reprint Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis, Medical Center, Sacramento, California 95817, USA
    Lipids 37:931-4. 2002
    ..Hence, following oral supplementation in humans, PYC significantly increases antioxidant capacity of plasma, as determined by ORAC, and exerts favorable effects on the lipid profile...
  77. ncbi request reprint C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Sacramento, Calif 95817, USA
    Circulation 107:398-404. 2003
    ..However, there are no studies examining the effect of CRP on PAI-1 in human aortic endothelial cells (HAECs)...
  78. pmc Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis
    Smriti K Raychaudhuri
    VA Medical Center, Mather, California, USA
    Metab Syndr Relat Disord 8:331-4. 2010
    ..The aim of this study was to determine the prevalence of metabolic syndrome in PsA...
  79. pmc High glucose induces IL-1beta expression in human monocytes: mechanistic insights
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Ave, Research Bldg 1, Sacramento, CA 95817, USA
    Am J Physiol Endocrinol Metab 293:E337-46. 2007
    ..Targeting signaling pathways mediating IL-1beta release could result in the amelioration of inflammation and possibly diabetic vasculopathies...
  80. ncbi request reprint The effect of weight loss and dietary fatty acids on inflammation
    Sridevi Devaraj
    VA Northern California Health System, Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Curr Atheroscler Rep 8:477-86. 2006
    ..Much further research is needed to define the role of individual dietary factors on the biomarkers of inflammation and the mechanism of the anti-inflammatory effects of weight loss...
  81. ncbi request reprint High-dose alpha-tocopherol therapy does not affect HDL subfractions in patients with coronary artery disease on statin therapy
    Uma Singh
    University of California Davis Medical Center, Sacramento, California 95817, USA
    Clin Chem 53:525-8. 2007
    ..Few data are available on the effect of AT therapy alone on HDL subfractions, which we addressed in this study...
  82. pmc Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo
    Mohan R Dasu
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, CA 95817, United States
    Atherosclerosis 202:76-83. 2009
    ..Thus, we investigated whether an ARB exerts anti-inflammatory effects via inhibiting TLR2 and TLR4 expression...
  83. pmc C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo
    Sridevi Devaraj
    The Laboratory for Atherosclerosis and Metabolic Research, Department of Medical Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, CA 95817, United States
    Atherosclerosis 203:67-74. 2009
    ..CRP-induced ROS appears to precede tissue factor release. These effects are abrogated by blocking Fc gamma receptors, CD32 and CD64. This in vivo demonstration provides further evidence for a role for CRP in atherothrombosis...
  84. pmc Bile acid sequestrants and diabetes: introduction and overview to the supplement
    I Jialal
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, USA
    Metab Syndr Relat Disord 8:S1-2. 2010
    ..These data make colesevelam an attractive therapy to get more patients to achieve their LDL-C and HbA1c goals...
  85. doi request reprint Small Interfering-RNA to Protein Kinase C-Delta Reduces the Proinflammatory Effects of Human C-Reactive Protein in Biobreeding Diabetic Rats
    I Jialal
    Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, CA, USA
    Horm Metab Res 45:326-8. 2013
    ....
  86. pmc Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California at Davis Medical Center, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 31:1796-804. 2011
    ..Toll-like receptors (TLR) could participate in diabetic vasculopathies. Whether TLR activation contributes to the proinflammatory state of T1DM and the pathogenesis of diabetic nephropathy remains unknown...
  87. ncbi request reprint Therapy and clinical trials
    Nicola Abate
    Curr Opin Lipidol 13:457-60. 2002
  88. ncbi request reprint Accelerated atherosclerosis, dyslipidemia, and oxidative stress in end-stage renal disease
    Surekha Mathur
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Curr Opin Nephrol Hypertens 11:141-7. 2002
    ..Clinical trials with statins and other drugs that improve dyslipidemia also need to be undertaken. These therapies could clearly lead to a reduction in cardiovascular morbidity and mortality in these patients...
  89. ncbi request reprint Coenzyme Q10 supplementation and heart failure
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California 95817, USA
    Nutr Rev 65:286-93. 2007
    ..However, much further research is required, especially in the use of state-of-the-art techniques to assess functional outcomes in patients with congestive heart failure...
  90. ncbi request reprint Remnant lipoproteins: measurement and clinical significance
    Ishwarlal Jialal
    Clin Chem 48:217-9. 2002
  91. ncbi request reprint Oxidative stress, alpha-tocopherol therapy, and atherosclerosis
    Andrea Harris
    University of Texas Southwestern Medical Center, Dallas, 75390 09073, USA
    Curr Atheroscler Rep 4:373-80. 2002
    ..Clearly, more clinical trials are required in individuals with increased oxidative stress before a definitive recommendation can be made with respect to AT supplementation in atherosclerosis...
  92. pmc Simvastatin (40 mg/day), adiponectin levels, and insulin sensitivity in subjects with the metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California, Davis Medical Center, Davis, CA, USA
    Am J Cardiol 100:1397-9. 2007
    ..In conclusion, although simvastatin is anti-inflammatory, it failed to affect adiponectin levels or improve insulin sensitivity in subjects with the MS...
  93. ncbi request reprint Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans
    Surekha Mathur
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    J Nutr 132:3663-7. 2002
    ..In conclusion, cocoa products supplementation in humans affects LDL oxidizability, but not urinary F(2) isoprostanes or markers of inflammation...
  94. ncbi request reprint Future directions in clinical vitamin E research: panel discussion B
    Lester Packer
    Ann N Y Acad Sci 1031:313-23. 2004
  95. ncbi request reprint Is vitamin C an antiinflammatory agent?
    Ishwarlal Jialal
    Am J Clin Nutr 83:525-6. 2006
  96. ncbi request reprint Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Canada
    Circulation 113:2135-50; discussion 2150. 2006
  97. pmc High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Metabolism 57:867-70. 2008
    ..03). Thus, in subjects with MetS, consumption of an energy-dense, fatty meal (FFS breakfast) results in increased postprandial oxidative stress compared to a heart-healthy meal (AHA)...
  98. ncbi request reprint Native pentameric C-reactive protein displays more potent pro-atherogenic activities in human aortic endothelial cells than modified C-reactive protein
    Sridevi Devaraj
    Department of Pathology, UCDavis Medical Center, Sacramento, CA 95817, USA
    Atherosclerosis 184:48-52. 2006
    ..001). Thus, native pentameric CRP compared to modified CRP exerts more potent atherogenic effects in human aortic endothelial cells...
  99. pmc Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease
    Sridevi Devaraj
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Clin Nutr 86:1392-8. 2007
    ..Oxidative stress and inflammation are crucial in atherogenesis. alpha-Tocopherol is both an antioxidant and an antiinflammatory agent...
  100. ncbi request reprint Therapy and clinical trials: ezetimibe
    Ishwarlal Jialal
    Curr Opin Lipidol 14:643-6. 2003
  101. ncbi request reprint Statins and biomarkers of inflammation
    Sridevi Devaraj
    Curr Atheroscler Rep 9:33-41. 2007
    ....

Research Grants14

  1. CLINICAL STUDIES IN NUTRITION AND METABOLISM
    Ishwarlal Jialal; Fiscal Year: 2007
    ....
  2. C-Reactive Protein And Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2007
    ..Thus, these studies will clearly provide us with further scientific evidence in support of the role of CRP in atherothrombosis. ..
  3. High Dose Alpha Tocopherol and Carotid Atherosclerosis
    Ishwarlal Jialal; Fiscal Year: 2004
    ..This study has the additional novelty of correlating biomarkers of oxidative stress and inflammation with a cardiovascular endpoint and will establish whether high dose AT decreases atherosclerosis progression. ..
  4. EFFECT OF HIGH DOSE VITAMIN E ON CAROTID ATHERSCLEROSIS
    Ishwarlal Jialal; Fiscal Year: 2001
    ..If this study show that high-dose AT supplementation is beneficial in retarding atherosclerosis this could emerge as an important adjunctive therapy in the management of cardiovascular disease. ..
  5. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..