Li Li Ji
Affiliation: University of Wisconsin
- Role of free radicals and antioxidant signaling in skeletal muscle health and pathologyLi Li Ji
University of Wisconsin Madison, Madison, WI 53706, USA
Infect Disord Drug Targets 9:428-44. 2009..Given the physiological role of skeletal muscle we will emphasize the importance of physical exercise in promoting cellular antioxidant defense and its benefits in the maintenance of muscle health...
- Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signalingLi Li Ji
The Biodynamics Laboratory, University of Wisconsin Madison, 2000 Observatory Drive, Madison, WI 53706, USA
Free Radic Biol Med 44:142-52. 2008..This mini-review will discuss the main mechanisms and gene targets for these signaling pathways during exercise and the biological significance of the adaptation...
- Role of nuclear factor kappaB and mitogen-activated protein kinase signaling in exercise-induced antioxidant enzyme adaptationLi Li Ji
The Biodynamics Laboratory, Department of Kinesiology, 2000 Observatory Drive, University of Wisconsin Madison, Madison, WI 53706 1189, USA
Appl Physiol Nutr Metab 32:930-5. 2007..This scenario explains why animals and humans involved in exercise training have demonstrated increased resistance to oxidative damage under a wide range of physiological and pathological stresses...
- Antioxidant signaling in skeletal muscle: a brief reviewLi Li Ji
The Biodynamics Laboratory, University of Wisconsin Madison, Madison, WI 53706, USA
Exp Gerontol 42:582-93. 2007..This mini-review will discuss the main mechanisms and gene targets for these antioxidant signaling pathways during exercise, inflammation and aging...
- Exercise and hormesis: activation of cellular antioxidant signaling pathwayLi Li Ji
University of Wisconsin Madison, USA
Ann N Y Acad Sci 1067:425-35. 2006..Our data suggest that ROS may serve as messenger molecules to activate adaptive responses through these redox-sensitive signaling pathways to maintain cellular oxidant-antioxidant homeostasis during exercise...
- Exercise-induced hormesis may help healthy agingLi Li Ji
The Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin Madison, 2000 Observatory Drive, Madison, WI 53706, USA
Dose Response 8:73-9. 2010....
- Acute exercise activates nuclear factor (NF)-kappaB signaling pathway in rat skeletal muscleL L Ji
Department of Kinesiology, University of Wisconsin, Madison, Wisconsin, USA
FASEB J 18:1499-506. 2004..The cascade of intracellular events may be the overture to elevated gene expression of manganese superoxide dismutase reported earlier (Pfluegers Arch. 442, 426-434, 2001)...
- Aging, exercise, and phytochemicals: promises and pitfallsLi Li Ji
Department of Kinesiology and Nutritional Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Ann N Y Acad Sci 1019:453-61. 2004..However, due to their structural and chemical diversity and complexity, many of the benefits as well as potential adverse effects remain to be examined...
- Chronic ginseng consumption attenuates age-associated oxidative stress in ratsYing Fu
Department of Kinesiology and Nutritional Science, University of Wisconsin Madison, Madison, WI 53706, USA
J Nutr 133:3603-9. 2003..These protective effects are explained in part by elevated antioxidant enzyme activities in the various tissues...
- Exercise activation of muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling is redox sensitiveChounghun Kang
The Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin at Madison, Madison, WI 53706, USA
Free Radic Biol Med 47:1394-400. 2009..The data indicate that contraction-activated PGC-1alpha signaling pathways in skeletal muscle are redox sensitive and that nonmitochondrial ROS play an important role in stimulating mitochondrial biogenesis...
- American ginseng supplementation induces an oxidative stress in postmenopausal womenJonathan R Dickman
Department of Kinesiology, University of Wisconsin Madison, Madison, Wisconsin, USA
J Am Coll Nutr 28:219-28. 2009..To determine whether American ginseng (Panax Quinquefolium) confers antioxidant protection to postmenopausal women at rest and after a mild aerobic exercise session...
- Exercise-induced modulation of antioxidant defenseLi Li Ji
Department of Kinesiology, Interdisciplinary Nutritional Science, and Institute on Aging, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Ann N Y Acad Sci 959:82-92. 2002..Aging does not abolish but seems to attenuate training adaptations of antioxidant enzymes. Thus, for senescent muscle, training should be assisted with supplementation of exogenous antioxidants to research the optimal level of defense...
- Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1αChounghun Kang
The Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USA The Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53706, USA
Exp Gerontol 48:1343-50. 2013..These data indicate that endurance training can attenuate aging-associated decline in mitochondrial protein synthesis in skeletal muscle partly due to upregulation of PGC-1α signaling...
- Avenanthramides are bioavailable and accumulate in hepatic, cardiac, and skeletal muscle tissue following oral gavage in ratsRyan T Koenig
Department of Kinesiology, University of Wisconsin Madison, 2000 Observatory Drive, Madison, Wisconsin 53706, USA
J Agric Food Chem 59:6438-43. 2011..With AVA remaining in the organs for up to 12 h, it seems possible to maintain an increased level of AVA in the rat via repeated feedings...
- Oxidant production and immune response after stretch injury in skeletal muscleS Brickson
Department of Family Medicine, University of Wisconsin Medical School, 621 Science Drive, Madison, WI 53711, USA
Med Sci Sports Exerc 33:2010-5. 2001..The increase in oxidant production at 4 h may be caused by an increase in activated neutrophils, whereas XO activity may contribute to oxidant generation at 24 h...
- Antioxidants and oxidative stress in exerciseL L Ji
Department of Kinesiology, Interdepartmental Program of Nutritional Sciences, and Institute on Aging, University of Wisconsin Madison, 53706, USA
Proc Soc Exp Biol Med 222:283-92. 1999..The delicate balance between pro-oxidants and antioxidants suggests that supplementation of antioxidants may be desirable for physically active individuals under certain physiological conditions by providing a larger protective margin...
- Exercise at old age: does it increase or alleviate oxidative stress?L L Ji
Department of Kinesiology, Nutritional Science, and Institute on Aging, University of Wisconsin Madison, 53706, USA
Ann N Y Acad Sci 928:236-47. 2001....
- Oxidative stress and aging. Role of exercise and its influences on antioxidant systemsL L Ji
Department of Kinesiology and Nutritional Sciences, University of Wisconsin Madison 53706, USA
Ann N Y Acad Sci 854:102-17. 1998....
- M1/70 attenuates blood-borne neutrophil oxidants, activation, and myofiber damage following stretch injuryS Brickson
Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53706, USA
J Appl Physiol (1985) 95:969-76. 2003..attenuates neutrophil activation status, 3). increases plasma IL-8 concentration, and 4). minimizes myofiber damage 24 h postmuscle stretch injury...
- Aged rat hearts are not more susceptible to ischemia-reperfusion injury in vivo: role of glutathioneS Leichtweis
Department of Kinesiology and Nutritional Science, University of Wisconsin, Madison, WI 53706, USA
Mech Ageing Dev 122:503-18. 2001..It is concluded that senescent hearts with intact circulatory and neural inputs are not more susceptible to I-R injury than adult hearts during myocardial I-R, partly because they have a greater GSH antioxidant protection...
- Avenanthramide supplementation attenuates exercise-induced inflammation in postmenopausal womenRyan Koenig
Department of Kinesiology, University of Wisconsin Madison, Madison, WI 53706, USA
Nutr J 13:21. 2014..Thus, chronic AVA supplementation decreased systemic and DW-induced inflammation and increased blood-borne antioxidant defense in postmenopausal women. ..
- Training down-regulates fatty acid synthase and body fat in obese Zucker ratsRussell G Fiebig
Interdepartmental Graduate Program in Nutritional Science, and Department of Kinesiology, University of Wisconsin Madison, Madison, WI, USA
Med Sci Sports Exerc 34:1106-14. 2002..The purpose of this study was to investigate whether chronic exercise training attenuates fatty acid synthase, the rate-limiting enzyme for hepatic lipogenesis, and the accumulation of body fat by using obese Zucker rats (OZR) as a model...
- Sleep deprivation and cellular responses to oxidative stressAnupama Gopalakrishnan
Department of Psychiatry, University of Wisconsin, Madison 53719, USA
Sleep 27:27-35. 2004....
- Growth performance and muscle oxidation in rats fed increasing amounts of high-tannin sorghumR E Larraín
Department of Animal Sciences, University of Wisconsin, Madison 53706, USA
J Anim Sci 85:3276-84. 2007..Feeding HTS reduced markers of protein oxidation in rat muscle after 6 d of refrigerated storage. If similar results are observed in animals such as swine or cattle, the use of HTS as animal feed should be reassessed...
- Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extractsChen Hsien Lee
Department of Food Science, University of Wisconsin, Madison 53706, USA
Nutr Cancer 53:91-103. 2005..Subsequent to the animal studies, betanin was isolated in pure form, identified by MS analysis, and confirmed to be QR inducers in the bioassay...
- Glutathione supplementation and training increases myocardial resistance to ischemia-reperfusion in vivoP R Ramires
Interdisciplinary Nutritional Science Program, Department of Kinesiology, University of Wisconsin, Madison, Wisconsin 53706, USA
Am J Physiol Heart Circ Physiol 281:H679-88. 2001....
- PGC-1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilizationChounghun Kang
Laboratory of Physiological Hygiene and Exercise Science, School of Kinesiology, University of Minnesota at Twin Cities, Minneapolis, Minnesota, USA and Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
FASEB J 29:4092-106. 2015..Kang, C., Goodman, C. A., Horberger, T. A., Ji, L. L. PGC-1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization...
- Interplay of oxidants and antioxidants during exercise: implications for muscle healthMaria Carmen Gomez-Cabrera
University of Valencia, Valencia, Spain
Phys Sportsmed 37:116-23. 2009..Adaptation of muscle to increased oxidative stress and the potential mechanisms involved will be highlighted. The role of redox-controlled cell signaling in skeletal muscle health and function is also described...
- Regulation of mitochondrial uncoupling respiration during exercise in rat heart: role of reactive oxygen species (ROS) and uncoupling protein 2Hai Bo
Tianjin Research Institute of Sports Medicine and Department of Health and Exercise Science, Tianjin University of Sport, Tianjin 300381, China
Free Radic Biol Med 44:1373-81. 2008....
- Effects of endurance training on three superoxide dismutase isoenzymes in human plasmaTomomi Ookawara
Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
Free Radic Res 37:713-9. 2003..The results also suggest the possibility of plasma EC-SOD assay as a new index of endurance training...
- Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humansMichail Tonkonogi
Department of Physiology and Pharmacology, Karolinska Institutet, Box 5626, 114 86, Stockholm, Sweden
Pflugers Arch 446:261-9. 2003..It is concluded that aging is associated with mitochondrial dysfunction, which appears to be unrelated to reduced physical activity. The hypothesis of increased oxidative stress in aged muscle could not be confirmed in this study...
- Decreasing xanthine oxidase-mediated oxidative stress prevents useful cellular adaptations to exercise in ratsMari Carmen Gomez-Cabrera
Catholic University of Valencia, Spain
J Physiol 567:113-20. 2005....
- Changes in nitric oxide and inducible nitric oxide synthase following stretch-induced injury to the tibialis anterior muscle of rabbitTomonobu Sakurai
Department of Kinesiology, Tokyo Metropolitan University, Tokyo, Japan
Jpn J Physiol 55:101-7. 2005..05) and at 48 h (p < 0.01) in injured versus sham-operated muscles. These results suggest that NO may play an active role during the postinjury recovery of skeletal muscle modulated by iNOS expression...