Hong Long Ji

Summary

Affiliation: University of Texas Health Center
Country: USA

Publications

  1. pmc δ ENaC: a novel divergent amiloride-inhibitable sodium channel
    Hong Long Ji
    Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1013-26. 2012
  2. pmc Characterization of a novel splice variant of δ ENaC subunit in human lungs
    Run Zhen Zhao
    Departments of Cellular and Molecular Biology, Texas Lung Injury Institute, Univ of Texas Health Science Ctr at Tyler, Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1262-72. 2012
  3. pmc 8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties
    Hong Guang Nie
    Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas, USA
    Am J Physiol Renal Physiol 298:F323-34. 2010
  4. pmc K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport
    Dong Yun Han
    Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Respir Res 11:65. 2010
  5. pmc 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels
    Dong Yun Han
    Department of Biochemistry, University of Texas Health Science Center at Tyler, USA
    Am J Respir Cell Mol Biol 45:1007-14. 2011
  6. pmc Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition
    Raul Molina
    Department of Biochemistry, University of Texas Health Science Center at Tyler, TX, USA
    Biochim Biophys Acta 1808:1818-26. 2011
  7. pmc Expression and regulation of epithelial Na+ channels by nucleotides in pleural mesothelial cells
    Hong Guang Nie
    Department of Biochemistry, Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 40:543-54. 2009
  8. pmc Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1
    Yashodhar P Bhandary
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Pathol 183:131-43. 2013
  9. pmc LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model
    Zhuang Wu
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Texas 75708, USA
    Infect Immun 79:2865-70. 2011
  10. pmc Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells
    Qin Hao
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    Am J Physiol Cell Physiol 303:C548-53. 2012

Collaborators

Detail Information

Publications12

  1. pmc δ ENaC: a novel divergent amiloride-inhibitable sodium channel
    Hong Long Ji
    Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, Texas, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1013-26. 2012
    ..Here, we review the progress of research on δ ENaC in genomics, biophysics, proteomics, physiology, pharmacology, and clinical medicine...
  2. pmc Characterization of a novel splice variant of δ ENaC subunit in human lungs
    Run Zhen Zhao
    Departments of Cellular and Molecular Biology, Texas Lung Injury Institute, Univ of Texas Health Science Ctr at Tyler, Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1262-72. 2012
    ..Channels comprising of this novel splice variant may contribute to the diversities of native epithelial Na(+) channels...
  3. pmc 8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties
    Hong Guang Nie
    Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas, USA
    Am J Physiol Renal Physiol 298:F323-34. 2010
    ....
  4. pmc K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport
    Dong Yun Han
    Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Respir Res 11:65. 2010
    ..We hypothesized that K+ channel openers may restore calcium channel blocker-inhibited alveolar fluid clearance (AFC) by up-regulating both apical and basolateral ion transport...
  5. pmc 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels
    Dong Yun Han
    Department of Biochemistry, University of Texas Health Science Center at Tyler, USA
    Am J Respir Cell Mol Biol 45:1007-14. 2011
    ..Our data suggest that elimination of self-inhibition of αβγ ENaC may be a novel mechanism for CPT-cGMP to stimulate salt reabsorption in human lungs...
  6. pmc Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition
    Raul Molina
    Department of Biochemistry, University of Texas Health Science Center at Tyler, TX, USA
    Biochim Biophys Acta 1808:1818-26. 2011
    ..Our data demonstrate that cpt-cAMP, a broadly used PKA activator, stimulates human αβγ and δβγ ENaC channels by relieving self-inhibition...
  7. pmc Expression and regulation of epithelial Na+ channels by nucleotides in pleural mesothelial cells
    Hong Guang Nie
    Department of Biochemistry, Texas Lung Injury Institute, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Am J Respir Cell Mol Biol 40:543-54. 2009
    ..Taken together, our data demonstrate that the ENaC channels are biochemically and functionally expressed in human pleural mesothelial cells, and can be up-regulated by cyclic AMP and cyclic GMP...
  8. pmc Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1
    Yashodhar P Bhandary
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Pathol 183:131-43. 2013
    ..Our findings indicate that disruption of p53-fibrinolytic system cross talk may serve as a novel intervention strategy to prevent lung injury and pulmonary fibrosis...
  9. pmc LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model
    Zhuang Wu
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Texas 75708, USA
    Infect Immun 79:2865-70. 2011
    ..Our study results indicate that LOX-1 is an important mediator of inflammation and neutrophil dysfunction in sepsis...
  10. pmc Tyrosine phosphatase PTP-MEG2 negatively regulates vascular endothelial growth factor receptor signaling and function in endothelial cells
    Qin Hao
    Department of Biochemistry, University of Texas Health Science Center, Tyler, Texas 75708, USA
    Am J Physiol Cell Physiol 303:C548-53. 2012
    ..Thus we have indentified VEGFR2 as a PTP-MEG2 substrate, and our findings indicate that PTP-MEG2 is a negative regulator of VEGFR2 signaling and function in ECs...
  11. doi request reprint Blockade of LOX-1 prevents endotoxin-induced acute lung inflammation and injury in mice
    Ping Zhang
    Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    J Innate Immun 1:358-65. 2009
    ..Collectively, these results indicate that LOX-1 may serve as a valuable therapeutic target in the prevention of acute lung inflammation and injury in sepsis...
  12. pmc Regulation of epithelial sodium channels by cGMP/PKGII
    Hong Guang Nie
    Departments of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    J Physiol 587:2663-76. 2009
    ..We therefore conclude that PKGII is an activator of lung epithelial Na(+) channels, which may expedite the resolution of oedematous fluid in alveolar sacs...

Research Grants5

  1. Regulation of lung epithelial sodium channels by cGMP
    Hong Long Ji; Fiscal Year: 2007
    ..The subject matter of this research is timely and important. Results of these studies may form the molecular basis for development of new therapeutic strategies (such as cGMP delivery) to combat pulmonary edema. ..
  2. Regulation of lung epithelial sodium channels by cGMP
    Hong Long Ji; Fiscal Year: 2009
    ..The subject matter of this research is timely and important. Results of these studies may form the molecular basis for development of new therapeutic strategies (such as cGMP delivery) to combat pulmonary edema. ..
  3. Regulation of lung epithelial sodium channels by cGMP
    Hong Long Ji; Fiscal Year: 2010
    ..The subject matter of this research is timely and important. Results of these studies may form the molecular basis for development of new therapeutic strategies (such as cGMP delivery) to combat pulmonary edema. ..
  4. Regulation of lung epithelial sodium channels by cGMP
    Hong Long Ji; Fiscal Year: 2009
    ..The subject matter of this research is timely and important. Results of these studies may form the molecular basis for development of new therapeutic strategies (such as cGMP delivery) to combat pulmonary edema. ..