Cheng Ji

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Research Center for Liver Disease and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Gastroenterology 124:1488-99. 2003
  2. pmc Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes
    Cheng Ji
    University of Southern California Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Hepatology 46:1586-96. 2007
  3. pmc Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver
    Cheng Ji
    Research Center for Liver Disease, Southern California Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Alcohol Clin Exp Res 32:1049-58. 2008
  4. pmc Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice
    Cheng Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 54:229-39. 2011
  5. ncbi request reprint Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Hepatol 45:717-24. 2006
  6. ncbi request reprint ER stress: can the liver cope?
    Cheng Ji
    Gastroenterology Liver Division, Keck School of Medicine and the Research Center for Liver Disease, University of Southern California and the USC UCLA Research Center for Alcoholic Liver and Pancreatic Disease, Los Angeles, CA 90033, USA
    J Hepatol 45:321-33. 2006
  7. pmc Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Alcohol Clin Exp Res 29:1496-503. 2005
  8. ncbi request reprint Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury
    Cheng Ji
    Research Center for Liver Disease, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, CA, USA
    Hepatology 40:442-51. 2004
  9. ncbi request reprint Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury
    Cheng Ji
    Faculty of Medicine, Gastroenterology Liver Division, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    World J Gastroenterol 10:1699-708. 2004
  10. pmc Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Gastroenterol Hepatol 23:S16-24. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Research Center for Liver Disease and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Gastroenterology 124:1488-99. 2003
    ..This novel ER stress mechanism of alcoholic liver injury was studied in the model of intragastric alcohol-fed mice...
  2. pmc Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes
    Cheng Ji
    University of Southern California Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Hepatology 46:1586-96. 2007
    ..Betaine partially reduced homocysteine-induced sterol regulatory element binding protein 1 expression in HepG2 cells and increased S-adenosylmethionine in primary mouse hepatocytes...
  3. pmc Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver
    Cheng Ji
    Research Center for Liver Disease, Southern California Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Alcohol Clin Exp Res 32:1049-58. 2008
    ..In this study, we investigated the direct role of BHMT in alcohol or homocysteine-induced liver injury...
  4. pmc Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice
    Cheng Ji
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 54:229-39. 2011
    ..g., major urinary proteins in the liver, fatty acid binding proteins, adipose differentiation-related protein, cysteine-rich with epidermal growth factor-like domains 2, nuclear protein 1, and growth differentiation factor 15)...
  5. ncbi request reprint Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Hepatol 45:717-24. 2006
    ..The contribution of SREBP-1c to alcohol-induced fatty liver and injury was studied...
  6. ncbi request reprint ER stress: can the liver cope?
    Cheng Ji
    Gastroenterology Liver Division, Keck School of Medicine and the Research Center for Liver Disease, University of Southern California and the USC UCLA Research Center for Alcoholic Liver and Pancreatic Disease, Los Angeles, CA 90033, USA
    J Hepatol 45:321-33. 2006
    ....
  7. pmc Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Alcohol Clin Exp Res 29:1496-503. 2005
    ..This study was undertaken to determine the role of CHOP in hepatocellular apoptosis and liver injury in this model...
  8. ncbi request reprint Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury
    Cheng Ji
    Research Center for Liver Disease, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, CA, USA
    Hepatology 40:442-51. 2004
    ..In conclusion, TNFalpha makes a moderate contribution to the ALT elevation, necroinflammation, apoptosis, a small contribution to the fatty liver and no contribution to hyperhomocysteinemia and ER stress in intragastric alcohol fed mice...
  9. ncbi request reprint Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury
    Cheng Ji
    Faculty of Medicine, Gastroenterology Liver Division, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    World J Gastroenterol 10:1699-708. 2004
    ....
  10. pmc Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Gastroenterol Hepatol 23:S16-24. 2008
    ..Dissection and differentiation of ER stress signaling may reveal clues on the specific importance of the ER stress response in contributing to liver injury and thus provide better strategies on prevention and treatment of liver disease...
  11. ncbi request reprint Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum
    Neil Kaplowitz
    USC UCLA Research Center for Alcoholic Liver, USC Research Center for Liver Disease, Division of Gastrointestinal, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Gastroenterol Hepatol 21:S7-9. 2006
    ....
  12. pmc Human immunodeficiency virus protease inhibitors modulate Ca2+ homeostasis and potentiate alcoholic stress and injury in mice and primary mouse and human hepatocytes
    Eddy Kao
    Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 56:594-604. 2012
    ..Alcohol combined with the HIV drugs significantly reduced intracellular calcium levels and potentiated cell death, which was comparable to the cell death caused by the SERCA inhibitor thapsigargin...
  13. ncbi request reprint Endoplasmic reticulum stress and liver injury
    Neil Kaplowitz
    Department of Medicine, USC UCLA Research Center for Alcoholic and Pancreatic Diseases and USC Research Center for Liver Diseases, Keck School of Medicine University of Southern California, Los Angeles, California CA 90033, USA
    Semin Liver Dis 27:367-77. 2007
    ..With increasing interest in the potential role of ER stress in liver disease, greater understanding of pathophysiology, prevention, and treatment of liver disease is anticipated...
  14. pmc Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats
    Masao Shinohara
    University of Southern California Research Center for Liver Disease, USC University of California Los Angeles Research Center for Alcoholic Liver and Pancreas Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Hepatology 51:796-805. 2010
    ....
  15. ncbi request reprint Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes
    Katsuhiko Matsumaru
    University of Southern California Research Center for Liver Disease, Keck School of Medicine, University of Southern California, USA
    Hepatology 37:1425-34. 2003
    ....
  16. pmc The contribution of endoplasmic reticulum stress to liver diseases
    Lily Dara
    University of Southern California Research Center for Liver Diseases, Los Angeles, CA, USA
    Hepatology 53:1752-63. 2011
    ..It is perhaps the nature of such a vicious cycle that is the key pathophysiologic concept. Therapeutic approaches aimed at interrupting the cycle may dampen the stress response and the ensuing injury...
  17. pmc Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
    Jun Xu
    Southern California Research Center for ALPD and Cirrhosis, Department of Pathology, Keck School of Medicine of the University of Southern CA 90089, USA
    J Hepatol 55:673-82. 2011
    ..We have produced a mouse model of synergistic steatohepatitis by recapitulating the natural history of the synergism seen in patients for mechanistic studies...
  18. pmc Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells
    Tin Aung Than
    University of Southern California Research Center for Liver Diseases, Southern California Research Center for Alcoholic, Liver and Pancreatic Disease, and Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 286:22047-54. 2011
    ..In contrast, silencing CRTC2 did not affect the induction of this pathway in response to rotenone. Thus, CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone...
  19. pmc Association of cyclin D and estrogen receptor α36 with hepatocellular adenomas of female mice under chronic endoplasmic reticulum stress
    Mo Yin Lau
    Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California 90033, USA
    J Gastroenterol Hepatol 28:576-83. 2013
    ..However, additional causes may exist due to heterogeneity of HCA. We investigated whether HCA are caused by endoplasmic reticulum (ER) stress...
  20. ncbi request reprint Multiple pathogenic factor-induced complications of cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia
    Hui Ying Zhang
    Director of Institute of Hepatology, Shanxi Medical University, 86 Xin jian Nan Road, Taiyuan 030001, Shanxi Province, China
    World J Gastroenterol 13:3500-7. 2007
    ..To develop and characterize a practical model of Hepatopulmonary syndrome (HPS) in rats...
  21. ncbi request reprint Intestinal endotoxemia plays a central role in development of hepatopulmonary syndrome in a cirrhotic rat model induced by multiple pathogenic factors
    Hui Ying Zhang
    Department of Pathophysiology, Changzhi Medical College, 161 Jie Fang Dong Jie, Changzhi 046000, Shanxi Province, China
    World J Gastroenterol 13:6385-95. 2007
    ..To characterize the correlation between severity of hepatopulmonary syndrome (HPS) and degree of hepatic dysfunction, and to explore how intestinal endotoxemia (IETM) affects the development of HPS in cirrhotic rats...

Research Grants3

  1. Role of aberrant regulation of organelle stress responses in alcohol-induced live
    Cheng Ji; Fiscal Year: 2009
    ..This research is to understand how alcohol promotes injury processes in the two organelles and how organelle damages contribute to liver disease which will open new avenues for preventing and treating liver disease. ..
  2. Effect of HIV protease inhibitor on alcohol induced ER stress and liver injury.
    Cheng Ji; Fiscal Year: 2010
    ..Understanding of additive/synergistic effects of HIV PIs and alcohol on the ER stress that worsens liver injury will provide better strategies to improve care for HIV-infected patients. ..
  3. Role of aberrant regulation of organelle stress responses in alcohol-induced live
    Cheng Ji; Fiscal Year: 2010
    ..This research is to understand how alcohol promotes injury processes in the two organelles and how organelle damages contribute to liver disease which will open new avenues for preventing and treating liver disease. ..