Mollie W Jewett

Summary

Affiliation: University of Central Florida
Country: USA

Publications

  1. pmc In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice
    Tisha Choudhury Ellis
    Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America
    PLoS Pathog 9:e1003567. 2013
  2. pmc Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA
    Mollie W Jewett
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Microbiology 157:2831-40. 2011
  3. pmc GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 191:6231-41. 2009
  4. pmc Use of the Cre-lox recombination system to investigate the lp54 gene requirement in the infectious cycle of Borrelia burgdorferi
    Aaron Bestor
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Infect Immun 78:2397-407. 2010
  5. pmc Genetic basis for retention of a critical virulence plasmid of Borrelia burgdorferi
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 66:975-90. 2007
  6. pmc Borrelia burgdorferi harbors a transport system essential for purine salvage and mammalian infection
    Sunny Jain
    Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, USA
    Infect Immun 80:3086-93. 2012
  7. pmc The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 64:1358-74. 2007
  8. pmc Rapid clearance of Lyme disease spirochetes lacking OspC from skin
    Kit Tilly
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 75:1517-9. 2007
  9. pmc Borrelia burgdorferi bb0426 encodes a 2'-deoxyribosyltransferase that plays a central role in purine salvage
    Kevin A Lawrence
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 72:1517-29. 2009
  10. pmc Enhanced detection of host response antibodies to Borrelia burgdorferi using immuno-PCR
    Micah D Halpern
    Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, FL, USA
    Clin Vaccine Immunol 20:350-7. 2013

Collaborators

Detail Information

Publications12

  1. pmc In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice
    Tisha Choudhury Ellis
    Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, United States of America
    PLoS Pathog 9:e1003567. 2013
    ..Therefore, through an initial IVET screen in B. burgdorferi we have identified a novel in vivo-induced virulence factor critical for the ability of the spirochete to evade the humoral immune response and persistently infect mice. ..
  2. pmc Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA
    Mollie W Jewett
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Microbiology 157:2831-40. 2011
    ..These findings are an important first step in understanding the catalytic function of this in vivo-essential protein...
  3. pmc GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    J Bacteriol 191:6231-41. 2009
    ..burgdorferi in the infection cycle and highlight a potential difference in the requirements for purine salvage in the disparate mammalian and tick environments...
  4. pmc Use of the Cre-lox recombination system to investigate the lp54 gene requirement in the infectious cycle of Borrelia burgdorferi
    Aaron Bestor
    Laboratory of Zoonotic Pathogens, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, USA
    Infect Immun 78:2397-407. 2010
    ..burgdorferi and surprisingly revealed that a large number of the highly conserved proteins encoded on lp54 are not required to complete the infectious cycle...
  5. pmc Genetic basis for retention of a critical virulence plasmid of Borrelia burgdorferi
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 66:975-90. 2007
    ..We conclude that the genetic linkage of critical physiological and virulence functions on cp26 is pertinent to its stable maintenance throughout the evolution of B. burgdorferi...
  6. pmc Borrelia burgdorferi harbors a transport system essential for purine salvage and mammalian infection
    Sunny Jain
    Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, Florida, USA
    Infect Immun 80:3086-93. 2012
    ..Together, our data establish that bbb22-23 encode purine permeases critical for B. burgdorferi mammalian infectivity, suggesting that this transport system may serve as a novel antimicrobial target for the treatment of Lyme disease...
  7. pmc The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi
    Mollie W Jewett
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 64:1358-74. 2007
    ..This work establishes a vital role for lp36 in the infectious cycle of B. burgdorferi and identifies the bbk17 gene as a component of this plasmid that contributes to mammalian infectivity...
  8. pmc Rapid clearance of Lyme disease spirochetes lacking OspC from skin
    Kit Tilly
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA
    Infect Immun 75:1517-9. 2007
    ..To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission...
  9. pmc Borrelia burgdorferi bb0426 encodes a 2'-deoxyribosyltransferase that plays a central role in purine salvage
    Kevin A Lawrence
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 72:1517-29. 2009
    ..This pathway provides additional biochemical flexibility for B. burgdorferi when it colonizes and infects different host tissues...
  10. pmc Enhanced detection of host response antibodies to Borrelia burgdorferi using immuno-PCR
    Micah D Halpern
    Burnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, FL, USA
    Clin Vaccine Immunol 20:350-7. 2013
    ..The results presented here indicate that our iPCR assay has the potential to provide an objective format that can be used for sensitive detection of multiple host response antibodies and isotypes to B. burgdorferi infection...
  11. pmc Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection
    Kit Tilly
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA
    Infect Immun 74:3554-64. 2006
    ..We conclude that OspC is indispensable for establishing infection by B. burgdorferi in mammals but is not required at any other point of the mouse-tick infection cycle...
  12. pmc lacZ reporter system for use in Borrelia burgdorferi
    Beth M Hayes
    Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Appl Environ Microbiol 76:7407-12. 2010
    ..The addition of lacZ to the repertoire of genetic tools available for use in B. burgdorferi should contribute to a better understanding of how B. burgdorferi gene expression is regulated during the infectious cycle...