Anahid Jewett

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Expression of MHC Class II, CD70, CD80, CD86 and pro-inflammatory cytokines is differentially regulated in oral epithelial cells following bacterial challenge
    D C Han
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Medicine and Dentistry, Los Angeles, CA 90095, USA
    Oral Microbiol Immunol 18:350-8. 2003
  2. ncbi request reprint Natural killer cells preferentially target cancer stem cells; role of monocytes in protection against NK cell mediated lysis of cancer stem cells
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA 90095 1668, USA
    Curr Drug Deliv 9:5-16. 2012
  3. pmc Strategies to rescue mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) from NK cell mediated cytotoxicity
    Anahid Jewett
    Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry and Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9874. 2010
  4. ncbi request reprint Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology and Division of Oral Biology and Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 12:1994-2003. 2006
  5. ncbi request reprint Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, the Jonsson Comprehensive Cancer Center, Dental Research Institute, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cancer Immunol Immunother 55:1052-63. 2006
  6. ncbi request reprint Emerging mechanisms of immunosuppression in oral cancers
    A Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Jonsson Comprehensive Cancer Center JCCC, Department of Head and Neck Surgery, UCLA School of Dentistry and Medicine 90095 1688, USA
    J Dent Res 85:1061-73. 2006
  7. doi request reprint Potential rescue, survival and differentiation of cancer stem cells and primary non-transformed stem cells by monocyte-induced split anergy in natural killer cells
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, University of California Los Angeles, CA 90095 1668, USA
    Cancer Immunol Immunother 61:265-74. 2012
  8. ncbi request reprint Cytokine dependent inverse regulation of CD54 (ICAM1) and major histocompatibility complex class I antigens by nuclear factor kappaB in HEp2 tumor cell line: effect on the function of natural killer cells
    Anahid Jewett
    Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA 90095, USA
    Hum Immunol 64:505-20. 2003
  9. ncbi request reprint Activation of c-Jun N-terminal kinase in the absence of NFkappaB function prior to induction of NK cell death triggered by a combination of anti-class I and anti-CD16 antibodies
    A Jewett
    Department of Oral Biology and Oral Medicine, Dental Research Institute, UCLA School of Medicine and Dentistry, University of California, Los Angeles, CA, USA
    Hum Immunol 62:320-31. 2001
  10. pmc Induction of apoptotic cell death in peripheral blood mononuclear and polymorphonuclear cells by an oral bacterium, Fusobacterium nucleatum
    A Jewett
    Department of Oral Biology and Oral Medicine, Dental Research Institute, University of California, Los Angeles, California 90095, USA
    Infect Immun 68:1893-8. 2000

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Expression of MHC Class II, CD70, CD80, CD86 and pro-inflammatory cytokines is differentially regulated in oral epithelial cells following bacterial challenge
    D C Han
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Medicine and Dentistry, Los Angeles, CA 90095, USA
    Oral Microbiol Immunol 18:350-8. 2003
    ....
  2. ncbi request reprint Natural killer cells preferentially target cancer stem cells; role of monocytes in protection against NK cell mediated lysis of cancer stem cells
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA 90095 1668, USA
    Curr Drug Deliv 9:5-16. 2012
    ..Therefore, patients with cancer may benefit from repeated allogeneic NK cell transplantation at the site of the tumor for specific elimination of cancer stem cells...
  3. pmc Strategies to rescue mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) from NK cell mediated cytotoxicity
    Anahid Jewett
    Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry and Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9874. 2010
    ....
  4. ncbi request reprint Coengagement of CD16 and CD94 receptors mediates secretion of chemokines and induces apoptotic death of naive natural killer cells
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology and Division of Oral Biology and Medicine, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 12:1994-2003. 2006
    ..Thus, we conclude that binding of antibodies to CD16 and CD94 NK cell receptors induces death of the NK cells and signals for the release of chemokines...
  5. ncbi request reprint Inhibition of nuclear factor kappa B (NFkappaB) activity in oral tumor cells prevents depletion of NK cells and increases their functional activation
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, the Jonsson Comprehensive Cancer Center, Dental Research Institute, School of Dentistry, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cancer Immunol Immunother 55:1052-63. 2006
    ..Moreover, NFkappaB-mediated increase in IL-6 secretion by oral tumors may in part be responsible for the observed inactivation and death of the immune effectors...
  6. ncbi request reprint Emerging mechanisms of immunosuppression in oral cancers
    A Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Jonsson Comprehensive Cancer Center JCCC, Department of Head and Neck Surgery, UCLA School of Dentistry and Medicine 90095 1688, USA
    J Dent Res 85:1061-73. 2006
    ..This review will focus on these emerging mechanisms of immunosuppression in oral cancers...
  7. doi request reprint Potential rescue, survival and differentiation of cancer stem cells and primary non-transformed stem cells by monocyte-induced split anergy in natural killer cells
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, University of California Los Angeles, CA 90095 1668, USA
    Cancer Immunol Immunother 61:265-74. 2012
    ..The concept of split anergy in NK cells and its contribution to cell differentiation, tissue repair and regeneration and in tumor resistance and progression will be discussed in this review...
  8. ncbi request reprint Cytokine dependent inverse regulation of CD54 (ICAM1) and major histocompatibility complex class I antigens by nuclear factor kappaB in HEp2 tumor cell line: effect on the function of natural killer cells
    Anahid Jewett
    Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA 90095, USA
    Hum Immunol 64:505-20. 2003
    ..Thus, NFkappaB regulates inversely the expression of ICAM-1 and MHC class I antigens on HEp2 tumor cells and this may contribute to the resistance of these cells to NK cell mediated cytotoxicity...
  9. ncbi request reprint Activation of c-Jun N-terminal kinase in the absence of NFkappaB function prior to induction of NK cell death triggered by a combination of anti-class I and anti-CD16 antibodies
    A Jewett
    Department of Oral Biology and Oral Medicine, Dental Research Institute, UCLA School of Medicine and Dentistry, University of California, Los Angeles, CA, USA
    Hum Immunol 62:320-31. 2001
    ..Overall, our studies suggest an important regulatory role for NFkappaB and JNK activities in MHC class I mediated NK cell death...
  10. pmc Induction of apoptotic cell death in peripheral blood mononuclear and polymorphonuclear cells by an oral bacterium, Fusobacterium nucleatum
    A Jewett
    Department of Oral Biology and Oral Medicine, Dental Research Institute, University of California, Los Angeles, California 90095, USA
    Infect Immun 68:1893-8. 2000
    ..The data also indicated that F. nucleatum-induced cell apoptosis requires activation of caspases and is protected by NF-kappaB. Possible mechanisms of F. nucleatum's role in the pathogenesis of periodontal disease are discussed...
  11. doi request reprint Rapid and potent induction of cell death and loss of NK cell cytotoxicity against oral tumors by F(ab')2 fragment of anti-CD16 antibody
    Anahid Jewett
    Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Dental Research Institute, UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Cancer Immunol Immunother 57:1053-66. 2008
    ....
  12. pmc Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells
    Han Ching Tseng
    Division of Oral Biology and Oral Medicine, School of Dentistry and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e11590. 2010
    ..Therefore, patients with cancer may benefit from repeated allogeneic NK cell transplantation for specific elimination of cancer stem cells...
  13. doi request reprint Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis
    Avina Paranjpe
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, The Jonsson Comprehensive Cancer Center JCCC, Dental Research Institute, Division of Oral Biology and Medicine, Los Angeles, CA, USA
    J Endod 34:1191-7. 2008
    ..Overall, the results reported in this article indicate that NAC is an effective chemoprotectant that can safely be used to protect the pulp and the surrounding tissues from adverse effects of dental restorative and endodontic materials...
  14. ncbi request reprint Novel strategies to enhance survival and growth of pulp cells after dental restorations
    Dipak Chaudhari
    University of California, Los Angeles School of Dentistry, 90095, USA
    J Calif Dent Assoc 40:409-17. 2012
    ..Therefore, application of NAC may protect the DPSCs from adverse effects after tooth restoration...
  15. pmc N-acetyl cysteine mediates protection from 2-hydroxyethyl methacrylate induced apoptosis via nuclear factor kappa B-dependent and independent pathways: potential involvement of JNK
    Avina Paranjpe
    Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Dental Research Institute, UCLA School of Dentistry and Medicine, University of California, Los Angeles, California 90095, USA
    Toxicol Sci 108:356-66. 2009
    ..Therefore, NAC protects oral keratinocytes from the toxic effects of HEMA through NF-kappaB dependent and independent pathways. Moreover, our data suggest the potential involvement of JNK pathway in NAC mediated protection...
  16. ncbi request reprint Potential contribution of naïve immune effectors to oral tumor resistance: role in synergistic induction of VEGF, IL-6, and IL-8 secretion
    Antonia Teruel
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, the Jonsson Comprehensive Cancer Center, Dental Research Institute, UCLA School of Dentistry, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    Cancer Immunol Immunother 57:359-66. 2008
    ..Overall, we show in this paper that naïve as well as non-viable immune effectors may contribute to the growth and resistance of oral tumors by triggering the secretion of key tumor cell growth factors...
  17. doi request reprint Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells
    Nicholas A Cacalano
    Department of Radiation Oncology, UCLA School of Dentistry and Medicine, Los Angeles, CA 90095, USA
    Apoptosis 13:1439-49. 2008
    ....
  18. ncbi request reprint Potent induction of TNF-alpha during interaction of immune effectors with oral tumors as a potential mechanism for the loss of NK cell viability and function
    Marcela Romero-Reyes
    UCLA School of Dentistry and Medicine, University of California, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, The Jonsson Comprehensive Cancer Center JCCC, Dental Research Institute, Los Angeles, CA 90095, USA
    Apoptosis 12:2063-75. 2007
    ..Strategies to neutralize TNF-alpha may be beneficial in the treatment of oral cancers...
  19. pmc N-acetylcysteine protects dental pulp stromal cells from HEMA-induced apoptosis by inducing differentiation of the cells
    Avina Paranjpe
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Dental Research Institute, Division of Oral Biology and Medicine, UCLA School of Dentistry and Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Free Radic Biol Med 43:1394-408. 2007
    ....
  20. doi request reprint The role of aggregation in Fusobacterium nucleatum- induced immune cell death
    TRI HUYNH
    Department of Preventive and Restorative Dental Sciences, Division of Endodontics, University of California, San Francisco, California, USA
    J Endod 37:1531-5. 2011
    ..nucleatum can induce significant apoptosis in peripheral blood mononuclear cells (PBMCs). In this in vitro study, we sought to determine what role this aggregation phenomenon has on the induction of apoptosis in PBMCs...
  21. doi request reprint N-acetyl cysteine (NAC)-mediated detoxification and functionalization of poly(methyl methacrylate) bone cement
    Naoki Tsukimura
    Jane and Jerry Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Biomaterials 30:3378-89. 2009
    ....
  22. pmc Fusobacterium nucleatum outer membrane proteins Fap2 and RadD induce cell death in human lymphocytes
    Christopher W Kaplan
    Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Infect Immun 78:4773-8. 2010
    ..nucleatum membranes are sufficient to induce cell death in Jurkat cells, suggesting that no active process or effector protein transfer was necessary to induce eukaryotic cell death...
  23. doi request reprint Differential effect of ionizing radiation exposure on multipotent and differentiation-restricted bone marrow mesenchymal stem cells
    Federico Mussano
    The Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry, Los Angeles, California 90095, USA
    J Cell Biochem 111:322-32. 2010
    ..In conclusion, the radiation toxicity predominantly affecting multipotent MSCs may occur at unexpectedly low doses, which may, in part, contribute to the catabolic pathology of bone tissue...
  24. ncbi request reprint Expression of apoptosis-associated genes by human dermal scar fibroblasts
    D V Messadi
    School of Dentistry, University of California Los Angeles, CA 90095 1668, USA
    Wound Repair Regen 7:511-7. 1999
    ..Compared with normal skin fibroblasts, keloid fibroblasts exhibited decreased expression of apoptosis-associated genes...
  25. pmc Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone
    Chiachien Jake Wang
    The Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, California 90095 1668, USA
    J Bone Miner Res 23:837-49. 2008
    ..Short collagen IX, the exclusive isoform expressed by osteoblasts, is synthesized through alternative transcription of the col9a1 gene. The function of short collagen IX in bone was characterized in col9a1-null mutant mice...
  26. pmc Dual functions of natural killer cells in selection and differentiation of stem cells; role in regulation of inflammation and regeneration of tissues
    Anahid Jewett
    1 The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, and Division of Oral Biology and Medicine, UCLA School of Dentistry, University of California, Los Angeles, CA 90095
    J Cancer 4:12-24. 2013
    ..The concept of split anergy in NK cells and generation of NK(reg) and its contribution to cell differentiation, tissue repair and regeneration and in tumor resistance will be discussed in this review...
  27. pmc Tumor induced inactivation of natural killer cell cytotoxic function; implication in growth, expansion and differentiation of cancer stem cells
    Anahid Jewett
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, and Division of Oral Biology and Medicine, UCLA School of Dentistry, University of California, Los Angeles, CA 90095, USA
    J Cancer 2:443-57. 2011
    ..The concept of split anergy in NK cells and its contribution to tissue repair and regeneration and in tumor resistance and progression will be discussed in this review...
  28. pmc Fusobacterium nucleatum apoptosis-inducing outer membrane protein
    C W Kaplan
    Molecular Biology Institute, Section of Periodontics, UCLA School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Dent Res 84:700-4. 2005
    ..nucleatum induction of apoptosis and, to the best of our knowledge, represent the first report of a genetically defined and phenotypically characterized mutation in F. nucleatum...
  29. doi request reprint Restored viability and function of dental pulp cells on poly-methylmethacrylate (PMMA)-based dental resin supplemented with N-acetyl cysteine (NAC)
    N Kojima
    Laboratory for Bone and Implant Sciences LBIS, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Los Angeles, CA 90095, United States
    Dent Mater 24:1686-93. 2008
    ....
  30. ncbi request reprint Resin monomer 2-hydroxyethyl methacrylate (HEMA) is a potent inducer of apoptotic cell death in human and mouse cells
    A Paranjpe
    Division of Oral Biology and Oral Medicine, UCLA School of Dentistry, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Los Angeles, CA 90095, USA
    J Dent Res 84:172-7. 2005
    ....
  31. pmc Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells
    Hiroshi Egusa
    Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Infect Immun 73:622-6. 2005
    ..albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans...