Vesna Jevtovic-Todorovic

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Neurobiol Aging 26:947-56. 2005
  2. pmc Developing brain and general anesthesia - is there a cause for concern?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System PO Box 800710, Charlottesville, VA 22908 USA
    F1000 Med Rep 2:68. 2010
  3. pmc Anesthesia-induced developmental neurodegeneration: the role of neuronal organelles
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System Charlottesville, VA, USA Neuroscience Graduate Program, University of Virginia Charlottesville, VA, USA
    Front Neurol 3:141. 2012
  4. pmc Functional implications of an early exposure to general anesthesia: are we changing the behavior of our children?
    Vesna Jevtovic-Todorovic
    Dept of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA, 22908 0710, USA
    Mol Neurobiol 48:288-93. 2013
  5. ncbi request reprint Developmental synaptogenesis and general anesthesia: a kiss of death?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, 22908, USA
    Curr Pharm Des 18:6225-31. 2012
  6. pmc Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA, USA
    Psychoneuroendocrinology 34:S178-85. 2009
  7. ncbi request reprint The role of peripheral T-type calcium channels in pain transmission
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology and Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908 0710, USA
    Cell Calcium 40:197-203. 2006
  8. ncbi request reprint Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain
    V Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Neuroscience 122:609-16. 2003
  9. ncbi request reprint General anesthetics and the developing brain: friends or foes?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Heath System, Charlottesville, Virginia 22908, USA
    J Neurosurg Anesthesiol 17:204-6. 2005
  10. ncbi request reprint Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosci 23:876-82. 2003

Research Grants

  1. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2005
  2. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2007
  3. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2006
  4. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
  5. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009

Collaborators

Detail Information

Publications49

  1. ncbi request reprint The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Neurobiol Aging 26:947-56. 2005
    ....
  2. pmc Developing brain and general anesthesia - is there a cause for concern?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System PO Box 800710, Charlottesville, VA 22908 USA
    F1000 Med Rep 2:68. 2010
    ..Since there is insufficient evidence establishing a clear association between animal and human findings, it would be premature to suggest major changes in current clinical practice...
  3. pmc Anesthesia-induced developmental neurodegeneration: the role of neuronal organelles
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System Charlottesville, VA, USA Neuroscience Graduate Program, University of Virginia Charlottesville, VA, USA
    Front Neurol 3:141. 2012
    ..This review will present evidence that neuronal organelles are critical and early targets of anesthesia-induced developmental neurotoxicity...
  4. pmc Functional implications of an early exposure to general anesthesia: are we changing the behavior of our children?
    Vesna Jevtovic-Todorovic
    Dept of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA, 22908 0710, USA
    Mol Neurobiol 48:288-93. 2013
    ..I also review limited and somewhat controversial evidence that examines the effects of nociception and surgical stimulation on anesthesia--induced developmental neurotoxicity. ..
  5. ncbi request reprint Developmental synaptogenesis and general anesthesia: a kiss of death?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, 22908, USA
    Curr Pharm Des 18:6225-31. 2012
    ..This review will summarize some of the presently available evidence regarding anesthesia-induced effects on developmental synaptogenesis and intellectual functioning...
  6. pmc Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA, USA
    Psychoneuroendocrinology 34:S178-85. 2009
    ..We believe that promising animal data warrant the exploration of their usefulness in clinical settings especially considering the fact that chronic pain sufferers are often young and otherwise healthy people...
  7. ncbi request reprint The role of peripheral T-type calcium channels in pain transmission
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology and Neuroscience Graduate Program, University of Virginia Health System, Charlottesville, VA 22908 0710, USA
    Cell Calcium 40:197-203. 2006
    ..In this article, we review past, present and future findings aimed at illuminating the role of peripheral T-type Ca2+ channels in nociception and the value of these channels as cellular targets for potential drug developments...
  8. ncbi request reprint Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain
    V Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Neuroscience 122:609-16. 2003
    ..Duration of NMDA receptor blockade appears to be an important determinant of whether neurons are reversibly injured or are driven to cell death by an NMDA antagonist drug...
  9. ncbi request reprint General anesthetics and the developing brain: friends or foes?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Heath System, Charlottesville, Virginia 22908, USA
    J Neurosurg Anesthesiol 17:204-6. 2005
  10. ncbi request reprint Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosci 23:876-82. 2003
    ....
  11. ncbi request reprint Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats
    V Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA 22908, USA
    Neuropharmacology 44:739-48. 2003
    ..In addition, the combination therapy was free from neurotoxic or behavioral side effects, and hyperactivity, a side effect associated with procyclidine monotherapy, was counteracted by clonidine...
  12. doi request reprint Anesthesia and the developing brain: are we getting closer to understanding the truth?
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Curr Opin Anaesthesiol 24:395-9. 2011
    ..We review new evidence that continues to challenge the safety of this practice...
  13. pmc Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice
    Janelle R Latham
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, USA
    Diabetes 58:2656-65. 2009
    ....
  14. ncbi request reprint Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908 0710, USA
    Pain 109:328-39. 2004
    ..Since thermal hyperalgesia is a common symptom of axonal injury, locally applied oxidizing agents could be used as a novel treatment to ameliorate neuropathic pain...
  15. ncbi request reprint New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids
    Sriyani Pathirathna
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, USA
    Pain 114:429-43. 2005
    ..Our results also reveal a role of GABA-gated ion channels in peripheral nociceptive signaling...
  16. pmc Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve
    Miljen M Jagodic
    Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908 0710, USA
    J Neurophysiol 99:3151-6. 2008
    ....
  17. ncbi request reprint Regulation of T-type calcium channels in the peripheral pain pathway
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA
    Channels (Austin) 1:238-45. 2007
    ....
  18. ncbi request reprint Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons
    Miljen M Jagodic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosci 27:3305-16. 2007
    ....
  19. pmc Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics
    Roman M Lazarenko
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908 0735, USA
    J Neurosci 30:7691-704. 2010
    ....
  20. ncbi request reprint 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA
    Mol Pharmacol 66:1223-35. 2004
    ....
  21. pmc In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy
    Richard B Messinger
    Department of Anesthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, VA 22908, USA
    Pain 145:184-95. 2009
    ..This confirms that Ca(V)3.2 T-channels, important signal amplifiers in peripheral sensory neurons, may contribute to the cellular hyperexcitability that ultimately leads to the development of painful PDN...
  22. pmc CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus
    Pavle M Joksovic
    Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908 0710, USA
    J Physiol 574:415-30. 2006
    ....
  23. ncbi request reprint Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Brain Res 951:336-40. 2002
    ..This suggests that peripherally acting T-type Ca(2+) channel blockers can be useful antinociceptive agents...
  24. ncbi request reprint The role of T-type calcium channels in peripheral and central pain processing
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA 22908 0710, USA
    CNS Neurol Disord Drug Targets 5:639-53. 2006
    ....
  25. ncbi request reprint Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats
    Sriyani Pathirathna
    Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA
    Pain 125:53-64. 2006
    ..Our findings imply that changes in the redox states of the peripheral nociceptors (favoring either reduced or oxidized forms of cysteine molecules) may function as a local intrinsic mechanism in controlling peripheral pain perception...
  26. ncbi request reprint General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain
    Lucy X Lu
    Department of Anasthesiology, University of Virginia Health System, P O Box 800710, Charlottesville, 22908, USA
    Apoptosis 11:1603-15. 2006
    ..beta-estradiol, a sex hormone that upregulates the protein levels of the activated Akt, protects against anesthesia-induced neuroapoptosis...
  27. ncbi request reprint Mechanical and thermal anti-nociception in rats after systemic administration of verapamil
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908 0710, USA
    Neurosci Lett 360:57-60. 2004
    ..Our data suggest that L-type Ca(2+) channels contribute to acute nociceptive signaling and that anti-nociceptive effects may result from the blockade of these channels...
  28. pmc Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels
    Peihan Orestes
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia
    Diabetes 62:3828-38. 2013
    ..Understanding the details of this regulatory pathway could facilitate the development of novel specific therapies for the treatment of painful PDN...
  29. pmc General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain
    Victoria Sanchez
    Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, USA
    Anesthesiology 115:992-1002. 2011
    ....
  30. pmc T-type voltage-gated calcium channels as targets for the development of novel pain therapies
    Slobodan M Todorovic
    Department of Anesthesiology and Neuroscience, University of Virginia School of Medicine, Charlottesville, 22908 0710, USA
    Br J Pharmacol 163:484-95. 2011
    ..We also discuss possible future developments aimed at selective modulation of function of these channels, which are highly expressed in nociceptors...
  31. doi request reprint Dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myelin protein expression after sciatic nerve injury in rats
    Ajit K Naik
    Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA 22980, USA
    Anesth Analg 114:674-82. 2012
    ..PMP22 expression correlates with peripheral myelin formation and nerve regeneration...
  32. pmc Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia Health System, Mail Box 800710, Charlottesville, VA 22908, U S A
    Br J Pharmacol 140:255-60. 2003
    ..Thus, peripherally applied anticonvulsants that block voltage-gated Na+ and Ca2+ channels may be useful analgesics...
  33. pmc Isoflurane impairs immature astroglia development in vitro: the role of actin cytoskeleton
    Nadia Lunardi
    Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, USA
    J Neuropathol Exp Neurol 70:281-91. 2011
    ....
  34. pmc Propofol-induced changes in neurotrophic signaling in the developing nervous system in vivo
    Jelena Popic
    Department of Neurobiology, Institute for Biological Research, University of Belgrade, Belgrade, Serbia
    PLoS ONE 7:e34396. 2012
    ..Elucidation of the underlying molecular mechanisms will improve our understanding of the age-dependent component of anesthesia-induced neurotoxicity...
  35. doi request reprint Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling
    Slobodan M Todorovic
    Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA
    Pflugers Arch 465:921-7. 2013
    ..2 channels with neuropathic pain disorders associated with mechanical peripheral nerve injury and with diabetic peripheral neuropathy. We also discuss the development of potential pain therapies aimed at these channels...
  36. pmc Clinical anesthesia causes permanent damage to the fetal guinea pig brain
    Sabina Rizzi
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Brain Pathol 18:198-210. 2008
    ..As detected early in post-natal life, this resulted in the loss of many neurons from vulnerable brain regions, demonstrating that anesthesia-induced neuroapoptosis can cause permanent brain damage...
  37. ncbi request reprint Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain
    Jun Heum Yon
    Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA 22908, USA
    Neurobiol Dis 21:522-30. 2006
    ....
  38. pmc Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain
    Sabina Rizzi
    Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, USA
    Ann N Y Acad Sci 1199:43-51. 2010
    ....
  39. pmc Early exposure to general anesthesia disturbs mitochondrial fission and fusion in the developing rat brain
    Annalisa Boscolo
    Department of Anesthesiology, University of Virginia Heath System, Charlottesville, VA, USA
    Anesthesiology 118:1086-97. 2013
    ..As mitochondria are exquisitely sensitive to anesthesia-induced damage, we examined how GA affects mitochondrial fusion/fission...
  40. pmc CaV3.2 T-Type Calcium Channels in Peripheral Sensory Neurons Are Important for Mibefradil-Induced Reversal of Hyperalgesia and Allodynia in Rats with Painful Diabetic Neuropathy
    Aleksandar Lj Obradovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, United States of America Department of Physiology, Faculty of Pharmacy University of Belgrade, Belgrade, Serbia
    PLoS ONE 9:e91467. 2014
    ..2 channels in peripheral nociceptors. Hence, peripherally acting voltage-dependent T-channel blockers could be very useful in the treatment of painful symptoms of PDN. ..
  41. doi request reprint Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy
    Slobodan M Todorovic
    Departments of Anesthesiology and Neuroscience, University of Virginia School of Medicine, Mail Box 800710, Charlottesville, VA, 22908 0710, USA
    Pflugers Arch 466:701-6. 2014
    ..Pharmacological targeting the specific pathogenic mechanism rather than the channel per se may cause fewer side effects and reduce the potential for drug abuse in patients with diabetes. ..
  42. doi request reprint PRO: Anesthesia-induced developmental neuroapoptosis: status of the evidence
    Vesna Jevtovic-Todorovic
    Anesth Analg 106:1659-63. 2008
  43. ncbi request reprint Drug-induced apoptotic neurodegeneration in the developing brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 12:488-98. 2002
    ....
  44. ncbi request reprint Chronic exposure to nitrous oxide increases [3H]MK801 binding in the cerebral cortex, but not in the hippocampus of adult mice
    Natascha Sommer
    Friedrich Alexander Universitat Erlangen Nurnberg, Germany
    Ann N Y Acad Sci 1053:301-8. 2005
    ..Immunocytochemical binding of NR1 antibodies in selected brain regions showed no changes in distribution pattern. The timing of this increase in [3H]MK801 binding correlates with the time period required for development of tolerance...
  45. pmc Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain
    Chainllie Young
    Department of Psychiatry, School of Medicine, Washington University in St Louis, Campus Box 8134, 660, South Euclid, St Louis, MO 63110, U S A
    Br J Pharmacol 146:189-97. 2005
    ..We conclude that relatively mild exposure to ketamine, midazolam or a combination of these drugs can trigger apoptotic neurodegeneration in the developing mouse brain...
  46. ncbi request reprint Anesthesia-induced developmental neuroapoptosis. Does it happen in humans?
    John W Olney
    Anesthesiology 101:273-5. 2004
  47. ncbi request reprint Do pediatric drugs cause developing neurons to commit suicide?
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Trends Pharmacol Sci 25:135-9. 2004
  48. ncbi request reprint The enigma of fetal alcohol neurotoxicity
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Med 34:109-19. 2002
    ....
  49. ncbi request reprint Recovery profiles of general anesthesia and spinal anesthesia for chemotherapeutic perfusion with circulatory block (stop-flow perfusion)
    Michele Carron
    Department of Pharmacology and Anesthesiology, University of Padova, Padova, Italy
    Anesth Analg 105:1500-3, table of contents. 2007
    ..We designed this clinical trial to compare the clinical profiles of GA and SA for stop-flow perfusion...

Research Grants6

  1. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2005
    ..In addition we propose to study the correlation between the rate of synaptogenesis (by using three different species) and the duration of anesthesia necessary to induce significant neuronal apoptosis in the developing brain. ..
  2. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2007
    ..In addition we propose to study the correlation between the rate of synaptogenesis (by using three different species) and the duration of anesthesia necessary to induce significant neuronal apoptosis in the developing brain. ..
  3. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2006
    ..In addition we propose to study the correlation between the rate of synaptogenesis (by using three different species) and the duration of anesthesia necessary to induce significant neuronal apoptosis in the developing brain. ..
  4. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    ..In addition we propose to study the correlation between the rate of synaptogenesis (by using three different species) and the duration of anesthesia necessary to induce significant neuronal apoptosis in the developing brain. ..
  5. Anesthesia-induced Developmental Neuroapoptosis
    Vesna Jevtovic Todorovic; Fiscal Year: 2009
    ..In addition we propose to study the correlation between the rate of synaptogenesis (by using three different species) and the duration of anesthesia necessary to induce significant neuronal apoptosis in the developing brain. ..